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  1. Article ; Online: Statins.

    Kulkarni, Spoorthy / Watts, Michaela M / Kostapanos, Michalis

    BMJ (Clinical research ed.)

    2024  Volume 384, Page(s) e072584

    Language English
    Publishing date 2024-01-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj-2022-072584
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Hypertension management in 2030: a kaleidoscopic view.

    Kulkarni, Spoorthy

    Journal of human hypertension

    2020  Volume 35, Issue 9, Page(s) 812–817

    Abstract: The last decade has witnessed the healthcare system going paperless with increased use of electronic healthcare records. Artificial intelligence tools including smartphones and smart watches have changed the landscape of day-to-day lives. Digitisation, ... ...

    Abstract The last decade has witnessed the healthcare system going paperless with increased use of electronic healthcare records. Artificial intelligence tools including smartphones and smart watches have changed the landscape of day-to-day lives. Digitisation, decentralisation of healthcare and empowerment of allied healthcare providers and patients themselves have made shared clinical decision-making a reality. The year 2020 quickly turned into an unprecedented time in our lives with the entry of COVID-19. Amidst a pandemic, healthcare systems rapidly adapted and transformed, and changes that otherwise would have taken a decade, took a mere few weeks (Webster, Lancet 395:1180-1, 2020). This essay reviews evidence of transformation in the realm of hypertension management, namely diagnosis, lifestyle changes, therapeutics and prevention of hypertension at both individual and population levels, and presents an extrapolation of how this transformation might shape the next decade.
    MeSH term(s) Artificial Intelligence ; COVID-19 ; Humans ; Hypertension/diagnosis ; Hypertension/drug therapy ; Pandemics ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-11-02
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 639472-3
    ISSN 1476-5527 ; 0950-9240
    ISSN (online) 1476-5527
    ISSN 0950-9240
    DOI 10.1038/s41371-020-00438-8
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  3. Article ; Online: Quo vadis (where are you going) pharmacovigilance?

    Kulkarni, Spoorthy / Rieder, Michael / Likic, Robert

    British journal of clinical pharmacology

    2022  Volume 89, Issue 2, Page(s) 428–430

    MeSH term(s) Humans ; Pharmacovigilance
    Language English
    Publishing date 2022-11-17
    Publishing country England
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 188974-6
    ISSN 1365-2125 ; 0306-5251 ; 0264-3774
    ISSN (online) 1365-2125
    ISSN 0306-5251 ; 0264-3774
    DOI 10.1111/bcp.15584
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    Zs.A 1118: Show issues Location:
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  4. Article: Hypertension management in 2030: a kaleidoscopic view

    Kulkarni, Spoorthy

    J. hum. hypertens

    Abstract: The last decade has witnessed the healthcare system going paperless with increased use of electronic healthcare records. Artificial intelligence tools including smartphones and smart watches have changed the landscape of day-to-day lives. Digitisation, ... ...

    Abstract The last decade has witnessed the healthcare system going paperless with increased use of electronic healthcare records. Artificial intelligence tools including smartphones and smart watches have changed the landscape of day-to-day lives. Digitisation, decentralisation of healthcare and empowerment of allied healthcare providers and patients themselves have made shared clinical decision-making a reality. The year 2020 quickly turned into an unprecedented time in our lives with the entry of COVID-19. Amidst a pandemic, healthcare systems rapidly adapted and transformed, and changes that otherwise would have taken a decade, took a mere few weeks (Webster, Lancet 395:1180-1, 2020). This essay reviews evidence of transformation in the realm of hypertension management, namely diagnosis, lifestyle changes, therapeutics and prevention of hypertension at both individual and population levels, and presents an extrapolation of how this transformation might shape the next decade.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #899900
    Database COVID19

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  5. Article ; Online: Renal Autotransplantation for Uncontrolled Hypertension in Nonatherosclerotic Renal Artery Stenosis-2 Case Reports and a Brief Review of the Literature.

    Goodman, James / Kulkarni, Spoorthy / Selvarajah, Viknesh / Hilliard, Nicholas / Russell, Neil / Wilkinson, Ian B

    Hypertension (Dallas, Tex. : 1979)

    2024  Volume 81, Issue 4, Page(s) 669–675

    Abstract: Fibromuscular dysplasia is the most common cause of renovascular hypertension in young adults under 40 years old. It is potentially amenable to renal artery angioplasty, which frequently normalizes blood pressure. However, limited options exist if ... ...

    Abstract Fibromuscular dysplasia is the most common cause of renovascular hypertension in young adults under 40 years old. It is potentially amenable to renal artery angioplasty, which frequently normalizes blood pressure. However, limited options exist if angioplasty is not technically possible, or restenosis occurs. Here, we describe 2 patients who presented with hypertension secondary to renal artery stenosis. In the first case, a young adult with hypertension secondary to renal artery stenosis (fibromuscular dysplasia), developed restenosis 11 weeks after an initially successful renal artery angioplasty. In the second case, a patient with neurofibromatosis type 1 was diagnosed with hypertension secondary to renal artery stenosis. Angioplasty was not possible due to multiple branch occlusions. Both individuals went on to have successful renal autotransplantations, which ultimately cured their hypertension. In this article, we review the background, indications, and blood pressure outcomes in relation to renal autotransplantation in nonatherosclerotic renal artery stenosis.
    MeSH term(s) Young Adult ; Humans ; Adult ; Renal Artery Obstruction/complications ; Renal Artery Obstruction/surgery ; Transplantation, Autologous/adverse effects ; Fibromuscular Dysplasia/complications ; Fibromuscular Dysplasia/surgery ; Angioplasty, Balloon ; Hypertension/complications ; Hypertension, Renovascular/surgery ; Hypertension, Renovascular/complications
    Language English
    Publishing date 2024-03-20
    Publishing country United States
    Document type Review ; Case Reports ; Journal Article
    ZDB-ID 423736-5
    ISSN 1524-4563 ; 0194-911X ; 0362-4323
    ISSN (online) 1524-4563
    ISSN 0194-911X ; 0362-4323
    DOI 10.1161/HYPERTENSIONAHA.123.19878
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: COVID-19 and hypertension

    Spoorthy Kulkarni / Bernadette L. Jenner / Ian Wilkinson

    Journal of the Renin-Angiotensin-Aldosterone System, Vol

    2020  Volume 21

    Keywords Medicine (General) ; R5-920 ; covid19
    Language English
    Publishing date 2020-05-01T00:00:00Z
    Publisher Hindawi - SAGE Publishing
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: COVID-19 and hypertension.

    Kulkarni, Spoorthy / Jenner, Bernadette L / Wilkinson, Ian

    Journal of the renin-angiotensin-aldosterone system : JRAAS

    2020  Volume 21, Issue 2, Page(s) 1470320320927851

    MeSH term(s) Angiotensin Receptor Antagonists/pharmacology ; Angiotensin-Converting Enzyme Inhibitors/pharmacology ; Betacoronavirus/physiology ; COVID-19 ; Coronavirus Infections/complications ; Humans ; Hypertension/complications ; Hypertension/virology ; Models, Biological ; Pandemics ; Peptidyl-Dipeptidase A/metabolism ; Pneumonia, Viral/complications ; Risk Factors ; SARS-CoV-2
    Chemical Substances Angiotensin Receptor Antagonists ; Angiotensin-Converting Enzyme Inhibitors ; Peptidyl-Dipeptidase A (EC 3.4.15.1)
    Keywords covid19
    Language English
    Publishing date 2020-05-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 2086948-4
    ISSN 1752-8976 ; 1470-3203
    ISSN (online) 1752-8976
    ISSN 1470-3203
    DOI 10.1177/1470320320927851
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    Zs.A 5668: Show issues Location:
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  8. Article: Two Cases of Severe Hypertension in JAK2 Mutation-Positive Myeloproliferative Neoplasms.

    Rao, Raunak / Kulkarni, Spoorthy / Wilkinson, Ian B

    Case reports in vascular medicine

    2020  Volume 2020, Page(s) 8887423

    Abstract: Background: Myeloproliferative neoplasms are a heterogeneous group of disorders resulting from the abnormal proliferation of one or more terminal myeloid cells-established complications include thrombosis and haemorrhagic events; however, there is ... ...

    Abstract Background: Myeloproliferative neoplasms are a heterogeneous group of disorders resulting from the abnormal proliferation of one or more terminal myeloid cells-established complications include thrombosis and haemorrhagic events; however, there is limited evidence to suggest an association with arterial hypertension. Herein, we report two independent cases of severe hypertension in JAK2 mutation-positive myeloproliferative neoplasms.
    Conclusions: These presentations highlight the utility of full blood count analysis in patients with severe hypertension. Hyperviscosity and constitutive JAK-STAT activation are amongst the proposed pathophysiology linking myeloproliferative neoplasms and hypertension. Further experimental and clinical research is necessary to identify and understand possible interactions between BP and myeloproliferative neoplasms.
    Language English
    Publishing date 2020-11-09
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2629916-1
    ISSN 2090-6994 ; 2090-6986
    ISSN (online) 2090-6994
    ISSN 2090-6986
    DOI 10.1155/2020/8887423
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  9. Article ; Online: Diagnosis and management of primary hyperaldosteronism in patients with hypertension: a practical approach endorsed by the British and Irish Hypertension Society.

    Faconti, Luca / Kulkarni, Spoorthy / Delles, Christian / Kapil, Vikas / Lewis, Philip / Glover, Mark / MacDonald, Thomas M / Wilkinson, Ian B

    Journal of human hypertension

    2023  Volume 38, Issue 1, Page(s) 8–18

    Abstract: Alongside the lack of homogeneity among international guidelines and consensus documents on primary hyperaldosteronism, the National UK guidelines on hypertension do not provide extensive recommendations regarding the diagnosis and management of this ... ...

    Abstract Alongside the lack of homogeneity among international guidelines and consensus documents on primary hyperaldosteronism, the National UK guidelines on hypertension do not provide extensive recommendations regarding the diagnosis and management of this condition. Local guidelines vary from area to area, and this is reflected in the current clinical practice in the UK. In an attempt to provide support to the clinicians involved in the screening of subjects with hypertension and clinical management of suspected cases of primary hyperaldosteronism the following document has been prepared on the behalf of the BIHS Guidelines and Information Service Standing Committee. Through remote video conferences, the authors of this document reviewed an initial draft which was then circulated among the BIHS Executive members for feedback. A survey among members of the BIHS was carried out in 2022 to assess screening strategies and clinical management of primary hyperaldosteronism in the different regions of the UK. Feedback and results of the survey were then discussed and incorporated in the final document which was approved by the panel after consensus was achieved considering critical review of existing literature and expert opinions. Grading of recommendations was not performed in light of the limited available data from properly designed randomized controlled trials.
    MeSH term(s) Humans ; Hypertension/diagnosis ; Hypertension/therapy ; Consensus ; Hyperaldosteronism/complications ; Hyperaldosteronism/diagnosis ; Hyperaldosteronism/therapy
    Language English
    Publishing date 2023-11-14
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 639472-3
    ISSN 1476-5527 ; 0950-9240
    ISSN (online) 1476-5527
    ISSN 0950-9240
    DOI 10.1038/s41371-023-00875-1
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