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  1. Article ; Online: Removal of Incidental Skin Cancer During Mohs Micrographic Surgery Indicated for a Different Primary Tumor.

    Darsha, Adrija K / Pousti, Bobak T / Loh, Tiffany Y / Hau, Jennifer T / Brian Jiang, Shang I

    Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.

    2024  Volume 50, Issue 4, Page(s) 327–330

    Abstract: Background: Mohs surgery is a tissue-sparing, microscopically controlled procedure used to treat biopsy-proven skin cancers. Because Mohs surgery allows for examination of the complete margin of each tissue layer removed, separate cancers can be treated ...

    Abstract Background: Mohs surgery is a tissue-sparing, microscopically controlled procedure used to treat biopsy-proven skin cancers. Because Mohs surgery allows for examination of the complete margin of each tissue layer removed, separate cancers can be treated concomitantly when identified. As early detection of skin cancer is beneficial for reducing morbidity, incidental tumors discovered during Mohs surgery are of significant interest.
    Objective: Our objective was to determine the prevalence and characteristics of incidental skin cancers found during Mohs surgery.
    Methods: A retrospective chart review of cases seen at University of California, San Diego, from 2014 to 2021 was performed.
    Results: Of 13,464 Mohs surgery cases, 4.53% ( n = 610) had incidental skin cancers found during removal of the initially identified tumor. Of the 610 cases, 88.4% ( n = 539) had basal cell carcinoma as the primary tumor and either squamous cell carcinoma (SCC) or SCC in situ as the incidental tumor. About 7.87% ( n = 48) had SCC as the primary tumor and basal cell carcinoma as the incidental tumor. All tumors were removed with clear margins and without significant complications.
    Conclusion: Diagnosis of incidental tumors during Mohs surgery enables early detection of skin cancer and circumvents the need for additional surgery, likely resulting in decreased morbidity and improved cost-effectiveness.
    MeSH term(s) Humans ; Mohs Surgery/methods ; Retrospective Studies ; Skin Neoplasms/diagnosis ; Skin Neoplasms/epidemiology ; Skin Neoplasms/surgery ; Carcinoma, Basal Cell/diagnosis ; Carcinoma, Basal Cell/epidemiology ; Carcinoma, Basal Cell/surgery ; Carcinoma, Squamous Cell/epidemiology ; Carcinoma, Squamous Cell/surgery ; Carcinoma, Squamous Cell/pathology
    Language English
    Publishing date 2024-01-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1227586-4
    ISSN 1524-4725 ; 1076-0512
    ISSN (online) 1524-4725
    ISSN 1076-0512
    DOI 10.1097/DSS.0000000000004081
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1212: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Novel Application of the 730 and 785 nm Picosecond Titanium Sapphire Lasers for the Treatment of Nevus of Ota.

    Loh, Tiffany Y / Wu, Douglas C

    Lasers in surgery and medicine

    2021  Volume 53, Issue 9, Page(s) 1141–1145

    Abstract: Background and objectives: Nevus of Ota is a benign dermal melanocytosis that may pose significant psychosocial distress to patients. Q-switched nanosecond lasers have traditionally been considered the first-line treatment but pain, bleeding, and ... ...

    Abstract Background and objectives: Nevus of Ota is a benign dermal melanocytosis that may pose significant psychosocial distress to patients. Q-switched nanosecond lasers have traditionally been considered the first-line treatment but pain, bleeding, and postinflammatory pigmentary alteration are common adverse effects. Picosecond devices have been increasingly used to treat nevus of Ota with promising results. We present two cases demonstrating novel applications of the 730 and 785 nm picosecond titanium sapphire lasers for the treatment of nevus of Ota in two patients with types III and IV skin.
    Study design/materials and methods: A 730 and 785 nm picosecond titanium sapphire laser with pulse durations of 250 and 300 picoseconds, respectively, were used to treat two cases of nevus of Ota. Four to seven treatment sessions were conducted at monthly intervals, and follow-up evaluation was performed 1-3 months following the final treatment session.
    Results: Both cases demonstrated greater than 75% clearance following treatment. There were no adverse events or pigmentary alteration noted as a result of picosecond titanium sapphire laser treatment.
    Conclusions: The 730 and 785 nm picosecond titanium sapphire lasers are safe and effective for the treatment of nevus of Ota. Lasers Surg. Med. 00:00-00, 2021. © 2021 Wiley Periodicals LLC.
    MeSH term(s) Aluminum Oxide ; Humans ; Lasers, Solid-State/therapeutic use ; Nevus of Ota/radiotherapy ; Nevus of Ota/surgery ; Skin Neoplasms/radiotherapy ; Skin Neoplasms/surgery ; Titanium ; Treatment Outcome
    Chemical Substances Titanium (D1JT611TNE) ; Aluminum Oxide (LMI26O6933)
    Language English
    Publishing date 2021-03-25
    Publishing country United States
    Document type Case Reports
    ZDB-ID 604493-1
    ISSN 1096-9101 ; 0196-8092
    ISSN (online) 1096-9101
    ISSN 0196-8092
    DOI 10.1002/lsm.23396
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1603: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Post-Operative Complications in Patients on Immune Checkpoint Inhibitors Undergoing Mohs Micrographic Surgery.

    Panian, Justine / Hirotsu, Kelsey E / Loh, Tiffany Y / Jiang, Shang I Brian

    Journal of cutaneous medicine and surgery

    2022  Volume 27, Issue 1, Page(s) 71–73

    MeSH term(s) Humans ; Mohs Surgery/adverse effects ; Immune Checkpoint Inhibitors ; Postoperative Complications/etiology ; Skin Neoplasms/surgery ; Skin Neoplasms/etiology
    Chemical Substances Immune Checkpoint Inhibitors
    Language English
    Publishing date 2022-11-21
    Publishing country United States
    Document type Letter
    ZDB-ID 1361720-5
    ISSN 1615-7109 ; 1203-4754
    ISSN (online) 1615-7109
    ISSN 1203-4754
    DOI 10.1177/12034754221139275
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4987: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: COVID-19 and its effect on medical student education in dermatology.

    Loh, Tiffany Y / Hsiao, Jennifer L / Shi, Vivian Y

    Journal of the American Academy of Dermatology

    2020  Volume 83, Issue 2, Page(s) e163–e164

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Dermatology ; Humans ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2 ; Students, Medical
    Keywords covid19
    Language English
    Publishing date 2020-05-12
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 603641-7
    ISSN 1097-6787 ; 0190-9622
    ISSN (online) 1097-6787
    ISSN 0190-9622
    DOI 10.1016/j.jaad.2020.05.026
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1540: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Coalescing plaques on the face, trunk, and upper extremities.

    Myrdal, Caitlyn N / Mesgarzadeh, Sheyda / Loh, Tiffany Y / Culpepper, Keliegh S / Curiel-Lewandrowski, Clara

    JAAD case reports

    2021  Volume 16, Page(s) 158–160

    Language English
    Publishing date 2021-08-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2834220-3
    ISSN 2352-5126
    ISSN 2352-5126
    DOI 10.1016/j.jdcr.2021.06.034
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Therapeutic Potential of Lebrikizumab in the Treatment of Atopic Dermatitis.

    Loh, Tiffany Y / Hsiao, Jennifer L / Shi, Vivian Y

    Journal of asthma and allergy

    2020  Volume 13, Page(s) 109–114

    Abstract: Background: Atopic dermatitis (AD) is a chronic, relapsing skin condition with a wide disease spectrum. Moderate-to-severe cases often need systemic treatment. Conventional immunosuppressants have extensive side effect profiles and require close ... ...

    Abstract Background: Atopic dermatitis (AD) is a chronic, relapsing skin condition with a wide disease spectrum. Moderate-to-severe cases often need systemic treatment. Conventional immunosuppressants have extensive side effect profiles and require close monitoring. In recent decades, there has been increasing interest in developing targeted systemic immunomodulators for AD, as they have been shown to have efficacy for AD as well as favorable safety profiles. Herein, we review the recent data on lebrikizumab, an interleukin (IL)-13 inhibitor, and its potential role in the treatment of AD.
    Objective: Review the mechanism of action, and available data on the efficacy and safety of lebrikizumab for the treatment of AD.
    Methods: PubMed, Google Scholar, and clinicaltrials.gov searches were performed with the following terms: "atopic dermatitis," "dermatitis," "eczema," "lebrikizumab," "IL-4," and "IL-13."
    Results: Two Phase II randomized controlled clinical trials have been conducted to evaluate the use of lebrikizumab in a total of 289 patients with moderate-severe AD and inadequate response to topical corticosteroids. Patients treated with lebrikizumab experienced significantly more improvement in their AD compared to placebo, as measured by Eczema Area and Severity Index (EASI)-50 and EASI-75 scores, pruritus scores, and reduction in body surface area (BSA). Its clinical efficacy appears to be dose-dependent, and it has a favorable side effect profile and is generally well tolerated.
    Conclusion: Lebrikizumab appears to be a promising emerging targeted biologic for the treatment of moderate-to-severe AD. Further Phase III studies investigating optimal dosing regimens and safety profile are needed.
    Language English
    Publishing date 2020-02-11
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 2494877-9
    ISSN 1178-6965
    ISSN 1178-6965
    DOI 10.2147/JAA.S211032
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  7. Article ; Online: COVID-19 and its effect on medical student education in dermatology

    Loh, Tiffany Y. / Hsiao, Jennifer L. / Shi, Vivian Y.

    Journal of the American Academy of Dermatology

    2020  Volume 83, Issue 2, Page(s) e163–e164

    Keywords Dermatology ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 603641-7
    ISSN 1097-6787 ; 0190-9622
    ISSN (online) 1097-6787
    ISSN 0190-9622
    DOI 10.1016/j.jaad.2020.05.026
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1540: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: An unusual presentation of seborrheic keratoses in a man with hereditary hemochromatosis.

    Loh, Tiffany Y / Cohen, Philip R

    Dermatology online journal

    2017  Volume 23, Issue 4

    Abstract: Hereditary hemochromatosis is an autosomal recessive disorder that disturbs iron metabolism and results in iron deposition throughout the body. Iron accumulation in various organs may cause a wide range of systemic symptoms and cutaneous manifestations ... ...

    Abstract Hereditary hemochromatosis is an autosomal recessive disorder that disturbs iron metabolism and results in iron deposition throughout the body. Iron accumulation in various organs may cause a wide range of systemic symptoms and cutaneous manifestations of the disease are particularly striking. Classically, hereditary hemochromatosis has been termed "bronze diabetes." Although diffuse hyperpigmentation is a well-described feature of this disease, other cutaneous symptoms may also occur, and a variety of anomalies may be observed. We present a case of long-standing hereditary hemochromatosis associated with hypopigmented plaques, which were found to be seborrheic keratoses on histologic examination. The cutaneous findings in hereditary hemochromatosis are summarized and an unusual case of seborrheic keratosis manifesting as hypopigmented plaques in a man with hereditary hemochromatosis is described. PubMed was used to search the following terms: hemochromatosis, hereditary, hyperpigmentation, hypopigmentation, keratosis, melanin, seborrheic, siderosis. Despite the generalized hyperpigmentation that is usually observed in hereditary hemochromatosis, seborrheic keratosis may present rarely as hypopigmented lesions in individuals affected by this disease. Therefore, seborrheic keratoses should be considered in the differential diagnosis in hemochromatosis patients who present with uncharacteristic pigmentation.
    Language English
    Publishing date 2017-04-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2026239-5
    ISSN 1087-2108 ; 1087-2108
    ISSN (online) 1087-2108
    ISSN 1087-2108
    Database MEDical Literature Analysis and Retrieval System OnLINE

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