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Article ; Online: Drug-induced liver injury due to tofacitinib: a case report.

Mardani, Masoud / Mohammadshahi, Jafar / Abolghasemi, Sara / Teimourpour, Roghayeh

2023 Volume 17, Issue 1, Page(s) 97

Abstract: Background: Drug-induced liver injury is an acute or chronic liver damage in response to drugs, herbals, and any chemical compound.: Case presentation: In the present work, liver failure following the use of tofacitinib was reported. The patient was ... ...

Abstract	Background: Drug-induced liver injury is an acute or chronic liver damage in response to drugs, herbals, and any chemical compound. Case presentation: In the present work, liver failure following the use of tofacitinib was reported. The patient was an 18-year-old iranian woman without any history of underlying disease. She complained of alopecia areata, and tofacitinib was administered for disease management. Following adherence to tofacitinib medication, partial recovery was obtained. At the time of hospitalization, the patient had a stable condition and only anorexia, jaundice, and elevation of liver enzymes were reported. During hospitalization, liver injury progressed and liver transplantation was suggested. After drug-induced liver injury diagnosis, the use of the drug was discontinued and the patient underwent supportive treatment. The patient recovered without any severe sequelae. Conclusions: Tofacitinib is a Janus kinase inhibitor that is useful in the treatment of disorders such as rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis. Until now, the severe side effect of this drug has not been reported and in most cases it is used as a last resort, but here we report a rare side effect of this drug.
MeSH term(s)	Female ; Humans ; Adolescent ; Protein Kinase Inhibitors/adverse effects ; Iran ; Alopecia Areata ; Chemical and Drug Induced Liver Injury/etiology ; Pyrroles/adverse effects
Chemical Substances	tofacitinib (87LA6FU830) ; Protein Kinase Inhibitors ; Pyrroles
Language	English
Publishing date	2023-03-18
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	2269805-X
ISSN	1752-1947 ; 1752-1947
ISSN (online)	1752-1947
ISSN	1752-1947
DOI	10.1186/s13256-023-03821-4
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Article ; Online: Immunogenicity and safety of a quadrivalent recombinant influenza vaccine manufactured in Iran (FluGuard) in volunteers aged 18-60 years: A double-blind, non-inferiority, randomized controlled trial.

Yadegarynia, Davood / Keyvanfar, Amirreza / Keyvani, Hossein / Tehrani, Shabnam / Sali, Shahnaz / Abolghasemi, Sara

Vaccine

2024 Volume 42, Issue 9, Page(s) 2254–2259

Abstract: Background: This study aimed to evaluate the non-inferiority of the FluGuard (a quadrivalent recombinant vaccine manufactured by Nivad Pharmed Salamat Company in Iran) by comparing its immunogenicity and safety with Vaxigrip Tetra (a quadrivalent ... ...

Abstract	Background: This study aimed to evaluate the non-inferiority of the FluGuard (a quadrivalent recombinant vaccine manufactured by Nivad Pharmed Salamat Company in Iran) by comparing its immunogenicity and safety with Vaxigrip Tetra (a quadrivalent inactivated vaccine manufactured by Sanofi Pasteur in France). Materials and methods: In this double-blind, randomized controlled trial, eligible volunteers aged 18-60 were randomized to receive either FluGuard or Vaxigrip Tetra vaccines. Immunogenicity was evaluated using the Hemagglutination Inhibition (HAI) assay and reported with the geometric mean titer (GMT), seroprotection, and seroconversion. In addition, vaccine safety was assessed by interviewing participants through phone calls. Results: Out of 110 randomized volunteers, 51 and 53 were entered into the final analysis in the Vaxigrip and FluGuard groups, respectively. Vaxigrip had a higher seroprotection rate for the H1N1 strain compared with FluGuard (98 % vs. 91 %). Besides, FluGuard had higher seroprotection rates for H3N2 (74 % vs. 69 %), B-Yamagata (87 % vs. 84 %), and B-Victoria (66 % vs. 41 %) strains compared with Vaxigrip. In all four strains, FluGuard was non-inferior to Vaxigrip with the upper bounds of the 95 % CI on the ratio of the GMTs < 1.5: H1N1 (1.25), H3N2 (0.94), B-Yamagata (0.62), and B-Victoria (0.59). Furthermore, FluGuard was non-inferior to Vaxigrip with the upper bounds of the 95 % CI on the difference between the seroconversion rates < 10 %: H1N1 (2 %), H3N2 (10 %), B-Yamagata (-10 %), and B-Victoria (-29 %). The prevalence of solicited adverse drug reactions did not differ between groups. Furthermore, participants did not experience serious adverse events. Conclusion: Our findings support the non-inferiority of the FluGuard vaccine to the Vaxigrip vaccine regarding immunogenicity and safety. Clinical trial registry: The study protocol was approved by the Iranian Registry of Clinical Trials (IRCT20210901052358N5).
MeSH term(s)	Humans ; Antibodies, Viral ; Double-Blind Method ; Hemagglutination Inhibition Tests ; HIV Seropositivity ; Immunogenicity, Vaccine ; Influenza A Virus, H1N1 Subtype ; Influenza A Virus, H3N2 Subtype ; Influenza Vaccines/adverse effects ; Influenza, Human/prevention & control ; Iran ; Vaccines, Combined ; Vaccines, Inactivated ; Volunteers ; Adolescent ; Young Adult ; Adult ; Middle Aged
Chemical Substances	Antibodies, Viral ; Influenza Vaccines ; Vaccines, Combined ; Vaccines, Inactivated
Language	English
Publishing date	2024-02-29
Publishing country	Netherlands
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	605674-x
ISSN	1873-2518 ; 0264-410X
ISSN (online)	1873-2518
ISSN	0264-410X
DOI	10.1016/j.vaccine.2024.02.073
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Article ; Online: Comparing Efficacy and Safety of Piperacillin/tazobactam and Amoxicillin/clavulanic acid in the Treatment of Complicated Urinary Tract Infections

Sara Abolghasemi / Mehrandokht Mardani / Shahnaz Sali / Iman Ghasemzadeh

Novelty in Biomedicine, Vol 10, Iss 3, Pp 159-

2022 Volume 166

Abstract: Background: There has been an increasing concern regarding high morbidity and mortality rate among patients with severe and complicated urinary tract infections (UTIs) and their related complications. Hence, there is a great demand for choosing the best ... ...

Abstract	Background: There has been an increasing concern regarding high morbidity and mortality rate among patients with severe and complicated urinary tract infections (UTIs) and their related complications. Hence, there is a great demand for choosing the best treatment protocol. In the study, we evaluated and compared the efficacy of piperacillin/tazobactam and amoxicillin/clavulanic acid for treating complicated urinary tract infections. Materials and Methods: This study enrolled 42 patients suffering from UTIs referred to Labbafinezhad hospital, Tehran, Iran. Subjects were randomly assigned to receive intravenous piperacillin/tazobactam or intravenous amoxicillin/clavulanic acid. Clinical manifestations, vital signs, laboratory parameters, and drug side effects within three days of completing the treatment protocols were evaluated and compared between the two groups. Data analysis was performed using SPSS version 16.0. A P-value of less than 0.05 was considered significant. Results: There was no significant difference in the frequency of pyuria and hematuria between the two groups before and after the intervention. The frequency of positive urine cultures for extended-spectrum beta-lactamase bacteria, Escherichia coli, was also similar between patient groups before intervention. However, a statistically significant difference in the rate of positive urine cultures for Klebsiella was found between the two groups. There was no significant difference between the two groups in terms of clinical signs and symptoms, including fever, dysuria, frequency, pain intensity, supra-pubic pain, or nausea and vomiting before the intervention, as well as within 72 hours after treatment. The vital signs were also similar between these two groups. No drug side effect was found among patients. Conclusion: Blocking the function of orexin-A in the lactating rats decreased the expression of lipogenic mammary enzymes and serum insulin. Conclusion: Using piperacillin/tazobactam or intravenous amoxicillin/clavulanic acid was effective and ...
Keywords	urinary tract infection ; antibiotic ; efficacy ; safety ; Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2022-08-01T00:00:00Z
Publisher	Shahid Beheshti University of Medical Sciences
Document type	Article ; Online
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Article: Assessment of Effectiveness and Adverse Effect of New Combination Chemotherapy (irinotecan, cisplatin, and dexamethasone) in Relapse and Refractory Hodgkin Lymphoma.

Tabarraee, Mahdi / Rezaee, Atefeh / Abolghasemi, Sara / Ghadiany, Mojtaba / Tavakoli Ardakani, Maria / Mahdizadeh, Mahshid / Hamidi, Neda / Ghasemi, Katayoon

International journal of hematology-oncology and stem cell research

2023 Volume 17, Issue 3, Page(s) 194–199

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2023-10-02
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2652853-8
ISSN	2008-2207 ; 2008-3009
ISSN (online)	2008-2207
ISSN	2008-3009
DOI	10.18502/ijhoscr.v17i3.13309
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Article ; Online: Anti-tuberculosis Induced Stevens-Johnson Syndrome Due to Misdiagnosis of Mycobacterium Abscessus Urinary Tract Infection as Tuberculosis.

Abolghasemi, Sara / Sali, Shahnaz / Mobasher Aghdam, Arad / Shahrbaf, Mohammad Amin

Iranian journal of kidney diseases

2021 Volume 15, Issue 3, Page(s) 235–237

Abstract: Mycobacterium abscessus complex is one of the most important groups of non-tuberculosis mycobacteria, which can cause infection in several organs of the human body. In this study, we report a rare cause of urinary tract infection which was presented with ...

Abstract	Mycobacterium abscessus complex is one of the most important groups of non-tuberculosis mycobacteria, which can cause infection in several organs of the human body. In this study, we report a rare cause of urinary tract infection which was presented with the chief complaint of hematuria and dysuria. The patient was treated by a clarithromycin based approach and the result of the culture and polymerase chain reaction were negative after 3 months of treatment. Informed consent was taken from the patient for publishing the case.
MeSH term(s)	Anti-Bacterial Agents/therapeutic use ; Clarithromycin ; Diagnostic Errors ; Humans ; Mycobacterium abscessus ; Stevens-Johnson Syndrome/drug therapy ; Tuberculosis/drug therapy ; Urinary Tract Infections/diagnosis ; Urinary Tract Infections/drug therapy
Chemical Substances	Anti-Bacterial Agents ; Clarithromycin (H1250JIK0A)
Language	English
Publishing date	2021-05-12
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2388271-2
ISSN	1735-8604 ; 1735-8582
ISSN (online)	1735-8604
ISSN	1735-8582
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Article ; Online: Impact of an antimicrobial stewardship program in the antimicrobial-resistant and prevalence of clostridioides difficile infection and amount of antimicrobial consumed in cancer patients.

Mardani, Masoud / Abolghasemi, Sara / Shabani, Shiva

BMC research notes

2020 Volume 13, Issue 1, Page(s) 246

Abstract: Objective: The The impact of a hospital antimicrobial stewardship was determined on antimicrobial-resistant, Clostridioides difficile rates and the amount of antimicrobial consumed in cancer patients.The intervention effects of antimicrobial stewardship ...

Abstract	Objective: The The impact of a hospital antimicrobial stewardship was determined on antimicrobial-resistant, Clostridioides difficile rates and the amount of antimicrobial consumed in cancer patients.The intervention effects of antimicrobial stewardship (ASP) plans in 2017-2018 and 2018-2019 were respectively evaluated among hematology/oncology and bone marrow transplant patients in Ayatollah Taleghani University Hospital, Tehran, Iran. In this interventional quasi-experimental study, the ASP repository was utilized to capture four survey questions encompassed in these immunocompromised patients: amount of antibiotics (meropenem and vancomycin) consumption gr-year, the number of positive Clostridioides difficile infection and multidrug-resistant positive cases in blood cultures. Results: The number of MDR cases in the periods of 2017-2018 and 2018-2019 were 145 and 75, respectively (p = 0.011). A significant reduction in all positive blood cultures from 2017-2018 to 2018-2019 was found (p = 0.001). 574 patients admitted to our hospital in these periods of 2017- 2018 and 2018- 2019were assessed for MPM and VMN use. The amounts of MPM prescriptions in 2018-2019 was significantly decreased from 22464 to 17262 g (p = 0.043). The significant reduction in antibiotic consumption, MDR organisms, and CDI can highly promote patients' health and decreasing medical costs and long-term defects for patients.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Anti-Bacterial Agents/administration & dosage ; Antimicrobial Stewardship/statistics & numerical data ; Clostridium Infections/drug therapy ; Clostridium Infections/epidemiology ; Comorbidity ; Drug Resistance, Bacterial ; Female ; Humans ; Immunocompromised Host ; Iran/epidemiology ; Male ; Meropenem/administration & dosage ; Middle Aged ; Neoplasms/epidemiology ; Neoplasms/therapy ; Prevalence ; Program Evaluation ; Vancomycin/administration & dosage ; Young Adult
Chemical Substances	Anti-Bacterial Agents ; Vancomycin (6Q205EH1VU) ; Meropenem (FV9J3JU8B1)
Language	English
Publishing date	2020-05-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2413336-X
ISSN	1756-0500 ; 1756-0500
ISSN (online)	1756-0500
ISSN	1756-0500
DOI	10.1186/s13104-020-05085-3
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Article: A Survey of Genotype and Resistance Patterns of Ventilator-Associated Pneumonia Organisms in ICU Patients.

Tehrani, Shabnam / Saffarfar, Vida / Hashemi, Ali / Abolghasemi, Sara

Tanaffos

2020 Volume 18, Issue 3, Page(s) 215–222

Abstract: Background: Ventilator-Associated Pneumonia (VAP) occurs in hospitalized patients who have undergone intubation and mechanical ventilation for more than 48 hours. Patients referred to the Intensive Care Unit (ICU) are also affected by VAP due to ... ...

Abstract	Background: Ventilator-Associated Pneumonia (VAP) occurs in hospitalized patients who have undergone intubation and mechanical ventilation for more than 48 hours. Patients referred to the Intensive Care Unit (ICU) are also affected by VAP due to specific conditions, especially by Gram-negative pathogens with advanced drug resistance. In this study, the pattern of antibiotic resistance of gram negative bacteria isolated from tracheal culture of VAP patients was investigated in ICU. Materials and methods: In this cross-sectional study, tracheal samples were collected from VAP patients admitted in the hospital's ICU from March 2017-February 2018. After isolation, bacterial isolates were identified using biochemical tests. Then, antimicrobial resistance pattern of these isolates was investigated using standard disc diffusion and E-test methods. Multiplex PCR were used to detect the Results: A total of 29 bacterial isolates were isolated from ICU patients, which were Conclusion: According to the present study, high resistance to most antibiotics in gram negative bacilli showed that antibiotic therapy should be based on the type of bacteria isolated by tracheal culture and, as far as possible, combination therapies should be used to maximize the coverage of other possible pathogens, and antibiotic resistance in ICU.
Language	English
Publishing date	2020-04-29
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2233372-1
ISSN	1735-0344
ISSN	1735-0344
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Article ; Online: Etiology and Clinical Features of Epididymo-orchitis: A Single-center Study in Tehran, Iran.

Abolghasemi, Sara / Alizadeh, Mohammad / Hashemi, Ali / Tehrani, Shabnam

Infectious disorders drug targets

2020 Volume 21, Issue 1, Page(s) 142–145

Abstract: CDATA[Introduction: Epididymo-orchitis is a common urological disease among men. Little is known about the clinical and epidemiological aspects of the disease in Iran. Thus, the present study was aimed at investigating the etiology, clinical sequelae and ...

Abstract	CDATA[Introduction: Epididymo-orchitis is a common urological disease among men. Little is known about the clinical and epidemiological aspects of the disease in Iran. Thus, the present study was aimed at investigating the etiology, clinical sequelae and risk factors of patients with epididymo- orchitis in Tehran, Iran. Methods: Patients presenting with epididymo-orchitis were prospectively analyzed in order to study the etiology and pattern of the disease. Bacteriological, molecular and serological tests were undertaken to look for Chlamydia trachomatis, Neisseria gonorrhoeae, Brucella spp., Mycoplasma spp, and other bacteria. Results: Fifty patients with epididymo-orchitis were evaluated according to their clinical symptoms, duration of symptoms, physical examination, and laboratory studies. The mean age of the patients was 53 years. Fever, dysuria, pain in the flanks, urinary frequency and discharges occurred in 58.0%, 50.0%, 50.0%, 28.0% and 6.0%, respectively. Bacterial pathogen was identified in 26% (13/50) of patients by urine culture. Escherichia coli was the etiological agent in 11/13 patients (84.6%). Two out of 50 patients (4.0%) were also positive for Chlamydia trachomatis. Two samples were serologically positive for Brucella spp. High Mean age, fever, urinary frequency, history of the underlying disease and history of urinary tract infections were found to have a significant association with the positive bacteriologic urine culture (P<0.05). Conclusions: The most common clinical manifestations were fever, dysuria, and abdominal pain. E. coli and C. trachomatis were the major causative agents. The use of a set of diagnostic approaches including clinical symptoms, urine culture and more precise techniques such as PCR should be taken into consideration for the definitive diagnosis.
Language	English
Publishing date	2020-02-18
Publishing country	United Arab Emirates
Document type	Journal Article
ZDB-ID	2234298-9
ISSN	2212-3989 ; 1871-5265
ISSN (online)	2212-3989
ISSN	1871-5265
DOI	10.2174/1871526520666200218115400
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Article ; Online: Levofloxacin Versus Ceftriaxone for the Treatment of Acute Pyelonephritis in Iranian Adults.

Tehrani, Shabnam / Elyasi, Fereshteh / Abolghasemi, Sara

Infectious disorders drug targets

2020 Volume 21, Issue 4, Page(s) 603–607

Abstract: Introduction: Acute pyelonephritis is among the most common bacterial infections. Options for initial treatment of pyelonephritis include an extended-spectrum cephalosporin or a fluoroquinolone. This study aimed to compare the clinical outcomes of ... ...

Abstract	Introduction: Acute pyelonephritis is among the most common bacterial infections. Options for initial treatment of pyelonephritis include an extended-spectrum cephalosporin or a fluoroquinolone. This study aimed to compare the clinical outcomes of patients receiving ceftriaxone to those who received levofloxacin for the treatment of acute pyelonephritis. Methods: In this randomized, open-label trial, hospitalized adults with acute pyelonephritis were treated with ceftriaxone (1g IV every 12 hours) or levofloxacin (750 mg IV daily) for at least 7 days. Clinical and microbiological characteristics were compared among patients treated with ceftriaxone and levofloxacin. Results: A total of 59 patients were randomized, 30 to the ceftriaxone group and 29 to the levofloxacin group. The clinical response was that 68.0% of patients in the ceftriaxone group and 56.0% of patients in the levofloxacin group were cured. The microbiological response, i.e. pathogen eradication rates was 68.7% in the ceftriaxone group and 21.4% in the levofloxacin group. (P value=0.00028) Escherichia coli was the most common pathogen (n = 31), followed by Klebsiella pneumoniae (n = 21). High resistance rates were detected for cotrimoxazole (55%), ciprofloxacin (48%), and ceftriaxone (34.4%) in isolated E.coli. Likewise, all K. pneumoniae isolates were resistant to ciprofloxacin. Conclusion: This study indicates that ceftriaxone was more effective than levofloxacin in the treatment of acute pyelonephritis, on the basis of microbiological response, but there were no statistically significant differences between the treatment groups in the rates of clinical cure. The resistance of uropathogens to the most used antibiotics was relatively high. Choosing the treatment regimen based on susceptibility testing results and shortening the duration of the therapy are now recommended to be the most important approaches to decrease the spread of antibiotic resistance worldwide.
MeSH term(s)	Adult ; Anti-Bacterial Agents/therapeutic use ; Ceftriaxone/therapeutic use ; Humans ; Iran ; Levofloxacin/therapeutic use ; Pyelonephritis/drug therapy ; Urinary Tract Infections/drug therapy
Chemical Substances	Anti-Bacterial Agents ; Levofloxacin (6GNT3Y5LMF) ; Ceftriaxone (75J73V1629)
Language	English
Publishing date	2020-07-28
Publishing country	United Arab Emirates
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	2234298-9
ISSN	2212-3989 ; 1871-5265
ISSN (online)	2212-3989
ISSN	1871-5265
DOI	10.2174/1871526520999200727154214
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Article: Fatal invasive pulmonary aspergillosis in an immunocompetent patient with COVID-19 due to

Abolghasemi, Sara / Hakamifard, Atousa / Sharifynia, Somayeh / Pourabdollah Toutkaboni, Mihan / Azhdari Tehrani, Hamed

Clinical case reports

2021 Volume 9, Issue 4, Page(s) 2414–2418

Abstract: Case reports of CAPA emerged. In most of the reports, the predominant species ... ...

Abstract	Case reports of CAPA emerged. In most of the reports, the predominant species is
Language	English
Publishing date	2021-03-16
Publishing country	England
Document type	Case Reports
ZDB-ID	2740234-4
ISSN	2050-0904
ISSN	2050-0904
DOI	10.1002/ccr3.4051
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