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  1. Article: COVID-19 and medical professionals: lessons for agriculture.

    Wolf, Steven A

    Agriculture and human values

    2020  Volume 37, Issue 3, Page(s) 567–568

    Keywords covid19
    Language English
    Publishing date 2020-05-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 743547-2
    ISSN 1572-8366 ; 0889-048X
    ISSN (online) 1572-8366
    ISSN 0889-048X
    DOI 10.1007/s10460-020-10103-y
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  3. Article ; Online: Differential effect of heteronymous feedback from femoral nerve and quadriceps muscle stimulation onto soleus H-reflex.

    Cuadra, Cristian / Wolf, Steven L / Lyle, Mark A

    PloS one

    2023  Volume 18, Issue 8, Page(s) e0290078

    Abstract: Excitatory feedback from muscle spindles, and inhibitory feedback from Golgi tendon organs and recurrent inhibitory circuits are widely distributed within the spinal cord to modulate activity between human lower limb muscles. Heteronymous feedback is ... ...

    Abstract Excitatory feedback from muscle spindles, and inhibitory feedback from Golgi tendon organs and recurrent inhibitory circuits are widely distributed within the spinal cord to modulate activity between human lower limb muscles. Heteronymous feedback is most commonly studied in humans by stimulating peripheral nerves, but the unique effect of non-spindle heteronymous feedback is difficult to determine due to the lower threshold of excitatory spindle axons. A few studies suggest stimulation of the muscle belly preferentially elicits non-spindle heteronymous feedback. However, there remains a lack of consensus on the differential effect of nerve and muscle stimulation onto the H-reflex, and the relation of the heteronymous effects onto H-reflex compared to that onto ongoing EMG has not been determined. In this cross-sectional study, we compared excitatory and inhibitory effects from femoral nerve and quadriceps muscle belly stimulation onto soleus H-reflex size in 15 able-bodied participants and in a subset also compared heteronymous effects onto ongoing soleus EMG at 10% and 20% max. Femoral nerve stimulation elicited greater excitation of the H-reflex compared to quadriceps stimulation. The differential effect was also observed onto ongoing soleus EMG at 20% max but not 10%. Femoral nerve and quadriceps stimulation elicited similar inhibition of the soleus H-reflexes, and these results were better associated with soleus EMG at 20%. The results support surface quadriceps muscles stimulation as a method to preferentially study heteronymous inhibition at least in healthy adults. The primary benefit of using muscle stimulation is expected to be in persons with abnormal, prolonged heteronymous excitation. These data further suggest heteronymous feedback should be evaluated with H-reflex or onto ongoing EMG of at least 20% max to identify group differences or modulation of heteronymous feedback in response to treatment or task.
    MeSH term(s) Adult ; Humans ; H-Reflex/physiology ; Quadriceps Muscle ; Femoral Nerve/physiology ; Feedback ; Cross-Sectional Studies ; Muscle, Skeletal/physiology ; Electric Stimulation ; Electromyography
    Language English
    Publishing date 2023-08-14
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0290078
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  4. Article ; Online: COVID-19 and medical professionals

    Wolf, Steven A.

    Agriculture and Human Values

    lessons for agriculture

    2020  Volume 37, Issue 3, Page(s) 567–568

    Keywords Agronomy and Crop Science ; covid19
    Language English
    Publisher Springer Science and Business Media LLC
    Publishing country us
    Document type Article ; Online
    ZDB-ID 743547-2
    ISSN 1572-8366 ; 0889-048X
    ISSN (online) 1572-8366
    ISSN 0889-048X
    DOI 10.1007/s10460-020-10103-y
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    In stock of ZB MED Bonn / Germany

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  5. Book ; Online: Energiewende und Megatrends : Wechselwirkungen von globaler Gesellschaftsentwicklung und Nachhaltigkeit (Edition 1)

    Janik, Julia / Wolf, Matthias / Engler, Steven

    2020  

    Keywords Development economics & emerging economies ; Business & Economics ; Development ; Sustainable Development
    Size 1 Online-Ressource
    Publisher transcript Verlag
    Document type Book ; Online
    Note German ; Open Access
    HBZ-ID HT021031140
    ISBN 9783839450710 ; 3839450713
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  6. Article ; Online: THE RISKS OF FIRST ONSET PRIMARY HYPERTENSION DIAGNOSIS IN THERMAL-INJURED PATIENTS.

    Efejuku, Tsola A / Wolf, Steven E / Song, Juquan / Golovko, Georgiy / El Ayadi, Amina

    Shock (Augusta, Ga.)

    2024  Volume 61, Issue 4, Page(s) 541–548

    Abstract: Abstract: Introduction: Hypertension is a prevalent condition in the United States and leads to an increased risk of developing various comorbidities. However, the impact of new-onset hypertension after severe burns on patient outcomes is not known. We ... ...

    Abstract Abstract: Introduction: Hypertension is a prevalent condition in the United States and leads to an increased risk of developing various comorbidities. However, the impact of new-onset hypertension after severe burns on patient outcomes is not known. We posit that hypertension onset after severe burn is associated with increased risk of developing comorbidities and mortality. Methods: Using the TriNetX database, burned patients diagnosed with essential hypertension after injury were compared with those who did not develop hypertension; neither had prior hypertension. Each cohort was grouped by sex, percent total body surface area (TBSA) burned, and age, then propensity matched for sex, race, ethnicity, and laboratory values. Outcomes assessed were acute kidney injury (AKI), hyperglycemia, heart failure, myocardial infarction (MI), and death. Results: Those diagnosed with hypertension after severe burn were 4.9 times more likely to develop AKI, 3.6 times for hyperglycemia, 5.3 times for heart failure, 4.7 times for acute MI, and 1.5 times for mortality. Sex analysis shows that men were at greater risk for AKI (1.5 times), heart failure (1.1 times), and death (1.4 times). Women were 1.3 times more likely to develop hyperglycemia. Percent TBSA burned grouping showed increased risk for all outcomes with increasing severity. Age grouping indicated an elevated risk of developing AKI, heart failure, acute MI, and death. Conclusion: New-onset hypertension diagnosis in severely burned patients is associated with acute kidney injury, heart failure, acute MI, and death. Overall, males, older patients, and those with a higher % TBSA burned are at a higher risk of developing these comorbidities.
    MeSH term(s) Female ; Humans ; Male ; Acute Kidney Injury/diagnosis ; Acute Kidney Injury/etiology ; Burns ; Essential Hypertension/complications ; Heart Failure ; Hyperglycemia/complications ; Hypertension/complications
    Language English
    Publishing date 2024-01-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1185432-7
    ISSN 1540-0514 ; 1073-2322
    ISSN (online) 1540-0514
    ISSN 1073-2322
    DOI 10.1097/SHK.0000000000002310
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    Zs.A 3985: Show issues Location:
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  7. Article ; Online: Skeletal muscle transcriptome is affected by age in severely burned mice.

    Song, Juquan / Widen, Steven G / Wolf, Steven E / El Ayadi, Amina

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 21584

    Abstract: Severe burn results in muscle wasting affecting quality of life in both children and adults. Biologic metabolic profiles are noticeably distinctive in childhood. We posit that muscle gene expression profiles are differentially regulated in response to ... ...

    Abstract Severe burn results in muscle wasting affecting quality of life in both children and adults. Biologic metabolic profiles are noticeably distinctive in childhood. We posit that muscle gene expression profiles are differentially regulated in response to severe burns in young animals. Twelve C57BL6 male mice, including young (5 weeks-old) and adults (11 weeks-old), received either scald burn, or sham procedure. Mouse muscle tissue was harvested 24 h later for Next Generation Sequence analysis. Our results showed 662 downregulated and 450 upregulated genes in gastrocnemius of young mice compared to adults without injury. After injury, we found 74/75 downregulated genes and 107/128 upregulated genes in both burned groups compared to respective uninjured age groups. VEGFA-VEGFR2, focal adhesion, and nuclear receptor meta-pathways were the top 3 gene pathways undergoing a differential change in response to age. Of note, the proteasome degradation pathway showed the most similar changes in both adult and young burned animals. This study demonstrates the characteristic profile of gene expression in skeletal muscle in young and adult burned mice. Prominent age effects were revealed in transcriptional levels with increased alterations of genes, miRNAs, pathways, and interactions.
    MeSH term(s) Animals ; Male ; Mice ; Burns/complications ; Burns/genetics ; Burns/metabolism ; Burns/pathology ; Muscle, Skeletal/metabolism ; Muscle, Skeletal/pathology ; Muscular Atrophy/etiology ; Muscular Atrophy/genetics ; Muscular Atrophy/metabolism ; Muscular Atrophy/pathology ; Proteasome Endopeptidase Complex/metabolism ; Quality of Life ; Transcriptome
    Chemical Substances Proteasome Endopeptidase Complex (EC 3.4.25.1)
    Language English
    Publishing date 2022-12-14
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-26040-1
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  8. Book ; Conference proceedings: Knowledge generation and technical change

    Wolf, Steven A.

    institutional innovation in agriculture ; [this volume grew out of a conference held on the University of California, Berkeley campus June 18 - 19, 1998]

    (Natural resource management and policy ; 19)

    2001  

    Institution Conference Knowledge Generation and Transfer: Implications for Agriculture in the 21st Century
    Author's details [Conference "Knowledge Generation and Transfer: Implications for Agriculture in the 21st Century"]. Ed. by Steven A. Wolf
    Series title Natural resource management and policy ; 19
    Collection
    Keywords Agricultural innovations ; Agriculture/Research ; Agriculture/Technology transfer ; Landwirtschaft ; Technische Innovation ; Forschung ; Technologietransfer
    Subject Techniktransfer ; Technologieexport ; Agrarwirtschaft ; Agrarsektor ; Landwirtschaftlicher Sektor ; Wissenschaftliche Forschung ; Forschungen ; Technische Neuerung ; Innovation
    Subject code 338.16
    Language English
    Size XXII, 371 S. : graph. Darst., 25 cm
    Publisher Kluwer Academic Publ
    Publishing place Boston u.a.
    Publishing country United States
    Document type Book ; Conference proceedings
    Note Includes bibliographical references
    HBZ-ID HT013484464
    ISBN 0-7923-7448-7 ; 978-0-7923-7448-0
    Database Catalogue ZB MED Nutrition, Environment, Agriculture

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    In stock of ZB MED Bonn / Germany

    Shelf markLoan statusLocation
    028/953 available for loan (reading room) Freihandmagazin (U1)

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  9. Article ; Online: Quadriceps muscle stimulation evokes heteronymous inhibition onto soleus with limited Ia activation compared to femoral nerve stimulation.

    Lyle, Mark A / Cuadra, Cristian / Wolf, Steven L

    Experimental brain research

    2022  Volume 240, Issue 9, Page(s) 2375–2388

    Abstract: Heteronymous excitatory feedback from muscle spindles and inhibitory feedback from Golgi tendon organs and recurrent inhibitory circuits can influence motor coordination. The functional role of inhibitory feedback is difficult to determine, because nerve ...

    Abstract Heteronymous excitatory feedback from muscle spindles and inhibitory feedback from Golgi tendon organs and recurrent inhibitory circuits can influence motor coordination. The functional role of inhibitory feedback is difficult to determine, because nerve stimulation, the primary method used in humans, cannot evoke inhibition without first activating the largest diameter muscle spindle axons. Here, we tested the hypothesis that quadriceps muscle stimulation could be used to examine heteronymous inhibition more selectively when compared to femoral nerve stimulation by comparing the effects of nerve and muscle stimulation onto ongoing soleus EMG held at 20% of maximal effort. Motor threshold and two higher femoral nerve and quadriceps stimulus intensities matched by twitch evoked torque magnitudes were examined. We found that significantly fewer participants exhibited excitation during quadriceps muscle stimulation when compared to nerve stimulation (14-29% vs. 64-71% of participants across stimulation intensities) and the magnitude of heteronymous excitation from muscle stimulation, when present, was much reduced compared to nerve stimulation. Muscle and nerve stimulation resulted in heteronymous inhibition that significantly increased with increasing stimulation evoked torque magnitudes. This study provides novel evidence that muscle stimulation may be used to more selectively examine inhibitory heteronymous feedback between muscles in the human lower limb when compared to nerve stimulation.
    MeSH term(s) Electric Stimulation ; Femoral Nerve/physiology ; H-Reflex/physiology ; Humans ; Muscle Spindles/physiology ; Muscle, Skeletal/physiology ; Quadriceps Muscle
    Language English
    Publishing date 2022-07-26
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1201-4
    ISSN 1432-1106 ; 0014-4819
    ISSN (online) 1432-1106
    ISSN 0014-4819
    DOI 10.1007/s00221-022-06422-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Comparing the Effectiveness of Glucocorticoids in Preventing Hypertrophic Scar Diagnosis in Burn Patients.

    Joglar, Alejandro / Song, Juquan / Golovko, George / Jay, Jayson / Wolf, Steven / El Ayadi, Amina

    Medicina (Kaunas, Lithuania)

    2023  Volume 59, Issue 11

    Abstract: Background and ... ...

    Abstract Background and Objectives
    MeSH term(s) Humans ; Cicatrix, Hypertrophic/drug therapy ; Cicatrix, Hypertrophic/etiology ; Cicatrix, Hypertrophic/prevention & control ; Glucocorticoids/adverse effects ; Burns/complications ; Burns/therapy ; Methylprednisolone/therapeutic use ; Dexamethasone/therapeutic use
    Chemical Substances Glucocorticoids ; Methylprednisolone (X4W7ZR7023) ; Dexamethasone (7S5I7G3JQL)
    Language English
    Publishing date 2023-11-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina59111970
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