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  1. Article ; Online: HIV and chronic lung disease.

    Leung, Janice M

    Current opinion in HIV and AIDS

    2022  Volume 18, Issue 2, Page(s) 93–101

    Abstract: Purpose of review: As people living with human immunodeficiency virus (HIV, PLWH) age, aging-related comorbidities have come into focus as major challenges to their overall health. In this review, an in-depth overview of the two most commonly ... ...

    Abstract Purpose of review: As people living with human immunodeficiency virus (HIV, PLWH) age, aging-related comorbidities have come into focus as major challenges to their overall health. In this review, an in-depth overview of the two most commonly encountered chronic lung diseases in PLWH, chronic obstructive pulmonary disease (COPD) and lung cancer, is provided.
    Recent findings: The risk for both COPD and lung cancer remains significantly higher in PLWH compared to the HIV-uninfected population, although fortunately rates of lung cancer appear to be declining over the last two decades. Outcomes for PLWH with these conditions, though, continue to be poor with worse survival rates in comparison to the general population. PLWH still face major barriers in accessing care for these conditions, including a higher likelihood of being underdiagnosed with COPD and a lower likelihood of being referred for lung cancer screening or treatment. A lack of evidence for optimal treatment strategies for both COPD and lung cancer still hampers the care of PLWH with these conditions.
    Summary: COPD and lung cancer represent substantial burdens of disease in PLWH. Improved access to standard-of-care screening and treatment and greater investigation into therapeutic responses specifically in this population are recommended.
    MeSH term(s) Humans ; Lung Neoplasms/diagnosis ; Lung Neoplasms/epidemiology ; Early Detection of Cancer ; HIV Infections/complications ; HIV Infections/epidemiology ; Pulmonary Disease, Chronic Obstructive/complications ; Pulmonary Disease, Chronic Obstructive/epidemiology ; Aging
    Language English
    Publishing date 2022-12-28
    Publishing country United States
    Document type Review ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2502511-9
    ISSN 1746-6318 ; 1746-630X
    ISSN (online) 1746-6318
    ISSN 1746-630X
    DOI 10.1097/COH.0000000000000777
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6812: Show issues Location:
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  2. Article ; Online: Predicting steroid responsiveness using airway smooth muscle in COPD: a HISTORIC study.

    Leung, Janice M / Sin, Don D

    The European respiratory journal

    2023  Volume 62, Issue 1

    MeSH term(s) Humans ; Double-Blind Method ; Respiratory System ; Pulmonary Disease, Chronic Obstructive/drug therapy ; Muscle, Smooth
    Language English
    Publishing date 2023-07-20
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.00956-2023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 292: Show issues

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  3. Article ; Online: Toward a Deeper Understanding of Chronic Obstructive Pulmonary Disease: The Role of Bronchoscopy in Therapeutic Discovery.

    Leung, Janice M

    Annals of the American Thoracic Society

    2019  Volume 16, Issue 4, Page(s) 431–432

    MeSH term(s) Bronchoscopy ; Humans ; Pulmonary Disease, Chronic Obstructive ; Research
    Language English
    Publishing date 2019-04-01
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2717461-X
    ISSN 2325-6621 ; 1943-5665 ; 2325-6621
    ISSN (online) 2325-6621 ; 1943-5665
    ISSN 2325-6621
    DOI 10.1513/AnnalsATS.201902-105ED
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    Zs.A 5828: Show issues Location:
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  4. Article ; Online: Smoking, ACE-2 and COVID-19: ongoing controversies.

    Leung, Janice M / Sin, Don D

    The European respiratory journal

    2020  Volume 56, Issue 1

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Humans ; Pandemics ; Pneumonia, Viral ; Pulmonary Disease, Chronic Obstructive ; SARS-CoV-2 ; Smokers ; Smoking
    Keywords covid19
    Language English
    Publishing date 2020-07-16
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.01759-2020
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  5. Article ; Online: Airway Epithelial-Derived Immune Mediators in COVID-19.

    Guo, Tony J F / Singhera, Gurpreet K / Leung, Janice M / Dorscheid, Delbert R

    Viruses

    2023  Volume 15, Issue 8

    Abstract: The airway epithelium, which lines the conducting airways, is central to the defense of the lungs against inhaled particulate matter and pathogens such as SARS-CoV-2, the virus that causes COVID-19. Recognition of pathogens results in the activation of ... ...

    Abstract The airway epithelium, which lines the conducting airways, is central to the defense of the lungs against inhaled particulate matter and pathogens such as SARS-CoV-2, the virus that causes COVID-19. Recognition of pathogens results in the activation of an innate and intermediate immune response which involves the release of cytokines and chemokines by the airway epithelium. This response can inhibit further viral invasion and influence adaptive immunity. However, severe COVID-19 is characterized by a hyper-inflammatory response which can give rise to clinical presentations including lung injury and lead to acute respiratory distress syndrome, viral pneumonia, coagulopathy, and multi-system organ failure. In response to SARS-CoV-2 infection, the airway epithelium can mount a maladaptive immune response which can delay viral clearance, perpetuate excessive inflammation, and contribute to the pathogenesis of severe COVID-19. In this article, we will review the barrier and immune functions of the airway epithelium, how SARS-CoV-2 can interact with the epithelium, and epithelial-derived cytokines and chemokines and their roles in COVID-19 and as biomarkers. Finally, we will discuss these immune mediators and their potential as therapeutic targets in COVID-19.
    MeSH term(s) Humans ; COVID-19 ; SARS-CoV-2 ; Immunologic Factors ; Cytokines ; Pneumonia, Viral
    Chemical Substances Immunologic Factors ; Cytokines
    Language English
    Publishing date 2023-07-29
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v15081655
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Cannabis smoking is associated with advanced epigenetic age.

    Hernandez Cordero, Ana I / Li, Xuan / Xi Yang, Chen / Ambalavanan, Amirtha / MacIsaac, Julia L / Kobor, Michael S / Doiron, Dany / Tan, Wan / Bourbeau, Jean / Sin, Don D / Duan, Qingling / Leung, Janice M

    The European respiratory journal

    2024  

    Language English
    Publishing date 2024-04-12
    Publishing country England
    Document type Letter
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.00458-2024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2322: Show issues Location:
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  8. Article ; Online: The Safety and Efficacy of Marijuana in Persons Living with HIV.

    Charron, Catherine B / Leung, Janice M

    AIDS reviews

    2019  Volume 21, Issue 2, Page(s) 84–92

    Abstract: The prevalence of the use of marijuana throughout the world is substantial. In light of ongoing increases in accessibility to marijuana, safety and efficacy must be established to guide recommendations for safe use. Of particular interest is at-risk ... ...

    Abstract The prevalence of the use of marijuana throughout the world is substantial. In light of ongoing increases in accessibility to marijuana, safety and efficacy must be established to guide recommendations for safe use. Of particular interest is at-risk populations such as persons living with HIV (PLWH) in whom there are higher rates of marijuana use and inherent risks of comorbid conditions. Databases and reference lists were searched for relevant studies investigating marijuana or cannabinoid use, HIV, and/or pulmonary diseases. The effect of marijuana on the human body is complex and not yet fully understood. The principal components, tetrahydrocannabinol, and cannabidiol interact with cannabinoid receptors. As some cannabinoid receptors are located in the immune system, many have investigated the effect of marijuana on the immune system. Although marijuana would appear to have anti-inflammatory properties, there are conflicting findings on its immune effect in PLWH. In the lung, marijuana smoke is thought to cause harm. Marijuana smokers have shown increased rates of respiratory symptoms, and a variety of changes on lung function has been reported. Limited data are available specific to the safety of marijuana on the lung, cognition, malignancy risk, and cardiovascular disease in PLWH who are already at increased risk of chronic diseases. Marijuana use is common in PLWH, but significant research gaps exist with regard to its safety and efficacy. Until further evidence on its safety is available, recommendations should be to avoid the use in PLWH.
    MeSH term(s) Adolescent ; Adult ; Animals ; Female ; HIV Infections/complications ; Humans ; Immunosuppressive Agents/adverse effects ; Male ; Marijuana Smoking/adverse effects ; Marijuana Smoking/epidemiology ; Middle Aged ; Prevalence ; Respiratory Tract Diseases/epidemiology ; Respiratory Tract Diseases/pathology ; Young Adult
    Chemical Substances Immunosuppressive Agents
    Language English
    Publishing date 2019-07-22
    Publishing country Spain
    Document type Journal Article ; Systematic Review
    ZDB-ID 2086783-9
    ISSN 1698-6997 ; 1139-6121
    ISSN (online) 1698-6997
    ISSN 1139-6121
    DOI 10.24875/AIDSRev.19000060
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5711: Show issues Location:
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  9. Article ; Online: COVID-19 and nicotine as a mediator of ACE-2.

    Leung, Janice M / Yang, Chen Xi / Sin, Don D

    The European respiratory journal

    2020  Volume 55, Issue 6

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Humans ; Nicotine ; Pandemics ; Pneumonia, Viral ; Pulmonary Disease, Chronic Obstructive ; SARS-CoV-2 ; Smokers
    Chemical Substances Nicotine (6M3C89ZY6R)
    Keywords covid19
    Language English
    Publishing date 2020-06-04
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.01261-2020
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  10. Article ; Online: Inhaled corticosteroids in COPD: the final verdict is….

    Leung, Janice M / Sin, Don D

    The European respiratory journal

    2018  Volume 52, Issue 6

    MeSH term(s) Administration, Inhalation ; Adrenal Cortex Hormones/administration & dosage ; Adrenal Cortex Hormones/therapeutic use ; Adrenergic beta-2 Receptor Agonists/therapeutic use ; Bronchodilator Agents/therapeutic use ; Drug Therapy, Combination ; Humans ; Pulmonary Disease, Chronic Obstructive/drug therapy ; Randomized Controlled Trials as Topic
    Chemical Substances Adrenal Cortex Hormones ; Adrenergic beta-2 Receptor Agonists ; Bronchodilator Agents
    Language English
    Publishing date 2018-12-13
    Publishing country England
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.01940-2018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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