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  1. Book: Obesity

    Sbraccia, Paolo / Finer, Nicholas

    pathogenesis, diagnosis, and treatment

    (Springer Reference : Endocrinology)

    2019  

    Author's details Paolo Sbraccia, Nicholas Finer editors
    Series title Springer Reference : Endocrinology
    Keywords Adipose organ ; Dietary treatment ; Eating disorders ; Neuroendocrinology of energy balance ; Pharmacological approaches ; Surgical approaches
    Subject code 610
    Language English
    Size XV, 440 Seiten, Illustrationen, Diagramme, 23.5 cm x 15.5 cm, 0 g
    Publisher Springer
    Publishing place Cham
    Publishing country Switzerland
    Document type Book
    HBZ-ID HT019972453
    ISBN 978-3-319-46932-4 ; 3-319-46932-0 ; 9783319469331 ; 9783319469348 ; 3319469339 ; 3319469347
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2019 A 250 available for loan (reading room) Lesesaal EG

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  2. Article ; Online: A new Editor-in-Chief.

    Finer, Nick

    Clinical obesity

    2022  Volume 12, Issue 5, Page(s) e12544

    Language English
    Publishing date 2022-07-26
    Publishing country England
    Document type Editorial
    ZDB-ID 2625816-X
    ISSN 1758-8111 ; 1758-8103
    ISSN (online) 1758-8111
    ISSN 1758-8103
    DOI 10.1111/cob.12544
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Future directions in obesity pharmacotherapy.

    Finer, Nick

    European journal of internal medicine

    2021  Volume 93, Page(s) 13–20

    Abstract: There is a growing unmet need for more effective treatment of obesity and its complications. While current anti-obesity medications are effective and offer real clinical benefits over diet and lifestyle interventions, they cannot meet the levels of ... ...

    Abstract There is a growing unmet need for more effective treatment of obesity and its complications. While current anti-obesity medications are effective and offer real clinical benefits over diet and lifestyle interventions, they cannot meet the levels of efficacy and reduction of hard endpoint outcomes seen with bariatric surgery. As knowledge on the control of body weight unravels, the complexity of this physiology opens the opportunity to new druggable targets. Currently, gut peptide analogues such as semaglutide, a glucagon like peptide-1 (GLP-1) receptor agonist, and the dual agonist GLP-1 and gastric inhibitory polypeptide (GIP) tirzepatide are the furthest advanced in clinical development and seem likely to meet current regulatory requirements within the next year or so. However, current regulatory requirements are out of step with the efficacy of new compounds and concepts relating to obesity and its complications. Many other drugs in early development will target different pathways of energy balance, raising the possibility of drug combinations to maximise efficacy as for other chronic disease such as hypertension and diabetes. This will allow more complex and personalised guidelines to evolve.
    MeSH term(s) Energy Metabolism ; Gastric Inhibitory Polypeptide/metabolism ; Gastric Inhibitory Polypeptide/therapeutic use ; Glucagon-Like Peptide 1 ; Glucagon-Like Peptide-1 Receptor ; Humans ; Obesity/drug therapy
    Chemical Substances Glucagon-Like Peptide-1 Receptor ; Gastric Inhibitory Polypeptide (59392-49-3) ; Glucagon-Like Peptide 1 (89750-14-1) ; tirzepatide (OYN3CCI6QE)
    Language English
    Publishing date 2021-05-21
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 1038679-8
    ISSN 1879-0828 ; 0953-6205
    ISSN (online) 1879-0828
    ISSN 0953-6205
    DOI 10.1016/j.ejim.2021.04.024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Weight loss interventions and nonalcoholic fatty liver disease: Optimizing liver outcomes.

    Finer, Nick

    Diabetes, obesity & metabolism

    2021  Volume 24 Suppl 2, Page(s) 44–54

    Abstract: The growth in prevalence of obesity, type 2 diabetes and nonalcoholic fatty liver disease (NAFLD) has become one of the most important global health challenges. The three chronic diseases are closely linked in their epidemiology and pathophysiology. ... ...

    Abstract The growth in prevalence of obesity, type 2 diabetes and nonalcoholic fatty liver disease (NAFLD) has become one of the most important global health challenges. The three chronic diseases are closely linked in their epidemiology and pathophysiology. Currently, weight loss is the most effective treatment for NAFLD (even in the minority of patients with NAFLD who do not have obesity) and is recommended in all national and international guidelines. Accumulating evidence has shown that weight loss, whether achieved by diet and lifestyle interventions, bariatric surgery or pharmacotherapy, can improve biomarkers of NAFLD, as well as prevent progression and, in some cases, reverse fibrosis. There is a dose dependency of weight loss with NAFLD improvement. Pharmacotherapy with antiobesity medications, alone or in combination with intensive lifestyle interventions or other weight-loss drugs, is closing the efficacy gap between diet and exercise and weight-loss surgery in efficacy at reversing obesity. Given the importance of providing effective weight-loss treatment to patients with NAFLD, weight management services need to be made increasingly available and embedded within hepatology services. This narrative review addresses the evidence that weight loss optimizes liver outcomes in people with NAFLD.
    MeSH term(s) Bariatric Surgery ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/epidemiology ; Diabetes Mellitus, Type 2/therapy ; Humans ; Liver ; Non-alcoholic Fatty Liver Disease/epidemiology ; Non-alcoholic Fatty Liver Disease/therapy ; Weight Loss
    Language English
    Publishing date 2021-10-24
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1454944-x
    ISSN 1463-1326 ; 1462-8902
    ISSN (online) 1463-1326
    ISSN 1462-8902
    DOI 10.1111/dom.14569
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Letter to the Editor regarding Mocanu et al. Ongoing Inconsistencies in Weight Loss Reporting Following Bariatric Surgery: a Systematic Review. Obesity Surgery https://doi.org/10.1007/s11695-018-03702-6Mocanu.

    Finer, Nick

    Obesity surgery

    2019  Volume 29, Issue 6, Page(s) 1942

    MeSH term(s) Bariatric Surgery ; Humans ; Longitudinal Studies ; Obesity, Morbid/surgery ; Weight Loss
    Language English
    Publishing date 2019-03-12
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1070827-3
    ISSN 1708-0428 ; 0960-8923
    ISSN (online) 1708-0428
    ISSN 0960-8923
    DOI 10.1007/s11695-019-03827-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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  6. Article: Sarcopenic obesity: under recognised and over treated?

    Finer, Nick

    Clinical medicine (London, England)

    2014  Volume 14, Issue 4, Page(s) 454

    MeSH term(s) Geriatric Assessment/methods ; Humans ; Sarcopenia/diagnosis
    Language English
    Publishing date 2014-07-31
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2048646-7
    ISSN 1473-4893 ; 1470-2118
    ISSN (online) 1473-4893
    ISSN 1470-2118
    DOI 10.7861/clinmedicine.14-4-454
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Comment on Balkau et al. Factors associated with weight gain in people with type 2 diabetes starting on insulin. Diabetes Care 2014;37:2108-2113.

    Finer, Nick

    Diabetes care

    2014  Volume 37, Issue 12, Page(s) e265

    MeSH term(s) Diabetes Mellitus, Type 2/prevention & control ; Diabetic Angiopathies/prevention & control ; Female ; Humans ; Hypoglycemic Agents/therapeutic use ; Insulin/therapeutic use ; Male ; Weight Gain/drug effects
    Chemical Substances Hypoglycemic Agents ; Insulin
    Language English
    Publishing date 2014-12
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 441231-x
    ISSN 1935-5548 ; 0149-5992
    ISSN (online) 1935-5548
    ISSN 0149-5992
    DOI 10.2337/dc14-1916
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  8. Article ; Online: COVID-19 and obesity.

    Finer, Nick / Garnett, Sarah P / Bruun, Jens M

    Clinical obesity

    2020  Volume 10, Issue 3, Page(s) e12365

    MeSH term(s) Age Factors ; Betacoronavirus/isolation & purification ; Body Mass Index ; COVID-19 ; Comorbidity ; Coronavirus Infections/diagnosis ; Coronavirus Infections/epidemiology ; Health Services Needs and Demand ; Humans ; Obesity/epidemiology ; Obesity/therapy ; Pandemics ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/epidemiology ; Risk Factors ; SARS-CoV-2 ; Severity of Illness Index ; United Kingdom/epidemiology
    Keywords covid19
    Language English
    Publishing date 2020-04-27
    Publishing country England
    Document type Editorial
    ZDB-ID 2625816-X
    ISSN 1758-8111 ; 1758-8103
    ISSN (online) 1758-8111
    ISSN 1758-8103
    DOI 10.1111/cob.12365
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  9. Article ; Online: Withdrawal of sibutramine. Editorial is judgment in advance of the facts.

    Finer, Nick

    BMJ (Clinical research ed.)

    2010  Volume 340, Page(s) c1346

    MeSH term(s) Anti-Obesity Agents/adverse effects ; Cardiovascular Diseases/chemically induced ; Clinical Trials as Topic ; Cyclobutanes/adverse effects ; Humans ; Obesity/prevention & control ; Safety-Based Drug Withdrawals
    Chemical Substances Anti-Obesity Agents ; Cyclobutanes ; sibutramine (WV5EC51866)
    Language English
    Publishing date 2010-03-10
    Publishing country England
    Document type Letter
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.c1346
    Database MEDical Literature Analysis and Retrieval System OnLINE

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