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Article ; Online: Natural components as surface engineering agents for CRISPR delivery.

Rabiee, Navid

2023 Volume 232, Page(s) 116333

Abstract: This perspective article discusses the potential of using natural and environmentally friendly components as surface engineering agents for CRISPR delivery. Traditional delivery methods for CRISPR have limitations and safety concerns, and surface ... ...

Abstract	This perspective article discusses the potential of using natural and environmentally friendly components as surface engineering agents for CRISPR delivery. Traditional delivery methods for CRISPR have limitations and safety concerns, and surface engineering has emerged as a promising approach. This perspective provides an overview of current research, including the use of lipids, proteins, natural components (like leaf extracts), and polysaccharides to modify the surface of nanoparticles and nanomaterials to improve delivery efficiency, stability, and (in some cases) cellular internalization ability. The advantages of using natural components include biocompatibility, biodegradability, engineered functionality, cost-effectiveness, and environmental friendliness. Also in-depth discusses about the challenges and future perspective of this field, such as a better understanding of underlying mechanisms and optimization of delivery methods for different cell line types and tissues, as well as the generation of novel inorganic nanomaterials, including MOF and MXene, for CRISPR delivery, and their synergistic potentials using leaf extracts and natural components provided. The use of natural components as surface engineering agents for CRISPR delivery has the potential to overcome the limitations of traditional delivery methods, eliminating the biological and physicochemical challenges, and represents a promising area of research.
MeSH term(s)	Clustered Regularly Interspaced Short Palindromic Repeats ; Nanoparticles ; Nanostructures
Chemical Substances	MXene
Language	English
Publishing date	2023-06-05
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	205699-9
ISSN	1096-0953 ; 0013-9351
ISSN (online)	1096-0953
ISSN	0013-9351
DOI	10.1016/j.envres.2023.116333
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Article ; Online: Natural components as surface engineering agents for CRISPR delivery

Rabiee, Navid

Environmental Research. 2023 Sept., v. 232 p.116333-

2023

Abstract	This perspective article discusses the potential of using natural and environmentally friendly components as surface engineering agents for CRISPR delivery. Traditional delivery methods for CRISPR have limitations and safety concerns, and surface engineering has emerged as a promising approach. This perspective provides an overview of current research, including the use of lipids, proteins, natural components (like leaf extracts), and polysaccharides to modify the surface of nanoparticles and nanomaterials to improve delivery efficiency, stability, and (in some cases) cellular internalization ability. The advantages of using natural components include biocompatibility, biodegradability, engineered functionality, cost-effectiveness, and environmental friendliness. Also in-depth discusses about the challenges and future perspective of this field, such as a better understanding of underlying mechanisms and optimization of delivery methods for different cell line types and tissues, as well as the generation of novel inorganic nanomaterials, including MOF and MXene, for CRISPR delivery, and their synergistic potentials using leaf extracts and natural components provided. The use of natural components as surface engineering agents for CRISPR delivery has the potential to overcome the limitations of traditional delivery methods, eliminating the biological and physicochemical challenges, and represents a promising area of research.
Keywords	biocompatibility ; biodegradability ; cell lines ; cost effectiveness ; leaves ; nanoparticles ; polysaccharides ; CRISPR ; Delivery systems ; Surface engineering ; Natural components
Language	English
Dates of publication	2023-09
Publishing place	Elsevier Inc.
Document type	Article ; Online
ZDB-ID	205699-9
ISSN	1096-0953 ; 0013-9351
ISSN (online)	1096-0953
ISSN	0013-9351
DOI	10.1016/j.envres.2023.116333
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: DNA/RNA-based electrochemical nanobiosensors for early detection of cancers.

Mikaeeli Kangarshahi, Babak / Naghib, Seyed Morteza / Rabiee, Navid

Critical reviews in clinical laboratory sciences

2024 , Page(s) 1–23

Abstract: Nucleic acids, like DNA and RNA, serve as versatile recognition elements in electrochemical biosensors, demonstrating notable efficacy in detecting various cancer biomarkers with high sensitivity and selectivity. These biosensors offer advantages such as ...

Abstract	Nucleic acids, like DNA and RNA, serve as versatile recognition elements in electrochemical biosensors, demonstrating notable efficacy in detecting various cancer biomarkers with high sensitivity and selectivity. These biosensors offer advantages such as cost-effectiveness, rapid response, ease of operation, and minimal sample preparation. This review provides a comprehensive overview of recent developments in nucleic acid-based electrochemical biosensors for cancer diagnosis, comparing them with antibody-based counterparts. Specific examples targeting key cancer biomarkers, including prostate-specific antigen, microRNA-21, and carcinoembryonic antigen, are highlighted. The discussion delves into challenges and limitations, encompassing stability, reproducibility, interference, and standardization issues. The review suggests future research directions, exploring new nucleic acid recognition elements, innovative transducer materials and designs, novel signal amplification strategies, and integration with microfluidic devices or portable instruments. Evaluating these biosensors in clinical settings using actual samples from cancer patients or healthy donors is emphasized. These sensors are sensitive and specific at detecting non-communicable and communicable disease biomarkers. DNA and RNA's self-assembly, programmability, catalytic activity, and dynamic behavior enable adaptable sensing platforms. They can increase biosensor biocompatibility, stability, signal transduction, and amplification with nanomaterials. In conclusion, nucleic acids-based electrochemical biosensors hold significant potential to enhance cancer detection and treatment through early and accurate diagnosis.
Language	English
Publishing date	2024-03-07
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	280641-1
ISSN	1549-781X ; 1040-8363 ; 0590-8191
ISSN (online)	1549-781X
ISSN	1040-8363 ; 0590-8191
DOI	10.1080/10408363.2024.2321202
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Article ; Online: Advancements in Bio-inspired Self-Powered Wireless Sensors: Materials, Mechanisms, and Biomedical Applications.

Farzin, Mohammad Ali / Naghib, Seyed Morteza / Rabiee, Navid

ACS biomaterials science & engineering

2024 Volume 10, Issue 3, Page(s) 1262–1301

Abstract: The rapid maturation of smart city ecosystems is intimately linked to advances in the Internet of Things (IoT) and self-powered sensing technologies. Central to this evolution are battery-less sensors that are critical for applications such as continuous ...

Abstract	The rapid maturation of smart city ecosystems is intimately linked to advances in the Internet of Things (IoT) and self-powered sensing technologies. Central to this evolution are battery-less sensors that are critical for applications such as continuous health monitoring through blood metabolites and vital signs, the recognition of human activity for behavioral analysis, and the operational enhancement of humanoid robots. The focus on biosensors that exploit the human body for energy-spanning wearable, attachable, and implantable variants has intensified, driven by their broad applicability in areas from underwater exploration to biomedical assays and earthquake monitoring. The heart of these sensors lies in their diverse energy harvesting mechanisms, including biofuel cells, and piezoelectric, triboelectric, and pyroelectric nanogenerators. Notwithstanding the wealth of research, the literature still lacks a holistic review that integrates the design challenges and implementation intricacies of such sensors. Our review seeks to fill this gap by thoroughly evaluating energy harvesting strategies from both material and structural perspectives and assessing their roles in powering an array of sensors for myriad uses. This exploration offers a comprehensive outlook on the state of self-powered sensing devices, tackling the nuances of their deployment and highlighting their potential to revolutionize data gathering in autonomous systems. The intent of this review is to chart the current landscape and future prospects, providing a pivotal reference point for ongoing research and innovation in self-powered wireless sensing technologies.
MeSH term(s)	Humans ; Ecosystem
Language	English
Publishing date	2024-02-20
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2373-9878
ISSN (online)	2373-9878
DOI	10.1021/acsbiomaterials.3c01633
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Article ; Online: Advancements in MXene-based composites for electronic skins.

Iravani, Siavash / Rabiee, Navid / Makvandi, Pooyan

Journal of materials chemistry. B

2024 Volume 12, Issue 4, Page(s) 895–915

Abstract: MXenes are a class of two-dimensional (2D) materials that have gained significant attention in the field of electronic skins (E-skins). MXene-based composites offer several advantages for E-skins, including high electrical conductivity, mechanical ... ...

Abstract	MXenes are a class of two-dimensional (2D) materials that have gained significant attention in the field of electronic skins (E-skins). MXene-based composites offer several advantages for E-skins, including high electrical conductivity, mechanical flexibility, transparency, and chemical stability. Their mechanical flexibility allows for conformal integration onto various surfaces, enabling the creation of E-skins that can closely mimic human skin. In addition, their high surface area facilitates enhanced sensitivity and responsiveness to external stimuli, making them ideal for sensing applications. Notably, MXene-based composites can be integrated into E-skins to create sensors that can detect various stimuli, such as temperature, pressure, strain, and humidity. These sensors can be used for a wide range of applications, including health monitoring, robotics, and human-machine interfaces. However, challenges related to scalability, integration, and biocompatibility need to be addressed. One important challenge is achieving long-term stability under harsh conditions such as high humidity. MXenes are susceptible to oxidation, which can degrade their electrical and mechanical properties over time. Another crucial challenge is the scalability of MXene synthesis, as large-scale production methods need to be developed to meet the demand for commercial applications. Notably, the integration of MXenes with other components, such as energy storage devices or flexible electronics, requires further developments to ensure compatibility and optimize overall performance. By addressing issues related to material stability, mechanical flexibility, scalability, sensing performance, and power supply, MXene-based E-skins can develop the fields of healthcare monitoring/diagnostics, prosthetics, motion monitoring, wearable electronics, and human-robot interactions. The integration of MXenes with emerging technologies, such as artificial intelligence or internet of things, can unlock new functionalities and applications for E-skins, ranging from healthcare monitoring to virtual reality interfaces. This review aims to examine the challenges, advantages, and limitations of MXenes and their composites in E-skins, while also exploring the future prospects and potential advancements in this field.
MeSH term(s)	Humans ; Artificial Intelligence ; Artificial Limbs ; Electric Conductivity ; Electronics ; Nitrites ; Transition Elements
Chemical Substances	MXene ; Nitrites ; Transition Elements
Language	English
Publishing date	2024-01-24
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2702241-9
ISSN	2050-7518 ; 2050-750X
ISSN (online)	2050-7518
ISSN	2050-750X
DOI	10.1039/d3tb02247a
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Genetically engineered bacteria: a new frontier in targeted drug delivery.

Fooladi, Saba / Rabiee, Navid / Iravani, Siavash

Journal of materials chemistry. B

2023 Volume 11, Issue 42, Page(s) 10072–10087

Abstract: Genetically engineered bacteria (GEB) have shown significant promise to revolutionize modern medicine. These engineered bacteria with unique properties such as enhanced targeting, versatility, biofilm disruption, reduced drug resistance, self- ... ...

Abstract	Genetically engineered bacteria (GEB) have shown significant promise to revolutionize modern medicine. These engineered bacteria with unique properties such as enhanced targeting, versatility, biofilm disruption, reduced drug resistance, self-amplification capabilities, and biodegradability represent a highly promising approach for targeted drug delivery and cancer theranostics. This innovative approach involves modifying bacterial strains to function as drug carriers, capable of delivering therapeutic agents directly to specific cells or tissues. Unlike synthetic drug delivery systems, GEB are inherently biodegradable and can be naturally eliminated from the body, reducing potential long-term side effects or complications associated with residual foreign constituents. However, several pivotal challenges such as safety and controllability need to be addressed. Researchers have explored novel tactics to improve their capabilities and overcome existing challenges, including synthetic biology tools (
MeSH term(s)	Humans ; Drug Delivery Systems ; Genetic Engineering ; Bacteria ; Drug Carriers ; Neoplasms/drug therapy
Chemical Substances	Drug Carriers
Language	English
Publishing date	2023-11-01
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2702241-9
ISSN	2050-7518 ; 2050-750X
ISSN (online)	2050-7518
ISSN	2050-750X
DOI	10.1039/d3tb01805a
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Article ; Online: Rapid and efficient removal of methylene blue dye from aqueous solutions using extract-modified Zn-Al LDH.

Bagherzadeh, Mojtaba / Salehi, Ghazal / Rabiee, Navid

Chemosphere

2023 Volume 350, Page(s) 141011

Abstract: Environmental pollution, particularly water pollution caused by organic substances like synthetic dyes, is a pressing global concern. This study focuses on enhancing the adsorption capacity of layered double hydroxides (LDHs) to remove methylene blue (MB) ...

Abstract	Environmental pollution, particularly water pollution caused by organic substances like synthetic dyes, is a pressing global concern. This study focuses on enhancing the adsorption capacity of layered double hydroxides (LDHs) to remove methylene blue (MB) dye from water. The synthesized materials are characterized using techniques like FT-IR, XRD, SEM, TEM, TGA, EDS, BET, BJH, AFM, and UV-Vis DRS. Adsorption experiments show that Zn-Al LDH@ext exhibits a significant adsorption capacity for MB dye compared to pristine LDH. In addition, Zn-Al LDH@ext shows a significant increase in stability, which is attributed to the presence of phenolic compounds in the extract and the interactions between the functional groups of the extract and LDH. The pH and adsorbent dosage optimizations show that pH 7 and 0.7 g of Zn-Al LDH@ext are optimal conditions for efficient MB removal. The study assessed adsorption kinetics through the examination of Langmuir, Freundlich, and Temkin isotherms. Additionally, four kinetic models, namely pseudo-first-order, pseudo-second-order, intraparticle diffusion, and Elovich, were analyzed. The results indicated that the Temkin isotherm (R
MeSH term(s)	Coloring Agents/chemistry ; Methylene Blue/chemistry ; Spectroscopy, Fourier Transform Infrared ; Water Pollutants, Chemical/analysis ; Hydroxides/chemistry ; Adsorption ; Kinetics ; Zinc/chemistry ; Hydrogen-Ion Concentration
Chemical Substances	Coloring Agents ; Methylene Blue (T42P99266K) ; Water Pollutants, Chemical ; Hydroxides ; Zinc (J41CSQ7QDS)
Language	English
Publishing date	2023-12-23
Publishing country	England
Document type	Journal Article
ZDB-ID	120089-6
ISSN	1879-1298 ; 0045-6535 ; 0366-7111
ISSN (online)	1879-1298
ISSN	0045-6535 ; 0366-7111
DOI	10.1016/j.chemosphere.2023.141011
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Article ; Online: Environmental implications of metal-organic frameworks and MXenes in biomedical applications: a perspective.

Farasati Far, Bahareh / Rabiee, Navid / Iravani, Siavash

RSC advances

2023 Volume 13, Issue 49, Page(s) 34562–34575

Abstract: Metal-organic frameworks (MOFs) and MXenes have demonstrated immense potential for biomedical applications, offering a plethora of advantages. MXenes, in particular, exhibit robust mechanical strength, hydrophilicity, large surface areas, significant ... ...

Abstract	Metal-organic frameworks (MOFs) and MXenes have demonstrated immense potential for biomedical applications, offering a plethora of advantages. MXenes, in particular, exhibit robust mechanical strength, hydrophilicity, large surface areas, significant light absorption potential, and tunable surface terminations, among other remarkable characteristics. Meanwhile, MOFs possess high porosity and large surface area, making them ideal for protecting active biomolecules and serving as carriers for drug delivery, hence their extensive study in the field of biomedicine. However, akin to other (nano)materials, concerns regarding their environmental implications persist. The number of studies investigating the toxicity and biocompatibility of MXenes and MOFs is growing, albeit further systematic research is needed to thoroughly understand their biosafety issues and biological effects prior to clinical trials. The synthesis of MXenes often involves the use of strong acids and high temperatures, which, if not properly managed, can have adverse effects on the environment. Efforts should be made to minimize the release of harmful byproducts and ensure proper waste management during the production process. In addition, it is crucial to assess the potential release of MXenes into the environment during their use in biomedical applications. For the biomedical applications of MOFs, several challenges exist. These include high fabrication costs, poor selectivity, low capacity, the quest for stable and water-resistant MOFs, as well as difficulties in recycling/regeneration and maintaining chemical/thermal/mechanical stability. Thus, careful consideration of the biosafety issues associated with their fabrication and utilization is vital. In addition to the synthesis and manufacturing processes, the ultimate utilization and fate of MOFs and MXenes in biomedical applications must be taken into account. While numerous reviews have been published regarding the biomedical applications of MOFs and MXenes, this perspective aims to shed light on the key environmental implications and biosafety issues, urging researchers to conduct further research in this field. Thus, the crucial aspects of the environmental implications and biosafety of MOFs and MXenes in biomedicine are thoroughly discussed, focusing on the main challenges and outlining future directions.
Language	English
Publishing date	2023-11-24
Publishing country	England
Document type	Journal Article ; Review
ISSN	2046-2069
ISSN (online)	2046-2069
DOI	10.1039/d3ra07092a
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Article ; Online: Comparative study of synthesis methods and pH-dependent adsorption of methylene blue dye on UiO-66 and NH

Daneshgar, Hossein / Sojdeh, Soheil / Salehi, Ghazal / Edrisi, Mohammad / Bagherzadeh, Mojtaba / Rabiee, Navid

Chemosphere

2024 Volume 353, Page(s) 141543

Abstract: Metal-organic frameworks (MOFs) are highly promising adsorbents with notable properties such as elevated adsorption capacities and versatile surface design capabilities. This study introduces two distinct synthesis methods, one lasting 1 h and the other ... ...

Abstract	Metal-organic frameworks (MOFs) are highly promising adsorbents with notable properties such as elevated adsorption capacities and versatile surface design capabilities. This study introduces two distinct synthesis methods, one lasting 1 h and the other 24 h, for UiO-66 and NH
MeSH term(s)	Methylene Blue ; Adsorption ; Water Pollutants, Chemical/chemistry ; Hydrogen-Ion Concentration ; Metal-Organic Frameworks ; Phthalic Acids
Chemical Substances	UiO-66 ; Methylene Blue (T42P99266K) ; Water Pollutants, Chemical ; Metal-Organic Frameworks ; Phthalic Acids
Language	English
Publishing date	2024-03-04
Publishing country	England
Document type	Journal Article
ZDB-ID	120089-6
ISSN	1879-1298 ; 0045-6535 ; 0366-7111
ISSN (online)	1879-1298
ISSN	0045-6535 ; 0366-7111
DOI	10.1016/j.chemosphere.2024.141543
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Article ; Online: Aptamer-engineered (nano)materials for theranostic applications.

Rabiee, Navid / Chen, Suxiang / Ahmadi, Sepideh / Veedu, Rakesh N

Theranostics

2023 Volume 13, Issue 15, Page(s) 5183–5206

Abstract: A diverse array of organic and inorganic materials, including nanomaterials, has been extensively employed in multifunctional biomedical applications. These applications encompass drug/gene delivery, tissue engineering, biosensors, photodynamic and ... ...

Abstract	A diverse array of organic and inorganic materials, including nanomaterials, has been extensively employed in multifunctional biomedical applications. These applications encompass drug/gene delivery, tissue engineering, biosensors, photodynamic and photothermal therapy, and combinatorial sciences. Surface and bulk engineering of these materials, by incorporating biomolecules and aptamers, offers several advantages such as decreased cytotoxicity, improved stability, enhanced selectivity/sensitivity toward specific targets, and expanded multifunctional capabilities. In this comprehensive review, we specifically focus on aptamer-modified engineered materials for diverse biomedical applications. We delve into their mechanisms, advantages, and challenges, and provide an in-depth analysis of relevant literature references. This critical evaluation aims to enhance the scientific community's understanding of this field and inspire new ideas for future research endeavors.
MeSH term(s)	Precision Medicine ; Drug Delivery Systems ; Nanostructures/therapeutic use ; Aptamers, Nucleotide ; Biosensing Techniques
Chemical Substances	Aptamers, Nucleotide
Language	English
Publishing date	2023-09-25
Publishing country	Australia
Document type	Journal Article ; Review
ZDB-ID	2592097-2
ISSN	1838-7640 ; 1838-7640
ISSN (online)	1838-7640
ISSN	1838-7640
DOI	10.7150/thno.85419
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