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  1. Article ; Online: Özofagus ülserinin nadir bir nedeni

    Adnan Taş / Mehmet Suat Yalçın / Şehmus Ölmez / Banu Kara

    Cukurova Medical Journal, Vol 41, Iss Supplement 1, Pp 126-

    kestane

    2016  Volume 127

    Keywords esophageal ulcer ; özofagus ülseri ; Medicine (General) ; R5-920
    Language English
    Publishing date 2016-12-01T00:00:00Z
    Publisher Cukurova University
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Nadir Bir Olgu

    Hakan ERÇİL / Umut ÜNAL / Güçlü GÜRLEN / Nevzat Can ŞENER / Tardu ÇINAR / Yalçın EVLİYAOĞLU

    Cukurova Medical Journal, Vol 38, Iss 4, Pp 794-

    Sporadik Mesane Paraganglioması

    2013  Volume 799

    Abstract: Paraganglioma nadir olarak görülen ve nöral krest orjinli paraganglia dokusundan gelişen bir ... takiplerine nüks izlenmedi. Mesane paragangliomasi nadir bir olgu olsa da, mesane tümörü ayırıcı tanısında ...

    Abstract Paraganglioma nadir olarak görülen ve nöral krest orjinli paraganglia dokusundan gelişen bir tümördür. Mesane paraganglioması, mesane duvarı içinde kromaffin hücrelerin embriyojenik artıklarından kaynaklandığı öne sürülmüştür. Biz bu çalışmamızda mesanede yerleşen primer paraganglioma olgusunu literatür eşliğinde irdeledik. 39 yaşında erkek hasta iki yıldır ağrısız pıhtılı idrar yapma şikayetiyle başvurduğu polikliniğimizde yapılan idrar tahlilinde hematürisi olması üzerine yapılan ultrasonografisinde mesanede 2x2 cmlik kitle saptandı. Patolojisi paraganglioma gelen hastaya parsiyel sistektomi uygulandı. Hastanın 6 aylık takiplerine nüks izlenmedi. Mesane paragangliomasi nadir bir olgu olsa da, mesane tümörü ayırıcı tanısında mutlaka akla getirilmelidir.
    Keywords - ; partial cystectomy ; bladder ; paraganglioma ; parsiyel sistektomi ; mesane ; Medicine (General) ; R5-920
    Language English
    Publishing date 2013-12-01T00:00:00Z
    Publisher Cukurova University
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Konjenital diafragmatik herni ve aortik koarktasyon nadir birlikteliğinin prenatal tanısı

    Mehmet Özgür AKKURT / And YAVUZ / Serenat Eriş YALÇIN / İltaç AKKURT / Mekin SEZİK

    Cukurova Medical Journal, Vol 42, Iss 2, Pp 376-

    2017  Volume 379

    Abstract: ... gösteren anomalisi kalp anomalisi olmakla beraber, aortic koarktasyon nadir görülmektedir. Bu olguda ... konjenital diafragma hernisi ve aortic koarktasyonu nadir birlikteliğinin prenatal tanısı sunulmuştur. ...

    Abstract Konjenital diafragmatik herni eşlik edebilecek diğer organ anomalileri riskinin arttığı, sık görülen bir toraks anomalisidir. Kesin etyolojisi bilinmemekle beraber, olası nedeni primordiyal diafragmanın amuskuler parçasındaki kusurdur. Konjenital diafragmatik hernili fetuslarda en sık birliktelik gösteren anomalisi kalp anomalisi olmakla beraber, aortic koarktasyon nadir görülmektedir. Bu olguda konjenital diafragma hernisi ve aortic koarktasyonu nadir birlikteliğinin prenatal tanısı sunulmuştur.
    Keywords aort koarktasyonu ; konjenital diafram hernisi ; prenatal tanı ; aortic coarctation ; congenital diaphragmatic hernia ; prenatal diagnosis ; Medicine (General) ; R5-920
    Language English
    Publishing date 2017-06-01T00:00:00Z
    Publisher Cukurova University
    Document type Article ; Online
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  4. Article ; Online: Adherence to medical treatment for Wilson's disease in children and adolescents: a cohort study from Turkey.

    Göktaş, Mehmet Akif / Yalcin, Nadir

    Orphanet journal of rare diseases

    2024  Volume 19, Issue 1, Page(s) 105

    Abstract: Background: This study aimed to assess medication adherence and demographic, clinical, and psychopathological parameters such as quality of life, depression, and anxiety levels that can affect pediatrics with Wilson's Disease (WD).: Methods: A ... ...

    Abstract Background: This study aimed to assess medication adherence and demographic, clinical, and psychopathological parameters such as quality of life, depression, and anxiety levels that can affect pediatrics with Wilson's Disease (WD).
    Methods: A prospective cohort study was conducted at an outpatient clinic in Turkey among pediatric patients (2 to 18 years) with WD between November 2022 and April 2023. The Medication Adherence Report Scale (MARS-5) as a subjective and Medication Possession Ratio (MPR) as an objective assessment were scored. Physical, genetic and biochemical parameters, the Pediatric Quality of Life Inventory (PedsQL) for both parents and patients, Childhood Depression Inventory, State Trait Anxiety Inventory were also administered.
    Results: A total of 30 pediatric outpatients who were prescribed D-penicillamine (n = 27) or trientine (n = 3) as chelators and zinc (n = 29) and pyridoxine (n = 19) as supplements were included. Proteinuria (n = 3), skin rash (n = 2), and gastrointestinal upset (n = 2) were observed. When the correlation between MARS-5 and duration of follow-up was examined, a significant negative correlation was found (p = 0.014). According to MPRs, non-adherence rates (missed doses ≥ 20%) were 29.6%, 17.2% and 5.3% for D-penicillamine, zinc and pyridoxine, respectively. PedsQL scores were higher than those of parents, with a positive correlation between them (p < 0.001). Also, there was a significant positive correlation between PedsQL and State Anxiety Inventory (p < 0.001). Comparing the change in urinary copper levels between different levels of treatment knowledge, significant differences were observed between high- and low levels (p = 0.043).
    Conclusions: Overall, nonadherence rates were 23.3% based on MARS-5 and 5.3-29.6% based on MPR. It is essential to consider factors such as the duration of follow-up, biochemical parameters, treatment knowledge, quality of life and anxiety as potential influencers of medication adherence.
    MeSH term(s) Adolescent ; Child ; Humans ; Cohort Studies ; Hepatolenticular Degeneration/drug therapy ; Hepatolenticular Degeneration/pathology ; Penicillamine/therapeutic use ; Prospective Studies ; Pyridoxine/therapeutic use ; Quality of Life ; Turkey ; Zinc/therapeutic use ; Child, Preschool
    Chemical Substances Penicillamine (GNN1DV99GX) ; Pyridoxine (KV2JZ1BI6Z) ; Zinc (J41CSQ7QDS)
    Language English
    Publishing date 2024-03-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 2225857-7
    ISSN 1750-1172 ; 1750-1172
    ISSN (online) 1750-1172
    ISSN 1750-1172
    DOI 10.1186/s13023-024-03113-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Concomitant drug use of nirmatrelvir/ritonavir and CYP3A4-modulating antimicrobial agents: an approach for drug use.

    Visscher, Robbert / Yalçın, Nadir / Bayraktar, Izgi / Bayraktar-Ekincioglu, Aygin

    European journal of hospital pharmacy : science and practice

    2024  Volume 31, Issue 2, Page(s) 180–182

    MeSH term(s) Ritonavir ; Cytochrome P-450 CYP3A ; Anti-Infective Agents/therapeutic use ; Lactams ; Leucine ; Nitriles ; Proline
    Chemical Substances nirmatrelvir (7R9A5P7H32) ; Ritonavir (O3J8G9O825) ; Cytochrome P-450 CYP3A (EC 1.14.14.1) ; Anti-Infective Agents ; Lactams ; Leucine (GMW67QNF9C) ; Nitriles ; Proline (9DLQ4CIU6V)
    Language English
    Publishing date 2024-02-22
    Publishing country England
    Document type Letter
    ZDB-ID 2650179-X
    ISSN 2047-9964 ; 2047-9956
    ISSN (online) 2047-9964
    ISSN 2047-9956
    DOI 10.1136/ejhpharm-2023-003795
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  6. Article ; Online: The Syntheses of Chromium Aluminum Carbide (Cr

    Kaya, Gul / Koc, Eda Ondul / Özdemir, Sadin / Yalçın, M Serkan / Ocakoglu, Kasim / Dizge, Nadir

    Applied biochemistry and biotechnology

    2024  

    Abstract: Chromium aluminum carbide ( ... ...

    Abstract Chromium aluminum carbide (Cr
    Language English
    Publishing date 2024-03-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 392344-7
    ISSN 1559-0291 ; 0273-2289
    ISSN (online) 1559-0291
    ISSN 0273-2289
    DOI 10.1007/s12010-024-04910-w
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    Zs.A 3053: Show issues Location:
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  7. Article ; Online: Fetal pharmacogenetic screening to improve neonatal pharmacotherapy: From feasibility to personalized practice.

    Yalcin, Nadir / Allegaert, Karel

    Molecular genetics and metabolism

    2022  Volume 137, Issue 1-2, Page(s) 210–212

    MeSH term(s) Female ; Infant, Newborn ; Pregnancy ; Humans ; Pharmacogenomic Testing ; Feasibility Studies ; Pharmacogenetics ; Precision Medicine ; Prenatal Diagnosis
    Language English
    Publishing date 2022-09-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1418518-0
    ISSN 1096-7206 ; 1096-7192
    ISSN (online) 1096-7206
    ISSN 1096-7192
    DOI 10.1016/j.ymgme.2022.09.003
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    Zs.A 617: Show issues Location:
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  8. Article ; Online: Management of drug-related problems including drug-drug interactions caused by nirmatrelvir/ritonavir in paediatric patients with SARS-CoV-2.

    Yalcin, Nadir / Demirkan, Kutay

    Archives of disease in childhood

    2022  Volume 108, Issue 10, Page(s) e16

    MeSH term(s) Humans ; Child ; Ritonavir/adverse effects ; SARS-CoV-2 ; COVID-19 ; COVID-19 Drug Treatment
    Chemical Substances nirmatrelvir (7R9A5P7H32) ; Ritonavir (O3J8G9O825)
    Language English
    Publishing date 2022-09-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 524-1
    ISSN 1468-2044 ; 0003-9888 ; 1359-2998
    ISSN (online) 1468-2044
    ISSN 0003-9888 ; 1359-2998
    DOI 10.1136/archdischild-2022-324168
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  9. Article ; Online: Web Survey of Turkish Pharmacy Students Comparing First and Fifth Years' Antidepressant Awareness and Stigmatizing Attitudes Regarding Depression and Anxiety.

    Yalçın, Nadir / Özkan, Gökçe Gül / Allegaert, Karel / Ak, Sertaç / Demirkan, Kutay

    Pharmacy (Basel, Switzerland)

    2024  Volume 12, Issue 2

    Abstract: The prevalence of depression and anxiety has increased day by day. Prejudice, self-stigma, and public stigma, on the other hand, continue to prevent patients from seeking adequate treatment, particularly in traditional communities. In this web-based, ... ...

    Abstract The prevalence of depression and anxiety has increased day by day. Prejudice, self-stigma, and public stigma, on the other hand, continue to prevent patients from seeking adequate treatment, particularly in traditional communities. In this web-based, cross-sectional study, both the presence of depression and anxiety, and the knowledge, attitude, and awareness of first- and fifth (final)-year pharmacy students were examined via an online survey. The aim was to demonstrate the potential impact of public information and five years of pharmacy school on knowledge, attitude, and awareness. Our study population consisted of first- and fifth-year pharmacy students enrolled in one faculty of pharmacy during the spring semester of 2022-2023. The Beck Depression Inventory and Beck Anxiety Scale were utilized to measure the presence of depression and anxiety, while the Depression and Antidepressant Awareness and Knowledge Scale (DAKAS) was applied to assess their knowledge, attitude, and awareness. Fifth-year participants (n = 101) exhibited noticeably fewer stigmatizing attitudes than first-year participants (n = 104) (
    Language English
    Publishing date 2024-03-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2737194-3
    ISSN 2226-4787 ; 2226-4787
    ISSN (online) 2226-4787
    ISSN 2226-4787
    DOI 10.3390/pharmacy12020045
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  10. Article ; Online: COVID-19 and antiepileptic drugs: an approach to guide practices when nirmatrelvir/ritonavir is co-prescribed.

    Yalcin, Nadir / Allegaert, Karel

    European journal of clinical pharmacology

    2022  Volume 78, Issue 10, Page(s) 1697–1701

    Abstract: Management and dose adjustment are a major concern for clinicians in the absence of specific clinical outcome data for patients on antiepileptic drugs (AEDs), in the event of short-term (5 days) nirmatrelvir/ritonavir co-exposure. Therefore, in this ... ...

    Abstract Management and dose adjustment are a major concern for clinicians in the absence of specific clinical outcome data for patients on antiepileptic drugs (AEDs), in the event of short-term (5 days) nirmatrelvir/ritonavir co-exposure. Therefore, in this report, we identified drugs that require dose adjustment because of drug-drug interactions (DDIs) between nirmatrelvir/ritonavir and AEDs. We hereby used four databases (Micromedex Drug Interaction, Liverpool Drug Interaction Group for COVID-19 Therapies, Medscape Drug Interaction Checker, and Lexicomp Drug Interactions) and DDI-Predictor.In the light of applying the DDI-Predictor, for carbamazepine, clobazam, oxcarbazepine, eslicarbazepine, phenytoin, phenobarbital, pentobarbital, rufinamide, and valproate as CYP3A4 inducers, we recommend that a dose adjustment of short-term nirmatrelvir/ritonavir as a substrate (victim) drug would be more appropriate instead of these AEDs to avoid impending DDI-related threats in patients with epilepsy.
    MeSH term(s) Anticonvulsants/therapeutic use ; COVID-19/drug therapy ; Carbamazepine/therapeutic use ; Clobazam ; Cytochrome P-450 CYP3A Inducers ; Drug Interactions ; Humans ; Oxcarbazepine ; Pentobarbital ; Phenobarbital ; Phenytoin ; Ritonavir/therapeutic use ; Valproic Acid/therapeutic use
    Chemical Substances Anticonvulsants ; Cytochrome P-450 CYP3A Inducers ; Clobazam (2MRO291B4U) ; Carbamazepine (33CM23913M) ; Valproic Acid (614OI1Z5WI) ; Phenytoin (6158TKW0C5) ; Pentobarbital (I4744080IR) ; Ritonavir (O3J8G9O825) ; Oxcarbazepine (VZI5B1W380) ; Phenobarbital (YQE403BP4D)
    Language English
    Publishing date 2022-08-05
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 121960-1
    ISSN 1432-1041 ; 0031-6970
    ISSN (online) 1432-1041
    ISSN 0031-6970
    DOI 10.1007/s00228-022-03370-7
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    Zs.A 672: Show issues Location:
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