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Article ; Online: Severe Osteoporosis With Pathogenic

Stringer, Felicity / Sims, Natalie A / Sachithanandan, Nirupa / Aleksova, Jasna

JCEM case reports

2024 Volume 2, Issue 3, Page(s) luae021

Abstract: A 24-year-old female patient was diagnosed with osteoporosis after presenting with numerous fractures throughout her childhood and adolescence. Risk factors included chronic constipation, severe vitamin D deficiency, and long-term high-dose steroid use ... ...

Abstract	A 24-year-old female patient was diagnosed with osteoporosis after presenting with numerous fractures throughout her childhood and adolescence. Risk factors included chronic constipation, severe vitamin D deficiency, and long-term high-dose steroid use for severe eczema. Metabolic bone disorder clinical exome screening (limited panel of metabolic bone disorders and gastrointestinal disorders) was undertaken and revealed a class 4 likely pathogenic variant in the
Language	English
Publishing date	2024-02-23
Publishing country	England
Document type	Case Reports
ISSN	2755-1520
ISSN (online)	2755-1520
DOI	10.1210/jcemcr/luae021
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Article: Gastric lipoma of the pylorus - case report of an incidental finding.

Georgiev, Aleksandar / Tsvetkova, Silvia / Aleksova, Lyubka / Ali, Metin

Radiology case reports

2021 Volume 16, Issue 7, Page(s) 1882–1884

Abstract: Gastric lipomas are very rare benign tumors. Only around 217 cases have been reported. Most gastric lipomas are found incidentally; however, larger neoplasms can be symptomatic. The presented 64 years old male with incidental finding of pyloric lipoma ... ...

Abstract	Gastric lipomas are very rare benign tumors. Only around 217 cases have been reported. Most gastric lipomas are found incidentally; however, larger neoplasms can be symptomatic. The presented 64 years old male with incidental finding of pyloric lipoma adds another example to the few documented in the literature. The patient had symptoms of breath shortness and lack of energy two months after COVID 19 pneumonia. A low dose CT scan with iodine contrast enhancement of the chest and upper abdomen led to the diagnose. The diagnosis of gastric lipoma can be achieved through diagnostic imaging or the combination of endoscopic techniques. Treatment can be carried out by endoscopy, robotic or classical surgery.
Language	English
Publishing date	2021-05-25
Publishing country	Netherlands
Document type	Case Reports
ZDB-ID	2406300-9
ISSN	1930-0433
ISSN	1930-0433
DOI	10.1016/j.radcr.2021.04.054
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Article ; Online: Endomyocardial Fibrosis, Apical Hypertrophy, or Both?

Sehly, Amro / Aleksova, Natasha / Chow, Benjamin J / Dwivedi, Girish

CASE (Philadelphia, Pa.)

2022 Volume 6, Issue 9, Page(s) 411–415

Language	English
Publishing date	2022-09-09
Publishing country	United States
Document type	Case Reports
ISSN	2468-6441
ISSN (online)	2468-6441
DOI	10.1016/j.case.2022.08.001
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Article ; Online: Chronic kidney disease-related sarcopenia as a prognostic indicator in elderly haemodialysis patients.

Elder, Madeleine / Moonen, Avalon / Crowther, Sjorjina / Aleksova, Jasna / Center, Jacqueline / Elder, Grahame J

BMC nephrology

2023 Volume 24, Issue 1, Page(s) 138

Abstract: Background: The mortality of dialysis patients greatly exceeds that of the general population and identifying predictive factors for mortality may provide opportunities for earlier intervention. This study assessed the influence of sarcopenia on ... ...

Abstract	Background: The mortality of dialysis patients greatly exceeds that of the general population and identifying predictive factors for mortality may provide opportunities for earlier intervention. This study assessed the influence of sarcopenia on mortality in patients on haemodialysis. Methods: This prospective, observational study enrolled 77 haemodialysis patients aged 60 years and over, of whom 33 (43%) were female, from two community dialysis centres. Baseline demographic and laboratory data were collected, and sarcopenia was diagnosed using grip strength, muscle mass by bioimpedance analysis (BIA) and muscle function by timed up-and-go according to European Working Group on Sarcopenia in Older People criteria. Nutritional status was assessed using a subjective nutritional assessment score, comprising functional changes in weight, appetite, gastrointestinal symptoms and energy.. A comorbidity score (maximum 7 points) was derived from the presence or absence of hypertension, ischaemic heart disease, vascular disease (cerebrovascular disease, peripheral vascular disease, and abdominal aortic aneurysm), diabetes mellitus, respiratory disease, a history of malignancy and psychiatric disease. Outcomes over six years were linked to the Australian and New Zealand Dialysis and Transplant Registry. Results: The median participant age was 71 years (range 60-87). Probable and confirmed sarcopenia was present in 55.9% and severe sarcopenia with reduced functional testing in 11.7%. Over 6 years, overall mortality was 50 of the 77 patients (65%), principally from cardiovascular events, dialysis withdrawal and infection. There were no significant survival differences between patients with no, probable, confirmed, or severe sarcopenia, or between tertiles of the nutritional assessment score. After adjustment for age, dialysis vintage, mean arterial pressure (MAP) and the total comorbidity score, no sarcopenia category predicted mortality. However, the total comorbidity score [Hazard Ratio (HR) 1.27, Confidence Intervals (CI) 1.02, 1.58, p = 0.03] and MAP (HR 0.96, CI 0.94, 0.99, P = < 0.01) predicted mortality. Conclusion: Sarcopenia is highly prevalent in elderly haemodialysis patients but is not an independent predictor of mortality. Haemodialysis patients have multiple competing risks for mortality which, in this study, was predicted by a lower MAP and a higher total comorbidity score. Trial registration: Recruitment commenced December 2011. The study was registered 10.01.2012 with the Australian New Zealand Clinical Trials Registry (ACTRN12612000048886).
MeSH term(s)	Aged ; Humans ; Female ; Middle Aged ; Aged, 80 and over ; Male ; Prognosis ; Prospective Studies ; Australia/epidemiology ; Sarcopenia/diagnosis ; Sarcopenia/epidemiology ; Renal Dialysis ; Renal Insufficiency, Chronic/epidemiology ; Renal Insufficiency, Chronic/therapy
Language	English
Publishing date	2023-05-19
Publishing country	England
Document type	Observational Study ; Journal Article
ZDB-ID	2041348-8
ISSN	1471-2369 ; 1471-2369
ISSN (online)	1471-2369
ISSN	1471-2369
DOI	10.1186/s12882-023-03175-5
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Article ; Online: Subcellular Effectors of Cocaine Cardiotoxicity: All Roads Lead to Mitochondria-A Systematic Review of the Literature.

Peruch, Michela / Giacomello, Emiliana / Radaelli, Davide / Concato, Monica / Addobbati, Riccardo / Fluca, Alessandra Lucia / Aleksova, Aneta / D'Errico, Stefano

International journal of molecular sciences

2023 Volume 24, Issue 19

Abstract: Cocaine abuse is a serious public health problem as this drug exerts a plethora of functional and histopathological changes that potentially lead to death. Cocaine causes complex multiorgan toxicity, including in the heart where the blockade of the ... ...

Abstract	Cocaine abuse is a serious public health problem as this drug exerts a plethora of functional and histopathological changes that potentially lead to death. Cocaine causes complex multiorgan toxicity, including in the heart where the blockade of the sodium channels causes increased catecholamine levels and alteration in calcium homeostasis, thus inducing an increased oxygen demand. Moreover, there is evidence to suggest that mitochondria alterations play a crucial role in the development of cocaine cardiotoxicity. We performed a systematic review according to the Preferred Reporting Items for Systemic Reviews and Meta-Analysis (PRISMA) scheme to evaluate the mitochondrial mechanisms determining cocaine cardiotoxicity. Among the initial 106 articles from the Pubmed database and the 17 articles identified through citation searching, 14 final relevant studies were extensively reviewed. Thirteen articles included animal models and reported the alteration of specific mitochondria-dependent mechanisms such as reduced energy production, imbalance of membrane potential, increased oxidative stress, and promotion of apoptosis. However, only one study evaluated human cocaine overdose samples and observed the role of cocaine in oxidative stress and the induction of apoptosis though mitochondria. Understanding the complex processes mediated by mitochondria through forensic analysis and experimental models is crucial for identifying potential therapeutic targets to mitigate or reverse cocaine cardiotoxicity in humans.
MeSH term(s)	Animals ; Humans ; Cardiotoxicity/etiology ; Cocaine/toxicity ; Cocaine-Related Disorders ; Heart ; Mitochondria ; Oxidative Stress
Chemical Substances	Cocaine (I5Y540LHVR)
Language	English
Publishing date	2023-09-25
Publishing country	Switzerland
Document type	Journal Article ; Review ; Systematic Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms241914517
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Article ; Online: Persistence of vitamin D deficiency among Italian patients with acute myocardial infarction.

Aleksova, Aneta / Janjusevic, Milijana / Zhou, Xin Ning Oriana / Zandonà, Lorenzo / Chicco, Andrea / Stenner, Elisabetta / Beltrami, Antonio Paolo / D'Errico, Stefano / Sinagra, Gianfranco / Marketou, Maria / Fluca, Alessandra Lucia / Zwas, Donna R

Nutrition, metabolism, and cardiovascular diseases : NMCD

2024 Volume 34, Issue 5, Page(s) 1283–1294

Abstract: Background and aims: Vitamin D deficiency is a common cardiovascular risk factor associated with the development of atherosclerosis. We evaluated changes in 25(OH)D concentrations in 1510 patients with acute myocardial infarction (AMI) over a long ... ...

Abstract	Background and aims: Vitamin D deficiency is a common cardiovascular risk factor associated with the development of atherosclerosis. We evaluated changes in 25(OH)D concentrations in 1510 patients with acute myocardial infarction (AMI) over a long observation period, including the COVID-19 pandemic. Methods and results: Patients were separated into four groups according to the year of enrolment, group 1 (2009-2010), group 2 (2014-2016), group 3 (2017-2019), and group 4 (2020-2022). The median 25(OH)D concentration in the overall cohort was 17.15 (10.3-24.7) ng/mL. The median plasma concentrations of 25(OH)D for groups 1, 2, 3, and 4 were 14.45 (7.73-22.58) ng/mL, 17.3 ng/mL (10.33-24.2), 18.95 (11.6-26.73) ng/mL and 19.05 (12.5-27.3) ng/mL, respectively. Although 25(OH)D levels increased over the years, the prevalence of vitamin D deficiency remained high in each group (68.4%, 61.4%, 53.8%, and 52% respectively). Hypovitaminosis D was predicted by the season influence (OR:2.03, p < 0.0001), higher body mass index (OR:1.25; p = 0.001), diabetes mellitus (OR:1.54; p = 0.001), smoking (OR:1.47; p = 0.001), older age (OR:1.07; p = 0.008), higher triglycerides levels (OR:1.02; p = 0.01), and female gender (OR:1.3; p = 0.038). After multivariable adjustment, vitamin D ≤ 20 ng/mL was an independent predictor of mortality. Conclusion: Vitamin D deficiency is highly prevalent and persistent in patients with AMI despite a trend towards increasing 25(OH)D concentrations over the years. The frequent lockdowns did not reduce the levels of 25(OH)D in the fourth group. Low levels of 25(OH)D are an independent predictor of mortality.
MeSH term(s)	Humans ; Female ; Pandemics ; Risk Factors ; Vitamin D Deficiency/diagnosis ; Vitamin D Deficiency/epidemiology ; Vitamin D ; Myocardial Infarction/diagnosis ; Myocardial Infarction/epidemiology ; Italy/epidemiology
Chemical Substances	Vitamin D (1406-16-2)
Language	English
Publishing date	2024-02-22
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1067704-5
ISSN	1590-3729 ; 0939-4753
ISSN (online)	1590-3729
ISSN	0939-4753
DOI	10.1016/j.numecd.2024.02.007
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Article: Pulmonary Embolism Presenting with Pulmonary Infarction: Update and Practical Review of Literature Data.

Gagno, Giulia / Padoan, Laura / D'Errico, Stefano / Baratella, Elisa / Radaelli, Davide / Fluca, Alessandra Lucia / Pierri, Alessandro / Janjusevic, Milijana / Aleksova Noveska, Elena / Cova, Maria Assunta / Copetti, Roberto / Cominotto, Franco / Sinagra, Gianfranco / Aleksova, Aneta

Journal of clinical medicine

2022 Volume 11, Issue 16

Abstract: Pulmonary infarction (PI) is a possible consequence of pulmonary embolism (PE). The real incidence of PI could be underestimated considering only non-fatal PE presentation. However, following postmortem examination, the prevalence of PI is considerably ... ...

Abstract	Pulmonary infarction (PI) is a possible consequence of pulmonary embolism (PE). The real incidence of PI could be underestimated considering only non-fatal PE presentation. However, following postmortem examination, the prevalence of PI is considerably higher. This evidence suggests the necessity of proper diagnostic protocol for identifying PI. Unfortunately, PI diagnosis can sometimes be challenging, due to the overlapping of symptoms with other diseases. Nowadays, the diagnosis is mainly based on radiological evaluation, although the combination with emerging imaging techniques such as ultrasound and nuclear scanning might improve the diagnostic algorithm for PI. This review aims to summarize the available data on the prevalence of PI, the main predisposing factors for the development of PI among patients with PE, to resume the possible diagnostic tools, and finally the clinical and prognostic implications.
Language	English
Publishing date	2022-08-21
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm11164916
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Article ; Online: Effects of increasing concentrations of fungicide Quadris

Aleksova, Michaella / Kenarova, Anelia / Boteva, Silvena / Georgieva, Stela / Chanev, Christo / Radeva, Galina

Archives of microbiology

2021 Volume 203, Issue 7, Page(s) 4385–4396

Abstract: A mesocosm experiment was conducted to assess the side effects of the fungicide ... ...

Abstract	A mesocosm experiment was conducted to assess the side effects of the fungicide Quadris
MeSH term(s)	Bacteria/drug effects ; Fungicides, Industrial/pharmacology ; Pyrimidines/pharmacology ; Sand ; Soil/chemistry ; Soil Microbiology ; Soil Pollutants/analysis ; Strobilurins/pharmacology
Chemical Substances	Fungicides, Industrial ; Pyrimidines ; Sand ; Soil ; Soil Pollutants ; Strobilurins ; azoxystrobin (NYH7Y08IPM)
Language	English
Publishing date	2021-06-12
Publishing country	Germany
Document type	Journal Article
ZDB-ID	124824-8
ISSN	1432-072X ; 0302-8933
ISSN (online)	1432-072X
ISSN	0302-8933
DOI	10.1007/s00203-021-02423-2
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Article ; Online: Old and Novel Therapeutic Approaches in the Management of Hyperglycemia, an Important Risk Factor for Atherosclerosis.

Janjusevic, Milijana / Fluca, Alessandra Lucia / Gagno, Giulia / Pierri, Alessandro / Padoan, Laura / Sorrentino, Annamaria / Beltrami, Antonio Paolo / Sinagra, Gianfranco / Aleksova, Aneta

International journal of molecular sciences

2022 Volume 23, Issue 4

Abstract: Hyperglycemia is considered one of the main risk factors for atherosclerosis, since high glucose levels trigger multiple pathological processes, such as oxidative stress and hyperproduction of pro-inflammatory mediators, leading to endothelial ... ...

Abstract	Hyperglycemia is considered one of the main risk factors for atherosclerosis, since high glucose levels trigger multiple pathological processes, such as oxidative stress and hyperproduction of pro-inflammatory mediators, leading to endothelial dysfunction. In this context, recently approved drugs, such as glucagon-like-peptide-1 receptor agonists (GLP-1RAs) and sodium-glucose cotransporter-2 inhibitors (SGLT2i), could be considered a powerful tool for to reduce glucose concentration and cardiovascular risk. Interestingly, many patients with type 2 diabetes mellitus (T2DM) and insulin resistance have been found to be deficient in vitamin D. Recent studies pointed out the unfavorable prognostic values of T2DM and vitamin D deficiency in patients with cardiac dysfunction, either when considered individually or together, which shed light on the role of vitamin D in general health status. New evidence suggests that SGLT2i could adversely affect the production of vitamin D, thereby increasing the risk of fractures, which are common in patients with T2DM. Therefore, given the biological effects of vitamin D as an anti-inflammatory mediator and a regulator of endothelial function and calcium equilibrium, these new findings should be taken into consideration as well. The aim of this review is to gather the latest advancements regarding the use of antidiabetic and antiplatelet drugs coupled with vitamin D supplementation to control glucose levels, therefore reducing the risk of coronary artery disease (CAD).
MeSH term(s)	Atherosclerosis/chemically induced ; Atherosclerosis/etiology ; Diabetes Mellitus, Type 2/chemically induced ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/drug therapy ; Glucagon-Like Peptide-1 Receptor/agonists ; Glucose/therapeutic use ; Humans ; Hyperglycemia/chemically induced ; Hyperglycemia/complications ; Hyperglycemia/drug therapy ; Hypoglycemic Agents/therapeutic use ; Risk Factors ; Sodium-Glucose Transporter 2 Inhibitors/pharmacology ; Vitamin D/therapeutic use
Chemical Substances	Glucagon-Like Peptide-1 Receptor ; Hypoglycemic Agents ; Sodium-Glucose Transporter 2 Inhibitors ; Vitamin D (1406-16-2) ; Glucose (IY9XDZ35W2)
Language	English
Publishing date	2022-02-20
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms23042336
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Article: The Role of Exercise-Induced Molecular Processes and Vitamin D in Improving Cardiorespiratory Fitness and Cardiac Rehabilitation in Patients With Heart Failure.

Aleksova, Aneta / Janjusevic, Milijana / Gagno, Giulia / Pierri, Alessandro / Padoan, Laura / Fluca, Alessandra Lucia / Carriere, Cosimo / Beltrami, Antonio Paolo / Sinagra, Gianfranco

Frontiers in physiology

2022 Volume 12, Page(s) 794641

Abstract: Heart failure (HF) still affects millions of people worldwide despite great advances in therapeutic approaches in the cardiovascular field. Remarkably, unlike pathological hypertrophy, exercise leads to beneficial cardiac hypertrophy characterized by ... ...

Abstract	Heart failure (HF) still affects millions of people worldwide despite great advances in therapeutic approaches in the cardiovascular field. Remarkably, unlike pathological hypertrophy, exercise leads to beneficial cardiac hypertrophy characterized by normal or enhanced contractile function. Exercise-based cardiac rehabilitation improves cardiorespiratory fitness and, as a consequence, ameliorates the quality of life of patients with HF. Particularly, multiple studies demonstrated the improvement in left ventricular ejection fraction (LVEF) among patients with HF due to the various processes in the myocardium triggered by exercise. Exercise stimulates IGF-1/PI3K/Akt pathway activation involved in muscle growth in both the myocardium and skeletal muscle by regulating protein synthesis and catabolism. Also, physical activity stimulates the activation of the mitogen-activated protein kinase (MAPK) pathway which regulates cellular proliferation, differentiation and apoptosis. In addition, emerging data pointed out the anti-inflammatory effects of exercises as well. Therefore, it is of utmost importance for clinicians to accurately evaluate the patient's condition by performing a cardiopulmonary exercise test and/or a 6-min walking test. Portable devices with the possibility to measure exercise capacity proved to be very useful in this setting as well. The aim of this review is to gather together the molecular processes triggered by the exercise and available therapies in HF settings that could ameliorate heart performance, with a special focus on strategies such as exercise-based cardiac rehabilitation.
Language	English
Publishing date	2022-01-11
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2564217-0
ISSN	1664-042X
ISSN	1664-042X
DOI	10.3389/fphys.2021.794641
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