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Article: Measuring Work of Breathing, Moving From Research to the Bedside?

Pons-Odena, Martí

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies

2019 Volume 20, Issue 7, Page(s) 688–689

MeSH term(s)	Child ; Diaphragm ; Humans ; Monitoring, Physiologic ; Respiration ; Respiration, Artificial ; Work of Breathing
Language	English
Publishing date	2019-07-05
Publishing country	United States
Document type	Editorial ; Comment
ZDB-ID	2052349-X
ISSN	1947-3893 ; 1529-7535
ISSN (online)	1947-3893
ISSN	1529-7535
DOI	10.1097/PCC.0000000000001989
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Zs.MO 472: Show issues

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Article: Noninvasive Respiratory Support for Pediatric Acute Respiratory Distress Syndrome: From the Second Pediatric Acute Lung Injury Consensus Conference.

Carroll, Christopher L / Napolitano, Natalie / Pons-Òdena, Marti / Iyer, Narayan Prabhu / Korang, Steven Kwasi / Essouri, Sandrine

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies

2023 Volume 24, Issue 12 Suppl 2, Page(s) S135–S147

Abstract: Objectives: To develop evidence-based recommendations for the Second Pediatric Acute Lung Injury Consensus Conference (PALICC) regarding the effectiveness of noninvasive respiratory support for pediatric acute respiratory distress syndrome (PARDS). ... ...

Abstract	Objectives: To develop evidence-based recommendations for the Second Pediatric Acute Lung Injury Consensus Conference (PALICC) regarding the effectiveness of noninvasive respiratory support for pediatric acute respiratory distress syndrome (PARDS). These include consideration of the timing and duration of noninvasive ventilation (NIV) and high-flow nasal cannula (HFNC), whether effectiveness varies by disease severity or by characteristics of treatment delivery, and best practices for the use of NIV. Data sources: MEDLINE (Ovid), Embase (Elsevier), and CINAHL Complete (EBSCOhost). Study selection: Searches included all studies involving the use of NIV or HFNC in children with PARDS or hypoxemic respiratory failure. Data extraction: Title/abstract review, full-text review, and data extraction using a standardized data extraction form. Data synthesis: The Grading of Recommendations Assessment, Development, and Evaluation approach was used to identify and summarize evidence and develop recommendations. Out of 6,336 studies, we identified 187 for full-text review. Four clinical recommendations were generated, related to indications, timing and duration of NIV in patients with PARDS, predictors of NIV failure and need for intubation (signs and symptoms of worsening disease including pulse oximetry saturation/Fio2 ratio), and use of NIV in resource-limited settings. Six good practice statements were generated related to how and where to deliver NIV, the importance of trained experienced staff and monitoring, types of NIV interfaces, the use of sedation, and the potential complications of this therapy. One research statement was generated related to indications of HFNC in patients with PARDS. Conclusions: NIV is a widely used modality for the treatment of respiratory failure in children and may be beneficial in a subset of patients with PARDS. However, there needs to be close monitoring for worsening disease and NIV failure.
MeSH term(s)	Humans ; Child ; Respiratory Distress Syndrome/therapy ; Respiratory Insufficiency/therapy ; Respiration, Artificial ; Intubation ; Oxygen Inhalation Therapy ; Noninvasive Ventilation ; Cannula ; Acute Lung Injury
Language	English
Publishing date	2023-01-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	2052349-X
ISSN	1947-3893 ; 1529-7535
ISSN (online)	1947-3893
ISSN	1529-7535
DOI	10.1097/PCC.0000000000003165
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Zs.A 5600: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Weaning from noninvasive respiratory support in children in acute settings: Expert consensus statement using modified Delphi methodology.

Mortamet, Guillaume / Milési, Christophe / Baudin, Florent / Yalindag, Nilufer / Kneyber, Martin / Pons-Odena, Marti

Pediatric pulmonology

2023 Volume 59, Issue 2, Page(s) 348–354

Abstract: Objective: To reach a consensus on the definition and modalities of weaning from noninvasive ventilation in acute settings.: Design: A modified Delphi survey using closed and open-ended questions.: Setting: Three rounds of consensus determination ... ...

Abstract	Objective: To reach a consensus on the definition and modalities of weaning from noninvasive ventilation in acute settings. Design: A modified Delphi survey using closed and open-ended questions. Setting: Three rounds of consensus determination were sent via electronic mail survey to 33 experts. The survey questionnaire had four sections: definition of weaning, definition of weaning failure, criteria to initiate weaning, and modalities of weaning. Questions where agreement had been reached on round 1 were no longer part of the survey in rounds 2 and 3. Subjects: Twenty-five international experts from 10 countries. Measurement and main results: Overall, this survey generated positive consensus from experts for 19/35 statements (9 with strong agreement and 10 with weak agreement) about weaning from noninvasive respiratory support. No negative consensus could be identified. Conclusion: The clinical practice statements issued address important aspects of definition of weaning, definition of weaning failure, criteria to initiate weaning, and modalities of weaning in acute settings.
MeSH term(s)	Child ; Humans ; Delphi Technique ; Ventilator Weaning ; Surveys and Questionnaires ; Consensus ; Noninvasive Ventilation
Language	English
Publishing date	2023-11-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	632784-9
ISSN	1099-0496 ; 8755-6863
ISSN (online)	1099-0496
ISSN	8755-6863
DOI	10.1002/ppul.26753
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Zs.A 2143: Show issues

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Article ; Online: The mean airway pressure may be the answer.

Perez-Baena, Luis / Pons-Òdena, Martí

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians

2018 Volume 33, Issue 1, Page(s) 172–173

MeSH term(s)	Humans ; Infant ; Noninvasive Ventilation ; Positive-Pressure Respiration
Language	English
Publishing date	2018-07-22
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	2077261-0
ISSN	1476-4954 ; 1057-0802 ; 1476-7058
ISSN (online)	1476-4954
ISSN	1057-0802 ; 1476-7058
DOI	10.1080/14767058.2018.1487945
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Zs.A 3510: Show issues

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Article: High-Flow Nasal Cannula Versus Noninvasive Ventilation: A Matter of Confusion.

Modesto I Alapont, Vicent / Pons-Òdena, Martí / Medina, Alberto

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies

2019 Volume 20, Issue 12, Page(s) 1210–1211

MeSH term(s)	Bronchiolitis ; Cannula ; Child ; Humans ; Noninvasive Ventilation ; Positive-Pressure Respiration ; Respiratory Insufficiency
Language	English
Publishing date	2019-12-19
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	2052349-X
ISSN	1947-3893 ; 1529-7535
ISSN (online)	1947-3893
ISSN	1529-7535
DOI	10.1097/PCC.0000000000002110
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 5600: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Treachery on the Rocks in the Pediatric Intensive Care Unit.

Pons-Odena, Martí / Medina, Alberto / Modesto-Alapont, Vicent

JAMA pediatrics

2019 Volume 173, Issue 7, Page(s) 699

MeSH term(s)	Child ; Humans ; Intensive Care Units, Pediatric ; Oxygen ; Oxygen Inhalation Therapy
Chemical Substances	Oxygen (S88TT14065)
Language	English
Publishing date	2019-05-13
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	2701223-2
ISSN	2168-6211 ; 2168-6203
ISSN (online)	2168-6211
ISSN	2168-6203
DOI	10.1001/jamapediatrics.2019.1188
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Um IV Zs.74: Show issues

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Article ; Online: Tracheal opening manoeuvre (PEEP-20) in a patient with bronchopulmonary dysplasia and severe tracheobronchomalacia with neurally adjusted ventilatory assist (NAVA).

Olguin Ciancio, Maite / Cambra, Francisco José / Pons-Odena, Martí

BMJ case reports

2020 Volume 13, Issue 1

Abstract: Bronchopulmonary dysplasia (BPD) is occasionally associated with tracheobronchomalacia, and it is this combination that can lead to serious outcomes. The most severe cases require tracheostomies, ventilatory support and eventually even tracheal stents or ...

Abstract	Bronchopulmonary dysplasia (BPD) is occasionally associated with tracheobronchomalacia, and it is this combination that can lead to serious outcomes. The most severe cases require tracheostomies, ventilatory support and eventually even tracheal stents or surgery. Ventilation in patients with tracheomalacia is complicated without a good patient-ventilator synchrony; the neurally adjusted ventilatory assist (NAVA) mode is potentially beneficial in these cases. This case report presents a patient affected by BPD and severe tracheobronchomalacia who was tracheostomised and ventilated 24 hours a day and who suffered from episodes of airway collapse despite using the NAVA mode. It was necessary to increase the positive end-expiratory pressure to 20 cmH
MeSH term(s)	Bronchopulmonary Dysplasia/therapy ; Humans ; Infant ; Positive-Pressure Respiration ; Tracheobronchomalacia/therapy ; Tracheostomy ; Ventilator Weaning
Language	English
Publishing date	2020-01-21
Publishing country	England
Document type	Case Reports ; Journal Article
ISSN	1757-790X
ISSN (online)	1757-790X
DOI	10.1136/bcr-2019-229471
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Article: Lung Recruitment Maneuvers Assessment by Bedside Lung Ultrasound in Pediatric Acute Respiratory Distress Syndrome.

Mor Conejo, Mireia / Guitart Pardellans, Carmina / Fresán Ruiz, Elena / Penela Sánchez, Daniel / Cambra Lasaosa, Francisco José / Jordan Garcia, Iolanda / Balaguer Gargallo, Mònica / Pons-Òdena, Martí

Children (Basel, Switzerland)

2022 Volume 9, Issue 6

Abstract: The use of recruitment maneuvers (RMs) is suggested to improve severe oxygenation failure in patients with acute respiratory distress syndrome (ARDS). Lung ultrasound (LUS) is a non-invasive, safe, and easily repeatable tool. It could be used to monitor ... ...

Abstract	The use of recruitment maneuvers (RMs) is suggested to improve severe oxygenation failure in patients with acute respiratory distress syndrome (ARDS). Lung ultrasound (LUS) is a non-invasive, safe, and easily repeatable tool. It could be used to monitor the lung recruitment process in real-time. This paper aims to evaluate bedside LUS for assessing PEEP-induced pulmonary reaeration during RMs in pediatric patients. A case of a child with severe ARDS due to
Language	English
Publishing date	2022-05-27
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2732685-8
ISSN	2227-9067
ISSN	2227-9067
DOI	10.3390/children9060789
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Article: Noninvasive Ventilation for Pediatric Acute Respiratory Distress Syndrome: Experience From the 2016/2017 Pediatric Acute Respiratory Distress Syndrome Incidence and Epidemiology Prospective Cohort Study.

Emeriaud, Guillaume / Pons-Òdena, Marti / Bhalla, Anoopindar K / Shein, Steven L / Killien, Elizabeth Y / Modesto I Alapont, Vicent / Rowan, Courtney / Baudin, Florent / Lin, John C / Grégoire, Gabrielle / Napolitano, Natalie / Mayordomo-Colunga, Juan / Diaz, Franco / Cruces, Pablo / Medina, Alberto / Smith, Lincoln / Khemani, Robinder G

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies

2023 Volume 24, Issue 9, Page(s) 715–726

Abstract: Objectives: The worldwide practice and impact of noninvasive ventilation (NIV) in pediatric acute respiratory distress syndrome (PARDS) is unknown. We sought to describe NIV use and associated clinical outcomes in PARDS.: Design: Planned ancillary ... ...

Abstract	Objectives: The worldwide practice and impact of noninvasive ventilation (NIV) in pediatric acute respiratory distress syndrome (PARDS) is unknown. We sought to describe NIV use and associated clinical outcomes in PARDS. Design: Planned ancillary study to the 2016/2017 prospective Pediatric Acute Respiratory Distress Syndrome Incidence and Epidemiology study. Setting: One hundred five international PICUs. Patients: Patients with newly diagnosed PARDS admitted during 10 study weeks. Interventions: None. Measurements and main results: Children were categorized by their respiratory support at PARDS diagnosis into NIV or invasive mechanical ventilation (IMV) groups. Of 708 subjects with PARDS, 160 patients (23%) received NIV at PARDS diagnosis (NIV group). NIV failure rate (defined as tracheal intubation or death) was 84 of 160 patients (53%). Higher nonrespiratory pediatric logistic organ dysfunction (PELOD-2) score, Pa o2 /F io2 was less than 100 at PARDS diagnosis, immunosuppression, and male sex were independently associated with NIV failure. NIV failure was 100% among patients with nonrespiratory PELOD-2 score greater than 2, Pa o2 /F io2 less than 100, and immunosuppression all present. Among patients with Pa o2 /F io2 greater than 100, children in the NIV group had shorter total duration of NIV and IMV, than the IMV at initial diagnosis group. We failed to identify associations between NIV use and PICU survival in a multivariable Cox regression analysis (hazard ratio 1.04 [95% CI, 0.61-1.80]) or mortality in a propensity score matched analysis ( p = 0.369). Conclusions: Use of NIV at PARDS diagnosis was associated with shorter exposure to IMV in children with mild to moderate hypoxemia. Even though risk of NIV failure was high in some children, we failed to identify greater hazard of mortality in these patients.
MeSH term(s)	Humans ; Child ; Male ; Respiration, Artificial ; Noninvasive Ventilation ; Prospective Studies ; Incidence ; Respiratory Distress Syndrome/epidemiology ; Respiratory Distress Syndrome/therapy ; Respiratory Distress Syndrome/diagnosis
Language	English
Publishing date	2023-05-31
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2052349-X
ISSN	1947-3893 ; 1529-7535
ISSN (online)	1947-3893
ISSN	1529-7535
DOI	10.1097/PCC.0000000000003281
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: COVID-19 and respiratory support devices.

Pons-Òdena, Marti / Valls, Arnau / Grifols, Jordi / Farré, Ramon / Cambra Lasosa, Francisco José / Rubin, Bruce K

Paediatric respiratory reviews

2020 Volume 35, Page(s) 61–63

Abstract: There are significant logistical challenges to providing respiratory support devices, beyond simple oxygen flow, when centres run out of supplies or do not have these devices at all, such as in low resource settings. At the peak of the COVID-19 crisis, ... ...

Abstract	There are significant logistical challenges to providing respiratory support devices, beyond simple oxygen flow, when centres run out of supplies or do not have these devices at all, such as in low resource settings. At the peak of the COVID-19 crisis, it was extremely difficult to import medical equipment and supplies, because most countries prohibited the medical industry from selling outside of their own countries. As a consequence, engineering teams worldwide volunteered to develop emergency devices, and medical experts in mechanical ventilation helped to guide the design and evaluation of prototypes. Although regulations vary among countries, given the emergency situation, some Regulatory Agencies facilitated expedited procedures. However, laboratory and animal model testing are crucial to minimize the potential risk for patients when treated with a device that may worsen clinical outcome if poorly designed or misused.
MeSH term(s)	Betacoronavirus ; COVID-19 ; Continuous Positive Airway Pressure/instrumentation ; Coronavirus Infections/therapy ; Device Approval ; Education, Professional, Retraining ; Equipment Design ; Equipment and Supplies/supply & distribution ; Humans ; Medical Device Legislation ; Noninvasive Ventilation/instrumentation ; Pandemics ; Personnel Staffing and Scheduling ; Pneumonia, Viral/therapy ; Respiration, Artificial/instrumentation ; Respiratory Distress Syndrome/therapy ; Respiratory Insufficiency/therapy ; SARS-CoV-2 ; Spain ; Ventilators, Mechanical/supply & distribution
Keywords	covid19
Language	English
Publishing date	2020-06-20
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2147664-0
ISSN	1526-0550 ; 1526-0542
ISSN (online)	1526-0550
ISSN	1526-0542
DOI	10.1016/j.prrv.2020.06.015
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