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Article ; Online: Acetyltransferase P300 Regulates Glucose Metabolic Reprogramming through Catalyzing Succinylation in Lung Cancer.

Ma, Qingzhi / Zeng, Qingmei / Wang, Kun / Qian, Meirui / Li, Jingzhuo / Wang, Hao / Zhang, Huijie / Jiang, Jianli / Chen, Zhinan / Huang, Wan

International journal of molecular sciences

2024 Volume 25, Issue 2

Abstract: Aberrant protein post-translational modification is a hallmark of malignant tumors. Lysine succinylation (Ksucc) plays a vital role in cell energy metabolism in various cancers. However, whether succinylation can be catalyzed by acetyltransferase p300 ... ...

Abstract	Aberrant protein post-translational modification is a hallmark of malignant tumors. Lysine succinylation (Ksucc) plays a vital role in cell energy metabolism in various cancers. However, whether succinylation can be catalyzed by acetyltransferase p300 remains unclear. In this study, we unveiled that p300 is a "writer" for succinylation, and p300-mediated Ksucc promotes cell glycometabolism in lung adenocarcinoma (LUAD). Specifically, our succinylome data revealed that
MeSH term(s)	Humans ; Adenocarcinoma of Lung/genetics ; Glucose ; Lung Neoplasms/genetics ; Metabolic Reprogramming ; E1A-Associated p300 Protein/genetics
Chemical Substances	Glucose (IY9XDZ35W2) ; EP300 protein, human (EC 2.3.1.48) ; E1A-Associated p300 Protein (EC 2.3.1.48)
Language	English
Publishing date	2024-01-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms25021057
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: COVID-19 and social distancing.

Qian, Meirui / Jiang, Jianli

Zeitschrift fur Gesundheitswissenschaften = Journal of public health

2020 Volume 30, Issue 1, Page(s) 259–261

Abstract: Aim: COVID-19 has spread rapidly worldwide since it began, greatly affecting peoples' lives, social economies and medical systems. At present, little is known about the disease, and vaccines are still under development. Therefore, in the face of severe ... ...

Abstract	Aim: COVID-19 has spread rapidly worldwide since it began, greatly affecting peoples' lives, social economies and medical systems. At present, little is known about the disease, and vaccines are still under development. Therefore, in the face of severe outbreaks, previous effective experience can help people better protect themselves and their families. The aim of this article is to discuss the social distancing measures for COVID-19. Subjects and methods: Literature and document search. Results: Recent research and a novel coronavirus pneumonia prediction model revealed social distancing measures and wearing masks are required to mitigate hospital system overload and prevent pathogen exposure. After a series of social distancing measures, there are 309 cities with zero cases and 34 cities with confirmed cases in China as of April 13, 2020. Conclusion: From China's experience with novel coronavirus pneumonia, we know that social distancing is the most effective measure at present. We need to win more time to allow limited medical resources to save lives.
Keywords	covid19
Language	English
Publishing date	2020-05-25
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	1149070-6
ISSN	2198-1833 ; 0943-1853
ISSN	2198-1833 ; 0943-1853
DOI	10.1007/s10389-020-01321-z
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Article ; Online: COVID-19 and social distancing

Qian, Meirui / Jiang, Jianli

Journal of Public Health ; ISSN 2198-1833 1613-2238

2020

Keywords	covid19
Language	English
Publisher	Springer Science and Business Media LLC
Publishing country	us
Document type	Article ; Online
DOI	10.1007/s10389-020-01321-z
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Identification and validation of a novel survival prediction model based on the T-cell phenotype in the tumor immune microenvironment and peripheral blood for gastric cancer prognosis.

Ma, Jing / Li, Jianhui / He, Nan / Qian, Meirui / Lu, Yuanyuan / Wang, Xin / Wu, Kaichun

Journal of translational medicine

2023 Volume 21, Issue 1, Page(s) 73

Abstract: Background: The correlation and difference in T-cell phenotypes between peripheral blood lymphocytes (PBLs) and the tumor immune microenvironment (TIME) in patients with gastric cancer (GC) is not clear. We aimed to characterize the phenotypes of CD8: ...

Abstract	Background: The correlation and difference in T-cell phenotypes between peripheral blood lymphocytes (PBLs) and the tumor immune microenvironment (TIME) in patients with gastric cancer (GC) is not clear. We aimed to characterize the phenotypes of CD8 Methods: Multiplex immunofluorescence staining and flow cytometry were used to detect the expression of inhibitory molecules (IMs) and active markers (AMs) in CD8 Results: The percentage of PD-1 Conclusion: We established a comprehensive and robust survival prediction model based on the T-cell phenotype in the TIME and PBLs for GC prognosis.
MeSH term(s)	Humans ; CD8-Positive T-Lymphocytes ; B7-H1 Antigen/metabolism ; Hepatitis A Virus Cellular Receptor 2/metabolism ; Stomach Neoplasms/pathology ; Programmed Cell Death 1 Receptor/metabolism ; Prognosis ; Lymphocytes, Tumor-Infiltrating ; Tumor Microenvironment
Chemical Substances	B7-H1 Antigen ; Hepatitis A Virus Cellular Receptor 2 ; Programmed Cell Death 1 Receptor
Language	English
Publishing date	2023-02-03
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2118570-0
ISSN	1479-5876 ; 1479-5876
ISSN (online)	1479-5876
ISSN	1479-5876
DOI	10.1186/s12967-023-03922-0
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Article ; Online: Id2 epigenetically controls CD8

Li, Yiming / Han, Mingwei / Wei, Haolin / Huang, Wan / Chen, Zhinan / Zhang, Tianjiao / Qian, Meirui / Jing, Lin / Nan, Gang / Sun, Xiuxuan / Dai, Shuhui / Wang, Kun / Jiang, Jianli / Zhu, Ping / Chen, Liang

Cellular & molecular immunology

2024 Volume 21, Issue 3, Page(s) 292–308

Abstract: ... ...

Abstract	CD8
MeSH term(s)	Mice ; Animals ; CD8-Positive T-Lymphocytes ; Hepatitis A Virus Cellular Receptor 2/metabolism ; T-Cell Exhaustion ; Neoplasms/pathology ; Histone Demethylases/metabolism ; Chromatin/metabolism
Chemical Substances	Hepatitis A Virus Cellular Receptor 2 ; Histone Demethylases (EC 1.14.11.-) ; Chromatin
Language	English
Publishing date	2024-01-29
Publishing country	China
Document type	Journal Article
ZDB-ID	2435097-7
ISSN	2042-0226 ; 1672-7681
ISSN (online)	2042-0226
ISSN	1672-7681
DOI	10.1038/s41423-023-01118-6
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Article ; Online: Identification and validation of a novel survival prediction model based on the T-cell phenotype in the tumor immune microenvironment and peripheral blood for gastric cancer prognosis

Jing Ma / Jianhui Li / Nan He / Meirui Qian / Yuanyuan Lu / Xin Wang / Kaichun Wu

Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-

2023 Volume 14

Abstract: Abstract Background The correlation and difference in T-cell phenotypes between peripheral blood lymphocytes (PBLs) and the tumor immune microenvironment (TIME) in patients with gastric cancer (GC) is not clear. We aimed to characterize the phenotypes of ...

Abstract	Abstract Background The correlation and difference in T-cell phenotypes between peripheral blood lymphocytes (PBLs) and the tumor immune microenvironment (TIME) in patients with gastric cancer (GC) is not clear. We aimed to characterize the phenotypes of CD8+ T cells in tumor infiltrating lymphocytes (TILs) and PBLs in patients with different outcomes and to establish a useful survival prediction model. Methods Multiplex immunofluorescence staining and flow cytometry were used to detect the expression of inhibitory molecules (IMs) and active markers (AMs) in CD8+TILs and PBLs, respectively. The role of these parameters in the 3-year prognosis was assessed by receiver operating characteristic analysis. Then, we divided patients into two TIME clusters (TIME-A/B) and two PBL clusters (PBL-A/B) by unsupervised hierarchical clustering based on the results of multivariate analysis, and used the Kaplan–Meier method to analyze the difference in prognosis between each group. Finally, we constructed and compared three survival prediction models based on Cox regression analysis, and further validated the efficiency and accuracy in the internal and external cohorts. Results The percentage of PD-1+CD8+TILs, TIM-3+CD8+TILs, PD-L1+CD8+TILs, and PD-L1+CD8+PBLs and the density of PD-L1+CD8+TILs were independent risk factors, while the percentage of TIM-3+CD8+PBLs was an independent protective factor. The patients in the TIME-B group showed a worse 3-year overall survival (OS) (HR: 3.256, 95% CI 1.318–8.043, P = 0.006), with a higher density of PD-L1+CD8+TILs (P < 0.001) and percentage of PD-1+CD8+TILs (P = 0.017) and PD-L1+CD8+TILs (P < 0.001) compared to the TIME-A group. The patients in the PBL-B group showed higher positivity for PD-L1+CD8+PBLs (P = 0.042), LAG-3+CD8+PBLs (P < 0.001), TIM-3+CD8+PBLs (P = 0.003), PD-L1+CD4+PBLs (P = 0.001), and LAG-3+CD4+PBLs (P < 0.001) and poorer 3-year OS (HR: 0.124, 95% CI 0.017–0.929, P = 0.015) than those in the PBL-A group. In our three survival prediction models, Model 3, ...
Keywords	Inhibitory molecule ; Tumor immune microenvironment ; Peripheral blood lymphocytes ; Survival prediction model ; Gastric cancer ; Medicine ; R
Subject code	616
Language	English
Publishing date	2023-02-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: COVID-19 and social distancing

Qian, Meirui / Jiang, Jianli

Z Gesundh Wiss

Abstract	Aim: COVID-19 has spread rapidly worldwide since it began, greatly affecting peoples' lives, social economies and medical systems. At present, little is known about the disease, and vaccines are still under development. Therefore, in the face of severe outbreaks, previous effective experience can help people better protect themselves and their families. The aim of this article is to discuss the social distancing measures for COVID-19. Subjects and methods: Literature and document search. Results: Recent research and a novel coronavirus pneumonia prediction model revealed social distancing measures and wearing masks are required to mitigate hospital system overload and prevent pathogen exposure. After a series of social distancing measures, there are 309 cities with zero cases and 34 cities with confirmed cases in China as of April 13, 2020. Conclusion: From China's experience with novel coronavirus pneumonia, we know that social distancing is the most effective measure at present. We need to win more time to allow limited medical resources to save lives.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #361219
Database	COVID19

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Article ; Online: Association between the cardiometabolic index and chronic kidney disease: a cross-sectional study.

Guo, Qian / Wang, Yani / Liu, Yuchen / Wang, Yun / Deng, Lin / Liao, Lihua / Lin, Xueqin / Wu, Mingxin / Sun, Meirui / Liao, Ying

International urology and nephrology

2023 Volume 56, Issue 5, Page(s) 1733–1741

Abstract: Background: Central obesity is a risk factor for chronic kidney disease (CKD). However, the exact correlation between the cardiometabolic index (CMI), an indicator of central obesity, and CKD remains unclear. Here, we aimed to investigate the ... ...

Abstract	Background: Central obesity is a risk factor for chronic kidney disease (CKD). However, the exact correlation between the cardiometabolic index (CMI), an indicator of central obesity, and CKD remains unclear. Here, we aimed to investigate the correlation between the CMI and CKD in the general American population. Methods: This cross-sectional study involved 64,313 members of the general population (≥ 20 years of age) with data in the National Health and Nutrition Examination Survey (NHANES) 1999-2020. The individuals were grouped into three categories by CMI tertile: T1 group (n = 7,029), T2 group (n = 7,356), and T3 group (n = 7,380). Logistic regression analysis was performed, with NHANES recommended weights, to assess the association between the CMI and CKD. Results: A total of 21,765 participants were included; the overall prevalence of CKD was 12.2%. From the low to the high CMI tertile, the prevalence of CKD increased from 8.9% to 16.0% (P < 0.001). After full adjustment for confounders, the higher tertile of CMI (OR: 1.08, 95% CI: 1.03 - 1.13, P = 0.002) had the higher risk of CKD. Compared with the T1 group, the groups with higher CMI levels had a higher CKD risk (T2: OR: 1.01, 95%CI: 0.87-1.18, P = 0.812; T3: OR: 1.22, 95%CI: 1.05-1.43, P = 0.013). Conclusions: Higher CMI was independently associated with higher CKD risk in the general population.
MeSH term(s)	Humans ; United States/epidemiology ; Cross-Sectional Studies ; Nutrition Surveys ; Obesity, Abdominal ; Renal Insufficiency, Chronic/epidemiology ; Obesity/epidemiology ; Risk Factors ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/etiology
Language	English
Publishing date	2023-12-08
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	204048-7
ISSN	1573-2584 ; 0301-1623 ; 0042-1162
ISSN (online)	1573-2584
ISSN	0301-1623 ; 0042-1162
DOI	10.1007/s11255-023-03888-4
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Zs.A 733: Show issues

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Article ; Online: The comprehensive pathophysiological changes in a novel rat model of postinflammatory visceral hypersensitivity.

Ma, Jing / Li, Jianhui / Qian, Meirui / He, Nan / Cao, Ying / Liu, Yaping / Wu, Kaichun / He, Shuixiang

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

2019 Volume 33, Issue 12, Page(s) 13560–13571

Abstract: So far, a comprehensive animal model that can mimic both the central and peripheral pathophysiological changes of irritable bowel syndrome (IBS) is lacking. Here, we developed a novel IBS rat model combining trinitro-benzene-sulfonic acid (TNBS) and ... ...

Abstract	So far, a comprehensive animal model that can mimic both the central and peripheral pathophysiological changes of irritable bowel syndrome (IBS) is lacking. Here, we developed a novel IBS rat model combining trinitro-benzene-sulfonic acid (TNBS) and chronic unpredictable mild stress (CUMS) (designated as TC-IBS) and compared it with the TNBS-induced and CUMS-induced models. TC-IBS showed a pronounced depression phenotype with increased corticotropin-releasing hormone receptor (CRHR)1 and CRHR2 expression at the frontal cortex and increased serum ACTH concentration. Visceral hypersensitivity (VH), as evidenced by colorectal distention (CRD) test, was highest in TC-IBS, accompanied by increased serum 5-hydroxytryptamine (5-HT) level and colonic 5-HT receptor 3A (5-HT
MeSH term(s)	Animals ; Behavior, Animal ; Depression/etiology ; Depression/metabolism ; Depression/pathology ; Disease Models, Animal ; Gastrointestinal Microbiome ; Hyperalgesia/etiology ; Hyperalgesia/metabolism ; Hyperalgesia/pathology ; Intestinal Mucosa/metabolism ; Intestinal Mucosa/pathology ; Irritable Bowel Syndrome/chemically induced ; Irritable Bowel Syndrome/metabolism ; Irritable Bowel Syndrome/physiopathology ; Male ; Rats ; Rats, Sprague-Dawley ; Receptors, Corticotropin-Releasing Hormone/genetics ; Receptors, Corticotropin-Releasing Hormone/metabolism ; Stress, Physiological ; Trinitrobenzenesulfonic Acid/toxicity ; Visceral Pain/etiology ; Visceral Pain/metabolism ; Visceral Pain/pathology
Chemical Substances	CRF receptor type 2 ; Receptors, Corticotropin-Releasing Hormone ; CRF receptor type 1 (5CLY6W2H1M) ; Trinitrobenzenesulfonic Acid (8T3HQG2ZC4)
Language	English
Publishing date	2019-09-28
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	639186-2
ISSN	1530-6860 ; 0892-6638
ISSN (online)	1530-6860
ISSN	0892-6638
DOI	10.1096/fj.201901489R
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Article ; Online: Differentiated tumor immune microenvironment of Epstein-Barr virus-associated and negative gastric cancer: implication in prognosis and immunotherapy.

Ma, Jing / Li, Jianhui / Hao, Yiming / Nie, Yongzhan / Li, Zengshan / Qian, Meirui / Liang, Qiaoyi / Yu, Jun / Zeng, Musheng / Wu, Kaichun

Oncotarget

2017 Volume 8, Issue 40, Page(s) 67094–67103

Abstract: Epstein-Barr virus-associated gastric cancer (EBVaGC) has been proposed to be a distinct subtype with a specific immune microenvironment. Here, we evaluated tumor-infiltrating T-cell subsets and the expression of programmed cell death protein 1 (PD-1) ... ...

Abstract	Epstein-Barr virus-associated gastric cancer (EBVaGC) has been proposed to be a distinct subtype with a specific immune microenvironment. Here, we evaluated tumor-infiltrating T-cell subsets and the expression of programmed cell death protein 1 (PD-1) and programmed death-ligand 1 (PD-L1) in 571 gastric cancers (GCs). Tissue microarrays were stained using EBER
Language	English
Publishing date	2017-05-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	2560162-3
ISSN	1949-2553 ; 1949-2553
ISSN (online)	1949-2553
ISSN	1949-2553
DOI	10.18632/oncotarget.17945
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