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  1. Article: Early onset inflammatory bowel disease: manifestations, genetics and diagnosis.

    Moazzami, Bobak / Moazzami, Kasra / Rezaei, Nima

    The Turkish journal of pediatrics

    2020  Volume 61, Issue 5, Page(s) 637–647

    Abstract: Moazzami B, Moazzami K, Rezaei N. Early onset inflammatory bowel disease: manifestations, genetics ...

    Abstract Moazzami B, Moazzami K, Rezaei N. Early onset inflammatory bowel disease: manifestations, genetics and diagnosis. Turk J Pediatr 2019; 61: 637-647. Crohn`s disease and ulcerative colitis are immunologically mediated chronic inflammatory conditions, collectively referred to as inflammatory bowel diseases (IBD). While most studies have described the condition in the adult population, recent evidences suggest that IBD in children may represent an etiologically distinct disease from the adult onset IBD. Since a significant proportion of patients diagnosed with IBD demonstrate their clinical manifestations during childhood, knowledge about the disease progression, severity and diagnosis in this particular patient population is crucial. Therefore, in the present study, the clinical manifestations, recent advancements in the genetics of early onset IBD and the clinical approach to diagnoses of IBD in children are described.
    MeSH term(s) Adolescent ; Age of Onset ; Child ; Child, Preschool ; Colitis, Ulcerative/diagnosis ; Colitis, Ulcerative/genetics ; Crohn Disease/diagnosis ; Crohn Disease/genetics ; Disease Progression ; Genetic Markers ; Genetic Predisposition to Disease ; Humans ; Severity of Illness Index
    Chemical Substances Genetic Markers
    Language English
    Publishing date 2020-04-16
    Publishing country Turkey
    Document type Journal Article ; Review
    ZDB-ID 123487-0
    ISSN 0041-4301
    ISSN 0041-4301
    DOI 10.24953/turkjped.2019.05.001
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    Zs.B 988: Show issues Location:
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  2. Article ; Online: Hyperinflammatory shock related to COVID-19 in a patient presenting with multisystem inflammatory syndrome in children: First case from Iran.

    Bahrami, Ahmad / Vafapour, Maryam / Moazzami, Bobak / Rezaei, Nima

    Journal of paediatrics and child health

    2020  Volume 57, Issue 6, Page(s) 922–925

    MeSH term(s) COVID-19 ; Child ; Humans ; Iran ; SARS-CoV-2 ; Shock ; Systemic Inflammatory Response Syndrome
    Keywords covid19
    Language English
    Publishing date 2020-07-08
    Publishing country Australia
    Document type Case Reports
    ZDB-ID 1024476-1
    ISSN 1440-1754 ; 1034-4810
    ISSN (online) 1440-1754
    ISSN 1034-4810
    DOI 10.1111/jpc.15048
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  3. Article ; Online: Efficacy of Plasmapheresis and Immunoglobulin Replacement Therapy (IVIG) on Patients with COVID-19.

    Pourahmad, Ramtin / Moazzami, Bobak / Rezaei, Nima

    SN comprehensive clinical medicine

    2020  Volume 2, Issue 9, Page(s) 1407–1411

    Abstract: Since the rapidly evolving outbreak of COVID-19, several empirical therapeutic options have been recommended including the use of antivirals, steroids, and vaccines. According to recent observations about different modalities in treatment of patients ... ...

    Abstract Since the rapidly evolving outbreak of COVID-19, several empirical therapeutic options have been recommended including the use of antivirals, steroids, and vaccines. According to recent observations about different modalities in treatment of patients infected with COVID-19, plasmapheresis and intravenous immunoglobulin (IVIg) have been reported to be an effective empirical therapeutic option to control the infection. In this review, we aimed to provide an overview on the possible application of plasmapheresis and intravenous immunoglobulin in patients with COVID-19.
    Keywords covid19
    Language English
    Publishing date 2020-07-31
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2947211-8
    ISSN 2523-8973 ; 2523-8973
    ISSN (online) 2523-8973
    ISSN 2523-8973
    DOI 10.1007/s42399-020-00438-2
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  4. Article: Effectiveness of dietary interventions on cardio-metabolic risk factors in patients with nonalcoholic fatty liver disease: a systematic review and meta-analysis of randomized controlled trials.

    Ghadimi, Maryam / Mohammadi, Reihaneh / Daneshzad, Elnaz / Moazzami, Bobak / Mohammadpour, Zinat

    Annals of gastroenterology

    2021  Volume 34, Issue 3, Page(s) 415–423

    Abstract: Background: Dietary modification is considered as one of the main strategies in the management of nonalcoholic fatty liver disease (NAFLD). The objective of this study was to systematically investigate the effect of dietary interventions on the cardio- ... ...

    Abstract Background: Dietary modification is considered as one of the main strategies in the management of nonalcoholic fatty liver disease (NAFLD). The objective of this study was to systematically investigate the effect of dietary interventions on the cardio-metabolic risk factors, including lipid profile and insulin resistance in this population.
    Methods: We searched electronic databases of PubMed and Scopus until January 2020 and included randomized controlled trials that compared the effect of dietary modifications vs. control on lipid profile and insulin resistance in patients with NAFLD. The random-effect analysis was performed to calculate pooled weighted mean differences (WMD).
    Results: Our finding showed that serum triglycerides (TG) (n=5, WMD -38.50 mg/dL, 95% confidence interval [CI] -61.68 to -15.31; P=0.001) and total cholesterol (TC) (n=4, WMD -18.70 mg/dL, 95%CI -34.85 to -2.53; P=0.023) decrease following diet intervention along with marginally significant weight reduction (n=5, WMD -3.61 mg/dL, 95%CI -7.25 to 0.04; P=0.053). There was no change in the homeostatic model assessment for insulin resistance, high- and low-density lipoprotein (LDL) levels (P>0.05). Subgroup analysis revealed that Mediterranean diet reduced TG (n=2, WMD -57.52 mg/dL, 95%CI -75.73 to -39.31; P<0.001) and weight (n=2, WMD -7.59 Kg, 95%CI -13.53 to -1.66; P=0.012), and also increased LDL level (n=2, WMD 29.73 mg/dL, 95%CI 13.82-45.65; P<0.001). However, standard hypocaloric diet improved TC (n=2, WMD -23.20 mg/dL, 95%CI -36.96 to -9.44; P=0.001) and LDL (n=2, WMD -16.82 mg/dL, 95%CI -29.44 to -4.19; P=0.009).
    Conclusion: Dietary modifications may improve serum TG, TC, and obesity in NAFLD.
    Language English
    Publishing date 2021-02-26
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 2032850-3
    ISSN 1108-7471
    ISSN 1108-7471
    DOI 10.20524/aog.2021.0601
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    Zs.A 2455: Show issues Location:
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  5. Article ; Online: Efficacy of Plasmapheresis and Immunoglobulin Replacement Therapy (IVIG) on Patients with COVID-19

    Pourahmad, Ramtin / Moazzami, Bobak / Rezaei, Nima

    SN Comprehensive Clinical Medicine

    2020  Volume 2, Issue 9, Page(s) 1407–1411

    Keywords covid19
    Language English
    Publisher Springer Science and Business Media LLC
    Publishing country us
    Document type Article ; Online
    ZDB-ID 2947211-8
    ISSN 2523-8973
    ISSN 2523-8973
    DOI 10.1007/s42399-020-00438-2
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: Hyperinflammatory shock related to COVID-19 in a patient presenting with multisystem inflammatory syndrome in children: First case from Iran

    Bahrami, Ahmad / Vafapour, Maryam / Moazzami, Bobak / Rezaei, Nima

    J. paediatr. child health

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #635423
    Database COVID19

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  7. Article ; Online: Continuous Glucose Monitoring-Guided Insulin Administration in Long-Term Care Facilities: A Randomized Clinical Trial.

    Idrees, Thaer / Castro-Revoredo, Iris A / Oh, Hyungseok D / Gavaller, Monica D / Zabala, Zohyra / Moreno, Emmelin / Moazzami, Bobak / Galindo, Rodolfo J / Vellanki, Priyathama / Cabb, Elena / Johnson, Theodore M / Peng, Limin / Umpierrez, Guillermo E

    Journal of the American Medical Directors Association

    2024  Volume 25, Issue 5, Page(s) 884–888

    Abstract: Objectives: To evaluate the efficacy of real-time continuous glucose monitoring (rt-CGM) in adjusting insulin therapy in long-term care facilities (LTCF).: Design: Prospective randomized clinical trial.: Settings and participants: Insulin-treated ... ...

    Abstract Objectives: To evaluate the efficacy of real-time continuous glucose monitoring (rt-CGM) in adjusting insulin therapy in long-term care facilities (LTCF).
    Design: Prospective randomized clinical trial.
    Settings and participants: Insulin-treated patients with type 2 diabetes (T2D) admitted to LTCF.
    Methods: Participants in the standard of care wore a blinded CGM with treatment adjusted based on point-of-care capillary glucose results before meals and bedtime (POC group). Participants in the intervention (CGM group) wore a Dexcom G6 CGM with treatment adjusted based on daily CGM profile. Treatment adjustment was performed by the LTCF medical team, with a duration of intervention up to 60 days. The primary endpoint was difference in time in range (TIR 70-180 mg/dL) between treatment groups.
    Results: Among 100 participants (age 74.73 ± 11 years, 80% admitted for subacute rehabilitation and 20% for nursing home care), there were no significant differences in baseline clinical characteristics between groups, and CGM data were compared for a median of 17 days. There were no differences in TIR (53.38% ± 30.16% vs 48.81% ± 28.03%, P = .40), mean daily mean CGM glucose (184.10 ± 43.4 mg/dL vs 190.0 ± 45.82 mg/dL, P = .71), or the percentage of time below range (TBR) <70 mg/dL (0.83% ± 2.59% vs 1.18% ± 3.54%, P = .51), or TBR <54 mg/dL (0.23% ± 0.85% vs 0.56% ± 2.24%, P = .88) between rt-CGM and POC groups.
    Conclusions and implications: The use of rtCGM is safe and effective in guiding insulin therapy in patients with T2D in LTCF resulting in a similar improvement in glycemic control compared to POC-guided insulin adjustment.
    MeSH term(s) Humans ; Male ; Aged ; Female ; Diabetes Mellitus, Type 2/drug therapy ; Insulin/administration & dosage ; Insulin/therapeutic use ; Long-Term Care ; Prospective Studies ; Hypoglycemic Agents/administration & dosage ; Hypoglycemic Agents/therapeutic use ; Aged, 80 and over ; Blood Glucose Self-Monitoring ; Blood Glucose/drug effects ; Middle Aged ; Continuous Glucose Monitoring
    Chemical Substances Insulin ; Hypoglycemic Agents ; Blood Glucose
    Language English
    Publishing date 2024-03-06
    Publishing country United States
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2171030-2
    ISSN 1538-9375 ; 1525-8610
    ISSN (online) 1538-9375
    ISSN 1525-8610
    DOI 10.1016/j.jamda.2024.01.031
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    Zs.A 5971: Show issues Location:
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  8. Article ; Online: Local intramuscular transplantation of autologous bone marrow mononuclear cells for critical lower limb ischaemia.

    Moazzami, Bobak / Mohammadpour, Zinat / Zabala, Zohyra E / Farokhi, Ermia / Roohi, Aria / Dolmatova, Elena / Moazzami, Kasra

    The Cochrane database of systematic reviews

    2022  Volume 7, Page(s) CD008347

    Abstract: Background: Peripheral arterial disease is a major health problem, and in about 1% to 2% of patients, the disease progresses to critical limb ischaemia (CLI), also known as critical limb-threatening ischaemia. In a substantial number of individuals with ...

    Abstract Background: Peripheral arterial disease is a major health problem, and in about 1% to 2% of patients, the disease progresses to critical limb ischaemia (CLI), also known as critical limb-threatening ischaemia. In a substantial number of individuals with CLI, no effective treatment options other than amputation are available, with around a quarter of these patients requiring a major amputation during the following year. This is the second update of a review first published in 2011.
    Objectives: To evaluate the benefits and harms of local intramuscular transplantation of autologous adult bone marrow mononuclear cells (BMMNCs) as a treatment for CLI.
    Search methods: We used standard, extensive Cochrane search methods. The latest search date was 8 November 2021.
    Selection criteria: We included all randomised controlled trials (RCTs) of CLI in which participants were randomly allocated to intramuscular administration of autologous adult BMMNCs or control (either no intervention, conventional conservative therapy, or placebo).
    Data collection and analysis: We used standard Cochrane methods. Our primary outcomes of interest were all-cause mortality, pain, and amputation. Our secondary outcomes were angiographic analysis, ankle-brachial index (ABI), pain-free walking distance, side effects and complications. We assessed the certainty of the evidence using the GRADE approach.
    Main results: We included four RCTs involving a total of 176 participants with a clinical diagnosis of CLI. Participants were randomised to receive either intramuscular cell implantation of BMMNCs or control. The control arms varied between studies, and included conventional therapy, diluted autologous peripheral blood, and saline. There was no clear evidence of an effect on mortality related to the administration of BMMNCs compared to control (risk ratio (RR) 1.00, 95% confidence interval (CI) 0.15 to 6.63; 3 studies, 123 participants; very low-certainty evidence). All trials assessed changes in pain severity, but the trials used different forms of pain assessment tools, so we were unable to pool data. Three studies individually reported that no differences in pain reduction were observed between the BMMNC and control groups. One study reported that reduction in rest pain was greater in the BMMNC group compared to the control group (very low-certainty evidence). All four trials reported the rate of amputation at the end of the study period. We are uncertain if amputations were reduced in the BMMNC group compared to the control group, as a possible small effect (RR 0.52, 95% CI 0.27 to 0.99; 4 studies, 176 participants; very low-certainty evidence) was lost after undertaking sensitivity analysis (RR 0.52, 95% CI 0.19 to 1.39; 2 studies, 89 participants). None of the included studies reported any angiographic analysis. Ankle-brachial index was reported differently by each study, so we were not able to pool the data. Three studies reported no changes between groups, and one study reported greater improvement in ABI (as haemodynamic improvement) in the BMMNC group compared to the control group (very low-certainty evidence). One study reported pain-free walking distance, finding no clear difference between BMMNC and control groups (low-certainty evidence). We pooled the data for side effects reported during the follow-up, and this did not show any clear difference between BMMNC and control groups (RR 2.13, 95% CI 0.50 to 8.97; 4 studies, 176 participants; very low-certainty evidence). We downgraded the certainty of the evidence due to the concerns about risk of bias, imprecision, and inconsistency.
    Authors' conclusions: We identified a small number of studies that met our inclusion criteria, and these differed in the controls they used and how they measured important outcomes. Limited data from these trials provide very low- to low-certainty evidence, and we are unable to draw conclusions to support the use of local intramuscular transplantation of BMMNC for improving clinical outcomes in people with CLI. Evidence from larger RCTs is needed in order to provide adequate statistical power to assess the role of this procedure.
    MeSH term(s) Adult ; Amputation, Surgical ; Bone Marrow ; Humans ; Ischemia/etiology ; Ischemia/surgery ; Peripheral Arterial Disease/complications ; Peripheral Arterial Disease/surgery ; Randomized Controlled Trials as Topic ; Transplantation, Autologous/adverse effects
    Language English
    Publishing date 2022-07-08
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Systematic Review
    ISSN 1469-493X
    ISSN (online) 1469-493X
    DOI 10.1002/14651858.CD008347.pub4
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  9. Article ; Online: Hyperinflammatory shock related to COVID ‐19 in a patient presenting with multisystem inflammatory syndrome in children

    Bahrami, Ahmad / Vafapour, Maryam / Moazzami, Bobak / Rezaei, Nima

    Journal of Paediatrics and Child Health ; ISSN 1034-4810 1440-1754

    First case from Iran

    2020  

    Keywords Pediatrics, Perinatology, and Child Health ; covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    DOI 10.1111/jpc.15048
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: National Trends in Glucagon Prescriptions Among U.S. Adults With Diabetes and End-Stage Kidney Disease Treated by Dialysis: 2013-2017.

    Galindo, Rodolfo J / Inselman, Shealeigh A / Umpierrez, Guillermo E / Moazzami, Bobak / Munoz Mendoza, Jair / Ali, Mohammed K / Tuttle, Katherine R / McCoy, Rozalina G

    Diabetes care

    2023  Volume 46, Issue 7, Page(s) e130–e132

    MeSH term(s) Adult ; Humans ; Renal Dialysis ; Glucagon ; Kidney Failure, Chronic/epidemiology ; Kidney Failure, Chronic/therapy ; Diabetes Mellitus/drug therapy ; Diabetes Mellitus/epidemiology ; Prescriptions
    Chemical Substances Glucagon (9007-92-5)
    Language English
    Publishing date 2023-05-10
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 441231-x
    ISSN 1935-5548 ; 0149-5992
    ISSN (online) 1935-5548
    ISSN 0149-5992
    DOI 10.2337/dc23-0554
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    Zs.MO 365: Show issues

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