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  1. AU=Burney Ikram A
  2. AU="Sciubba, Adalberto"
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  1. Article ; Online: An Unusual Presentation of Choriocarcinoma in a Postmenopausal Woman: A case report.

    Zribi, Aref / Mazroui, Reem Al / Sayani, Raza / Burney, Ikram A

    Sultan Qaboos University medical journal

    2024  Volume 24, Issue 1, Page(s) 135–138

    Abstract: Choriocarcinoma (CC) is a malignant neoplasm of the trophoblastic tissue, with a potential to metastasise to distant organs. Limited case of gestational CC develops after a long latent period. We report a 52-year-old postmenopausal woman who developed ... ...

    Abstract Choriocarcinoma (CC) is a malignant neoplasm of the trophoblastic tissue, with a potential to metastasise to distant organs. Limited case of gestational CC develops after a long latent period. We report a 52-year-old postmenopausal woman who developed metastatic choriocarcinoma presumably of gestational origin, 8 years after the last pregnancy and 2 years after the last menstrual period. The patient was brought to the emergency room of a tertiary care centre in Muscat, Oman, in 2022 and was diagnosed with CC metastatic to the brain, spleen, lung and the kidney. The β-human chorionic gonadotrophin level was found to be raised (1,292,867 mIU/mL). The International Federation of Gynecologic Oncology risk score was calculated to be 14 (very high risk). The patient was initially treated with whole-brain radiotherapy and splenic artery embolisation because of a hemoperitoneum. Afterwards the patient received systemic treatment using the standard EMA/CO regimen till complete serological remission.
    MeSH term(s) Pregnancy ; Humans ; Female ; Middle Aged ; Postmenopause ; Choriocarcinoma/diagnosis ; Embolization, Therapeutic ; Emergency Service, Hospital ; Hemoperitoneum
    Language English
    Publishing date 2024-02-28
    Publishing country Oman
    Document type Case Reports
    ZDB-ID 2650196-X
    ISSN 2075-0528 ; 2075-0528
    ISSN (online) 2075-0528
    ISSN 2075-0528
    DOI 10.18295/squmj.5.2023.036
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Immunotherapy in Cancer: Incremental Gain or a Quantum Leap?

    Burney, Ikram A

    Oman medical journal

    2016  Volume 32, Issue 1, Page(s) 1–2

    Language English
    Publishing date 2016-12-09
    Publishing country Oman
    Document type Editorial
    ZDB-ID 2571431-4
    ISSN 2070-5204 ; 1999-768X
    ISSN (online) 2070-5204
    ISSN 1999-768X
    DOI 10.5001/omj.2017.01
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Durable Response to Pazopanib in a Patient with Fumarate Hydratase-Mutant Tubulocystic Renal Cell Carcinoma.

    Othman, Anjum / Kumar, Shiyam / Qureshi, Asim / Jawa, Zabah M / Burney, Ikram A

    Case reports in oncology

    2023  Volume 16, Issue 1, Page(s) 234–242

    Abstract: Tubulocystic carcinoma of the kidney (TC-RCC) is a rare renal tumor and has been recently included as a distinct entity in WHO classification of renal neoplasms. We report the case of a patient with metastatic tubulocystic RCC whose disease progressed ... ...

    Abstract Tubulocystic carcinoma of the kidney (TC-RCC) is a rare renal tumor and has been recently included as a distinct entity in WHO classification of renal neoplasms. We report the case of a patient with metastatic tubulocystic RCC whose disease progressed through standard of care treatment for nonclear RCC. However, genetic analysis revealed a germline pathogenic variant of fumarate hydratase (FH) gene, and the patient had a sustained and durable response to pazopanib.
    Language English
    Publishing date 2023-04-14
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2458961-5
    ISSN 1662-6575
    ISSN 1662-6575
    DOI 10.1159/000528697
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Complete Response to Sorafenib in Locally Recurrent Unresectable Aggressive Fibromatosis.

    Burney, Ikram A / Kakaria, Anupam K / Al-Jahdhami, Suad

    Sultan Qaboos University medical journal

    2021  Volume 21, Issue 2, Page(s) e327–e328

    MeSH term(s) Fibromatosis, Aggressive/drug therapy ; Humans ; Neoplasm Recurrence, Local ; Sorafenib/pharmacology ; Sorafenib/therapeutic use
    Chemical Substances Sorafenib (9ZOQ3TZI87)
    Language English
    Publishing date 2021-06-21
    Publishing country Oman
    Document type Journal Article
    ZDB-ID 2650196-X
    ISSN 2075-0528 ; 2075-0528
    ISSN (online) 2075-0528
    ISSN 2075-0528
    DOI 10.18295/squmj.2021.21.02.027
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Immunotherapy in Cancer

    Ikram A Burney

    Oman Medical Journal, Vol 32, Iss 1, Pp 1-

    Incremental Gain or a Quantum Leap?

    2017  Volume 2

    Keywords Immunotherapy ; Cancer ; Medicine ; R
    Language English
    Publishing date 2017-01-01T00:00:00Z
    Publisher Oman Medical Specialty Board
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Successful Treatment of a Case of Crescentic Glomerulonephritis in a Patient with Primary Peritoneal Carcinoma: A case report.

    Zribi, Aref / Nagy, Amro / Riyami, Marwa Al / Burney, Ikram A

    Sultan Qaboos University medical journal

    2022  Volume 24, Issue 1, Page(s) 119–122

    Abstract: Crescentic glomerulonephritis has been associated with several solid tumour malignancies. Only a few cases of nephropathy have been reported in association with tubo-ovarian/peritoneal malignancies. We report a 55-year-old female patient who presented to ...

    Abstract Crescentic glomerulonephritis has been associated with several solid tumour malignancies. Only a few cases of nephropathy have been reported in association with tubo-ovarian/peritoneal malignancies. We report a 55-year-old female patient who presented to a tertiary care centre, Muscat, Oman, in 2022. She developed combined immune complex-mediated glomerulonephritis and pauci-immune necrotising crescentic vasculitis simultaneously with the diagnosis of tubo-ovarian/peritoneal cancer. The baseline estimated glomerular filtration rate (eGFR) was 13 mL/min. The patient received two doses of rituximab and three doses of pulse corticosteroids, leading to significant improvement in renal function and the disappearance of her proteinuria. The eGFR improved to >60mL/min; her proteinuria gradually resolved after 10 weeks of treatment. She was then given a combination chemotherapy treatment for tubo-ovarian/peritoneal cancer leading to a normalisation of her CA-125 after three months of therapy.
    MeSH term(s) Female ; Humans ; Middle Aged ; Patients ; Glomerulonephritis/drug therapy ; CA-125 Antigen ; Proteinuria ; Carcinoma
    Chemical Substances CA-125 Antigen
    Language English
    Publishing date 2022-09-11
    Publishing country Oman
    Document type Case Reports
    ZDB-ID 2650196-X
    ISSN 2075-0528 ; 2075-0528
    ISSN (online) 2075-0528
    ISSN 2075-0528
    DOI 10.18295/squmj.1.2023.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Evolution of the Management of Brain Metastases: A Bibliometric Analysis.

    Burney, Ikram A / Aal Hamad, Aya H / Hashmi, Syed F A / Ahmad, Nisar / Pervez, Nadeem

    Cancers

    2023  Volume 15, Issue 23

    Abstract: A systematic review of the published literature was conducted to analyze the management evolution of brain metastases from different cancers. Using the keywords "brain metastasis", "brain metastases", "CNS metastasis", "CNS metastases", "phase III" AND/ ... ...

    Abstract A systematic review of the published literature was conducted to analyze the management evolution of brain metastases from different cancers. Using the keywords "brain metastasis", "brain metastases", "CNS metastasis", "CNS metastases", "phase III" AND/OR "Randomized Controlled Trial" (RCT), relevant articles were searched for on the SCOPUS database. A total of 1986 articles were retrieved, published over a 45-year period (1977-2022). Relevant articles were defined as clinical studies describing the treatment or prevention of brain metastases from any cancer. Articles on imaging, quality of life, cognitive impairment after treatment, or primary brain tumors were excluded. After a secondary analysis, reviewing the abstracts and/or full texts, 724 articles were found to be relevant. Publications significantly increased in the last 10 years. A total of 252 articles (34.8%) were published in 12 core journals, receiving 50% of the citations. The number of publications in Frontiers in Oncology, BMC Cancer, and Radiotherapy and Oncology have increased considerably over the last few years. There were 111 randomized controlled trials, 128 review articles, and 63 meta-analyses. Most randomized trials reported on brain metastases management from unselected tumors (49), lung cancer (47), or breast cancer (11). In the last 5 years (2017 to 2022), management of brain metastasis has moved on from WBRT, the use of chemotherapy, and radio-sensitization to three directions. First, Radiosurgery or Radiotherapy (SRS/SRT), or hippocampal-sparing WBRT is employed to reduce radiation toxicity. Second, it has moved to the use of novel agents, such as tyrosine kinase inhibitors (TKI) and immune checkpoint inhibitors (ICI) and third, to the use of molecularly directed therapy such as TKIs, in asymptomatic low volume metastasis, obviating the need for WBRT.
    Language English
    Publishing date 2023-11-24
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15235570
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Artificial Intelligence and the Gartner Cycle: Time to Introduce in Undergraduate Medical Education.

    Burney, Ikram Ali / Ahmed, Nisar

    Journal of the College of Physicians and Surgeons--Pakistan : JCPSP

    2024  Volume 34, Issue 3, Page(s) 253–255

    Abstract: Null. ...

    Abstract Null.
    MeSH term(s) Humans ; Artificial Intelligence ; Education, Medical, Undergraduate ; Students, Medical
    Language English
    Publishing date 2024-02-29
    Publishing country Pakistan
    Document type Editorial
    ZDB-ID 2276646-7
    ISSN 1681-7168 ; 1022-386X
    ISSN (online) 1681-7168
    ISSN 1022-386X
    DOI 10.29271/jcpsp.2024.03.253
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6532: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Precision Medicine Where have we reached and where are we headed?

    Ikram A. Burney / Ritu Lakhtakia

    Sultan Qaboos University Medical Journal, Vol 17, Iss 3, Pp 255-

    2017  Volume 258

    Abstract: ... ...

    Abstract NA
    Keywords na ; Medicine ; R
    Language English
    Publishing date 2017-08-01T00:00:00Z
    Publisher Sultan Qaboos University
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  10. Article: The Prevalence and Patterns of Toxicity With Immune Checkpoint Inhibitors in Solid Tumors: A Real-World Experience From a Tertiary Care Center in Oman.

    Salman, Bushra / AlWard, Nameer M / Al-Hashami, Zamzam / Al-Sharqi, Hadil / Al-Sayegh, Hasan / Burney, Ikram A

    Cureus

    2023  Volume 15, Issue 10, Page(s) e47050

    Abstract: Introduction Immune checkpoint inhibitors (ICIs) have revolutionized the management of multiple cancers over the last decade. They work by employing the immune system and exhibiting activity over T cells resulting in immune upregulation. Despite their ... ...

    Abstract Introduction Immune checkpoint inhibitors (ICIs) have revolutionized the management of multiple cancers over the last decade. They work by employing the immune system and exhibiting activity over T cells resulting in immune upregulation. Despite their widespread use, they produce side effects that can limit their use. The immune-related adverse events (irAEs) can be sometimes significant. The irAEs caused by ICIs may occur at any time during the treatment and can vary in grade (G). We sought to study the prevalence and toxicity patterns of ICIs in Oman. Methods One hundred forty-one adult patients (≥18 years) who received at least one dose of nivolumab, pembrolizumab, atezolizumab, or durvalumab between 2016 and 2022 were included. The data were analyzed retrospectively using univariable and multiple-variable logistic regressions. The Wilcoxon rank-sum test and Cochran-Armitage trend test were also used to summarize the continuous and ordinal data. Results Out of the 141 patients, 80 patients (56.7%) received pembrolizumab, and 48 (34%) received nivolumab. Common irAEs included endocrine abnormalities, pneumonitis, and colitis. Thirty patients (21.3%) experienced varying irAE grade toxicity. Out of the 30, 23 patients (82%) developed grade 2 and 3 irAEs. Discussion Predictive analysis showed that male sex and lower hemoglobin (Hb) and bilirubin levels were all significant predictors (p < 0.05) when associated with irAE occurrence. The prevalence of irAEs was similar compared to other reports, literature reviews, or meta-analyses. Female sex has been mentioned previously also to be a predictive factor for endocrine-related toxicities.
    Language English
    Publishing date 2023-10-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.47050
    Database MEDical Literature Analysis and Retrieval System OnLINE

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