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Article: COVID-19 and the Efficacy of Different Types of Respiratory Protective Equipment Used by Health Care Providers in a Health Care Setting.

Malik, Talia

2020 Volume 12, Issue 4, Page(s) e7621

Abstract: Coronavirus, the virus that caused the global pandemic at the beginning of 2020 and affected millions across the globe, presented as an enormous challenge to health care providers around the world. With increasing numbers of infected patients presenting ... ...

Abstract	Coronavirus, the virus that caused the global pandemic at the beginning of 2020 and affected millions across the globe, presented as an enormous challenge to health care providers around the world. With increasing numbers of infected patients presenting daily, health care workers are struggling to take effective measures to protect themselves from transmission against the highly contagious coronavirus. This case helps us understand the implications of coronavirus-infected patients on the health care providers directly responsible for the management of these patients and the relative efficacy of different types of respiratory protective equipment mainly N95 masks and surgical masks in preventing the spread of infection among those at the front lines providing care.
Keywords	covid19
Language	English
Publishing date	2020-04-10
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.7621
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Article ; Online: Hepatic Adenomatosis In A 32-Year-Old Male With No Risk Factors For Hepatic Adenoma.

Malik, Talia Farrukh / Akram, Salma

Journal of Ayub Medical College, Abbottabad : JAMC

2022 Volume 34Suppl 1, Issue 3, Page(s) S725–S726

Abstract: Hepatic Adenomatosis most commonly arises in the background of hepatic adenoma in young women and less commonly in men with underlying risk factors. Rarely, it can arise in young men with none of the associated risk factors and thus can go undetected for ...

Abstract	Hepatic Adenomatosis most commonly arises in the background of hepatic adenoma in young women and less commonly in men with underlying risk factors. Rarely, it can arise in young men with none of the associated risk factors and thus can go undetected for a prolonged period resulting in delayed intervention and avoidable complications. We present a rare case of a 32-year-old asymptomatic male that presented for routine evaluation and was subsequently diagnosed with Hepatic Adenomatosis.
MeSH term(s)	Female ; Male ; Humans ; Adult ; Risk Factors ; Colorectal Neoplasms ; Nasopharyngeal Neoplasms ; Adenoma/complications ; Adenoma/diagnosis ; Adenoma/surgery
Language	English
Publishing date	2022-11-19
Publishing country	Pakistan
Document type	Case Reports
ZDB-ID	2192473-9
ISSN	1819-2718 ; 1025-9589
ISSN (online)	1819-2718
ISSN	1025-9589
DOI	10.55519/JAMC-03-S1-9128
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Zs.A 6109: Show issues

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Article: COVID-19 and the Efficacy of Different Types of Respiratory Protective Equipment Used by Health Care Providers in a Health Care Setting

Malik, Talia

Cureus

Abstract: Coronavirus, the virus that caused the global pandemic at the beginning of 2020 and affected millions across the globe, presented as an enormous challenge to health care providers around the world With increasing numbers of infected patients presenting ... ...

Abstract	Coronavirus, the virus that caused the global pandemic at the beginning of 2020 and affected millions across the globe, presented as an enormous challenge to health care providers around the world With increasing numbers of infected patients presenting daily, health care workers are struggling to take effective measures to protect themselves from transmission against the highly contagious coronavirus This case helps us understand the implications of coronavirus-infected patients on the health care providers directly responsible for the management of these patients and the relative efficacy of different types of respiratory protective equipment mainly N95 masks and surgical masks in preventing the spread of infection among those at the front lines providing care
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #257002
Database	COVID19

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Article: A Case of Type II Achalasia Presenting With Markedly Elevated Troponins.

Malik, Talia F / Khan, Daniel / Shah, Pallavi / Moon, Andrew M

Cureus

2023 Volume 15, Issue 1, Page(s) e33408

Abstract: Achalasia is an esophageal motility disorder that presents with dysphagia to solids and liquids and regurgitation of undigested food. Cardiac troponin (cTn) is a sensitive biomarker for myocardial injury, and elevated levels suggest an increased risk of ... ...

Abstract	Achalasia is an esophageal motility disorder that presents with dysphagia to solids and liquids and regurgitation of undigested food. Cardiac troponin (cTn) is a sensitive biomarker for myocardial injury, and elevated levels suggest an increased risk of mortality from acute coronary syndrome (ACS). Non-cardiac gastrointestinal (GI) causes of troponin elevation are rare and have generally been described in cases of critical illness (e.g., significant gastrointestinal bleeding (GIB) or acute liver failure). We report a rare case of type II achalasia presenting with markedly elevated troponins. This case illustrates an important GI-related mimic of ACS that should be considered by frontline providers and gastroenterologists.
Language	English
Publishing date	2023-01-05
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.33408
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Article: Efficacy and safety of endoscopic submucosal dissection for colorectal dysplasia in patients with inflammatory bowel disease: a systematic review and meta-analysis.

Malik, Talia F / Sabesan, Vaishnavi / Mohan, Babu P / Rahman, Asad Ur / Othman, Mohamed O / Draganov, Peter V / Kochhar, Gursimran S

Clinical endoscopy

2024

Abstract: Background/aims: In this meta-analysis, we studied the safety and efficacy of endoscopic submucosal dissection (ESD) for colorectal dysplasia in patients with inflammatory bowel disease (IBD).: Methods: Multiple databases were searched, and studies ... ...

Abstract	Background/aims: In this meta-analysis, we studied the safety and efficacy of endoscopic submucosal dissection (ESD) for colorectal dysplasia in patients with inflammatory bowel disease (IBD). Methods: Multiple databases were searched, and studies were retrieved based on pre-specified criteria until October 2022. The outcomes assessed were resection rates, procedural complications, local recurrence, metachronous tumors, and the need for surgery after ESD in IBD. Standard meta-analysis methods were followed using the random-effects model, and I2% was used to assess heterogeneity. Results: Twelve studies comprising 291 dysplastic lesions in 274 patients were included with a median follow-up of 25 months. The pooled en-bloc resection, R0 resection, and curative resection rates were 92.5% (95% confidence interval [CI], 87.9%-95.4%; I2=0%), 81.5% (95% CI, 72.5%-88%; I2=43%), and 48.9% (95% CI, 32.1%-65.9%; I2=87%), respectively. The local recurrence rate was 3.9% (95% CI, 2%-7.5%; I2=0%). The pooled rates of bleeding and perforation were 7.7% (95% CI, 4.5%-13%; I2=10%) and 5.3% (95% CI, 3.1%-8.9%; I2=0%), respectively. The rates of metachronous recurrence and additional surgery following ESD were 10% (95% CI, 5.2%-18.2%; I2=55%) and 13% (95% CI, 8.5%-19.3%; I2=54%), respectively. Conclusions: ESD is safe and effective for the resection of dysplastic lesions in IBD with an excellent pooled rate of en-bloc and R0 resection.
Language	English
Publishing date	2024-02-29
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2643507-X
ISSN	2234-2443 ; 2234-2400
ISSN (online)	2234-2443
ISSN	2234-2400
DOI	10.5946/ce.2023.205
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Article ; Online: Endoscopic sleeve gastroplasty reintervention score using supervised machine learning.

Ali, Hassam / Patel, Pratik / Malik, Talia Farrukh / Pamarthy, Rahul / Mohan, Babu P / Asokkumar, Ravishankar / Lopez-Nava, Gontrand / Adler, Douglas G

Gastrointestinal endoscopy

2023 Volume 98, Issue 5, Page(s) 747–754.e5

Abstract: Background and aims: Reintervention after endoscopic sleeve gastroplasty (ESG) can be indicated because of postprocedural adverse events from various preinterventional or postprocedural comorbidities. We developed and internally validated an ESG ... ...

Abstract	Background and aims: Reintervention after endoscopic sleeve gastroplasty (ESG) can be indicated because of postprocedural adverse events from various preinterventional or postprocedural comorbidities. We developed and internally validated an ESG reintervention score (ESG-RS) that determines the individualized risk of reintervention within the first 30 days after ESG. Methods: We used data from a sample of 3583 patients who underwent ESG in the Metabolic and Bariatric Surgery Accreditation Quality Improvement Program database (2016-2021). The least absolute shrinkage and selection operator (LASSO)-penalized regression was used to select the most promising predictors of reintervention after ESG within 30 days. The predictive variables extracted by LASSO regression were entered into multivariate analysis to generate an ESG-RS by using the coefficients of the statistically significant variables. The model performance was assessed using receiver-operator curves by 10-fold cross-validation. Results: Eleven variables were selected by LASSO regression and used in the final multivariate analysis. The ESG-RS was inferred using 5 factors (history of previous foregut surgery, preoperative anticoagulation use, female gender, American Society of Anesthesiologists class ≥II, and hypertension) weighted by their regression coefficients in the multivariable logistic regression model. The area under the curve of the ESG-RS was .74 (95% confidence interval, .70-.78). For the ESG-RS, the optimal cutpoint was 67.9 (high risk vs low risk), with a sensitivity of .76 and specificity of .71. Conclusions: The ESG-RS aids clinicians in preoperative risk stratification of patients undergoing ESG while clarifying factors contributing to a higher risk of reintervention.
Language	English
Publishing date	2023-05-31
Publishing country	United States
Document type	Journal Article
ZDB-ID	391583-9
ISSN	1097-6779 ; 0016-5107
ISSN (online)	1097-6779
ISSN	0016-5107
DOI	10.1016/j.gie.2023.05.059
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Zs.B 283: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 519: Show issues

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Article ; Online: Cold Versus Hot Endoscopic Mucosal Resection for Sessile Serrated Colorectal Polyps ≥10 mm: A Systematic Review and Meta-analysis.

Malik, Talia F / Mohan, Babu P / Deliwala, Smit / Kassab, Lena L / Chandan, Saurabh / Sharma, Neil R / Adler, Douglas G

Journal of clinical gastroenterology

2023

Abstract: Introduction: We performed a systematic review and meta-analysis studying the efficacy and safety of cold versus hot endoscopic mucosal resection (EMR) for resection of sessile serrated polyps (SSPs) ≥10 mm.: Methods: Multiple databases were searched ...

Abstract	Introduction: We performed a systematic review and meta-analysis studying the efficacy and safety of cold versus hot endoscopic mucosal resection (EMR) for resection of sessile serrated polyps (SSPs) ≥10 mm. Methods: Multiple databases were searched until January 2023 for studies reporting outcomes of cold versus hot EMR for SSPs ≥10 mm. The primary outcome was the residual SSP rate. Secondary outcomes included technical success rate, R0 resection rate, and adverse events. We used standard meta-analysis methods using the random-effects model, and I2% was used to assess heterogeneity. Results: Thirteen studies were included in the final analysis. In all, 1896 SSPs were included with a mean polyp size of 23.7 mm (range, 15.9 to 33). A total of 1452 SSPs were followed up for a median follow-up duration of 15.3 months (range, 6 to 37). The pooled residual SSP rate for cold EMR was 4.5% (95% CI: 1.0-17.4), and 5.1% (95% CI: 2.4-10.4) for hot EMR (P=0.9). The pooled rates of technical success, R0 resection, immediate bleeding, and perforation were comparable. Hot EMR was significantly associated with lower piecemeal resection (59.2% vs. 99.3%, P<0.001), higher en-bloc resection (41.4% vs. 1.4%, P<0.001), and delayed bleeding rate (4% vs. 0.7%, P=0.05) compared to cold EMR. Conclusions: Cold EMR has similar efficacy compared to hot EMR for resection of SSP ≥ 10 mm, despite limitations in piecemeal R0 resection rate reporting. Although hot EMR was associated with a higher rate of en-bloc resection, it also showed an increased risk of delayed bleeding compared to cold EMR.
Language	English
Publishing date	2023-11-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	448460-5
ISSN	1539-2031 ; 0192-0790
ISSN (online)	1539-2031
ISSN	0192-0790
DOI	10.1097/MCG.0000000000001951
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Zs.A 1523: Show issues

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Article: Operator-specific outcomes in endoscopic sleeve gastroplasty: a propensity-matched analysis of the US population using a multicenter database.

Ali, Hassam / Inayat, Faisal / Malik, Talia F / Patel, Pratik / Nawaz, Gul / Taj, Sobaan / Rehman, Attiq Ur / Afzal, Arslan / Ishtiaq, Rizwan / Afzal, Muhammad Sohaib / Advani, Rashmi / Watson, Rabindra R

Proceedings (Baylor University. Medical Center)

2023 Volume 36, Issue 5, Page(s) 592–599

Abstract: Background: Endoscopic sleeve gastroplasty (ESG) has emerged as an effective endoscopic bariatric procedure over the past decade. Data comparing short-term outcomes of ESG based on operator specialty is scarce. We aimed to assess the impact of operator ... ...

Abstract	Background: Endoscopic sleeve gastroplasty (ESG) has emerged as an effective endoscopic bariatric procedure over the past decade. Data comparing short-term outcomes of ESG based on operator specialty is scarce. We aimed to assess the impact of operator specialization on patient outcomes using a large bariatric-specific database. Methods: We identified a retrospective cohort of patients who underwent ESG by gastroenterologists using the Metabolic and Bariatric Surgery Accreditation Quality Improvement Program database (2020-2021). A matched comparison cohort of patients who underwent ESG by surgeons was identified and underwent 1:1 propensity score matching based on age, race, gender, American Society of Anesthesiologists physical status classification, and preoperative body mass index. Results: After matching, 154 patients were included in the final analysis. Of these, 77 patients underwent ESG by surgeons and 77 by gastroenterologists. In the matched cohort, the median operation time was lower in ESG by surgeons compared to gastroenterologists ( Conclusions: Operator choice does not affect ESG-related adverse events or 30-day outcomes in patients undergoing ESG.
Language	English
Publishing date	2023-07-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	2703932-8
ISSN	1525-3252 ; 0899-8280
ISSN (online)	1525-3252
ISSN	0899-8280
DOI	10.1080/08998280.2023.2228180
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Zs.A 6987: Show issues

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Article ; Online: P2RX7 at the Host-Pathogen Interface of Infectious Diseases.

Soare, Alexandra Y / Freeman, Tracey L / Min, Alice K / Malik, Hagerah S / Osota, Elizabeth O / Swartz, Talia H

Microbiology and molecular biology reviews : MMBR

2021 Volume 85, Issue 1

Abstract: The P2X7 receptor (P2RX7) is an important molecule that functions as a danger sensor, detecting extracellular nucleotides from injured cells and thus signaling an inflammatory program to nearby cells. It is expressed in immune cells and plays important ... ...

Abstract	The P2X7 receptor (P2RX7) is an important molecule that functions as a danger sensor, detecting extracellular nucleotides from injured cells and thus signaling an inflammatory program to nearby cells. It is expressed in immune cells and plays important roles in pathogen surveillance and cell-mediated responses to infectious organisms. There is an abundance of literature on the role of P2RX7 in inflammatory diseases and the role of these receptors in host-pathogen interactions. Here, we describe the current knowledge of the role of P2RX7 in the host response to a variety of pathogens, including viruses, bacteria, fungi, protozoa, and helminths. We describe
MeSH term(s)	Alarmins/immunology ; Animals ; Bacteria/immunology ; Fungi/immunology ; Helminths/immunology ; Host-Pathogen Interactions/immunology ; Host-Pathogen Interactions/physiology ; Humans ; Inflammation/immunology ; Parasites/immunology ; Receptors, Purinergic P2X7/immunology ; Signal Transduction/immunology ; Viruses/immunology
Chemical Substances	Alarmins ; P2RX7 protein, human ; Receptors, Purinergic P2X7
Language	English
Publishing date	2021-01-13
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1376131-6
ISSN	1098-5557 ; 1070-6275 ; 1092-2172
ISSN (online)	1098-5557 ; 1070-6275
ISSN	1092-2172
DOI	10.1128/MMBR.00055-20
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Ud II Zs.96: Show issues

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Article ; Online: P2X1 Selective Antagonists Block HIV-1 Infection through Inhibition of Envelope Conformation-Dependent Fusion.

Soare, Alexandra Y / Malik, Hagerah S / Durham, Natasha D / Freeman, Tracey L / Alvarez, Raymond / Patel, Foramben / Satija, Namita / Upadhyay, Chitra / Hioe, Catarina E / Chen, Benjamin K / Swartz, Talia H

Journal of virology

2020 Volume 94, Issue 6

Abstract: Purinergic receptors are well-established modulators of inflammatory processes, primarily through detection of extracellular nucleotides that are released by dying or infected cells. Emerging literature has demonstrated that inhibition of these ... ...

Abstract	Purinergic receptors are well-established modulators of inflammatory processes, primarily through detection of extracellular nucleotides that are released by dying or infected cells. Emerging literature has demonstrated that inhibition of these inflammatory receptors can block HIV-1 productive infection and HIV-1-associated inflammation. The specificity of receptor type and mechanism of interaction has not yet been determined. Here, we characterize the inhibitory activity of P2X1 receptor antagonists, NF279 and NF449, in cell lines, primary cells, and a variety of HIV-1 envelope (Env) clades. NF279 and NF449 blocked productive infection at the level of viral membrane fusion, with a range of inhibitory activities against different HIV-1 Env isolates. A mutant virus carrying a truncation deletion of the C-terminal tail of HIV-1 Env glycoprotein 41 (gp41) showed reduced sensitivity to P2X1 antagonists, indicating that the sensitivity of inhibition by these molecules may be modulated by Env conformation. In contrast, a P2X7 antagonist, A438079, had a limited effect on productive infection and fusion. NF279 and NF449 interfered with the ability of the gp120 variable regions 1 and 2 (V1V2)-targeted broadly neutralizing antibody PG9 to block productive infection, suggesting that these drugs may antagonize HIV-1 Env at gp120 V1V2 to block viral membrane fusion. Our observations indicate that P2X1 antagonism can inhibit HIV-1 replication at the level of viral membrane fusion through interaction with Env. Future studies will probe the nature of these compounds in inhibiting HIV-1 fusion and the development of small molecules to block HIV-1 entry via this mechanism.
MeSH term(s)	HIV Envelope Protein gp120/genetics ; HIV Envelope Protein gp120/metabolism ; HIV Infections/drug therapy ; HIV Infections/genetics ; HIV Infections/metabolism ; HIV Infections/pathology ; HIV-1/genetics ; HIV-1/metabolism ; Humans ; Mutation ; Purinergic P2X Receptor Antagonists/pharmacology ; Virus Internalization/drug effects
Chemical Substances	HIV Envelope Protein gp120 ; Purinergic P2X Receptor Antagonists
Language	English
Publishing date	2020-02-28
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	80174-4
ISSN	1098-5514 ; 0022-538X
ISSN (online)	1098-5514
ISSN	0022-538X
DOI	10.1128/JVI.01622-19
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