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  1. Article: COVID-19 and the Gut Microbiome: More than a Gut Feeling.

    van der Lelie, Daniel / Taghavi, Safiyh

    mSystems

    2020  Volume 5, Issue 4

    Abstract: Due to its fundamental role in the induction, training, and function of the immune system, it is critical to include characterizations of the gut microbiome in clinical trials and studies that aim to broaden our understanding of coronavirus disease 2019 ( ...

    Abstract Due to its fundamental role in the induction, training, and function of the immune system, it is critical to include characterizations of the gut microbiome in clinical trials and studies that aim to broaden our understanding of coronavirus disease 2019 (COVID-19). Understanding the "gut-lung axes," where gut microbiome composition influences the lung's susceptibility to viral infections and viral infections of the lung alter gut microbiome composition toward proinflammatory functional dysbiosis, will be critical in addressing COVID-19, including disease progression, the importance of preexisting conditions, and the risk for developing complications. These insights may further help to develop better intervention strategies for COVID-19 and other diseases caused by respiratory viruses.
    Keywords covid19
    Language English
    Publishing date 2020-07-21
    Publishing country United States
    Document type Journal Article
    ISSN 2379-5077
    ISSN 2379-5077
    DOI 10.1128/mSystems.00453-20
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  2. Article ; Online: COVID-19 and the Gut Microbiome

    van der Lelie, Daniel / Taghavi, Safiyh

    mSystems

    More than a Gut Feeling

    2020  Volume 5, Issue 4

    Abstract: ABSTRACT Due to its fundamental role in the induction, training, and function of the immune system, it is critical to include characterizations of the gut microbiome in clinical trials and studies that aim to broaden our understanding of coronavirus ... ...

    Abstract ABSTRACT Due to its fundamental role in the induction, training, and function of the immune system, it is critical to include characterizations of the gut microbiome in clinical trials and studies that aim to broaden our understanding of coronavirus disease 2019 (COVID-19). Understanding the “gut-lung axes,” where gut microbiome composition influences the lung’s susceptibility to viral infections and viral infections of the lung alter gut microbiome composition toward proinflammatory functional dysbiosis, will be critical in addressing COVID-19, including disease progression, the importance of preexisting conditions, and the risk for developing complications. These insights may further help to develop better intervention strategies for COVID-19 and other diseases caused by respiratory viruses.
    Keywords covid19
    Language English
    Publisher American Society for Microbiology
    Publishing country us
    Document type Article ; Online
    ISSN 2379-5077
    DOI 10.1128/msystems.00453-20
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: COVID-19 and the Gut Microbiome

    Daniel van der Lelie / Safiyh Taghavi

    mSystems, Vol 5, Iss 4, p e00453-

    More than a Gut Feeling

    2020  Volume 20

    Abstract: Due to its fundamental role in the induction, training, and function of the immune system, it is critical to include characterizations of the gut microbiome in clinical trials and studies that aim to broaden our understanding of coronavirus disease 2019 ( ...

    Abstract Due to its fundamental role in the induction, training, and function of the immune system, it is critical to include characterizations of the gut microbiome in clinical trials and studies that aim to broaden our understanding of coronavirus disease 2019 (COVID-19). Understanding the “gut-lung axes,” where gut microbiome composition influences the lung’s susceptibility to viral infections and viral infections of the lung alter gut microbiome composition toward proinflammatory functional dysbiosis, will be critical in addressing COVID-19, including disease progression, the importance of preexisting conditions, and the risk for developing complications.Due to its fundamental role in the induction, training, and function of the immune system, it is critical to include characterizations of the gut microbiome in clinical trials and studies that aim to broaden our understanding of coronavirus disease 2019 (COVID-19). Understanding the “gut-lung axes,” where gut microbiome composition influences the lung’s susceptibility to viral infections and viral infections of the lung alter gut microbiome composition toward proinflammatory functional dysbiosis, will be critical in addressing COVID-19, including disease progression, the importance of preexisting conditions, and the risk for developing complications. These insights may further help to develop better intervention strategies for COVID-19 and other diseases caused by respiratory viruses.
    Keywords covid-19 ; gut microbiome ; Microbiology ; QR1-502 ; covid19
    Subject code 610
    Language English
    Publishing date 2020-07-01T00:00:00Z
    Publisher American Society for Microbiology
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Book ; Online: COVID-19 and the gut microbiome

    van der Lelie, Daniel / Taghavi, Safiyh

    more than a gut feeling

    2020  

    Abstract: Due to its fundamental role in the induction, training, and function of the immune system, it is critical to include the gut microbiome in clinical trials and studies that aim to broaden our understanding of COVID-19. A clear link seems to exist between ... ...

    Abstract Due to its fundamental role in the induction, training, and function of the immune system, it is critical to include the gut microbiome in clinical trials and studies that aim to broaden our understanding of COVID-19. A clear link seems to exist between gut microbiome health and COVID-19 progression. Understanding the “gut-lung axes”, where gut microbiome composition influences the lung’s susceptibility to viral infections and viral infections of the lung alter gut microbiome composition toward proinflammatory functional dysbiosis will be critical in addressing COVID-19, including disease progression, the importance of preexisting conditions, and the risk for developing complications. These insights will help to identify biomarkers and druggable targets and develop intervention strategies based on live biotherapeutics and nutrition to overcome gut microbiome dysbiosis and restore intestinal homeostasis as contributing factors to COVID-19.
    Keywords covid19
    Publisher Center for Open Science
    Publishing country us
    Document type Book ; Online
    DOI 10.31219/osf.io/f2x4r
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: The microbiome as a source of new enterprises and job creation: Considering clinical faecal and synthetic microbiome transplants and therapeutic regulation.

    van der Lelie, Daniel / Taghavi, Safiyh / Henry, Christopher / Gilbert, Jack A

    Microbial biotechnology

    2017  Volume 10, Issue 1, Page(s) 4–5

    MeSH term(s) Fecal Microbiota Transplantation/methods ; Fecal Microbiota Transplantation/standards ; Gastrointestinal Microbiome ; Health Policy ; Humans ; Microbiota ; Transplants/standards
    Language English
    Publishing date 2017
    Publishing country United States
    Document type Editorial
    ZDB-ID 2406063-X
    ISSN 1751-7915 ; 1751-7907
    ISSN (online) 1751-7915
    ISSN 1751-7907
    DOI 10.1111/1751-7915.12597
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  6. Article ; Online: Microbial terroir for wine grapes.

    Gilbert, Jack A / van der Lelie, Daniel / Zarraonaindia, Iratxe

    Proceedings of the National Academy of Sciences of the United States of America

    2013  Volume 111, Issue 1, Page(s) 5–6

    MeSH term(s) Climate ; Vitis/microbiology ; Vitis/physiology ; Wine/microbiology
    Language English
    Publishing date 2013-12-05
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.1320471110
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1148: Show issues Location:
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  7. Article ; Online: Rationally designed bacterial consortia to treat chronic immune-mediated colitis and restore intestinal homeostasis.

    van der Lelie, Daniel / Oka, Akihiko / Taghavi, Safiyh / Umeno, Junji / Fan, Ting-Jia / Merrell, Katherine E / Watson, Sarah D / Ouellette, Lisa / Liu, Bo / Awoniyi, Muyiwa / Lai, Yunjia / Chi, Liang / Lu, Kun / Henry, Christopher S / Sartor, R Balfour

    Nature communications

    2021  Volume 12, Issue 1, Page(s) 3105

    Abstract: Environmental factors, mucosal permeability and defective immunoregulation drive overactive immunity to a subset of resident intestinal bacteria that mediate multiple inflammatory conditions. GUT-103 and GUT-108, live biotherapeutic products rationally ... ...

    Abstract Environmental factors, mucosal permeability and defective immunoregulation drive overactive immunity to a subset of resident intestinal bacteria that mediate multiple inflammatory conditions. GUT-103 and GUT-108, live biotherapeutic products rationally designed to complement missing or underrepresented functions in the dysbiotic microbiome of IBD patients, address upstream targets, rather than targeting a single cytokine to block downstream inflammation responses. GUT-103, composed of 17 strains that synergistically provide protective and sustained engraftment in the IBD inflammatory environment, prevented and treated chronic immune-mediated colitis. Therapeutic application of GUT-108 reversed established colitis in a humanized chronic T cell-mediated mouse model. It decreased pathobionts while expanding resident protective bacteria; produced metabolites promoting mucosal healing and immunoregulatory responses; decreased inflammatory cytokines and Th-1 and Th-17 cells; and induced interleukin-10-producing colonic regulatory cells, and IL-10-independent homeostatic pathways. We propose GUT-108 for treating and preventing relapse for IBD and other inflammatory conditions characterized by unbalanced microbiota and mucosal permeability.
    MeSH term(s) Animals ; Bacteria/genetics ; Bacteria/metabolism ; Bile Acids and Salts/metabolism ; Colitis/immunology ; Colitis/microbiology ; Colitis/therapy ; Cytokines/metabolism ; Disease Models, Animal ; Dysbiosis/microbiology ; Dysbiosis/therapy ; Feces/microbiology ; Gastrointestinal Microbiome/immunology ; Gastrointestinal Microbiome/physiology ; Germ-Free Life/immunology ; Germ-Free Life/physiology ; Homeostasis ; Humans ; Inflammation/metabolism ; Intestinal Mucosa/metabolism ; Intestinal Mucosa/microbiology ; Metabolomics ; Mice ; Mice, Inbred C57BL ; Mice, Knockout
    Chemical Substances Bile Acids and Salts ; Cytokines
    Language English
    Publishing date 2021-05-28
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-021-23460-x
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  8. Article: Complete Genome Sequence of Clostridium sp. Strain DL-VIII, a Novel Solventogenic Clostridium Species Isolated from Anaerobic Sludge.

    Taghavi, Safiyh / Izquierdo, Javier A / van der Lelie, Daniel

    Genome announcements

    2013  Volume 1, Issue 4

    Abstract: We report the genome sequence of Clostridium sp. strain DL-VIII, a novel Gram-positive, endospore-forming, solventogenic bacterium isolated from activated anaerobic sludge of a wastewater treatment plant. Aside from a complete sol operon, the 6,477,357- ... ...

    Abstract We report the genome sequence of Clostridium sp. strain DL-VIII, a novel Gram-positive, endospore-forming, solventogenic bacterium isolated from activated anaerobic sludge of a wastewater treatment plant. Aside from a complete sol operon, the 6,477,357-bp genome of DL-VIII reveals genes for several unique enzymes with applications in lignocellulose degradation, including two phenolic acid decarboxylases.
    Language English
    Publishing date 2013-08-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2704277-7
    ISSN 2169-8287
    ISSN 2169-8287
    DOI 10.1128/genomeA.00605-13
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  9. Article ; Online: Rationally designed bacterial consortia to treat chronic immune-mediated colitis and restore intestinal homeostasis

    Daniel van der Lelie / Akihiko Oka / Safiyh Taghavi / Junji Umeno / Ting-Jia Fan / Katherine E. Merrell / Sarah D. Watson / Lisa Ouellette / Bo Liu / Muyiwa Awoniyi / Yunjia Lai / Liang Chi / Kun Lu / Christopher S. Henry / R. Balfour Sartor

    Nature Communications, Vol 12, Iss 1, Pp 1-

    2021  Volume 17

    Abstract: Fecal microbiota transplantation and probiotics have been tested/used as potential therapeutics against inflammatory bowel diseases (IBD). Here the authors use a bottom-up rational consortium design approach that combines well-characterized strains ... ...

    Abstract Fecal microbiota transplantation and probiotics have been tested/used as potential therapeutics against inflammatory bowel diseases (IBD). Here the authors use a bottom-up rational consortium design approach that combines well-characterized strains isolated from healthy human stool samples to produce two consortia of metabolically interdependent strains for the treatment of IBD.
    Keywords Science ; Q
    Language English
    Publishing date 2021-05-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
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  10. Article ; Online: Biotransformation of ferulic acid to 4-vinylguaiacol by Enterobacter soli and E. aerogenes.

    Hunter, William J / Manter, Daniel K / van der Lelie, Daniel

    Current microbiology

    2012  Volume 65, Issue 6, Page(s) 752–757

    Abstract: We investigated the conversion of ferulic acid to 4-vinylguaiacol (4-VG), vanillin, vanillyl alcohol, and vanillic acid by five Enterobacter strains. These high-value chemicals are usually synthesized by chemical methods but biological synthesis adds ... ...

    Abstract We investigated the conversion of ferulic acid to 4-vinylguaiacol (4-VG), vanillin, vanillyl alcohol, and vanillic acid by five Enterobacter strains. These high-value chemicals are usually synthesized by chemical methods but biological synthesis adds market value. Ferulic acid, a relatively inexpensive component of agricultural crops, is plentiful in corn hulls, cereal bran, and sugar-beet pulp. Two Enterobacter strains, E. soli, and E. aerogenes, accumulated 550-600 ppm amounts of 4-VG when grown in media containing 1,000 ppm ferulic acid; no accumulations were observed with the other strains. Decreasing the amount of ferulic acid present in the media increased the conversion efficiency. When ferulic acid was supplied in 500, 250, or 125 ppm amounts E. aerogenes converted ~72 % of the ferulic acid present to 4-VG while E. soli converted ~100 % of the ferulic acid to 4-VG when supplied with 250 or 125 ppm amounts of ferulic acid. Also, lowering the pH improved the conversion efficiency. At pH 5.0 E. aerogenes converted ~84 % and E. soli converted ~100 % of 1,000 ppm ferulic acid to 4-VG. Only small, 1-5 ppm, accumulations of vanillin, vanillyl alcohol, and vanillic acid were observed. E. soli has a putative phenolic acid decarboxylase (PAD) that is 168 amino acids long and is similar to PADs in other enterobacteriales; this protein is likely involved in the bioconversion of ferulic acid to 4-VG. E. soli or E. aerogenes might be useful as a means of biotransforming ferulic acid to 4-VG.
    MeSH term(s) Biotechnology/methods ; Biotransformation ; Coumaric Acids/metabolism ; Culture Media ; Enterobacter/classification ; Enterobacter/growth & development ; Enterobacter/metabolism ; Enterobacter aerogenes/growth & development ; Enterobacter aerogenes/metabolism ; Guaiacol/analogs & derivatives ; Guaiacol/metabolism ; Hydrogen-Ion Concentration
    Chemical Substances Coumaric Acids ; Culture Media ; Guaiacol (6JKA7MAH9C) ; 4-vinylguaiacol (7786-61-0) ; ferulic acid (AVM951ZWST)
    Language English
    Publishing date 2012-09-18
    Publishing country United States
    Document type Evaluation Study ; Journal Article
    ZDB-ID 134238-1
    ISSN 1432-0991 ; 0343-8651
    ISSN (online) 1432-0991
    ISSN 0343-8651
    DOI 10.1007/s00284-012-0222-4
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1446: Show issues Location:
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