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  1. Article ; Online: Long term follow-up of refractory/relapsed acute myeloid leukemia patients treated with the FLAG-Ida regimen as bridge therapy to allotransplantation: 10-year results from a single centre experience.

    Delia, Mario / Gagliardi, Vito Pier / Carluccio, Paola / Attolico, Immacolata / Contento, Corinne / Di Gennaro, Daniela / Albano, Francesco / Musto, Pellegrino

    Leukemia research

    2023  Volume 129, Page(s) 107069

    MeSH term(s) Humans ; Bridge Therapy ; Follow-Up Studies ; Leukemia, Myeloid, Acute/drug therapy ; Idarubicin ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Cytarabine ; Granulocyte Colony-Stimulating Factor ; Vidarabine ; Recurrence
    Chemical Substances Idarubicin (ZRP63D75JW) ; Cytarabine (04079A1RDZ) ; Granulocyte Colony-Stimulating Factor (143011-72-7) ; Vidarabine (FA2DM6879K)
    Language English
    Publishing date 2023-03-24
    Publishing country England
    Document type Letter
    ZDB-ID 752396-8
    ISSN 1873-5835 ; 0145-2126
    ISSN (online) 1873-5835
    ISSN 0145-2126
    DOI 10.1016/j.leukres.2023.107069
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Abdominoplasty after massive weight loss. Safety preservation fascia technique and clinical outcomes in a large single series-comparative study.

    Cannistrà, Claudio / Lori, Eleonora / Arapis, Konstantinos / Gallo, Gaetano / Varanese, Marzia / Pironi, Daniele / De Luca, Alessandro / Frusone, Federico / Amabile, Maria Ida / Sorrenti, Salvatore / Gagliardi, Federica / Tripodi, Domenico

    Frontiers in surgery

    2024  Volume 11, Page(s) 1337948

    Abstract: Introduction: Weight loss after bariatric surgery causes very important modifications to the patient's silhouette. Abdominal fat and skin excess reduction are associated with several complications. The most frequent are seroma and hematoma whereas major ...

    Abstract Introduction: Weight loss after bariatric surgery causes very important modifications to the patient's silhouette. Abdominal fat and skin excess reduction are associated with several complications. The most frequent are seroma and hematoma whereas major complications, such as pulmonary embolism, are less frequent. This study aimed to describe our technical procedure for abdominoplasty in patients with massive weight loss after bariatric surgery.
    Methods: In total, 196 patients were included. All patients who underwent abdominoplasty classic (group A) and abdominoplasty with the preservation and lift of Scarpa fascia (group B) and with umbilical transposition between May 2018 and May 2021 were included. Patients with concomitant correction of ventral hernia were excluded. Demographic and operative data were analyzed according to comorbidities and postoperative complications.
    Results: There were 160 (81.6%) women. The mean age was 43.6 years; the mean weight was 86.7 kg; and the mean BMI was 28.6 kg/m
    Conclusion: Preserving Scarpa Fascia during surgical post-bariatric patient procedures reduces the seroma formation and the scar complication and reduces the tension of the inguinal-pubic region with correction of our deformation after weight loss. Improves reducing the drain and reducing seroma incidence suction and hospital stay.
    Language English
    Publishing date 2024-01-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2773823-1
    ISSN 2296-875X
    ISSN 2296-875X
    DOI 10.3389/fsurg.2024.1337948
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: COVID-19 and the Kidney: From Epidemiology to Clinical Practice.

    Gagliardi, Ida / Patella, Gemma / Michael, Ashour / Serra, Raffaele / Provenzano, Michele / Andreucci, Michele

    Journal of clinical medicine

    2020  Volume 9, Issue 8

    Abstract: The new respiratory infectious disease coronavirus disease 2019 (COVID-19) that originated in Wuhan, China, in December 2019 and caused by a new strain of zoonotic coronavirus, named severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2), to date ... ...

    Abstract The new respiratory infectious disease coronavirus disease 2019 (COVID-19) that originated in Wuhan, China, in December 2019 and caused by a new strain of zoonotic coronavirus, named severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2), to date has killed over 630,000 people and infected over 15,000,000 worldwide. Most of the deceased patients had pre-existing comorbidities; over 20% had chronic kidney disease (CKD). Furthermore, although SARS-CoV-2 infection is characterized mainly by diffuse alveolar damage and acute respiratory failure, acute kidney injury (AKI) has developed in a high percentage of cases. As AKI has been shown to be associated with worse prognosis, we believe that the impact of SARS-CoV-2 on the kidney should be investigated. This review sets out to describe the main renal aspects of SARS-CoV-2 infection and the role of the virus in the development and progression of kidney damage. In this article, attention is focused on the epidemiology, etiology and pathophysiological mechanisms of kidney damage, histopathology, clinical features in nephropathic patients (CKD, hemodialysis, peritoneal dialysis, AKI, transplantation) and prevention and containment strategies. Although there remains much more to be learned with regards to this disease, nonetheless it is our hope that this review will aid in the understanding and management of SARS-CoV-2 infection.
    Keywords covid19
    Language English
    Publishing date 2020-08-04
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm9082506
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: COVID-19 and the Kidney

    Ida Gagliardi / Gemma Patella / Ashour Michael / Raffaele Serra / Michele Provenzano / Michele Andreucci

    Journal of Clinical Medicine, Vol 9, Iss 2506, p

    From Epidemiology to Clinical Practice

    2020  Volume 2506

    Abstract: The new respiratory infectious disease coronavirus disease 2019 (COVID-19) that originated in Wuhan, China, in December 2019 and caused by a new strain of zoonotic coronavirus, named severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2), to date ... ...

    Abstract The new respiratory infectious disease coronavirus disease 2019 (COVID-19) that originated in Wuhan, China, in December 2019 and caused by a new strain of zoonotic coronavirus, named severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2), to date has killed over 630,000 people and infected over 15,000,000 worldwide. Most of the deceased patients had pre-existing comorbidities; over 20% had chronic kidney disease (CKD). Furthermore, although SARS-CoV-2 infection is characterized mainly by diffuse alveolar damage and acute respiratory failure, acute kidney injury (AKI) has developed in a high percentage of cases. As AKI has been shown to be associated with worse prognosis, we believe that the impact of SARS-CoV-2 on the kidney should be investigated. This review sets out to describe the main renal aspects of SARS-CoV-2 infection and the role of the virus in the development and progression of kidney damage. In this article, attention is focused on the epidemiology, etiology and pathophysiological mechanisms of kidney damage, histopathology, clinical features in nephropathic patients (CKD, hemodialysis, peritoneal dialysis, AKI, transplantation) and prevention and containment strategies. Although there remains much more to be learned with regards to this disease, nonetheless it is our hope that this review will aid in the understanding and management of SARS-CoV-2 infection.
    Keywords SARS-CoV-2 ; acute kidney injury ; dialysis ; renal transplantation ; pandemic ; Medicine ; R ; covid19
    Subject code 610
    Language English
    Publishing date 2020-08-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: A Retrospective Case Series in Fournier's Disease: And Its Emergency Management et Grafting Technique for Penis Coverage.

    Tripodi, Domenico / Guastafierro, Antonio / Gagliardi, Federica / Amabile, Maria Ida / Lori, Eleonora / Cirocchi, Roberto / Pironi, Daniele / Forte, Flavio / Cannistra, Claudio / Sorrenti, Salvatore

    Emergency medicine international

    2022  Volume 2022, Page(s) 6710777

    Abstract: Fournier's gangrene is a necrotizing soft tissue infection of the genital, perineal, and perirectal areas. A primary isolated involvement of the penis is rare, but it can be affected in some circumstances. The purpose of this case series is to present ... ...

    Abstract Fournier's gangrene is a necrotizing soft tissue infection of the genital, perineal, and perirectal areas. A primary isolated involvement of the penis is rare, but it can be affected in some circumstances. The purpose of this case series is to present the findings of our thirteen years' experience in the reconstruction of the penis in Fournier's gangrene and our full-thickness grafting technique to cover the penis rod. We retrospectively reviewed patient data who underwent a penis reconstruction following Fournier's gangrene in 2018. The data was analyzed to report the estimated percentage of complications, of patients with primary or secondary gangrene of the penis, the number of reinterventions, and finally the percentage of deaths or recovery. 23 patients underwent reconstruction with our technique of full-thickness skin graft. In all cases, the skin graft was harvested from the upper arm with an arrow shape mark. No further penile revision surgery was required, and neither patient complained about retraction, nor traction, or pain during erection. The donor site healed without any complications. We believe that the coverage of the penis using our grafting technique is safe, easily reproducible, and demonstrates excellent esthetic and functional results.
    Language English
    Publishing date 2022-09-25
    Publishing country Egypt
    Document type Journal Article
    ZDB-ID 2596429-X
    ISSN 2090-2859 ; 2090-2840
    ISSN (online) 2090-2859
    ISSN 2090-2840
    DOI 10.1155/2022/6710777
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Mesenteric Cyst with GI Symptoms: A Fluid Approach to Treatment-Case Report and Literature Review.

    Gagliardi, Federica / Lauro, Augusto / Tripodi, Domenico / Amabile, Maria Ida / Palumbo, Piergaspare / Di Matteo, Filippo Maria / Palazzini, Giorgio / Forte, Flavio / Frattaroli, Stefano / Khouzam, Simone / Marino, Ignazio R / D'Andrea, Vito / Sorrenti, Salvatore / Pironi, Daniele

    Digestive diseases and sciences

    2022  Volume 67, Issue 3, Page(s) 786–798

    Abstract: Mesenteric cysts are defined as a heterogeneous group of intra-abdominal cystic lesions of the mesentery or omentum that may be found in any portion of the gastrointestinal tract from the duodenum to the rectum. The clinical condition is entirely ... ...

    Abstract Mesenteric cysts are defined as a heterogeneous group of intra-abdominal cystic lesions of the mesentery or omentum that may be found in any portion of the gastrointestinal tract from the duodenum to the rectum. The clinical condition is entirely asymptomatic in many patients, particularly with small cysts. The diagnosis is typically incidental and secondary to imaging performed for other purposes. In symptomatic patients, the clinical picture is characterized by nonspecific gastrointestinal signs and symptoms. Treatment may be surgical or via interventional radiology. We report the case of a 55-year-old female patient complaining of left-sided abdominal discomfort and constipation lasting three months. An abdominal ultrasound showed the presence of a 10 × 14 × 16 cm anechoic cystic mass filling the whole anterior and left abdominal cavity, confirmed by CT and MRI. The cyst, removed laparoscopically, was histologically a simple mesothelial cyst. We reviewed the international literature over the last 10 years of all cases with mesenteric cysts > 10 cm in evaluating gastrointestinal symptoms at diagnosis, histology, performed treatment, and outcome.
    MeSH term(s) Cysts/complications ; Cysts/diagnostic imaging ; Cysts/surgery ; Female ; Humans ; Magnetic Resonance Imaging ; Mesenteric Cyst/diagnostic imaging ; Mesenteric Cyst/surgery ; Mesentery/diagnostic imaging ; Middle Aged ; Ultrasonography
    Language English
    Publishing date 2022-01-21
    Publishing country United States
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 304250-9
    ISSN 1573-2568 ; 0163-2116
    ISSN (online) 1573-2568
    ISSN 0163-2116
    DOI 10.1007/s10620-021-07352-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Precision Nephrology Is a Non-Negligible State of Mind in Clinical Research: Remember the Past to Face the Future.

    Provenzano, Michele / De Nicola, Luca / Pena, Michelle J / Capitoli, Giulia / Garofalo, Carlo / Borrelli, Silvio / Gagliardi, Ida / Antolini, Laura / Andreucci, Michele

    Nephron

    2020  Volume 144, Issue 10, Page(s) 463–478

    Abstract: CKD is a major public health problem. It is characterized by a multitude of risk factors that, when aggregated, can strongly modify outcome. While major risk factors, namely, albuminuria and low estimated glomerular filtration rate (eGFR) have been well ... ...

    Abstract CKD is a major public health problem. It is characterized by a multitude of risk factors that, when aggregated, can strongly modify outcome. While major risk factors, namely, albuminuria and low estimated glomerular filtration rate (eGFR) have been well analyzed, a large variability in disease progression still remains. This happens because (1) the weight of each risk factor varies between populations (general population or CKD cohort), countries, and single individuals and (2) response to nephroprotective drugs is so heterogeneous that a non-negligible part of patients maintains a high cardiorenal risk despite optimal treatment. Precision nephrology aims at individualizing cardiorenal prognosis and therapy. The purpose of this review is to focus on the risk stratification in different areas, such as clinical practice, population research, and interventional trials, and to describe the strategies used in observational or experimental studies to afford individual-level evidence. The future of precision nephrology is also addressed. Observational studies can in fact provide more adequate findings by collecting more information on risk factors and building risk prediction models that can be applied to each individual in a reliable fashion. Similarly, new clinical trial designs can reduce the individual variability in response to treatment and improve individual outcomes.
    MeSH term(s) Albuminuria/diagnosis ; Albuminuria/physiopathology ; Disease Progression ; Glomerular Filtration Rate ; Humans ; Nephrology/trends ; Precision Medicine/trends ; Prognosis ; Renal Insufficiency, Chronic/diagnosis ; Renal Insufficiency, Chronic/therapy ; Risk Factors ; Treatment Outcome
    Language English
    Publishing date 2020-08-18
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 207121-6
    ISSN 2235-3186 ; 1423-0186 ; 1660-8151 ; 0028-2766
    ISSN (online) 2235-3186 ; 1423-0186
    ISSN 1660-8151 ; 0028-2766
    DOI 10.1159/000508983
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Non-Oncological Radiotherapy: A Review of Modern Approaches.

    Nardone, Valerio / D'Ippolito, Emma / Grassi, Roberta / Sangiovanni, Angelo / Gagliardi, Federico / De Marco, Giuseppina / Menditti, Vittorio Salvatore / D'Ambrosio, Luca / Cioce, Fabrizio / Boldrini, Luca / Salvestrini, Viola / Greco, Carlo / Desideri, Isacco / De Felice, Francesca / D'Onofrio, Ida / Grassi, Roberto / Reginelli, Alfonso / Cappabianca, Salvatore

    Journal of personalized medicine

    2022  Volume 12, Issue 10

    Abstract: Despite being usually delivered in oncological patients, radiotherapy can be used as a successful treatment for several non-malignant disorders. Even though this use of radiotherapy has been scarcely investigated since the 1950s, more recent interest has ...

    Abstract Despite being usually delivered in oncological patients, radiotherapy can be used as a successful treatment for several non-malignant disorders. Even though this use of radiotherapy has been scarcely investigated since the 1950s, more recent interest has actually shed the light on this approach. Thus, the aim of this narrative review is to analyze the applications of non-oncological radiotherapy in different disorders. Key references were derived from a PubMed query. Hand searching and clinicaltrials.gov were also used. This review contains a narrative report and a critical discussion of non-oncological radiotherapy approaches. In conclusion, non-oncological radiotherapy is a safe and efficacious approach to treat several disorders that needs to be further investigated and used in clinical practice.
    Language English
    Publishing date 2022-10-09
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662248-8
    ISSN 2075-4426
    ISSN 2075-4426
    DOI 10.3390/jpm12101677
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Sodium Intake and Chronic Kidney Disease.

    Borrelli, Silvio / Provenzano, Michele / Gagliardi, Ida / Michael, Ashour / Liberti, Maria Elena / De Nicola, Luca / Conte, Giuseppe / Garofalo, Carlo / Andreucci, Michele

    International journal of molecular sciences

    2020  Volume 21, Issue 13

    Abstract: In Chronic Kidney Disease (CKD) patients, elevated blood pressure (BP) is a frequent finding and is traditionally considered a direct consequence of their sodium sensitivity. Indeed, sodium and fluid retention, causing hypervolemia, leads to the ... ...

    Abstract In Chronic Kidney Disease (CKD) patients, elevated blood pressure (BP) is a frequent finding and is traditionally considered a direct consequence of their sodium sensitivity. Indeed, sodium and fluid retention, causing hypervolemia, leads to the development of hypertension in CKD. On the other hand, in non-dialysis CKD patients, salt restriction reduces BP levels and enhances anti-proteinuric effect of renin-angiotensin-aldosterone system inhibitors in non-dialysis CKD patients. However, studies on the long-term effect of low salt diet (LSD) on cardio-renal prognosis showed controversial findings. The negative results might be the consequence of measurement bias (spot urine and/or single measurement), reverse epidemiology, as well as poor adherence to diet. In end-stage kidney disease (ESKD), dialysis remains the only effective means to remove dietary sodium intake. The mismatch between intake and removal of sodium leads to fluid overload, hypertension and left ventricular hypertrophy, therefore worsening the prognosis of ESKD patients. This imposes the implementation of a LSD in these patients, irrespective of the lack of trials proving the efficacy of this measure in these patients. LSD is, therefore, a rational and basic tool to correct fluid overload and hypertension in all CKD stages. The implementation of LSD should be personalized, similarly to diuretic treatment, keeping into account the volume status and true burden of hypertension evaluated by ambulatory BP monitoring.
    MeSH term(s) Blood Pressure ; Diet, Sodium-Restricted ; Humans ; Hypertension/diet therapy ; Hypertension/etiology ; Hypertension/physiopathology ; Hypertrophy, Left Ventricular/diet therapy ; Hypertrophy, Left Ventricular/etiology ; Hypertrophy, Left Ventricular/physiopathology ; Kidney Failure, Chronic/complications ; Kidney Failure, Chronic/diet therapy ; Kidney Failure, Chronic/physiopathology ; Prognosis ; Renal Dialysis ; Renal Insufficiency, Chronic/complications ; Renal Insufficiency, Chronic/diet therapy ; Renal Insufficiency, Chronic/physiopathology ; Renin-Angiotensin System/physiology ; Sodium Chloride, Dietary/administration & dosage ; Water-Electrolyte Imbalance/diet therapy ; Water-Electrolyte Imbalance/etiology ; Water-Electrolyte Imbalance/physiopathology
    Chemical Substances Sodium Chloride, Dietary
    Language English
    Publishing date 2020-07-03
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms21134744
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Algorithm of rational approach to reconstruction in Fournier's disease.

    Tripodi, Domenico / Amabile, Maria Ida / Gagliardi, Federica / Frusone, Federico / Varanese, Marzia / De Luca, Alessandro / Pironi, Daniele / D' Andrea, Vito / Sorrenti, Salvatore / Cannistrà, Claudio

    Open medicine (Warsaw, Poland)

    2021  Volume 16, Issue 1, Page(s) 1028–1037

    Abstract: Background: Fournier's gangrene is a rare form of necrotizing fasciitis that affects the genital area up to the perineal region and sometimes the abdominal wall.: Objectives: Our article aims to show that in the treatment of extensive forms of ... ...

    Abstract Background: Fournier's gangrene is a rare form of necrotizing fasciitis that affects the genital area up to the perineal region and sometimes the abdominal wall.
    Objectives: Our article aims to show that in the treatment of extensive forms of Fournier's gangrene, correct use of flap and skin grafts and a quick reconstruction of the exposed tissues avoid scarring retraction of the testicles and deformation of the penis.
    Materials and methods: We retrospectively reviewed the clinical and photographic data of Fournier's gangrene cases treated at our Institute. The data were evaluated to obtain an estimate of the results of the reconstructive technique used, in terms of percentage of occurred healings and eventual complications.
    Results: A total of 34 patients underwent surgery for Fournier's gangrene. In nine cases (26.5%), we had minor complications: in four patients, suffering from diabetes and obesity, a retard in attachment of graft occurred, while in five patients with perianal problems there was a delay in healing due to the onset of local infection.
    Conclusion: The reconstruction approach described here may reduce surgical times. In Fournier's gangrene, the exposed tissues must be reconstructed as quickly as possible.
    Language English
    Publishing date 2021-07-09
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 2829380-0
    ISSN 2391-5463
    ISSN 2391-5463
    DOI 10.1515/med-2021-0294
    Database MEDical Literature Analysis and Retrieval System OnLINE

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