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  1. Article ; Online: COVID-19 and the Liver: The Perils of Non-Peer-Reviewed Science in Times of a Pandemic.

    Debes, Jose D

    Gastroenterology

    2020  Volume 159, Issue 4, Page(s) 1620

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Humans ; Liver ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-04-10
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80112-4
    ISSN 1528-0012 ; 0016-5085
    ISSN (online) 1528-0012
    ISSN 0016-5085
    DOI 10.1053/j.gastro.2020.04.007
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  2. Article ; Online: Virtual empathy and liver cancer.

    Debes, Jose D

    Liver international : official journal of the International Association for the Study of the Liver

    2020  Volume 40, Issue 10, Page(s) 2571

    MeSH term(s) COVID-19/epidemiology ; COVID-19/prevention & control ; Carcinoma, Hepatocellular/diagnosis ; Carcinoma, Hepatocellular/psychology ; Emotional Intelligence ; Empathy ; Humans ; Liver Neoplasms/diagnosis ; Liver Neoplasms/psychology ; Oncologists/psychology ; Physician-Patient Relations ; Telemedicine/ethics ; Truth Disclosure/ethics
    Keywords covid19
    Language English
    Publishing date 2020-07-01
    Publishing country United States
    Document type Letter
    ZDB-ID 2102783-3
    ISSN 1478-3231 ; 1478-3223
    ISSN (online) 1478-3231
    ISSN 1478-3223
    DOI 10.1111/liv.14576
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  3. Article ; Online: DNA methylation markers in the detection of hepatocellular carcinoma.

    Fu, Siyu / Debes, José D / Boonstra, André

    European journal of cancer (Oxford, England : 1990)

    2023  Volume 191, Page(s) 112960

    Abstract: Hepatocellular carcinoma (HCC) is the most common primary liver malignancy and has a poor prognosis. Epigenetic modification has been shown to be deregulated during HCC development by dramatically impacting the differentiation, proliferation, and ... ...

    Abstract Hepatocellular carcinoma (HCC) is the most common primary liver malignancy and has a poor prognosis. Epigenetic modification has been shown to be deregulated during HCC development by dramatically impacting the differentiation, proliferation, and function of cells. One important epigenetic modification is DNA methylation during which methyl groups are added to cytosines without changing the DNA sequence itself. Studies found that methylated DNA markers can be specific for detection of HCC. On the basis of these findings, the utility of methylated DNA markers as novel biomarkers for early-stage HCC has been measured in blood, and indeed superior sensitivity and specificity have been found in several studies when compared to current surveillance methods. However, a variety of factors currently limit the immediate application of these exciting biomarkers. In this review, we provide a detailed rationalisation of the approach and basis for the use of methylation biomarkers for HCC detection and summarise recent studies on methylated DNA markers in HCC focusing on the importance of the aetiological cause of liver disease in the mechanisms leading to cancer.
    MeSH term(s) Humans ; Carcinoma, Hepatocellular/diagnosis ; Carcinoma, Hepatocellular/genetics ; Carcinoma, Hepatocellular/pathology ; Liver Neoplasms/diagnosis ; Liver Neoplasms/genetics ; Liver Neoplasms/pathology ; DNA Methylation ; Genetic Markers ; Biomarkers, Tumor/genetics
    Chemical Substances Genetic Markers ; Biomarkers, Tumor
    Language English
    Publishing date 2023-06-28
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 82061-1
    ISSN 1879-0852 ; 0277-5379 ; 0959-8049 ; 0964-1947
    ISSN (online) 1879-0852
    ISSN 0277-5379 ; 0959-8049 ; 0964-1947
    DOI 10.1016/j.ejca.2023.112960
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Revaccination for Hepatitis B in Previous Nonresponders Following Hepatitis C Eradication.

    Powell, Jesse G / Goble, Spencer R / Debes, Jose D

    The Journal of infectious diseases

    2023  Volume 229, Issue 2, Page(s) 341–345

    Abstract: Background: Patients with chronic hepatitis C virus (HCV) do not respond to hepatitis B virus (HBV) vaccination as efficiently as the general population. We assessed if revaccination after HCV treatment resulted in improved response.: Methods: ... ...

    Abstract Background: Patients with chronic hepatitis C virus (HCV) do not respond to hepatitis B virus (HBV) vaccination as efficiently as the general population. We assessed if revaccination after HCV treatment resulted in improved response.
    Methods: Previous HBV vaccine nonresponders were prospectively recruited for revaccination after HCV eradication. Hepatitis B surface antibody (HBsAb) testing was performed 1 month after series completion.
    Results: Follow-up HBsAb testing was performed in 31 of 34 enrolled patients with 21 (67.7%) reactive results. There were no significant differences in HBsAb reactivity based on age, sex, race, or advanced fibrosis presence.
    Conclusions: HBV vaccine nonresponders should be considered for revaccination following HCV cure.
    MeSH term(s) Humans ; Immunization, Secondary ; Hepatitis C, Chronic/drug therapy ; Hepatitis C, Chronic/prevention & control ; Hepatitis B/prevention & control ; Hepatitis B virus ; Hepatitis B Vaccines ; Hepatitis B Antibodies ; Hepatitis B Surface Antigens ; Hepatitis C
    Chemical Substances Hepatitis B Vaccines ; Hepatitis B Antibodies ; Hepatitis B Surface Antigens
    Language English
    Publishing date 2023-02-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3019-3
    ISSN 1537-6613 ; 0022-1899
    ISSN (online) 1537-6613
    ISSN 0022-1899
    DOI 10.1093/infdis/jiad301
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  5. Article: Hepatitis C and hepatocellular carcinoma in Latin America: Elimination as a path to cancer prevention.

    Goble, Spencer / Mattos, Angelo Z / Mendizabal, Manuel / Debes, Jose D

    Annals of hepatology

    2023  Volume 28, Issue 6, Page(s) 101149

    Language English
    Publishing date 2023-09-01
    Publishing country Mexico
    Document type Editorial
    ZDB-ID 2188733-0
    ISSN 1665-2681
    ISSN 1665-2681
    DOI 10.1016/j.aohep.2023.101149
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  6. Article ; Online: After Curing Hepatitis C Virus Infection.

    Debes, Jose D

    Annals of internal medicine

    2018  Volume 168, Issue 9, Page(s) 682

    MeSH term(s) Hepacivirus ; Hepatitis C ; Hepatitis C, Chronic ; Humans ; Veterans
    Language English
    Publishing date 2018-05-01
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/L18-0013
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  8. Article ; Online: Early hepatocellular carcinoma in South America: What is to blame?

    Debes, Jose D

    Liver international : official journal of the International Association for the Study of the Liver

    2018  Volume 38, Issue 5, Page(s) 957–958

    MeSH term(s) Carcinoma, Hepatocellular ; Demography ; Humans ; Liver Neoplasms ; Risk Factors ; South America
    Language English
    Publishing date 2018-04-27
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2102783-3
    ISSN 1478-3231 ; 1478-3223
    ISSN (online) 1478-3231
    ISSN 1478-3223
    DOI 10.1111/liv.13717
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  9. Article: Response to "On the risk of further excluding outcast patient populations in South America".

    Debes, Jose D / Anugwom, Chimaobi / Farah, Marina / Diaz-Ferrer, Javier

    Annals of hepatology

    2023  Volume 28, Issue 2, Page(s) 100903

    MeSH term(s) Humans ; South America/epidemiology ; Genetic Variation
    Language English
    Publishing date 2023-02-15
    Publishing country Mexico
    Document type Letter ; Comment
    ZDB-ID 2188733-0
    ISSN 1665-2681
    ISSN 1665-2681
    DOI 10.1016/j.aohep.2023.100903
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