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  1. Article: Network-based pharmacological analysis of the molecular mechanism of Gong Ying detoxification lotion with soaking agent in the treatment of diabetic foot ulcers

    YingRui, Wang / Zheng, Liu / GuoYan, Liu / Hongjie, Wang / YuLian, Liu / BoWen, Wang

    Pharmacological research. 2022,

    2022  

    Abstract: Network-based pharmacological analysis of the molecular mechanism of Gong Ying detoxification ... the active ingredients of the drug in the Gong Ying detoxification lotion, and used the UniProt database to obtain ... enrichment, and finally Cytoscape software used to construct the " Gong Ying detoxification lotion component ...

    Abstract Network-based pharmacological analysis of the molecular mechanism of Gong Ying detoxification lotion with soaking agent in the treatment of diabetic foot ulcers. We used the traditional Chinese medicine system pharmacology analysis platform (Tcmsp) and the BATMAN-TCM database to retrieve the active ingredients of the drug in the Gong Ying detoxification lotion, and used the UniProt database to obtain the predicted target and to explore the potential targets of the Diabetic foot ulcers; the String platform was used to construct the protein interaction Action network; the data were analyzed by GO and KEGG pathway enrichment, and finally Cytoscape software used to construct the " Gong Ying detoxification lotion component-Diabetic foot ulcers target-pathway" network. The core active ingredients of Gong Ying detoxification lotion in the treatment of Diabetic foot ulcers were found to be quercetin, choline, wogonin. The biological pathways mainly involved involve classical pathways operating in cancer including the HIF-1 signaling pathway. This study in reveals the characteristics of multi-target and multi-path combination of Gong Ying to treat Diabetic foot ulcers, and provides research ideas and theoretical basis for further treatment of Diabetic foot ulcers.
    Keywords Oriental traditional medicine ; choline ; computer software ; databases ; diabetic foot ; drugs ; pharmacology ; quercetin ; research
    Language English
    Publishing place Elsevier B.V.
    Document type Article
    Note Pre-press version
    ISSN 2667-1425
    DOI 10.1016/j.prmcm.2022.100084
    Database NAL-Catalogue (AGRICOLA)

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  2. Article ; Online: Network-based pharmacological analysis of the molecular mechanism of Gong Ying detoxification lotion with soaking agent in the treatment of diabetic foot ulcers

    Wang YingRui / Liu Zheng / Liu GuoYan / Wang Hongjie / Liu YuLian / Wang BoWen

    Pharmacological Research - Modern Chinese Medicine, Vol 3, Iss , Pp 100084- (2022)

    2022  

    Abstract: Network-based pharmacological analysis of the molecular mechanism of Gong Ying detoxification ... the active ingredients of the drug in the Gong Ying detoxification lotion, and used the UniProt database to obtain ... enrichment, and finally Cytoscape software used to construct the '' Gong Ying detoxification lotion component ...

    Abstract Network-based pharmacological analysis of the molecular mechanism of Gong Ying detoxification lotion with soaking agent in the treatment of diabetic foot ulcers. We used the traditional Chinese medicine system pharmacology analysis platform (Tcmsp) and the BATMAN-TCM database to retrieve the active ingredients of the drug in the Gong Ying detoxification lotion, and used the UniProt database to obtain the predicted target and to explore the potential targets of the Diabetic foot ulcers; the String platform was used to construct the protein interaction Action network; the data were analyzed by GO and KEGG pathway enrichment, and finally Cytoscape software used to construct the '' Gong Ying detoxification lotion component-Diabetic foot ulcers target-pathway'' network. The core active ingredients of Gong Ying detoxification lotion in the treatment of Diabetic foot ulcers were found to be quercetin, choline, wogonin. The biological pathways mainly involved involve classical pathways operating in cancer including the HIF-1 signaling pathway. This study in reveals the characteristics of multi-target and multi-path combination of Gong Ying to treat Diabetic foot ulcers, and provides research ideas and theoretical basis for further treatment of Diabetic foot ulcers.
    Keywords Public antidote wasolytic wash ; Network pharmacology ; Diabetic foot ulcers ; Molecular mechanism ; External treatment of traditional chinese medicine ; Other systems of medicine ; RZ201-999 ; Therapeutics. Pharmacology ; RM1-950
    Subject code 004
    Language English
    Publishing date 2022-06-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article: Quality evaluation of Sinopodophyllum hexandrum (Royle) Ying based on active compounds, bioactivities and RP-HPLC fingerprint

    Liu, Wei / Yin, Dong-xue / Tang, Nan / Zhang, Tong / Wang, Jia / Qin, De-hua / Zhang, Zheng

    Industrial crops and products. 2021 Dec. 15, v. 174

    2021  

    Abstract: Sinopodophyllum hexandrum (Royle) Ying is a perennial medicinal plant that produces the anti-cancer ...

    Abstract Sinopodophyllum hexandrum (Royle) Ying is a perennial medicinal plant that produces the anti-cancer lignan compositions especially podophyllotoxin. Since podophyllotoxin commercial production via chemical synthesis, biotechnological intervention or cultivation has yet to meet the increasing demand, mining the potentially available plant organs to discover more natural podophyllotoxin sources is essential. This study investigated the reversed-phase high performance liquid chromatography (RP-HPLC) fingerprint, active chemicals (lignans, flavonoids, and phenolic profiles), and bioactivities (antimicrobial and cytotoxic activities) of distinct S. hexandrum plant organs. Among different plant organs, the rhizome is a preponderant organ due to high active compounds especially podophyllotoxin at 71.615☓10³ μg/mL, high bioactivity with low minimum inhibitory concentration (MIC)/minimal bactericidal concentration (MBC)/minimal fungicidal concentration (MFC) value of 5/5/5 mg/mL, and low CIR₅₀ value of 0.0718 μg/mL, followed by root. Chemometrics analysis techniques, including correlation analysis (CA), similarity analysis (SA), hierarchical cluster analysis (HCA), principal component analysis (PCA), and discriminant analysis (DA), were further employed to facilitate accurate quality assessment of different plant organs from S. hexandrum. The findings unambiguously validated the clustering of seven samples into four major groups (G1–G4), with G1 (rhizome)>G2 (root)>G4 (fruit, blossom, and leaf)>G3 (stem and petiole) as the consistent quality ordering, despite significant differences in chemical compositions and bioactivities. Considered the practical application, the rhizome is, therefore, a preferred medicinal organ, and root could be considered as a substitute resource. The rhizome or root extraction could be used as a potential raw material source for natural antimicrobial agents and cancer cell inhibitors in the food, medicine, and healthcare industries. This research added to our understanding of the integrated exploitation and utilization extension of S. hexandrum resources. RP-HPLC fingerprinting in combination with chemometrics approaches was also confirmed as a highly reliable method for assessing the quality of S. hexandrum and other industrial crops.
    Keywords Podophyllum hexandrum ; chemometrics ; cluster analysis ; cytotoxicity ; discriminant analysis ; flavonoids ; fruits ; health services ; medicinal plants ; medicine ; minimum inhibitory concentration ; neoplasm cells ; petioles ; podophyllotoxin ; principal component analysis ; raw materials ; reversed-phase high performance liquid chromatography ; rhizomes ; synthesis
    Language English
    Dates of publication 2021-1215
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 1132158-1
    ISSN 1872-633X ; 0926-6690
    ISSN (online) 1872-633X
    ISSN 0926-6690
    DOI 10.1016/j.indcrop.2021.114159
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 5577: Show issues

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  4. Book: Ying Han, Han Ying shen jing nei ke ci hui shou ce

    Zheng, Liangcheng

    2008  

    Author's details zhu bian Zheng Liangcheng, Zhou Chilong, Xie Peizeng
    MeSH term(s) Neurology ; Nervous System ; Nervous System Diseases
    Language Chinese
    Size 752 p.
    Edition Di 1 ban.
    Publisher Jun shi yi xue ke xue chu ban she
    Publishing place Beijing
    Document type Book
    ISBN 9787802450578 ; 7802450578
    Database Catalogue of the US National Library of Medicine (NLM)

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  5. Book: Ying han zi dong hua ci hui

    Zheng, Dazhong

    2010  

    Title variant Ying-han zidonghua cihui ; An Englisch-Chinese dictionary of automation
    Author's details Zheng da zhong bian
    Language Chinese ; English
    Size 872 S
    Publisher Qing hua da xue chu ban she
    Publishing place Bei jing
    Document type Book
    ISBN 9787302213734 ; 7302213739
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  6. Book: Ying Han pi fu bing xue ci hui

    Zheng, Maorong

    2010  

    Title variant English-Chinese dictionary of dermatology
    Author's details zhu bian Zheng Maorong
    MeSH term(s) Skin Diseases
    Language Chinese
    Size ii, 423 p. ;, 21 cm.
    Edition Di 1 ban.
    Publisher Di 2 jun yi da xue chu ban she
    Publishing place Shanghai
    Document type Book
    ISBN 9787810609678 ; 781060967X
    Database Catalogue of the US National Library of Medicine (NLM)

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  7. Book: Yi xue ying xiang yi nan bing li jie du

    Zheng, Suisheng

    2013  

    Author's details zhu bian Zheng Suisheng, Liu Bin, Luan Weizhi
    MeSH term(s) Diagnostic Imaging
    Language Chinese
    Size 6, 609 pages :, illustrations
    Edition Di 1 ban.
    Document type Book
    ISBN 9787533755713 ; 7533755715
    Database Catalogue of the US National Library of Medicine (NLM)

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    Inter-library loan at ZB MED

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  8. Book: Jing luo shu xue xue (Han ying dui zhao)

    Zheng, Meifeng

    2012  

    Title variant Meridians and acupoints (Chinese-English)
    Author's details zhu bian (yi), Zheng Meifeng ; fu zhu bian, Wu Qiang ; bian (yi) wei (an xing shi bi hua pai xu), Ji Feng [and 10 others] ; zhu bian dan wei, Fujian Zhong yi yao da xue = Meridians and acupoints (Chinese-English) / compiler and translator-in-chief, Zheng Meifeng ; vice-compiler-in-chief, Wu Qiang ; compiling and translating committee, Ji Feng [and 10 others] ; Editors' unit, Fujian University of TCM
    MeSH term(s) Meridians ; Acupuncture Therapy/methods
    Language Chinese ; English
    Size 8, 483 pages :, illustrations
    Edition Di 1 ban.
    Document type Book
    ISBN 9787513205825 ; 7513205825
    Database Catalogue of the US National Library of Medicine (NLM)

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  9. Book: Bian ying xing bi yan

    Zheng, Hongxiang

    1999  

    Title translation Rhinallergosis.
    Author's details Zheng Hongxiang zhu bian
    MeSH term(s) Rhinitis
    Language Chinese
    Size 3, 239 p. :, ill.
    Edition Di 1 ban.
    Publisher Beijing yi ke da xue chu ban she
    Publishing place Beijing
    Document type Book
    ISBN 9787810349796 ; 7810349791
    Database Catalogue of the US National Library of Medicine (NLM)

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  10. Book: Mao zhu jing ying xue

    Zheng, Yushan / Hong, Wei

    1999  

    Author's details Zheng Yushan, Hong Wei bian zhu
    Keywords Bamboo.
    Language Chinese
    Size 2, 4, 521 p., [4] p. of plates :, ill. (some col.) ;, 26 cm.
    Edition Di 1 ban.
    Publisher Xiamen da xue chu ban she
    Publishing place Fuzhou Shi
    Document type Book
    ISBN 756151428X ; 9787561514283
    Database NAL-Catalogue (AGRICOLA)

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