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  1. Article ; Online: Inflammatory Signature of Human Hypertension: From Regulatory to Exhausted T Cells.

    Mikolajczyk, Tomasz P / Guzik, Tomasz J

    JACC. Basic to translational science

    2023  Volume 8, Issue 3, Page(s) 337–339

    Language English
    Publishing date 2023-03-27
    Publishing country United States
    Document type Editorial
    ISSN 2452-302X
    ISSN (online) 2452-302X
    DOI 10.1016/j.jacbts.2022.11.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Global accord on the integration of artificial intelligence in medical science publishing: implications of the Bletchley Declaration.

    Guzik, Tomasz J / Sitek, Arkadiusz

    Cardiovascular research

    2023  Volume 119, Issue 17, Page(s) 2681–2682

    MeSH term(s) Artificial Intelligence ; Publishing
    Language English
    Publishing date 2023-11-22
    Publishing country England
    Document type Editorial
    ZDB-ID 80340-6
    ISSN 1755-3245 ; 0008-6363
    ISSN (online) 1755-3245
    ISSN 0008-6363
    DOI 10.1093/cvr/cvad170
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 565: Show issues Location:
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  3. Article ; Online: Skin sodium, lymphatics, and blood pressure: a non-canonical mechanism of salt-sensitive hypertension.

    Nosalski, Ryszard / Guzik, Tomasz J

    European heart journal

    2023  Volume 44, Issue 29, Page(s) 2743–2745

    MeSH term(s) Humans ; Blood Pressure ; Sodium ; Lymphangiogenesis ; Hypertension/etiology ; Hypertension/physiopathology ; Sodium Chloride, Dietary/adverse effects
    Chemical Substances Sodium (9NEZ333N27) ; Sodium Chloride, Dietary
    Language English
    Publishing date 2023-06-27
    Publishing country England
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehad290
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1563: Show issues Location:
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    Zs.MO 640: Show issues

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  4. Article ; Online: Acute Pulmonary Embolism and Immunity in Animal Models.

    Imiela, Anna M / Mikołajczyk, Tomasz P / Guzik, Tomasz J / Pruszczyk, Piotr

    Archivum immunologiae et therapiae experimentalis

    2024  Volume 72, Issue 1

    Abstract: Venous thromboembolism, encompassing acute pulmonary embolism (APE) and deep vein thrombosis (DVT), is a potentially fatal disease with complex pathophysiology. Traditionally, the Virchow triad provided a framework for understanding the pathogenic ... ...

    Abstract Venous thromboembolism, encompassing acute pulmonary embolism (APE) and deep vein thrombosis (DVT), is a potentially fatal disease with complex pathophysiology. Traditionally, the Virchow triad provided a framework for understanding the pathogenic contributors to thrombus formation, which include endothelial dysfunction, alterations in blood flow and blood hypercoagulability. In the last years, it has become apparent that immunity plays a central role in thrombosis, interacting with classical prothrombotic mechanisms, oxidative stress and vascular factors. Thrombosis amplifies inflammation, and exaggerated inflammatory processes can trigger thrombosis mainly due to the activation of leukocytes, platelets, and endothelial cells. APE-related endothelium injury is a major trigger for immune system activation. Endothelium is also a key component mediating inflammatory reaction and it is relevant to maintain vascular permeability. Exaggerated right ventricular wall stress and overload, with coexisting systemic hypotension and hypoxemia, result in myocardial injury and necrosis. Hypoxia, tissue factor activation and cytokine storm are engaged in the thrombo-inflammatory processes. Thrombus development is characterized by inflammatory state vascular wall caused mainly by an early extravasation of leukocytes and intense selectins and cytokines production. Nevertheless, immunity of DVT is well described, little is known about potential chemokine and cellular differences between thrombus that develops in the vein and thrombus that detaches and lodges in the pulmonary circulation being a cause of APE. There is a paucity of data considering inflammatory state in the pulmonary artery wall during an acute episode of pulmonary embolism. The main aim of this review is to summarize the knowledge of immunity in acute phase of pulmonary embolism in experimental models.
    MeSH term(s) Animals ; Endothelial Cells ; Pulmonary Embolism/complications ; Thrombosis/complications ; Inflammation ; Models, Animal ; Hominidae
    Language English
    Publishing date 2024-01-24
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 282209-x
    ISSN 1661-4917 ; 0004-069X
    ISSN (online) 1661-4917
    ISSN 0004-069X
    DOI 10.2478/aite-2024-0003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 393: Show issues Location:
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  5. Article ; Online: Leaders in cardiovascular research: Eugene Braunwald.

    Braunwald, Eugene / Guzik, Tomasz J

    Cardiovascular research

    2022  Volume 118, Issue 7, Page(s) e48–e50

    MeSH term(s) Cardiology ; Cardiovascular System ; Heart
    Language English
    Publishing date 2022-07-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 80340-6
    ISSN 1755-3245 ; 0008-6363
    ISSN (online) 1755-3245
    ISSN 0008-6363
    DOI 10.1093/cvr/cvac033
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Understanding and controlling the increasing burden of cardiovascular diseases in Africa.

    Olowoyo, Paul / Maffia, Pasquale / Guzik, Tomasz J / Owolabi, Mayowa

    Cardiovascular research

    2024  Volume 120, Issue 4, Page(s) e9–e13

    MeSH term(s) Humans ; Cardiovascular Diseases/diagnosis ; Cardiovascular Diseases/epidemiology ; Africa/epidemiology ; Cause of Death ; Risk Factors
    Language English
    Publishing date 2024-02-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 80340-6
    ISSN 1755-3245 ; 0008-6363
    ISSN (online) 1755-3245
    ISSN 0008-6363
    DOI 10.1093/cvr/cvad173
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Old, but gold? Not the case for the immune system when promoting systemic ageing.

    Bollini, Sveva / Guzik, Tomasz J

    Cardiovascular research

    2022  Volume 118, Issue 2, Page(s) e14–e16

    MeSH term(s) Gold ; Immune System
    Chemical Substances Gold (7440-57-5)
    Language English
    Publishing date 2022-01-19
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80340-6
    ISSN 1755-3245 ; 0008-6363
    ISSN (online) 1755-3245
    ISSN 0008-6363
    DOI 10.1093/cvr/cvab366
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: The ATP connection: a new therapeutic promise of P2X7 targeting in hypertension and vascular injury.

    Sulicka-Grodzicka, Joanna / Guzik, Tomasz J

    Journal of hypertension

    2023  Volume 41, Issue 11, Page(s) 1696–1698

    MeSH term(s) Humans ; Vascular System Injuries ; Hypertension/drug therapy ; Adenosine Triphosphate
    Chemical Substances Adenosine Triphosphate (8L70Q75FXE)
    Language English
    Publishing date 2023-10-05
    Publishing country Netherlands
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 605532-1
    ISSN 1473-5598 ; 0263-6352 ; 0952-1178
    ISSN (online) 1473-5598
    ISSN 0263-6352 ; 0952-1178
    DOI 10.1097/HJH.0000000000003543
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1885: Show issues Location:
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    Zs.MO 614: Show issues

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  9. Article ; Online: JCAD: a new GWAS target to reduce residual cardiovascular risk?

    Guzik, Tomasz J / Channon, Keith M

    European heart journal

    2022  Volume 44, Issue 20, Page(s) 1834–1836

    MeSH term(s) Humans ; Phosphatidylinositol 3-Kinases ; Proto-Oncogene Proteins c-akt ; Cardiovascular Diseases/genetics ; Cardiovascular Diseases/prevention & control ; Genome-Wide Association Study ; Risk Factors ; Heart Disease Risk Factors ; Thrombosis
    Chemical Substances Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1)
    Language English
    Publishing date 2022-11-15
    Publishing country England
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehac708
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Salty secrets of the brain: the link between stress, salt, and hypertension.

    Ludwig-Słomczyńska, Agnieszka H / Guzik, Tomasz J

    Cardiovascular research

    2023  Volume 119, Issue 8, Page(s) 1619–1621

    MeSH term(s) Humans ; Hypertension/diagnosis ; Sodium Chloride, Dietary/adverse effects ; Sodium Chloride ; Brain ; Salt Stress
    Chemical Substances Sodium Chloride, Dietary ; Sodium Chloride (451W47IQ8X)
    Language English
    Publishing date 2023-05-19
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 80340-6
    ISSN 1755-3245 ; 0008-6363
    ISSN (online) 1755-3245
    ISSN 0008-6363
    DOI 10.1093/cvr/cvad071
    Database MEDical Literature Analysis and Retrieval System OnLINE

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