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  1. Article ; Online: Normotensive pulmonary embolism: nothing to sneeze at.

    Jiang, Rong / Dai, Hai-Long

    Journal of thrombosis and haemostasis : JTH

    2023  Volume 21, Issue 11, Page(s) 3072–3074

    MeSH term(s) Humans ; Blood Pressure ; Risk Assessment ; Pulmonary Embolism/diagnosis ; Pulmonary Embolism/epidemiology
    Language English
    Publishing date 2023-08-01
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2112661-6
    ISSN 1538-7836 ; 1538-7933
    ISSN (online) 1538-7836
    ISSN 1538-7933
    DOI 10.1016/j.jtha.2023.06.008
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    Zs.A 5805: Show issues Location:
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    Zs.MO 295: Show issues

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  2. Article ; Online: Effect of limb remote ischemic preconditioning on the endogenous melatonin signaling in patients undergoing hepatectomy: A pilot prospective study.

    Ding, Yu / Dai, Jing-Ya / Jia, Hui / Fu, Hai-Long

    Asian journal of surgery

    2023  Volume 46, Issue 7, Page(s) 2863–2864

    MeSH term(s) Humans ; Hepatectomy ; Prospective Studies ; Melatonin ; Ischemic Preconditioning ; Reperfusion Injury
    Chemical Substances Melatonin (JL5DK93RCL)
    Language English
    Publishing date 2023-02-01
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 1068461-x
    ISSN 0219-3108 ; 1015-9584
    ISSN (online) 0219-3108
    ISSN 1015-9584
    DOI 10.1016/j.asjsur.2023.01.081
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  3. Article ; Online: The origin of different bending stiffness between double-stranded RNA and DNA revealed by magnetic tweezers and simulations.

    Dong, Hai-Long / Zhang, Chen / Dai, Liang / Zhang, Yan / Zhang, Xing-Hua / Tan, Zhi-Jie

    Nucleic acids research

    2024  Volume 52, Issue 5, Page(s) 2519–2529

    Abstract: The subtle differences in the chemical structures of double-stranded (ds) RNA and DNA lead to significant variations in their biological roles and medical implications, largely due to their distinct biophysical properties, such as bending stiffness. ... ...

    Abstract The subtle differences in the chemical structures of double-stranded (ds) RNA and DNA lead to significant variations in their biological roles and medical implications, largely due to their distinct biophysical properties, such as bending stiffness. Although it is well known that A-form dsRNA is stiffer than B-form dsDNA under physiological salt conditions, the underlying cause of this difference remains unclear. In this study, we employ high-precision magnetic-tweezer experiments along with molecular dynamics simulations and reveal that the relative bending stiffness between dsRNA and dsDNA is primarily determined by the structure- and salt-concentration-dependent ion distribution around their helical structures. At near-physiological salt conditions, dsRNA shows a sparser ion distribution surrounding its phosphate groups compared to dsDNA, causing its greater stiffness. However, at very high monovalent salt concentrations, phosphate groups in both dsRNA and dsDNA become fully neutralized by excess ions, resulting in a similar intrinsic bending persistence length of approximately 39 nm. This similarity in intrinsic bending stiffness of dsRNA and dsDNA is coupled to the analogous fluctuations in their total groove widths and further coupled to the similar fluctuation of base-pair inclination, despite their distinct A-form and B-form helical structures.
    MeSH term(s) Base Pairing ; DNA/chemistry ; Nucleic Acid Conformation ; Phosphates ; RNA, Double-Stranded/chemistry ; Molecular Biology/methods ; Molecular Dynamics Simulation
    Chemical Substances DNA (9007-49-2) ; Phosphates ; RNA, Double-Stranded
    Language English
    Publishing date 2024-02-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 186809-3
    ISSN 1362-4962 ; 1362-4954 ; 0301-5610 ; 0305-1048
    ISSN (online) 1362-4962 ; 1362-4954
    ISSN 0301-5610 ; 0305-1048
    DOI 10.1093/nar/gkae063
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  4. Article ; Online: A 49-Year-Old Woman With Progressive Dyspnea.

    Dai, Hai-Long / Zhang, Wei-Hua / Guang, Xue-Feng

    JAMA cardiology

    2022  Volume 7, Issue 2, Page(s) e214920

    MeSH term(s) Cardiomyopathies/complications ; Cardiomyopathies/diagnosis ; Cardiomyopathies/physiopathology ; Cardiomyopathies/therapy ; Ecchymosis/diagnosis ; Ecchymosis/etiology ; Echocardiography ; Electrocardiography ; Female ; Heart Failure/diagnosis ; Heart Failure/etiology ; Heart Failure/physiopathology ; Heart Failure/therapy ; Humans ; Hypertension, Pulmonary/diagnosis ; Hypertension, Pulmonary/etiology ; Hypertension, Pulmonary/therapy ; Immunoglobulin Light-chain Amyloidosis/complications ; Immunoglobulin Light-chain Amyloidosis/diagnosis ; Immunoglobulin Light-chain Amyloidosis/physiopathology ; Immunoglobulin Light-chain Amyloidosis/therapy ; Middle Aged ; Orbital Diseases/diagnosis ; Orbital Diseases/etiology ; Peripheral Blood Stem Cell Transplantation ; Transplantation, Autologous
    Language English
    Publishing date 2022-02-09
    Publishing country United States
    Document type Case Reports ; Journal Article
    ISSN 2380-6591
    ISSN (online) 2380-6591
    DOI 10.1001/jamacardio.2021.4920
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  5. Article ; Online: p38 MAPK Endogenous Inhibition Improves Neurological Deficits in Global Cerebral Ischemia/Reperfusion Mice.

    Hou, Kun / Xiao, Zhi-Cheng / Dai, Hai-Long

    Neural plasticity

    2022  Volume 2022, Page(s) 3300327

    Abstract: Cerebral ischemia/reperfusion (I/R) injury is a complex pathophysiological process that can lead to neurological function damage and the formation of cerebral infarction. The p38 MAPK pathway has attracted considerable attention in cerebral I/R injury ( ... ...

    Abstract Cerebral ischemia/reperfusion (I/R) injury is a complex pathophysiological process that can lead to neurological function damage and the formation of cerebral infarction. The p38 MAPK pathway has attracted considerable attention in cerebral I/R injury (IRI), but little research has been carried out on its direct role in vivo. In this study, to observe the effects of p38 MAPK endogenous inhibition on cerebral IRI, p38 heterozygous knockdown (p38
    MeSH term(s) Animals ; Apoptosis ; Brain Ischemia ; Cerebral Infarction/drug therapy ; Infarction, Middle Cerebral Artery/drug therapy ; Mice ; Neuroprotective Agents/pharmacology ; Reperfusion ; Reperfusion Injury ; p38 Mitogen-Activated Protein Kinases/metabolism
    Chemical Substances Neuroprotective Agents ; p38 Mitogen-Activated Protein Kinases (EC 2.7.11.24)
    Language English
    Publishing date 2022-06-29
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1454938-4
    ISSN 1687-5443 ; 2090-5904 ; 0792-8483
    ISSN (online) 1687-5443
    ISSN 2090-5904 ; 0792-8483
    DOI 10.1155/2022/3300327
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  6. Article ; Online: COVID-19 and the pulmonary vascular injury.

    Dai, Hai-Long / Guang, Xue-Feng

    Journal of the renin-angiotensin-aldosterone system : JRAAS

    2020  Volume 21, Issue 4, Page(s) 1470320320972276

    MeSH term(s) Angiotensin-Converting Enzyme 2 ; Animals ; Betacoronavirus/physiology ; COVID-19 ; Coronavirus Infections/complications ; Endothelium, Vascular/enzymology ; Humans ; Pandemics ; Peptidyl-Dipeptidase A/metabolism ; Pneumonia, Viral/complications ; Renin-Angiotensin System/physiology ; SARS-CoV-2 ; Vascular Diseases/virology
    Chemical Substances Peptidyl-Dipeptidase A (EC 3.4.15.1) ; ACE2 protein, human (EC 3.4.17.23) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23)
    Keywords covid19
    Language English
    Publishing date 2020-11-11
    Publishing country England
    Document type Letter
    ZDB-ID 2086948-4
    ISSN 1752-8976 ; 1470-3203
    ISSN (online) 1752-8976
    ISSN 1470-3203
    DOI 10.1177/1470320320972276
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  7. Article ; Online: Efficacy of different strategies of remote ischemic preconditioning delivery in liver surgery: A meta-analysis of randomized controlled trials.

    Ding, Yu / Dai, Jing-Ya / Zhang, Ya-Qing / Fu, Hai-Long

    Asian journal of surgery

    2022  Volume 45, Issue 12, Page(s) 2945–2946

    MeSH term(s) Humans ; Randomized Controlled Trials as Topic ; Ischemic Preconditioning ; Liver
    Language English
    Publishing date 2022-06-30
    Publishing country China
    Document type Letter
    ZDB-ID 1068461-x
    ISSN 0219-3108 ; 1015-9584
    ISSN (online) 0219-3108
    ISSN 1015-9584
    DOI 10.1016/j.asjsur.2022.06.115
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  8. Article ; Online: Pediatric restrictive cardiomyopathy: a case report.

    Dai, Hai-Long / Wang, Qing-Hui / Su, Xuan / Ding, Yun-Chuan / Guang, Xue-Feng

    The Journal of international medical research

    2023  Volume 51, Issue 8, Page(s) 3000605231188276

    Abstract: Restrictive cardiomyopathy (RCM) is a rare childhood cardiomyopathy that is a challenging diagnostic problem for clinicians. We describe a case of an 8-year-old girl with a 2-year history of shortness of breath on exertion. Electrocardiogram and ... ...

    Abstract Restrictive cardiomyopathy (RCM) is a rare childhood cardiomyopathy that is a challenging diagnostic problem for clinicians. We describe a case of an 8-year-old girl with a 2-year history of shortness of breath on exertion. Electrocardiogram and echocardiography showed biatrial enlargement, while cardiac magnetic resonance showed biatrial dilation and normal pericardial thickness. Left and right heart catheterization revealed a left ventricular (LV) end-diastolic pressure (EDP) of 20 mmHg, right ventricular (RV) EDP of 13 mmHg, and pulmonary arterial systolic pressure of 51 mmHg. LV and RV pressure traces showed that LV and RV pressures moved concordantly with respiration, and that the systolic area index was 0.98. Cardiac catheterization data were therefore supportive of RCM. Next-generation sequencing identified a heterozygous variant of the troponin I gene (
    MeSH term(s) Female ; Humans ; Child ; Cardiomyopathy, Restrictive/diagnostic imaging ; Cardiomyopathy, Restrictive/genetics ; Anticoagulants ; Cardiac Catheterization ; Cerebral Infarction ; Pericardium
    Chemical Substances Anticoagulants
    Language English
    Publishing date 2023-08-28
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 184023-x
    ISSN 1473-2300 ; 0300-0605 ; 0142-2596
    ISSN (online) 1473-2300
    ISSN 0300-0605 ; 0142-2596
    DOI 10.1177/03000605231188276
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  9. Article ; Online: Experience of copy number variation sequencing applied in spontaneous abortion.

    Dai, Yi-Fang / Wu, Xiao-Qing / Huang, Hai-Long / He, Shu-Qiong / Guo, Dan-Hua / Li, Ying / Lin, Na / Xu, Liang-Pu

    BMC medical genomics

    2024  Volume 17, Issue 1, Page(s) 15

    Abstract: Purpose: We evaluated the value of copy number variation sequencing (CNV-seq) and quantitative fluorescence (QF)-PCR for analyzing chromosomal abnormalities (CA) in spontaneous abortion specimens.: Methods: A total of 650 products of conception (POCs) ...

    Abstract Purpose: We evaluated the value of copy number variation sequencing (CNV-seq) and quantitative fluorescence (QF)-PCR for analyzing chromosomal abnormalities (CA) in spontaneous abortion specimens.
    Methods: A total of 650 products of conception (POCs) were collected from spontaneous abortion between April 2018 and May 2020. CNV-seq and QF-PCR were performed to determine the characteristics and frequencies of copy number variants (CNVs) with clinical significance. The clinical features of the patients were recorded.
    Results: Clinically significant chromosomal abnormalities were identified in 355 (54.6%) POCs, of which 217 (33.4%) were autosomal trisomies, 42(6.5%) were chromosomal monosomies and 40 (6.2%) were pathogenic CNVs (pCNVs). Chromosomal trisomy occurs mainly on chromosomes 15, 16, 18, 21and 22. Monosomy X was not associated with the maternal or gestational age. The frequency of chromosomal abnormalities in miscarriages from women with a normal live birth history was 55.3%; it was 54.4% from women without a normal live birth history (P > 0.05). There were no significant differences among women without, with 1, and with ≥ 2 previous miscarriages regarding the rate of chromosomal abnormalities (P > 0.05); CNVs were less frequently detected in women with advanced maternal age than in women aged ≤ 29 and 30-34 years (P < 0.05).
    Conclusion: Chromosomal abnormalities are the most common cause of pregnancy loss, and maternal and gestational ages are strongly associated with fetal autosomal trisomy aberrations. Embryo chromosomal examination is recommended regardless of the gestational age, modes of conception or previous abortion status.
    MeSH term(s) Pregnancy ; Humans ; Female ; Abortion, Spontaneous/genetics ; DNA Copy Number Variations ; Trisomy/genetics ; Chromosome Aberrations ; Turner Syndrome
    Language English
    Publishing date 2024-01-08
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2411865-5
    ISSN 1755-8794 ; 1755-8794
    ISSN (online) 1755-8794
    ISSN 1755-8794
    DOI 10.1186/s12920-023-01699-1
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  10. Article: Pulmonary Hypertension in a Patient With Kartagener's Syndrome and a Novel Homozygous Nonsense Mutation in CCDC40 Gene: A Case Report.

    Dai, Hai-Long / Wang, Duolao / Guang, Xue-Feng / Zhang, Wei-Hua

    Frontiers in medicine

    2022  Volume 9, Page(s) 860684

    Abstract: Kartagener's syndrome is a subgroup of primary ciliary dyskinesia (PCD), a genetically heterogeneous condition characterised by sinusitis, bronchiectasis, and situs in versus. Genetic testing has importance for their diagnosis. Here, we report a chinese ... ...

    Abstract Kartagener's syndrome is a subgroup of primary ciliary dyskinesia (PCD), a genetically heterogeneous condition characterised by sinusitis, bronchiectasis, and situs in versus. Genetic testing has importance for their diagnosis. Here, we report a chinese patient with Kartagener's syndrome. Transthoracic echocardiography showed severely elevated right ventricular systolic pressure. Right heart catheterisation demonstrated a pre-capillary pulmonary hypertension. Whole-exome sequencing indicated that she had a novel homozygous nonsense mutation, c.2845C > T, p.Gln949*, in exon 18 of CCDC40 and a heterozygotic mutation, c.73G > A, p.Ala25Thr, in exon 1 of DNAH11. She was diagnosed as Kartagener's syndrome with pulmonary hypertension. Her symptoms improved significantly by treatment of antibiotics, expectorant drugs, bronchodilators, and oxygen therapy treatment. Our findings extend the mutation spectrum of CCDC40 gene related Kartagener's syndrome, which is very important for gene diagnosis of the disease.
    Language English
    Publishing date 2022-03-30
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2022.860684
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