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Book: Kurs spezielle Pathologie

Claus, Jessica / Fechner, Carsten / Zimpfer, Annette / Erbersdobler, Andreas

mit AMBOSS-Verknüpfung

2021

Author's details	Jessica Claus, Carsten Fechner, Annette Zimpfer, Andreas Erbersdobler
Keywords	Kurs ; Präparat ; Histopathologie ; Pathologiekurs ; Pathologie ; Histologie ; AMBOSS ; Skript ; Allgemeine Pathologie ; Rostock
Subject	Allgemeine Pathologie ; Spezielle Pathologie ; Klinische Pathologie ; Allgemeine Krankheitslehre
Subject code	616.07
Language	German
Size	XI, 224 Seiten, Illustrationen, 28 cm, 699 g
Publisher	Springer
Publishing place	Berlin
Publishing country	Germany
Document type	Book
HBZ-ID	HT021398271
ISBN	978-3-662-62893-5 ; 3-662-62893-7 ; 9783662628942 ; 3662628945
Database	Catalogue ZB MED Medicine, Health

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2022 A 793	available for loan (reading room)	Lesesaal EG

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Article ; Online: 3D Printed Percutaneous Transhepatic Cholangiography and Drainage (PTCD) Simulator for Interventional Radiology.

Fechner, Carsten / Reyes Del Castillo, Tomás / Roos, Justus Erasmus / Zech, Christoph Johannes / Takes, Martin / López Benítez, Rubén

Cardiovascular and interventional radiology

2023 Volume 46, Issue 4, Page(s) 500–507

Abstract: Purpose: Learning how to perform percutaneous transhepatic bile duct drainage (PTCD) is challenging for interventional radiology (IR) trainees. Therefore, simulators are crucial for IR training and are being increasingly demanded in the evolving ... ...

Abstract	Purpose: Learning how to perform percutaneous transhepatic bile duct drainage (PTCD) is challenging for interventional radiology (IR) trainees. Therefore, simulators are crucial for IR training and are being increasingly demanded in the evolving healthcare environment of value-based care. To facilitate interventional training, we tried to evaluate our newly developed liver phantom for further use in IR training. Methods: We developed a liver phantom with a flexible hollow biliary tree, hydrogel-based liver parenchyma, plastic ribs, and silicone skin. The phantom was evaluated by 20 radiology residents from two hospitals. After an introduction, all participants tried to obtain biliary access by fluoroscopic guidance within 25 min. Puncture time, fluoroscopy time, and kerma area product were measured. After 7 days, the participants repeated the procedure on an altered and more difficult model. Additionally, a survey was handed out to every participant (20 residents, 5 experts, and 5 IR fellows) to evaluate the phantom in terms of accuracy and haptic feedback, as well as general questions regarding simulation. Results: The residents performed significantly faster and were more self-confident on Day 7 than on Day 1, significantly decreasing puncture time, fluoroscopy time, and kerma area product (p ≤ 0.0001). The participants were very satisfied with their simulation experience and would trust themselves more in real-life scenarios. Conclusion: We were able to develop a phantom with high anatomical accuracy for fluoroscopy and ultrasound-guided interventions. The phantom successfully helped residents learn and improve their PTCD performance.
MeSH term(s)	Humans ; Radiology, Interventional ; Cholangiography/methods ; Biliary Tract ; Drainage/methods ; Printing, Three-Dimensional
Language	English
Publishing date	2023-01-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	603082-8
ISSN	1432-086X ; 0342-7196 ; 0174-1551
ISSN (online)	1432-086X
ISSN	0342-7196 ; 0174-1551
DOI	10.1007/s00270-022-03347-0
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Article: Bronchoalveolar lavage-detected SARS-CoV-2 infection in presence of serial negative nasopharyngeal swabs: a case report.

Caci, Grazia / Minervini, Fabrizio / Fechner, Carsten / Roos, Justus E / Obermann, Ellen C / Azzola, Andrea

Annals of translational medicine

2021 Volume 9, Issue 7, Page(s) 583

Abstract: We describe a case of a SARS coronavirus 2 (SARS-CoV-2) infection in a Swiss 54-years-old immunocompromised patient (lymphoma, therapy with the anti-CD20 ... ...

Abstract	We describe a case of a SARS coronavirus 2 (SARS-CoV-2) infection in a Swiss 54-years-old immunocompromised patient (lymphoma, therapy with the anti-CD20 antibody
Language	English
Publishing date	2021-04-13
Publishing country	China
Document type	Case Reports
ZDB-ID	2893931-1
ISSN	2305-5847 ; 2305-5839
ISSN (online)	2305-5847
ISSN	2305-5839
DOI	10.21037/atm-20-4307
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Article ; Online: More bang for your buck: Improved use of GPU nodes for GROMACS 2018.

Kutzner, Carsten / Páll, Szilárd / Fechner, Martin / Esztermann, Ansgar / de Groot, Bert L / Grubmüller, Helmut

Journal of computational chemistry

2019 Volume 40, Issue 27, Page(s) 2418–2431

Abstract: We identify hardware that is optimal to produce molecular dynamics (MD) trajectories on Linux compute clusters with the GROMACS 2018 simulation package. Therefore, we benchmark the GROMACS performance on a diverse set of compute nodes and relate it to ... ...

Abstract	We identify hardware that is optimal to produce molecular dynamics (MD) trajectories on Linux compute clusters with the GROMACS 2018 simulation package. Therefore, we benchmark the GROMACS performance on a diverse set of compute nodes and relate it to the costs of the nodes, which may include their lifetime costs for energy and cooling. In agreement with our earlier investigation using GROMACS 4.6 on hardware of 2014, the performance to price ratio of consumer GPU nodes is considerably higher than that of CPU nodes. However, with GROMACS 2018, the optimal CPU to GPU processing power balance has shifted even more toward the GPU. Hence, nodes optimized for GROMACS 2018 and later versions enable a significantly higher performance to price ratio than nodes optimized for older GROMACS versions. Moreover, the shift toward GPU processing allows to cheaply upgrade old nodes with recent GPUs, yielding essentially the same performance as comparable brand-new hardware. © 2019 Wiley Periodicals, Inc.
Language	English
Publishing date	2019-07-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1479181-X
ISSN	1096-987X ; 0192-8651
ISSN (online)	1096-987X
ISSN	0192-8651
DOI	10.1002/jcc.26011
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Article ; Online: Colchicine prevents disease progression in viral myocarditis via modulating the NLRP3 inflammasome in the cardiosplenic axis.

Pappritz, Kathleen / Lin, Jie / El-Shafeey, Muhammad / Fechner, Henry / Kühl, Uwe / Alogna, Alessio / Spillmann, Frank / Elsanhoury, Ahmed / Schulz, Rainer / Tschöpe, Carsten / Van Linthout, Sophie

ESC heart failure

2022 Volume 9, Issue 2, Page(s) 925–941

Abstract: Aim: The acute phase of a coxsackievirus 3 (CVB3)-induced myocarditis involves direct toxic cardiac effects and the systemic activation of the immune system, including the cardiosplenic axis. Consequently, the nucleotide-binding oligomerization domain- ... ...

Abstract	Aim: The acute phase of a coxsackievirus 3 (CVB3)-induced myocarditis involves direct toxic cardiac effects and the systemic activation of the immune system, including the cardiosplenic axis. Consequently, the nucleotide-binding oligomerization domain-like receptor pyrin domain-containing-3 (NLRP3) inflammasome pathway is activated, which plays a role in disease pathogenesis and progression. The anti-inflammatory drug colchicine exerts its effects, in part, via reducing NLRP3 activity, and has been shown to improve several cardiac diseases, including acute coronary syndrome and pericarditis. The aim of the present study was to evaluate the potential of colchicine to improve experimental CVB3-induced myocarditis. Methods and results: C57BL6/j mice were intraperitoneally injected with 1 × 10 Conclusions: Colchicine improves LV function in CVB3-induced myocarditis, involving a decrease in cardiac and splenic NLRP3 inflammasome activity, without exacerbation of CVB3 load.
MeSH term(s)	Animals ; Colchicine/pharmacology ; Colchicine/therapeutic use ; Disease Progression ; Humans ; Inflammasomes/metabolism ; Inflammasomes/therapeutic use ; Mice ; Myocarditis/drug therapy ; Myocarditis/prevention & control ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism
Chemical Substances	Inflammasomes ; NLR Family, Pyrin Domain-Containing 3 Protein ; Nlrp3 protein, mouse ; Colchicine (SML2Y3J35T)
Language	English
Publishing date	2022-02-17
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2814355-3
ISSN	2055-5822 ; 2055-5822
ISSN (online)	2055-5822
ISSN	2055-5822
DOI	10.1002/ehf2.13845
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Article ; Online: Enhanced suppression of adenovirus replication by triple combination of anti-adenoviral siRNAs, soluble adenovirus receptor trap sCAR-Fc and cidofovir.

Pozzuto, Tanja / Röger, Carsten / Kurreck, Jens / Fechner, Henry

Antiviral research

2015 Volume 120, Page(s) 72–78

Abstract: Adenoviruses (Ad) generally induce mild self-limiting respiratory or intestinal infections but can also cause serious disease with fatal outcomes in immunosuppressed patients. Antiviral drug therapy is an important treatment for adenoviral infections but ...

Abstract	Adenoviruses (Ad) generally induce mild self-limiting respiratory or intestinal infections but can also cause serious disease with fatal outcomes in immunosuppressed patients. Antiviral drug therapy is an important treatment for adenoviral infections but its efficiency is limited. Recently, we have shown that gene silencing by RNA interference (RNAi) is a promising new approach to inhibit adenoviral infection. In the present in vitro study, we examined whether the efficiency of an RNAi-based anti-adenoviral therapy can be further increased by combination with a virus receptor trap sCAR-Fc and with the antiviral drug cidofovir. Initially, three siRNAs, siE1A_4, siIVa2_2 and Pol-si2, targeting the adenoviral E1A, IVa2 and DNA polymerase mRNAs, respectively, were used for gene silencing. Replication of the Ad was inhibited in a dose dependent manner by each siRNA, but the efficiency of inhibition differed (Pol-si2>siIVa2_2>siE1A_4). Double or triple combinations of the siRNAs compared with single siRNAs did not result in a measurably higher suppression of Ad replication. Combination of the siRNAs (alone or mixes of two or three siRNAs) with sCAR-Fc markedly increased the suppression of adenoviral replication compared to the same siRNA treatment without sCAR-Fc. Moreover, the triple combination of a mix of all three siRNAs, sCAR-Fc and cidofovir was about 23-fold more efficient than the combination of siRNAs mix/sCAR-Fc and about 95-fold more efficient than the siRNA mix alone. These data demonstrate that co-treatment of cells with sCAR-Fc and cidofovir is suitable to increase the efficiency of anti-adenoviral siRNAs.
MeSH term(s)	Adenoviridae/drug effects ; Adenoviridae/physiology ; Antiviral Agents/metabolism ; Cytosine/analogs & derivatives ; Cytosine/metabolism ; DNA, Viral/analysis ; Drug Synergism ; HeLa Cells ; Humans ; Organophosphonates/metabolism ; RNA, Small Interfering/metabolism ; Receptors, Virus/metabolism ; Virus Internalization/drug effects ; Virus Replication/drug effects
Chemical Substances	Antiviral Agents ; DNA, Viral ; Organophosphonates ; RNA, Small Interfering ; Receptors, Virus ; adenovirus receptor ; Cytosine (8J337D1HZY) ; cidofovir (JIL713Q00N)
Language	English
Publishing date	2015-08
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	306628-9
ISSN	1872-9096 ; 0166-3542
ISSN (online)	1872-9096
ISSN	0166-3542
DOI	10.1016/j.antiviral.2015.05.010
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Article ; Online: COVID-19 and the role of imaging: early experiences in Central Switzerland.

Fechner, Carsten / Strobel, Klaus / Treumann, Thomas / Sonderegger, Beat / Azzola, Andrea / Fornaro, Jürgen / Schrading, Simone / Roos, Justus E

Swiss medical weekly

2020 Volume 150, Page(s) w20304

Abstract: The SARS-CoV-2 virus (COVID-19) was initially observed in a group of Chinese patients with unclear pneumonia in Wuhan, Hubei [1] in late December 2019. The first positive case in Switzerland was confirmed on 25 February 2020 in a patient from canton ... ...

Abstract	The SARS-CoV-2 virus (COVID-19) was initially observed in a group of Chinese patients with unclear pneumonia in Wuhan, Hubei [1] in late December 2019. The first positive case in Switzerland was confirmed on 25 February 2020 in a patient from canton Tessin, who most likely caught the virus during a visit to Milan, Italy [2]. The country has since been preparing for an imminent public health emergency caused by the pandemic. As of 14 May 2020, the Swiss healthcare system is facing a total of 30,463 corona virus-positive people [3]. With numbers of new infections decreasing after the first pandemic wave, the continuing endemic situation will continue to be a major challenge for the Swiss healthcare system. It remains crucial to separate the clinically low-symptomatic from the severely affected patients in order to offer a specific therapeutic strategy to every SARS-CoV-2 patient. Reports from Chinese cohorts describe an increasing role of imaging strategies in the detection and surveillance of COVID-19 patients because of insufficient testing sensitivity of real-time reverse transcription polymerase chain reaction (RT-PCR) tests [4]. Chest computed tomography (CT), with a reported sensitivity of up to 97% [5, 6], gained importance particularly in patients with false negative RT-PCR results. In this short communication, we describe our first clinical experiences with 55 COVID-19 patients in Central Switzerland, who were either imaged with a standard chest x-ray, chest CT, or both. We provide an illustrative and schematic description of typical COVID-19 imaging features and suggest that imaging plays an important role in the clinical work-up of suspected or confirmed COVID-19 patients. This study was approved by the national ethics review committee (EKNZ, Switzerland) and patients’ informed consent was waived.
MeSH term(s)	Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Critical Illness ; Humans ; Incidence ; Intensive Care Units ; Italy ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2 ; Switzerland
Keywords	covid19
Language	English
Publishing date	2020-06-22
Publishing country	Switzerland
Document type	Journal Article ; Comment
ZDB-ID	2036179-8
ISSN	1424-3997 ; 1424-7860
ISSN (online)	1424-3997
ISSN	1424-7860
DOI	10.4414/smw.2020.20304
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Article ; Online: An optimized 3D-printed perfusion bioreactor for homogeneous cell seeding in bone substitute scaffolds for future chairside applications.

Engel, Nadja / Fechner, Carsten / Voges, Annika / Ott, Robert / Stenzel, Jan / Siewert, Stefan / Bergner, Carina / Khaimov, Valeria / Liese, Jan / Schmitz, Klaus-Peter / Krause, Bernd Joachim / Frerich, Bernhard

Scientific reports

2021 Volume 11, Issue 1, Page(s) 22228

Abstract: A clinical implementation of cell-based bone regeneration in combination with scaffold materials requires the development of efficient, controlled and reproducible seeding procedures and a tailor-made bioreactor design. A perfusion system for efficient, ... ...

Abstract	A clinical implementation of cell-based bone regeneration in combination with scaffold materials requires the development of efficient, controlled and reproducible seeding procedures and a tailor-made bioreactor design. A perfusion system for efficient, homogeneous, and rapid seeding with human adipogenic stem cells in bone substitute scaffolds was designed. Variants concerning medium inlet and outlet port geometry, i.e. cylindrical or conical diffuser, cell concentration, perfusion mode and perfusion rates were simulated in silico. Cell distribution during perfusion was monitored by dynamic [
MeSH term(s)	Animals ; Biomarkers ; Bioreactors ; Bone Regeneration ; Bone Substitutes ; Cell Culture Techniques ; Cell Differentiation ; Cells, Cultured ; Equipment Design ; Humans ; Immunohistochemistry ; Mesenchymal Stem Cells/cytology ; Mesenchymal Stem Cells/metabolism ; Osteogenesis ; Perfusion ; Positron Emission Tomography Computed Tomography ; Printing, Three-Dimensional ; Tissue Engineering/methods ; Tissue Scaffolds
Chemical Substances	Biomarkers ; Bone Substitutes
Language	English
Publishing date	2021-11-15
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-021-01516-8
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Article ; Online: Percutaneous transhepatic biliary puncture simulator: a cord network prototype.

Lopez Benítez, Rubén / Reyes Del Castillo, Tomás / Benz, David / Fechner, Carsten / Szabo, Lorant / Kara, Levent / Monnard, Etienne / Kostrzewa, Michael / Roos, Justus E

Advances in simulation (London, England)

2021 Volume 6, Issue 1, Page(s) 27

Abstract: Background: The aim of this study was to present a percutaneous transhepatic biliary puncture simulator that can be used without radiation exposure and that reflects the conventional anatomy of the biliary ducts and its vicinity structures.: Methods: ...

Abstract	Background: The aim of this study was to present a percutaneous transhepatic biliary puncture simulator that can be used without radiation exposure and that reflects the conventional anatomy of the biliary ducts and its vicinity structures. Methods: An anatomically based model of the biliary tree was developed using a cord network fixed to a wooden frame. The skin, ribs, intercostal muscles, and right lower lobe pleura were simulated using foam sponge, plastic tubes, a polystyrene foam panel, and an air pad, respectively. For the puncture, we used a 20-G Chiba needle and a wire with distal double arches; these were used to troll a cord, simulating the successful puncture of a bile duct. A camera was also placed above the model to allow the trainees to train eye-hand coordination while viewing the image on a monitor in real time. The simulator was tested with 60 radiology residents to evaluate the confidence and skills transferability of the training model. Results: After receiving an introduction of the system and 5 min of training under tutor surveillance, all participants were able to troll a cord of the biliary simulator by themselves in less than 4 min. Only one participant punctured the simulated pleura. The participants' evaluations showed positive results, with increased user confidence and skills transferability after the training session. Conclusions: This proposed simulator can be an effective tool to improve a trainee's confidence and competence while achieving procedural and non-procedural interventional radiology skills related to the liver. Trial registration: Retrospectively registered.
Language	English
Publishing date	2021-08-06
Publishing country	England
Document type	Journal Article
ISSN	2059-0628
ISSN (online)	2059-0628
DOI	10.1186/s41077-021-00178-w
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Article ; Online: COVID-19 and the role of imaging

Fechner, Carsten / Strobel, Klaus / Treumann, Thomas / Sonderegger, Beat / Azzola, Andrea / Fornaro, Jrgen / Schrading, Simone / Roos, Justus E.

Swiss Medical Weekly ; ISSN 1424-3997

early experiences in Central Switzerland

2020

Keywords	General Medicine ; covid19
Language	English
Publisher	EMH Swiss Medical Publishers, Ltd.
Publishing country	ch
Document type	Article ; Online
DOI	10.4414/smw.2020.20304
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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