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  1. Article ; Online: COVID-19: is the ACE2 just a foe?

    Jakovac, Hrvoje

    American journal of physiology. Lung cellular and molecular physiology

    2020  Volume 318, Issue 5, Page(s) L1025–L1026

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Humans ; Pandemics ; Peptidyl-Dipeptidase A ; Pneumonia, Viral ; SARS-CoV-2
    Chemical Substances Peptidyl-Dipeptidase A (EC 3.4.15.1)
    Keywords covid19
    Language English
    Publishing date 2020-04-01
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1013184-x
    ISSN 1522-1504 ; 1040-0605
    ISSN (online) 1522-1504
    ISSN 1040-0605
    DOI 10.1152/ajplung.00119.2020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Sex differences in COVID-19 course and outcome: progesterone should not be neglected.

    Jakovac, Hrvoje

    Journal of applied physiology (Bethesda, Md. : 1985)

    2020  Volume 129, Issue 5, Page(s) 1007–1008

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections/blood ; Coronavirus Infections/immunology ; Coronavirus Infections/therapy ; Disease Progression ; Female ; Humans ; Male ; Pandemics ; Pneumonia, Viral/blood ; Pneumonia, Viral/immunology ; Pneumonia, Viral/therapy ; Progesterone/blood ; Progesterone/immunology ; SARS-CoV-2 ; Sex Characteristics ; Treatment Outcome
    Chemical Substances Progesterone (4G7DS2Q64Y)
    Keywords covid19
    Language English
    Publishing date 2020-10-21
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 219139-8
    ISSN 1522-1601 ; 0021-8987 ; 0161-7567 ; 8750-7587
    ISSN (online) 1522-1601
    ISSN 0021-8987 ; 0161-7567 ; 8750-7587
    DOI 10.1152/japplphysiol.00740.2020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: COVID-19 and vitamin D-Is there a link and an opportunity for intervention?

    Jakovac, Hrvoje

    American journal of physiology. Endocrinology and metabolism

    2020  Volume 318, Issue 5, Page(s) E589

    MeSH term(s) Betacoronavirus ; Coronavirus Infections/drug therapy ; Humans ; Pandemics ; Pneumonia, Viral/drug therapy ; Vitamin D/therapeutic use
    Chemical Substances Vitamin D (1406-16-2)
    Keywords covid19
    Language English
    Publishing date 2020-05-14
    Publishing country United States
    Document type Letter
    ZDB-ID 603841-4
    ISSN 1522-1555 ; 0193-1849
    ISSN (online) 1522-1555
    ISSN 0193-1849
    DOI 10.1152/ajpendo.00138.2020
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  4. Article ; Online: COVID-19 and hypertension: is the HSP60 culprit for the severe course and worse outcome?

    Jakovac, Hrvoje

    American journal of physiology. Heart and circulatory physiology

    2020  Volume 319, Issue 4, Page(s) H793–H796

    Abstract: The 60-kDa heat shock protein (HSP60) is a chaperone essential for mitochondrial proteostasis ensuring thus sufficient aerobic energy production. In pathological conditions, HSP60 can be translocated from the mitochondria and excreted from the cell. In ... ...

    Abstract The 60-kDa heat shock protein (HSP60) is a chaperone essential for mitochondrial proteostasis ensuring thus sufficient aerobic energy production. In pathological conditions, HSP60 can be translocated from the mitochondria and excreted from the cell. In turn, the extracellular HSP60 has a strong ability to trigger and enhance inflammatory response with marked proinflammatory cytokine induction, which is mainly mediated by Toll-like receptor binding. Previous studies have found increased circulating levels of HSP60 in hypertensive patients, as well as enhanced HSP60 expression and membrane translocation in the hypertrophic myocardium. These observations are of particular interest, since they could provide a possible pathophysiological explanation of the severe course and worse outcome of severe acute respiratory syndrome coronavirus 2 infection in hypertensive patients, repeatedly reported during the recent coronavirus disease 2019 (COVID-19) pandemic and related to hyperinflammatory response and cytokine storm development during the third phase of the disease. In this regard, pharmacological inhibition of HSP60 could attract attention to potentially ameliorate inappropriate inflammatory reaction in severe COVID-19 patients. Among HSP60 antagonizing drugs, mizoribine is the most intriguing, since it is clinically approved and exerts antiviral activity. However, this topic requires to be further scrutinized.
    MeSH term(s) Animals ; Betacoronavirus/pathogenicity ; Chaperonin 60/antagonists & inhibitors ; Chaperonin 60/metabolism ; Coronavirus Infections/drug therapy ; Coronavirus Infections/epidemiology ; Coronavirus Infections/metabolism ; Coronavirus Infections/virology ; Host-Pathogen Interactions ; Humans ; Hypertension/epidemiology ; Hypertension/metabolism ; Hypertension/physiopathology ; Immunosuppressive Agents/therapeutic use ; Inflammation Mediators/antagonists & inhibitors ; Inflammation Mediators/metabolism ; Pandemics ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/metabolism ; Pneumonia, Viral/virology ; Prognosis ; Ribonucleosides/therapeutic use ; Signal Transduction
    Chemical Substances Chaperonin 60 ; Immunosuppressive Agents ; Inflammation Mediators ; Ribonucleosides ; mizoribine (4JR41A10VP)
    Keywords covid19
    Language English
    Publishing date 2020-09-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603838-4
    ISSN 1522-1539 ; 0363-6135
    ISSN (online) 1522-1539
    ISSN 0363-6135
    DOI 10.1152/ajpheart.00506.2020
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  8. Article ; Online: Sex differences in COVID-19 course and outcome

    Jakovac, Hrvoje

    https://journals.physiology.org/doi/10.1152/japplphysiol.00740.2020 ; Journal of Applied Physiology ; Volume 129 ; Issue 5

    progesterone should not be neglected

    2020  

    Keywords BIOMEDICINA I ZDRAVSTVO. Temeljne medicinske znanosti ; ; BIOMEDICINE AND HEALTHCARE. Basic Medical Sciences ; ; Covid-19 ; SARS-CoV-2 ; covid19
    Language English
    Publishing date 2020-11-01
    Publishing country hr
    Document type Article ; Online
    ZDB-ID 219139-8
    ISSN 1522-1601 ; 0021-8987 ; 0161-7567 ; 8750-7587
    ISSN (online) 1522-1601
    ISSN 0021-8987 ; 0161-7567 ; 8750-7587
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: COVID-19 - is the ACE2 just a foe?

    Jakovac, Hrvoje

    https://journals.physiology.org/doi/10.1152/ajplung.00119.2020 ; American Journal of Physiology-Lung Cellular and Molecular Physiology

    2020  

    Keywords BIOMEDICINA I ZDRAVSTVO. Temeljne medicinske znanosti ; BIOMEDICINE AND HEALTHCARE. Basic Medical Sciences ; ACE2 ; COVID-19 ; RAS ; SARS-CoV-2 ; lung injury ; BIOMEDICINA I ZDRAVSTVO. Kliničke medicinske znanosti. Infektologija ; BIOMEDICINE AND HEALTHCARE. Clinical Medical Sciences. Infectology ; covid19
    Language English
    Publishing date 2020-04-01
    Publishing country hr
    Document type Article ; Online
    ZDB-ID 1013184-x
    ISSN 1522-1504 ; 1040-0605
    ISSN (online) 1522-1504
    ISSN 1040-0605
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.89: Show issues Location:
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  10. Article ; Online: COVID-19 and vitamin D—Is there a link and an opportunity for intervention?

    Jakovac, Hrvoje

    https://journals.physiology.org/doi/10.1152/ajpendo.00138.2020 ; American Journal of Physiology-Endocrinology and Metabolism ; Volume 318 ; Issue 5

    2020  

    Keywords BIOMEDICINA I ZDRAVSTVO. Temeljne medicinske znanosti ; ; BIOMEDICINE AND HEALTHCARE. Basic Medical Sciences ; ; COVID-19 ; SARS-CoV-2 ; ARDS ; lung injury ; immunomodulation ; vitamin D ; BIOMEDICINA I ZDRAVSTVO. Kliničke medicinske znanosti. Infektologija ; ; BIOMEDICINE AND HEALTHCARE. Clinical Medical Sciences. Infectology ; covid19
    Language English
    Publishing date 2020-05-01
    Publishing country hr
    Document type Article ; Online
    ZDB-ID 603841-4
    ISSN 1522-1555 ; 0193-1849
    ISSN (online) 1522-1555
    ISSN 0193-1849
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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