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  1. Book ; Online: Chapter 4: Posthuman feminism and feminist new materialism: towards an ethico-onto-epistemology in research practices

    Cozza, Michela / Gherardi, Silvia

    2023  

    Keywords JFFK ; Affect; Agencement; Ethico-onto-epistemology; Feminist new materialism; Posthuman feminism; Subjectivity; Feminist analyses of popular culture
    Language English
    Size 1 Online-Ressource
    Publisher Edward Elgar Publishing
    Publishing place Cheltenham, UK
    Document type Book ; Online
    Note English
    HBZ-ID HT030646953
    ISBN 9781800377035 ; 1800377037
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online: Chapter 5 Elderliness : The agential inseparability of ageing and assistive technologies

    Cozza, Michela

    2021  

    Keywords Sociology ; Disability: social aspects ; Society & culture: general ; Child & developmental psychology ; socio-gerontechnology; Alexander Peine; Barbara Marshall; Wendy Martin; Louis Neven; ageing; technology; gerontology; digital technology; age studies; science and technology studies; STS; social media; neighbourhoods; ageing-in-place; co-housing; activism; dementia; public policy; later life; new materialism; technoscience; agency; participatory methods; ageism
    Size 1 electronic resource (16 pages)
    Publisher Taylor and Francis
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021047069
    ISBN 9780367682125 ; 0367682125
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Book ; Online: Chapter 9 Academy in my flesh

    gherardi, silvia / Cozza, Michela / Hoppe, Magnus

    Affective athleticism and performative writing

    2023  

    Keywords Sociology: work & labour ; Organization & management of education ; Higher & further education, tertiary education ; Academia; Academic labour; Affective capitalism; Counterpolitics; Higher education; Marketisation; Neoliberalism; Power; Social justice; University
    Language English
    Size 1 electronic resource (32 pages)
    Publisher Policy Press
    Publishing place Bristol
    Document type Book ; Online
    Note English
    HBZ-ID HT030380449
    ISBN 9781447357841 ; 1447357841
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  4. Article ; Online: Monitoring Nrf2/ARE Pathway Activity with a New Zebrafish Reporter System.

    Badenetti, Lorenzo / Manzoli, Rosa / Rubin, Michela / Cozza, Giorgio / Moro, Enrico

    International journal of molecular sciences

    2023  Volume 24, Issue 7

    Abstract: Among multiple cytoprotective mechanisms, eukaryotic cells exhibit a complex transcriptional program relying on the Nrf2 transcription factor, which is generally recruited upon biological stressors including oxidative-stress-based cellular insults. The ... ...

    Abstract Among multiple cytoprotective mechanisms, eukaryotic cells exhibit a complex transcriptional program relying on the Nrf2 transcription factor, which is generally recruited upon biological stressors including oxidative-stress-based cellular insults. The relevance of this master regulator has remarkably emerged in recent years in several research fields such as cancer, inflammatory disorders and age-related neurological diseases. Here, we document the generation and characterization of a novel Nrf2/ARE pathway biosensor fish which exhibits a dynamic spatiotemporal expression profile during the early developmental stages. The transgenic line is responsive to known Nrf2 pathway modulators but also to Edaravone, which direct activity on the Nrf2 pathway has never been documented in a live transgenic fish model. We also show that the reporter is faithfully activated during fin regeneration, and its degree of expression is slightly affected in a glucocerebrosidase (Gba1) morphant zebrafish model. Therefore, this novel transgenic fish may represent a valuable tool to be exploited for the characterization of zebrafish models of human diseases, as well as for primary high-throughput drug screening.
    MeSH term(s) Animals ; Humans ; Zebrafish/genetics ; Zebrafish/metabolism ; NF-E2-Related Factor 2/genetics ; NF-E2-Related Factor 2/metabolism ; Oxidative Stress/genetics ; Animals, Genetically Modified/genetics ; Antioxidants/metabolism ; Zebrafish Proteins/metabolism
    Chemical Substances NF-E2-Related Factor 2 ; Antioxidants ; Zebrafish Proteins
    Language English
    Publishing date 2023-04-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24076804
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Monitoring Nrf2/ARE Pathway Activity with a New Zebrafish Reporter System

    Lorenzo Badenetti / Rosa Manzoli / Michela Rubin / Giorgio Cozza / Enrico Moro

    International Journal of Molecular Sciences, Vol 24, Iss 6804, p

    2023  Volume 6804

    Abstract: Among multiple cytoprotective mechanisms, eukaryotic cells exhibit a complex transcriptional program relying on the Nrf2 transcription factor, which is generally recruited upon biological stressors including oxidative-stress-based cellular insults. The ... ...

    Abstract Among multiple cytoprotective mechanisms, eukaryotic cells exhibit a complex transcriptional program relying on the Nrf2 transcription factor, which is generally recruited upon biological stressors including oxidative-stress-based cellular insults. The relevance of this master regulator has remarkably emerged in recent years in several research fields such as cancer, inflammatory disorders and age-related neurological diseases. Here, we document the generation and characterization of a novel Nrf2/ARE pathway biosensor fish which exhibits a dynamic spatiotemporal expression profile during the early developmental stages. The transgenic line is responsive to known Nrf2 pathway modulators but also to Edaravone, which direct activity on the Nrf2 pathway has never been documented in a live transgenic fish model. We also show that the reporter is faithfully activated during fin regeneration, and its degree of expression is slightly affected in a glucocerebrosidase (Gba1) morphant zebrafish model. Therefore, this novel transgenic fish may represent a valuable tool to be exploited for the characterization of zebrafish models of human diseases, as well as for primary high-throughput drug screening.
    Keywords Nrf2 ; zebrafish ; transgenic reporter ; drug ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 500
    Language English
    Publishing date 2023-04-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: Materialities of care for older people: caring together/apart in the political economy of caring apparatus.

    Cozza, Michela / Bruzzone, Silvia / Crevani, Lucia

    Health sociology review : the journal of the Health Section of the Australian Sociological Association

    2021  Volume 30, Issue 3, Page(s) 308–322

    Abstract: By applying a posthuman perspective to the analysis of care for older people (COP), we analyse the agential cuts (together/apart) enacted by humans (mainly caregivers and older people) and more-than-humans (a camera intra-acting with other objects) whose ...

    Abstract By applying a posthuman perspective to the analysis of care for older people (COP), we analyse the agential cuts (together/apart) enacted by humans (mainly caregivers and older people) and more-than-humans (a camera intra-acting with other objects) whose agential entanglement configures and reconfigures the political economy of the caring apparatus. Our study identifies 'targeting', 'monitoring', and 'aligning' as interrelated caring practices, thus contributing to advance a posthuman understanding of welfare technology, and advancing a critical use of the possibilities enacted by technologies.
    MeSH term(s) Aged ; Caregivers ; Humans ; Social Welfare ; Technology
    Language English
    Publishing date 2021-10-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2146435-2
    ISSN 1839-3551 ; 1446-1242
    ISSN (online) 1839-3551
    ISSN 1446-1242
    DOI 10.1080/14461242.2021.1976067
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5941: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Double Attack to Oxidative Stress in Neurodegenerative Disorders: MAO-B and Nrf2 as Elected Targets.

    Basagni, Filippo / Di Paolo, Maria Luisa / Cozza, Giorgio / Dalla Via, Lisa / Fagiani, Francesca / Lanni, Cristina / Rosini, Michela / Minarini, Anna

    Molecules (Basel, Switzerland)

    2023  Volume 28, Issue 21

    Abstract: Oxidative stress and neuroinflammation play a pivotal role in triggering the neurodegenerative pathological cascades which characterize neurodegenerative disorders, such as Alzheimer's and Parkinson's diseases. In search for potential efficient ... ...

    Abstract Oxidative stress and neuroinflammation play a pivotal role in triggering the neurodegenerative pathological cascades which characterize neurodegenerative disorders, such as Alzheimer's and Parkinson's diseases. In search for potential efficient treatments for these pathologies, that are still considered unmet medical needs, we started from the promising properties of the antidiabetic drug pioglitazone, which has been repositioned as an MAO-B inhibitor, characterized by promising neuroprotective properties. Herein, with the aim to broaden its neuroprotective profile, we tried to enrich pioglitazone with direct and indirect antioxidant properties by hanging polyphenolic and electrophilic features that are able to trigger Nrf2 pathway and the resulting cytoprotective genes' transcription, as well as serve as radical scavengers. After a preliminary screening on MAO-B inhibitory properties, caffeic acid derivative
    MeSH term(s) Humans ; Antioxidants/pharmacology ; Antioxidants/metabolism ; NF-E2-Related Factor 2/metabolism ; Pioglitazone/pharmacology ; Oxidative Stress ; Neurodegenerative Diseases/metabolism ; Monoamine Oxidase/metabolism
    Chemical Substances Antioxidants ; NF-E2-Related Factor 2 ; Pioglitazone (X4OV71U42S) ; Monoamine Oxidase (EC 1.4.3.4)
    Language English
    Publishing date 2023-11-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules28217424
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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  8. Article ; Online: Double Attack to Oxidative Stress in Neurodegenerative Disorders

    Filippo Basagni / Maria Luisa Di Paolo / Giorgio Cozza / Lisa Dalla Via / Francesca Fagiani / Cristina Lanni / Michela Rosini / Anna Minarini

    Molecules, Vol 28, Iss 21, p

    MAO-B and Nrf2 as Elected Targets

    2023  Volume 7424

    Abstract: Oxidative stress and neuroinflammation play a pivotal role in triggering the neurodegenerative pathological cascades which characterize neurodegenerative disorders, such as Alzheimer’s and Parkinson’s diseases. In search for potential efficient ... ...

    Abstract Oxidative stress and neuroinflammation play a pivotal role in triggering the neurodegenerative pathological cascades which characterize neurodegenerative disorders, such as Alzheimer’s and Parkinson’s diseases. In search for potential efficient treatments for these pathologies, that are still considered unmet medical needs, we started from the promising properties of the antidiabetic drug pioglitazone, which has been repositioned as an MAO-B inhibitor, characterized by promising neuroprotective properties. Herein, with the aim to broaden its neuroprotective profile, we tried to enrich pioglitazone with direct and indirect antioxidant properties by hanging polyphenolic and electrophilic features that are able to trigger Nrf2 pathway and the resulting cytoprotective genes’ transcription, as well as serve as radical scavengers. After a preliminary screening on MAO-B inhibitory properties, caffeic acid derivative 2 emerged as the best inhibitor for potency and selectivity over MAO-A, characterized by a reversible mechanism of inhibition. Furthermore, the same compound proved to activate Nrf2 pathway by potently increasing Nrf2 nuclear translocation and strongly reducing ROS content, both in physiological and stressed conditions. Although further biological investigations are required to fully clarify its neuroprotective properties, we were able to endow the pioglitazone scaffold with potent antioxidant properties, representing the starting point for potential future pioglitazone-based therapeutics for neurodegenerative disorders.
    Keywords pioglitazone ; MAO-B ; Nrf2 ; electrophile ; cinnamic acid ; oxidative stress ; Organic chemistry ; QD241-441
    Subject code 540
    Language English
    Publishing date 2023-11-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article: DNA Methylation in Algae and Its Impact on Abiotic Stress Responses.

    Ferrari, Michele / Muto, Antonella / Bruno, Leonardo / Cozza, Radiana

    Plants (Basel, Switzerland)

    2023  Volume 12, Issue 2

    Abstract: Epigenetics, referring to heritable gene regulatory information that is independent of changes in DNA sequences, is an important mechanism involved both in organism development and in the response to environmental events. About the epigenetic marks, DNA ... ...

    Abstract Epigenetics, referring to heritable gene regulatory information that is independent of changes in DNA sequences, is an important mechanism involved both in organism development and in the response to environmental events. About the epigenetic marks, DNA methylation is one of the most conserved mechanisms, playing a pivotal role in organism response to several biotic and abiotic stressors. Indeed, stress can induce changes in gene expression through hypo- or hyper-methylation of DNA at specific loci and/or in DNA methylation at the genome-wide level, which has an adaptive significance and can direct genome evolution. Exploring DNA methylation in responses to abiotic stress could have important implications for improving stress tolerance in algae. This article summarises the DNA methylation pattern in algae and its impact on abiotic stress, such as heavy metals, nutrients and temperature. Our discussion provides information for further research in algae for a better comprehension of the epigenetic response under abiotic stress, which could favour important implications to sustain algae growth under abiotic stress conditions, often related to high biosynthesis of interesting metabolites.
    Language English
    Publishing date 2023-01-05
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2704341-1
    ISSN 2223-7747
    ISSN 2223-7747
    DOI 10.3390/plants12020241
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Gender and technology

    Cozza, Michela

    Organizational communication and sustainable development : ICTs for mobility , p. 256-274

    mind the gap!

    2010  , Page(s) 256–274

    Author's details Michela Cozza
    Keywords Geschlechterforschung ; Digitale Spaltung ; Informationstechnik ; Internet ; Gleichstellungspolitik
    Language English
    Publisher Information Science Reference
    Publishing place Hershey, Pa. [u.a.]
    Document type Article
    ISBN 978-1-605-66822-2 ; 1-605-66822-2
    Database ECONomics Information System

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