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  1. Article ; Online: Cobalamin and folic acid deficiencies presenting with features of a thrombotic microangiopathy: a case series.

    Ceuleers, Britt / Stappers, Sofie / Lemmens, Jan / Rutsaert, Lynn

    Acta clinica Belgica

    2021  Volume 77, Issue 4, Page(s) 787–791

    Abstract: ... Case ... ...

    Abstract Case presentation
    MeSH term(s) Diagnosis, Differential ; Folic Acid Deficiency/complications ; Folic Acid Deficiency/diagnosis ; Humans ; Thrombotic Microangiopathies/diagnosis ; Thrombotic Microangiopathies/etiology ; Vitamin B 12/therapeutic use ; Vitamin B 12 Deficiency/complications ; Vitamin B 12 Deficiency/diagnosis
    Chemical Substances Vitamin B 12 (P6YC3EG204)
    Language English
    Publishing date 2021-09-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 390201-8
    ISSN 2295-3337 ; 0001-5512 ; 1784-3286
    ISSN (online) 2295-3337
    ISSN 0001-5512 ; 1784-3286
    DOI 10.1080/17843286.2021.1983707
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    Ua VI Zs.283: Show issues Location:
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  2. Article ; Online: Inhaled liposomal amphotericin-B as a prophylactic treatment for COVID-19-associated pulmonary aspergillosis/aspergillus tracheobronchitis.

    Van Ackerbroeck, Sofie / Rutsaert, Lynn / Roelant, Ella / Dillen, Kathleen / Wauters, Joost / Van Regenmortel, Niels

    Critical care (London, England)

    2021  Volume 25, Issue 1, Page(s) 298

    MeSH term(s) Administration, Inhalation ; Aged ; Amphotericin B/administration & dosage ; Amphotericin B/pharmacology ; Amphotericin B/therapeutic use ; Aspergillosis/drug therapy ; Aspergillosis/epidemiology ; Aspergillosis/prevention & control ; Belgium/epidemiology ; COVID-19/complications ; COVID-19/epidemiology ; Cohort Studies ; Female ; Humans ; Male ; Middle Aged ; Retrospective Studies
    Chemical Substances liposomal amphotericin B ; Amphotericin B (7XU7A7DROE)
    Language English
    Publishing date 2021-08-19
    Publishing country England
    Document type Letter ; Observational Study
    ZDB-ID 2041406-7
    ISSN 1466-609X ; 1364-8535
    ISSN (online) 1466-609X
    ISSN 1364-8535
    DOI 10.1186/s13054-021-03728-w
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    Zs.A 5517: Show issues Location:
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  3. Article: COVID-19-associated invasive pulmonary aspergillosis.

    Rutsaert, Lynn / Steinfort, Nicky / Van Hunsel, Tine / Bomans, Peter / Naesens, Reinout / Mertes, Helena / Dits, Hilde / Van Regenmortel, Niels

    Annals of intensive care

    2020  Volume 10, Issue 1, Page(s) 71

    Keywords covid19
    Language English
    Publishing date 2020-06-01
    Publishing country Germany
    Document type Letter
    ZDB-ID 2617094-2
    ISSN 2110-5820
    ISSN 2110-5820
    DOI 10.1186/s13613-020-00686-4
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  4. Article ; Online: COVID-19-associated invasive pulmonary aspergillosis

    Lynn Rutsaert / Nicky Steinfort / Tine Van Hunsel / Peter Bomans / Reinout Naesens / Helena Mertes / Hilde Dits / Niels Van Regenmortel

    Annals of Intensive Care, Vol 10, Iss 1, Pp 1-

    2020  Volume 4

    Keywords Medical emergencies. Critical care. Intensive care. First aid ; RC86-88.9 ; covid19
    Language English
    Publishing date 2020-06-01T00:00:00Z
    Publisher SpringerOpen
    Document type Article ; Online
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  5. Article ; Online: COVID-19-associated invasive pulmonary aspergillosis

    Rutsaert, Lynn / Steinfort, Nicky / Van Hunsel, Tine / Bomans, Peter / Naesens, Reinout / Mertes, Helena / Dits, Hilde / Van Regenmortel, Niels

    Annals of Intensive Care

    2020  Volume 10, Issue 1

    Keywords Critical Care and Intensive Care Medicine ; covid19
    Language English
    Publisher Springer Science and Business Media LLC
    Publishing country us
    Document type Article ; Online
    ZDB-ID 2617094-2
    ISSN 2110-5820
    ISSN 2110-5820
    DOI 10.1186/s13613-020-00686-4
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  6. Article: COVID-19-associated invasive pulmonary aspergillosis

    Rutsaert, Lynn / Steinfort, Nicky / Van Hunsel, Tine / Bomans, Peter / Naesens, Reinout / Mertes, Helena / Dits, Hilde / Van Regenmortel, Niels

    Ann. Intensive Care

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #459237
    Database COVID19

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  7. Article ; Online: Prognostic Impact of Bronchoalveolar Lavage Fluid Galactomannan and Aspergillus Culture Results on Survival in COVID-19 Intensive Care Unit Patients: a

    Giacobbe, Daniele Roberto / Prattes, Juergen / Wauters, Joost / Dettori, Silvia / Signori, Alessio / Salmanton-García, Jon / Maertens, Johan / Bourgeois, Marc / Reynders, Marijke / Rutsaert, Lynn / Van Regenmortel, Niels / Lormans, Piet / Feys, Simon / Klimko, Nikolay / Shadrivova, Olga / Cornely, Oliver A / Rautemaa-Richardson, Riina / Koehler, Philipp / Lagrou, Katrien /
    Bassetti, Matteo / Hoenigl, Martin

    Journal of clinical microbiology

    2022  Volume 60, Issue 4, Page(s) e0229821

    Abstract: Critically ill patients with coronavirus disease 2019 (COVID-19) may develop COVID-19-associated pulmonary aspergillosis (CAPA), which impacts their chances of survival. Whether positive bronchoalveolar lavage fluid (BALF) mycological tests can be used ... ...

    Abstract Critically ill patients with coronavirus disease 2019 (COVID-19) may develop COVID-19-associated pulmonary aspergillosis (CAPA), which impacts their chances of survival. Whether positive bronchoalveolar lavage fluid (BALF) mycological tests can be used as a survival proxy remains unknown. We conducted a
    MeSH term(s) Aspergillus ; Bronchoalveolar Lavage Fluid ; COVID-19/complications ; Critical Illness ; Galactose/analogs & derivatives ; Humans ; Intensive Care Units ; Invasive Pulmonary Aspergillosis/complications ; Invasive Pulmonary Aspergillosis/diagnosis ; Mannans ; Mycology ; Prognosis ; Pulmonary Aspergillosis ; Sensitivity and Specificity
    Chemical Substances Mannans ; galactomannan (11078-30-1) ; Galactose (X2RN3Q8DNE)
    Language English
    Publishing date 2022-03-24
    Publishing country United States
    Document type Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 390499-4
    ISSN 1098-660X ; 0095-1137
    ISSN (online) 1098-660X
    ISSN 0095-1137
    DOI 10.1128/jcm.02298-21
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    Zs.A 1188: Show issues Location:
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  8. Article ; Online: Risk factors and outcome of pulmonary aspergillosis in critically ill coronavirus disease 2019 patients-a multinational observational study by the European Confederation of Medical Mycology.

    Prattes, Juergen / Wauters, Joost / Giacobbe, Daniele Roberto / Salmanton-García, Jon / Maertens, Johan / Bourgeois, Marc / Reynders, Marijke / Rutsaert, Lynn / Van Regenmortel, Niels / Lormans, Piet / Feys, Simon / Reisinger, Alexander Christian / Cornely, Oliver A / Lahmer, Tobias / Valerio, Maricela / Delhaes, Laurence / Jabeen, Kauser / Steinmann, Joerg / Chamula, Mathilde /
    Bassetti, Matteo / Hatzl, Stefan / Rautemaa-Richardson, Riina / Koehler, Philipp / Lagrou, Katrien / Hoenigl, Martin

    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

    2021  Volume 28, Issue 4, Page(s) 580–587

    Abstract: Objectives: Coronavirus disease 2019 (COVID-19) -associated pulmonary aspergillosis (CAPA) has emerged as a complication in critically ill COVID-19 patients. The objectives of this multinational study were to determine the prevalence of CAPA in patients ...

    Abstract Objectives: Coronavirus disease 2019 (COVID-19) -associated pulmonary aspergillosis (CAPA) has emerged as a complication in critically ill COVID-19 patients. The objectives of this multinational study were to determine the prevalence of CAPA in patients with COVID-19 in intensive care units (ICU) and to investigate risk factors for CAPA as well as outcome.
    Methods: The European Confederation of Medical Mycology (ECMM) conducted a multinational study including 20 centres from nine countries to assess epidemiology, risk factors and outcome of CAPA. CAPA was defined according to the 2020 ECMM/ISHAM consensus definitions.
    Results: A total of 592 patients were included in this study, including 11 (1.9%) patients with histologically proven CAPA, 80 (13.5%) with probable CAPA, 18 (3%) with possible CAPA and 483 (81.6%) without CAPA. CAPA was diagnosed a median of 8 days (range 0-31 days) after ICU admission predominantly in older patients (adjusted hazard ratio (aHR) 1.04 per year; 95% CI 1.02-1.06) with any form of invasive respiratory support (HR 3.4; 95% CI 1.84-6.25) and receiving tocilizumab (HR 2.45; 95% CI 1.41-4.25). Median prevalence of CAPA per centre was 10.7% (range 1.7%-26.8%). CAPA was associated with significantly lower 90-day ICU survival rate (29% in patients with CAPA versus 57% in patients without CAPA; Mantel-Byar p < 0.001) and remained an independent negative prognostic variable after adjusting for other predictors of survival (HR 2.14; 95% CI 1.59-2.87, p ≤ 0.001).
    Conclusion: Prevalence of CAPA varied between centres. CAPA was significantly more prevalent among older patients, patients receiving invasive ventilation and patients receiving tocilizumab, and was an independent strong predictor of ICU mortality.
    MeSH term(s) Aged ; COVID-19/complications ; COVID-19/epidemiology ; COVID-19/therapy ; Critical Illness ; Humans ; Intensive Care Units ; Invasive Pulmonary Aspergillosis/diagnosis ; Invasive Pulmonary Aspergillosis/drug therapy ; Invasive Pulmonary Aspergillosis/epidemiology ; Mycology ; Pulmonary Aspergillosis/complications ; Pulmonary Aspergillosis/epidemiology ; Risk Factors ; SARS-CoV-2
    Language English
    Publishing date 2021-08-26
    Publishing country England
    Document type Journal Article ; Observational Study
    ZDB-ID 1328418-6
    ISSN 1469-0691 ; 1470-9465 ; 1198-743X
    ISSN (online) 1469-0691
    ISSN 1470-9465 ; 1198-743X
    DOI 10.1016/j.cmi.2021.08.014
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4541: Show issues Location:
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  9. Article ; Online: Multinational Observational Cohort Study of COVID-19-Associated Pulmonary Aspergillosis

    Janssen, Nico A F / Nyga, Rémy / Vanderbeke, Lore / Jacobs, Cato / Ergün, Mehmet / Buil, Jochem B / van Dijk, Karin / Altenburg, Josje / Bouman, Catherine S C / van der Spoel, Hans I / Rijnders, Bart J A / Dunbar, Albert / Schouten, Jeroen A / Lagrou, Katrien / Bourgeois, Marc / Reynders, Marijke / van Regenmortel, Niels / Rutsaert, Lynn / Lormans, Piet /
    Feys, Simon / Debavaye, Yves / Tamion, Fabienne / Costa, Damien / Maizel, Julien / Dupont, Hervé / Chouaki, Taieb / Nseir, Saad / Sendid, Boualem / Brüggemann, Roger J M / van de Veerdonk, Frank L / Wauters, Joost / Verweij, Paul E

    Emerging infectious diseases

    2021  Volume 27, Issue 11, Page(s) 2892–2898

    Abstract: We performed an observational study to investigate intensive care unit incidence, risk factors, and outcomes of coronavirus disease-associated pulmonary aspergillosis (CAPA). We found 10%-15% CAPA incidence among 823 patients in 2 cohorts. Several ... ...

    Abstract We performed an observational study to investigate intensive care unit incidence, risk factors, and outcomes of coronavirus disease-associated pulmonary aspergillosis (CAPA). We found 10%-15% CAPA incidence among 823 patients in 2 cohorts. Several factors were independently associated with CAPA in 1 cohort and mortality rates were 43%-52%.
    MeSH term(s) COVID-19 ; Cohort Studies ; Humans ; Invasive Pulmonary Aspergillosis ; Pulmonary Aspergillosis ; SARS-CoV-2
    Language English
    Publishing date 2021-09-14
    Publishing country United States
    Document type Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 1380686-5
    ISSN 1080-6059 ; 1080-6040
    ISSN (online) 1080-6059
    ISSN 1080-6040
    DOI 10.3201/eid2711.211174
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  10. Article ; Online: Multinational Observational Cohort Study of COVID-19–Associated Pulmonary Aspergillosis

    Nico A.F. Janssen / Rémy Nyga / Lore Vanderbeke / Cato Jacobs / Mehmet Ergün / Jochem B. Buil / Karin van Dijk / Josje Altenburg / Catherine S.C. Bouman / Hans I. van der Spoel / Bart J.A. Rijnders / Albert Dunbar / Jeroen A. Schouten / Katrien Lagrou / Marc Bourgeois / Marijke Reynders / Niels van Regenmortel / Lynn Rutsaert / Piet Lormans /
    Simon Feys / Yves Debavaye / Fabienne Tamion / Damien Costa / Julien Maizel / Hervé Dupont / Taieb Chouaki / Saad Nseir / Boualem Sendid / Roger J.M. Brüggemann / Frank L. van de Veerdonk / Joost Wauters / Paul E. Verweij

    Emerging Infectious Diseases, Vol 27, Iss 11, Pp 2892-

    2021  Volume 2898

    Abstract: We performed an observational study to investigate intensive care unit incidence, risk factors, and outcomes of coronavirus disease–associated pulmonary aspergillosis (CAPA). We found 10%–15% CAPA incidence among 823 patients in 2 cohorts. Several ... ...

    Abstract We performed an observational study to investigate intensive care unit incidence, risk factors, and outcomes of coronavirus disease–associated pulmonary aspergillosis (CAPA). We found 10%–15% CAPA incidence among 823 patients in 2 cohorts. Several factors were independently associated with CAPA in 1 cohort and mortality rates were 43%–52%.
    Keywords respiratory infections ; severe acute respiratory syndrome coronavirus 2 ; SARS-CoV-2 ; SARS ; COVID-19 ; coronavirus disease ; Medicine ; R ; Infectious and parasitic diseases ; RC109-216
    Language English
    Publishing date 2021-11-01T00:00:00Z
    Publisher Centers for Disease Control and Prevention
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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