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  1. Article ; Online: COVID-19-associated meningoencephalitis complicated with intracranial hemorrhage: a case report.

    Al-Olama, Mohammad / Rashid, Anas / Garozzo, Debora

    Acta neurochirurgica

    2020  Volume 162, Issue 7, Page(s) 1495–1499

    Abstract: The coronavirus pandemic that started in December 2019 is mainly related to clinical pictures consistent with respiratory symptoms; nevertheless, reports about neurological complications have recently appeared in the medical literature. We describe a ... ...

    Abstract The coronavirus pandemic that started in December 2019 is mainly related to clinical pictures consistent with respiratory symptoms; nevertheless, reports about neurological complications have recently appeared in the medical literature. We describe a case of a 36-year-old coronavirus-positive patient that was admitted on emergency basis; his clinical presentation included neurological symptoms such as drowsiness and mild confusion. Imaging revealed findings consistent with meningoencephalitis complicated by intracerebral hematoma and subdural hematoma. The latter was surgically evacuated after it became chronic and evidence of coronavirus was found in the fluid. Our experience confirms that neurological complications might be a likely event in COVID-19. Although uncommon, the possible occurrence of meningoencephalitis should be kept in mind by physicians involved in the management of COVID-19 patients. Early recognition of brain involvement may provide better prognosis, preventing evolution into intracerebral hemorrhagic events.
    Keywords covid19
    Language English
    Publishing date 2020-05-20
    Publishing country Austria
    Document type Journal Article
    ZDB-ID 80010-7
    ISSN 0942-0940 ; 0001-6268
    ISSN (online) 0942-0940
    ISSN 0001-6268
    DOI 10.1007/s00701-020-04402-w
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  2. Article ; Online: COVID-19-associated meningoencephalitis complicated with intracranial hemorrhage

    Al-olama, Mohammad / Rashid, Anas / Garozzo, Debora

    Acta Neurochirurgica

    a case report

    2020  Volume 162, Issue 7, Page(s) 1495–1499

    Keywords Surgery ; Clinical Neurology ; covid19
    Language English
    Publisher Springer Science and Business Media LLC
    Publishing country us
    Document type Article ; Online
    ZDB-ID 80010-7
    ISSN 0942-0940 ; 0001-6268
    ISSN (online) 0942-0940
    ISSN 0001-6268
    DOI 10.1007/s00701-020-04402-w
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  3. Article: COVID-19-associated meningoencephalitis complicated with intracranial hemorrhage: a case report

    Al-Olama, Mohammad / Rashid, Anas / Garozzo, Debora

    Acta Neurochir (Wien)

    Abstract: The coronavirus pandemic that started in December 2019 is mainly related to clinical pictures consistent with respiratory symptoms; nevertheless, reports about neurological complications have recently appeared in the medical literature. We describe a ... ...

    Abstract The coronavirus pandemic that started in December 2019 is mainly related to clinical pictures consistent with respiratory symptoms; nevertheless, reports about neurological complications have recently appeared in the medical literature. We describe a case of a 36-year-old coronavirus-positive patient that was admitted on emergency basis; his clinical presentation included neurological symptoms such as drowsiness and mild confusion. Imaging revealed findings consistent with meningoencephalitis complicated by intracerebral hematoma and subdural hematoma. The latter was surgically evacuated after it became chronic and evidence of coronavirus was found in the fluid. Our experience confirms that neurological complications might be a likely event in COVID-19. Although uncommon, the possible occurrence of meningoencephalitis should be kept in mind by physicians involved in the management of COVID-19 patients. Early recognition of brain involvement may provide better prognosis, preventing evolution into intracerebral hemorrhagic events.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #306410
    Database COVID19

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  4. Article: Endoscopic-assisted Surgery in the Treatment of Isolated Frontosphenoidal Craniosynostosis.

    Ravi, Subhashree / AlSaadawi, Ghaith / Al Olama, Mohammad / Stenger, Charl / Mendonca, Derek A

    Plastic and reconstructive surgery. Global open

    2023  Volume 11, Issue 1, Page(s) e4788

    Abstract: Isolated frontosphenoidal craniosynostosis is extremely rare, due to which diagnosis can be challenging. All the isolated cases reported have been treated by open surgical technique. We present a unique case report of an infant with an isolated ... ...

    Abstract Isolated frontosphenoidal craniosynostosis is extremely rare, due to which diagnosis can be challenging. All the isolated cases reported have been treated by open surgical technique. We present a unique case report of an infant with an isolated frontosphenoidal synostosis corrected by a novel endoscopic surgical technique. The patient was a 5-month-old boy with worsening abnormal head shape indicating progressive right frontal bossing, left orbital displacement, and right occipital plagiocephaly. Computed tomography scan confirmed the diagnosis of left isolated frontosphenoidal craniosynostosis. Endoscopic-assisted surgical release was done starting with a 2.5-cm incision in the left temple area followed by a 2-cm strip osteotomy to excise the fused frontosphenoidal suture. Custom-made orthotic helmet therapy was started 2-weeks postsurgery, with excellent progress noted in the head shape confirmed by laser scans. The benefits of the endoscopic technique include smaller incision, decreased blood loss and need for blood transfusion, and decreased stay in hospital. This is the first case report showing the application of a novel endoscopic-assisted surgical treatment in an isolated frontosphenoidal craniosynostosis with no complications noted.
    Language English
    Publishing date 2023-01-23
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2851682-5
    ISSN 2169-7574 ; 2169-7574
    ISSN (online) 2169-7574
    ISSN 2169-7574
    DOI 10.1097/GOX.0000000000004788
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  5. Article ; Online: Preoperative Dyeing Technique for Decreasing Radiation Exposure in Unilateral Biportal Endoscopic Spine Surgery.

    Kim, Seung-Kook / Park, Cheol-Woong / Olama, Mohammad Al / Lee, Hae-Soung / Shorrab, Ahmed / Hwang, Joo-Young / Lim, Soo Taek / Lee, Su-Chan

    World neurosurgery

    2023  Volume 175, Page(s) e455–e464

    Abstract: Background: Minimally invasive surgery has many advantages, including early recovery and cosmetic preservation. However, the higher radiation exposure to physicians and patients has drawbacks. Preoperative tissue dyeing techniques are feasible options ... ...

    Abstract Background: Minimally invasive surgery has many advantages, including early recovery and cosmetic preservation. However, the higher radiation exposure to physicians and patients has drawbacks. Preoperative tissue dyeing techniques are feasible options for reducing radiation exposure and procedure time, but their efficacy has not yet been evaluated. Therefore, this study aimed to evaluate surgical outcomes and reduce radiation exposure during unilateral biportal endoscopy surgery.
    Methods: This was a prospective, case-controlled analysis in a tertiary hospital. Patients receiving experimental tissue dye and controls in the nondye group were compared from May 2020 to September 2021. The ipsilateral posterolateral approach (IPA) and the far lateral approach (FLA) were analyzed separately among all single-level spinal procedures without instrumentation. Operative details (operation time, improvement of back and leg pain, and length of hospital stay) and radiation exposure (dose and duration) were compared.
    Results: A total of 88 cases were included, consisting of 64 interlaminar approaches (experimental: 33, control: 31) and 24 FLAs (experimental: 13 and control: 11). In the IPA approach, the patient and physician radiation exposure doses and duration decreased significantly. Conversely, for the FLA, only the duration of the physician exposure decreased significantly.
    Conclusions: Preoperative tissue dyeing techniques using IPA can reduce radiation exposure for physicians and patients. However, a decrease in the duration of radiation was observed only in physicians using the FLA. The dyeing technique is effective in IPA, but the efficacy of FLA is doubtful.
    MeSH term(s) Humans ; Lumbar Vertebrae/surgery ; Prospective Studies ; Endoscopy/methods ; Minimally Invasive Surgical Procedures ; Radiation Exposure/prevention & control ; Treatment Outcome
    Language English
    Publishing date 2023-04-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2534351-8
    ISSN 1878-8769 ; 1878-8750
    ISSN (online) 1878-8769
    ISSN 1878-8750
    DOI 10.1016/j.wneu.2023.03.122
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  6. Article ; Online: The Importance of Early Detection of Genetic Diseases

    Suma Elcy Varghese / Rana Hassan Mohammad El Otol / Fatma Sultan Al Olama / Salah Ahmad Mohamed Elbadawi

    Dubai Medical Journal, Pp 82-

    2021  Volume 90

    Abstract: Background: Early detection of diseases in newborn may help in early intervention and treatment, which may either cure the disease or improve the outcome of the patient. Dubai’s Health Authority has a newborn screening program which includes screening ... ...

    Abstract Background: Early detection of diseases in newborn may help in early intervention and treatment, which may either cure the disease or improve the outcome of the patient. Dubai’s Health Authority has a newborn screening program which includes screening for metabolic and genetic conditions, for hearing and vision, and for congenital heart disease. Objectives: The objectives of this study are to assess the outcome of the newborn genetic screening program, to correlate the association between the outcome of the program and demographic variables and to find out the percentage of the number of infants who were confirmed to have the genetic disease (by confirmatory tests) out of the total infants who had positive screening test results. Methods: During the period of the study from January 2018 to December 2018, a total of 7,027 newborns were tested in Dubai Health Authority facilities by the newborn genetic screening program (known as the “Step One Screening”). Blood samples were collected by heel prick on a collection paper. All samples were transported to PerkinElmer Genomics in the USA where the tests were done. The genetic disorders identified were correlated with different variables like gender and nationality. The data were entered in an excel sheet and analyzed by using SPSS software. All infants aged 0–3 months who have done newborn genetic screening at Dubai Health Authority facilities between January and December 2018 were included. Results: The incidence of screened disorders was 1:7,027 for congenital adrenal hyperplasia, 1:1,757 for congenital hypothyroidism, 1:1,757 for inborn errors of metabolism, 1:2,342 for biotinidase deficiency, 1:1,171 for hemoglobinopathies, 1:12 for hemoglobinopathy traits, and 1:10 for different genetic mutations of G6PD deficiency. Conclusions: There is a high incidence of different genetic diseases detected by newborn screening. These results justify unifying the program in the UAE and preventive programs like premarital screening and genetic counseling.
    Keywords screening ; newborn ; inborn errors of metabolism ; hemoglobinopathies ; hemoglobinopathy trait ; sickle cell ; thalassemia ; congenital adrenal hyperplasia ; congenital hypothyroidism ; g6pd deficiency ; Medicine ; R
    Subject code 630
    Language English
    Publishing date 2021-03-01T00:00:00Z
    Publisher Karger Publishers
    Document type Article ; Online
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  7. Article ; Online: Empowering 8 Billion Minds: Enabling Better Mental Health for All via the Ethical Adoption of Technologies.

    Doraiswamy, P Murali / London, Elisha / Varnum, Peter / Harvey, Barbara / Saxena, Shekhar / Tottman, Simon / Campbell, Sir Philip / Ibáñez, Alvaro Fernández / Manji, Husseini / Al Olama, Mohammad Abdul Aziz Sultan / Chou, I-Han / Herrman, Helen / Jeong, Sung-Jin / Le, Tan / Montojo, Caroline / Reve, Bjarte / Rommelfanger, Karen S / Stix, Charlotte / Thakor, Nitish /
    Chow, Kim Hei-Man / Welchman, Andrew E / Candeias, Vanessa

    NAM perspectives

    2019  Volume 2019

    Language English
    Publishing date 2019-10-28
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2578-6865
    ISSN (online) 2578-6865
    DOI 10.31478/201910b
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  8. Article ; Online: Introducing Cichorium Pumilum as a potential therapeutical agent against drug-induced benign breast tumor in rats.

    Al-Akhras, M-Ali H / Aljarrah, Khaled / Al-Khateeb, Hasan / Jaradat, Adnan / Al-Omari, Abdelkarim / Al-Nasser, Amjad / Masadeh, Majed M / Amin, Amr / Hamza, Alaaeldin / Mohammed, Karima / Al Olama, Mohammad / Daoud, Sayel

    Electromagnetic biology and medicine

    2012  Volume 31, Issue 4, Page(s) 299–309

    Abstract: Cichorium Pumilum (chicory) is could be a promising cancer treatment in which a photosensitizing drug concentrates in benign tumor cells and activated by quanta at certain wavelength. Such activated extracts could lead to cell death and tumor ablation. ... ...

    Abstract Cichorium Pumilum (chicory) is could be a promising cancer treatment in which a photosensitizing drug concentrates in benign tumor cells and activated by quanta at certain wavelength. Such activated extracts could lead to cell death and tumor ablation. Previous studies have shown that Cichorium Pumilum (chicory) contains photosensitive compounds such as cichoriin, anthocyanins, lactucin, and Lactucopicrin. In the present study, the protective effect of sun light-activated Cichorium against the dimethylbenz[a]anthracene (DMBA) induced benign breast tumors to female Sprague-Dawley rats was investigated. Chicory's extract has significantly increase P.carbonyl (PC) and malondialdehyde (MDA) and decreases the hepatic levels of total antioxidant capacity (TAC) and superoxide dismutase (SOD) in benign breast tumors-induced group compared to control. It also significantly decrease the number of estrogen receptors ER-positive cells in tumor masses. These results suggest that chicory extracts could be used as herbal photosensitizing agent in treating benign breast tumor in rats.
    MeSH term(s) Animals ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Antioxidants/metabolism ; Asteraceae/chemistry ; Catalase/metabolism ; Female ; Gene Expression Regulation, Neoplastic/drug effects ; Gene Expression Regulation, Neoplastic/radiation effects ; Lipid Peroxidation/drug effects ; Lipid Peroxidation/radiation effects ; Liver/drug effects ; Liver/metabolism ; Liver/radiation effects ; Mammary Neoplasms, Experimental/chemically induced ; Mammary Neoplasms, Experimental/drug therapy ; Mammary Neoplasms, Experimental/metabolism ; Mammary Neoplasms, Experimental/pathology ; Photosensitizing Agents/pharmacology ; Photosensitizing Agents/therapeutic use ; Plant Extracts/pharmacology ; Plant Extracts/therapeutic use ; Rats ; Rats, Sprague-Dawley ; Receptors, Estrogen/metabolism ; Superoxide Dismutase/metabolism
    Chemical Substances Antineoplastic Agents ; Antioxidants ; Photosensitizing Agents ; Plant Extracts ; Receptors, Estrogen ; Catalase (EC 1.11.1.6) ; Superoxide Dismutase (EC 1.15.1.1)
    Language English
    Publishing date 2012-12
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2026727-7
    ISSN 1536-8386 ; 1061-9526
    ISSN (online) 1536-8386
    ISSN 1061-9526
    DOI 10.3109/15368378.2012.662193
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