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  1. Article ; Online: COVID-19-associated mild encephalitis/encephalopathy with a reversible splenial lesion.

    Hayashi, Misayo / Sahashi, Yuki / Baba, Yasutomo / Okura, Hiroyuki / Shimohata, Takayoshi

    Journal of the neurological sciences

    2020  Volume 415, Page(s) 116941

    MeSH term(s) Aged ; Betacoronavirus ; Brain Diseases/complications ; Brain Diseases/diagnostic imaging ; Brain Diseases/pathology ; COVID-19 ; Coronavirus Infections/complications ; Coronavirus Infections/diagnostic imaging ; Coronavirus Infections/pathology ; Corpus Callosum/diagnostic imaging ; Corpus Callosum/pathology ; Encephalitis/complications ; Encephalitis/diagnostic imaging ; Encephalitis/pathology ; Humans ; Male ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/diagnostic imaging ; Pneumonia, Viral/pathology ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-05-27
    Publishing country Netherlands
    Document type Case Reports ; Letter
    ZDB-ID 80160-4
    ISSN 1878-5883 ; 0022-510X ; 0374-8642
    ISSN (online) 1878-5883
    ISSN 0022-510X ; 0374-8642
    DOI 10.1016/j.jns.2020.116941
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  2. Article: COVID-19-associated mild encephalitis/encephalopathy with a reversible splenial lesion

    Hayashi, Misayo / Sahashi, Yuki / Baba, Yasutomo / Okura, Hiroyuki / Shimohata, Takayoshi

    J Neurol Sci

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #381839
    Database COVID19

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  3. Article ; Online: COVID-19-associated mild encephalitis/encephalopathy with a reversible splenial lesion

    Hayashi, Misayo / Sahashi, Yuki / Baba, Yasutomo / Okura, Hiroyuki / Shimohata, Takayoshi

    Journal of the Neurological Sciences

    2020  Volume 415, Page(s) 116941

    Keywords Neurology ; Clinical Neurology ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 80160-4
    ISSN 1878-5883 ; 0022-510X ; 0374-8642
    ISSN (online) 1878-5883
    ISSN 0022-510X ; 0374-8642
    DOI 10.1016/j.jns.2020.116941
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  4. Article ; Online: Sitting maneuver to uncover latent left ventricular outflow tract obstruction in patients without hypertrophic cardiomyopathy.

    Sekine, Ayako / Watanabe, Takatomo / Nakabo, Ayumi / Ichiryu, Hajime / Endo, Susumu / Hayashi, Misayo / Naruse, Genki / Nakayama, Juri / Takada, Ayae / Fujimoto, Shingo / Ozawa, Noriko / Inada, Takayuki / Nohisa, Yuzuru / Kikuchi, Ryosuke / Kanamori, Hiromitsu / Okura, Hiroyuki

    Journal of cardiology

    2023  Volume 83, Issue 6, Page(s) 401–406

    Abstract: Background: Left ventricular outflow tract obstruction [LVOTO; pressure gradient (PG) ≥30 mmHg] is observed in some patients without hypertrophic cardiomyopathy (HCM), and it may develop especially in older patients without HCM (non-HCM). The aim of ... ...

    Abstract Background: Left ventricular outflow tract obstruction [LVOTO; pressure gradient (PG) ≥30 mmHg] is observed in some patients without hypertrophic cardiomyopathy (HCM), and it may develop especially in older patients without HCM (non-HCM). The aim of this study is to investigate if the Valsalva or an upright sitting maneuver can unveil latent LVOTO in patients with non-HCM.
    Methods: A total of 33 non-HCM patients with a late peaking or dagger-shaped pulsed Doppler waveform of the LVOT and PG <30 mmHg were included. The Doppler flow velocity of the LVOT was measured at rest, after the Valsalva and a sitting maneuver. Peak PG of ≥30 mmHg after either maneuver was defined as latent LVOTO. The angle between the left ventricular septum and the aorta in the parasternal long-axis view and the apical three-chamber view was measured.
    Results: Twenty (61 %) of the 33 patients (mean age 74 ± 9 years) were diagnosed with latent LVOTO. Of these, five (25 %) patients were diagnosed after both the Valsalva and sitting maneuver, and 15 (75 %) were diagnosed only after the sitting maneuver. The latent LVOTO group had a significantly smaller angle than the no-LVOTO group between the ventricular septum and the aorta in the parasternal long axis views (107 ± 8° vs. 117 ± 8°, p < 0.01).
    Conclusion: The sitting maneuver is better than the Valsalva maneuver in unveiling latent LVOTO in older, non-HCM patients.
    MeSH term(s) Humans ; Aged ; Aged, 80 and over ; Ventricular Outflow Obstruction, Left ; Sitting Position ; Ventricular Outflow Obstruction/diagnostic imaging ; Ventricular Outflow Obstruction/etiology ; Cardiomyopathy, Hypertrophic ; Valsalva Maneuver
    Language English
    Publishing date 2023-11-22
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 639364-0
    ISSN 1876-4738 ; 0386-2887 ; 0914-5087
    ISSN (online) 1876-4738
    ISSN 0386-2887 ; 0914-5087
    DOI 10.1016/j.jjcc.2023.11.006
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  5. Article ; Online: Reversible splenial lesion of the corpus callosum associated with meningococcal meningitis.

    Hayashi, Yuichi / Yasunishi, Masahiro / Hayashi, Misayo / Asano, Takahiko / Kimura, Akio / Inuzuka, Takashi

    Journal of the neurological sciences

    2017  Volume 373, Page(s) 81–82

    MeSH term(s) Corpus Callosum/diagnostic imaging ; Diagnosis, Differential ; Disease Progression ; Female ; Humans ; Magnetic Resonance Imaging ; Meningitis, Meningococcal/diagnostic imaging ; Meningitis, Meningococcal/drug therapy ; Young Adult
    Language English
    Publishing date 2017-02-15
    Publishing country Netherlands
    Document type Case Reports ; Letter
    ZDB-ID 80160-4
    ISSN 1878-5883 ; 0022-510X ; 0374-8642
    ISSN (online) 1878-5883
    ISSN 0022-510X ; 0374-8642
    DOI 10.1016/j.jns.2016.12.035
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  6. Article ; Online: Cardiac Papillary Fibroelastoma Originating from the Mitral Valve Chordae.

    Kawamura, Itta / Hayashi, Misayo / Kanamori, Hiromitsu / Kawasaki, Masanori / Nishigaki, Kazuhiko / Minatoguchi, Shinya / Mizuno, Yusuke / Takemura, Hirofumi

    Internal medicine (Tokyo, Japan)

    2015  Volume 54, Issue 24, Page(s) 3161–3164

    Abstract: Cardiac papillary fibroelastoma (CPF) is a rare benign primary cardiac neoplasm. In particular, CPF originating from the mitral valve chordae is extremely rare. A 74-year-old man was hospitalized for the evaluation of a cardiac mass in the left ventricle. ...

    Abstract Cardiac papillary fibroelastoma (CPF) is a rare benign primary cardiac neoplasm. In particular, CPF originating from the mitral valve chordae is extremely rare. A 74-year-old man was hospitalized for the evaluation of a cardiac mass in the left ventricle. Echocardiography revealed a mobile, spherical, pedunculated 2.1×2.1 cm mass at the mitral valve chordae with no mitral regurgitation. The patient underwent excision of the mass without repairing the mitral valve. A histological examination confirmed the mass to be a papillary fibroelastoma.
    MeSH term(s) Aged ; Fibroma/diagnosis ; Fibroma/pathology ; Fibroma/surgery ; Heart Neoplasms/diagnosis ; Heart Neoplasms/pathology ; Heart Neoplasms/surgery ; Heart Ventricles/pathology ; Humans ; Male ; Mitral Valve/diagnostic imaging ; Mitral Valve/pathology ; Mitral Valve Insufficiency ; Ultrasonography
    Language English
    Publishing date 2015
    Publishing country Japan
    Document type Case Reports ; Journal Article
    ZDB-ID 32371-8
    ISSN 1349-7235 ; 0021-5120 ; 0918-2918
    ISSN (online) 1349-7235
    ISSN 0021-5120 ; 0918-2918
    DOI 10.2169/internalmedicine.54.4896
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  7. Article: Infantile Cases of Sitosterolaemia with Novel Mutations in the ABCG5 Gene: Extreme Hypercholesterolaemia is Exacerbated by Breastfeeding.

    Tada, Hayato / Kawashiri, Masa-Aki / Takata, Mutsuko / Matsunami, Kunihiro / Imamura, Atsushi / Matsuyama, Misayo / Sawada, Hirotake / Nunoi, Hiroyuki / Konno, Tetsuo / Hayashi, Kenshi / Nohara, Atsushi / Inazu, Akihiro / Kobayashi, Junji / Mabuchi, Hiroshi / Yamagishi, Masakazu

    JIMD reports

    2015  Volume 21, Page(s) 115–122

    Abstract: Few data exists regarding the clinical impact of breastfeeding in infantile sitosterolaemic cases. We report four Japanese infantile cases of sitosterolaemia, an extremely rare inherited disease characterised by increased serum levels of plant sitosterol, ...

    Abstract Few data exists regarding the clinical impact of breastfeeding in infantile sitosterolaemic cases. We report four Japanese infantile cases of sitosterolaemia, an extremely rare inherited disease characterised by increased serum levels of plant sitosterol, presenting with severe hypercholesterolaemia and systemic xanthomas exacerbated by breastfeeding. In these four cases, genetic analyses were performed for low-density lipoprotein (LDL) receptor, proprotein convertase subtilisin/kexin type 9 (PCSK9), LDL receptor adaptor protein 1 and ATP-binding cassette (ABC) subfamily G member 5 and 8 (ABCG5 and ABCG8) genes. We assessed their clinical manifestations, including responsiveness to a variety of treatments, especially to weaning from breastfeeding and use of ezetimibe. Two pairs of mutations in the ABCG5 gene in each case, including two novel mutations (c.130C>T or p.Ser44Ala and c.1813_1817delCTTTT or p.Pro558GlufsX14) and two known mutations (c.1306G>A or p.Arg389His and c.1336C>T or p.Arg446X), were identified. Significant reductions in cholesterol levels were obtained by means of weaning from breastfeeding alone. Substantial reductions in sitosterol levels, without any apparent side effects, were observed with ezetimibe. In conclusion, we have identified infantile Japanese sitosterolaemic subjects with extreme hypercholesterolaemia exacerbated by breastfeeding. Their unique response to weaning from breastfeeding, as well as to use of ezetimibe, could provide insights into the metabolic basis of sterols in humans.
    Language English
    Publishing date 2015-02-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2672872-2
    ISSN 2192-8312 ; 2192-8304
    ISSN (online) 2192-8312
    ISSN 2192-8304
    DOI 10.1007/8904_2014_404
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  8. Article ; Online: Familial episodic limb pain in kindreds with novel Nav1.9 mutations.

    Kabata, Risako / Okuda, Hiroko / Noguchi, Atsuko / Kondo, Daiki / Fujiwara, Michimasa / Hata, Kenichiro / Kato, Yoshifumi / Ishikawa, Ken / Tanaka, Manabu / Sekine, Yuji / Hishikawa, Nozomi / Mizukami, Tomoyuki / Ito, Junichi / Akasaka, Manami / Sakurai, Ken / Yoshida, Takeshi / Minoura, Hironori / Hayashi, Takashi / Inoshita, Kohei /
    Matsuyama, Misayo / Kinjo, Noriko / Cao, Yang / Inoue, Sumiko / Kobayashi, Hatasu / Harada, Kouji H / Youssefian, Shohab / Takahashi, Tsutomu / Koizumi, Akio

    PloS one

    2018  Volume 13, Issue 12, Page(s) e0208516

    Abstract: We previously performed genetic analysis in six unrelated families with infantile limb pain episodes, characterized by cold-induced deterioration and mitigation in adolescence, and reported two new mutations p.R222H/S in SCN11A responsible for these ... ...

    Abstract We previously performed genetic analysis in six unrelated families with infantile limb pain episodes, characterized by cold-induced deterioration and mitigation in adolescence, and reported two new mutations p.R222H/S in SCN11A responsible for these episodes. As no term described this syndrome (familial episodic pain: FEP) in Japanese, we named it as"". In the current study, we recruited an additional 42 new unrelated Japanese FEP families, between March 2016 and March 2018, and identified a total of 11 mutations in SCN11A: p.R222H in seven families, and p.R225C, p.F814C, p.F1146S, or p.V1184A, in independent families. A founder mutation, SCN11A p.R222H was confirmed to be frequently observed in patients with FEP in the Tohoku region of Japan. We also identified two novel missense variants of SCN11A, p.F814C and p.F1146S. To evaluate the effects of these latter two mutations, we generated knock-in mouse models harboring p.F802C (F802C) and p.F1125S (F1125S), orthologues of the human p.F814C and p.F1146S, respectively. We then performed electrophysiological investigations using dorsal root ganglion neurons dissected from the 6-8 week-old mice. Dissected neurons of F802C and F1125S mice showed increased resting membrane potentials and firing frequency of the action potentials (APs) by high input-current stimulus compared with WT mice. Furthermore, the firing probability of evoked APs increased in low stimulus input in F1125S mice, whereas several AP parameters and current threshold did not differ significantly between either of the mutations and WT mice. These results suggest a higher level of excitability in the F802C or F1125S mice than in WT, and indicate that these novel mutations are gain of function mutations. It can be expected that a considerable number of potential patients with FEP may be the result of gain of function SCN11A mutations.
    MeSH term(s) Adolescent ; Adult ; Aged ; Animals ; Child, Preschool ; Cohort Studies ; Extremities ; Family ; Female ; Gene Knock-In Techniques ; Humans ; Infant ; Japan ; Male ; Mice ; Mice, Transgenic ; Musculoskeletal Pain/genetics ; Musculoskeletal Pain/pathology ; Mutation, Missense ; NAV1.9 Voltage-Gated Sodium Channel/genetics ; Pedigree ; Syndrome
    Chemical Substances NAV1.9 Voltage-Gated Sodium Channel ; SCN11A protein, human
    Language English
    Publishing date 2018-12-17
    Publishing country United States
    Document type Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0208516
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  9. Article ; Online: Familial episodic limb pain in kindreds with novel Nav1.9 mutations.

    Risako Kabata / Hiroko Okuda / Atsuko Noguchi / Daiki Kondo / Michimasa Fujiwara / Kenichiro Hata / Yoshifumi Kato / Ken Ishikawa / Manabu Tanaka / Yuji Sekine / Nozomi Hishikawa / Tomoyuki Mizukami / Junichi Ito / Manami Akasaka / Ken Sakurai / Takeshi Yoshida / Hironori Minoura / Takashi Hayashi / Kohei Inoshita /
    Misayo Matsuyama / Noriko Kinjo / Yang Cao / Sumiko Inoue / Hatasu Kobayashi / Kouji H Harada / Shohab Youssefian / Tsutomu Takahashi / Akio Koizumi

    PLoS ONE, Vol 13, Iss 12, p e

    2018  Volume 0208516

    Abstract: We previously performed genetic analysis in six unrelated families with infantile limb pain episodes, characterized by cold-induced deterioration and mitigation in adolescence, and reported two new mutations p.R222H/S in SCN11A responsible for these ... ...

    Abstract We previously performed genetic analysis in six unrelated families with infantile limb pain episodes, characterized by cold-induced deterioration and mitigation in adolescence, and reported two new mutations p.R222H/S in SCN11A responsible for these episodes. As no term described this syndrome (familial episodic pain: FEP) in Japanese, we named it as"". In the current study, we recruited an additional 42 new unrelated Japanese FEP families, between March 2016 and March 2018, and identified a total of 11 mutations in SCN11A: p.R222H in seven families, and p.R225C, p.F814C, p.F1146S, or p.V1184A, in independent families. A founder mutation, SCN11A p.R222H was confirmed to be frequently observed in patients with FEP in the Tohoku region of Japan. We also identified two novel missense variants of SCN11A, p.F814C and p.F1146S. To evaluate the effects of these latter two mutations, we generated knock-in mouse models harboring p.F802C (F802C) and p.F1125S (F1125S), orthologues of the human p.F814C and p.F1146S, respectively. We then performed electrophysiological investigations using dorsal root ganglion neurons dissected from the 6-8 week-old mice. Dissected neurons of F802C and F1125S mice showed increased resting membrane potentials and firing frequency of the action potentials (APs) by high input-current stimulus compared with WT mice. Furthermore, the firing probability of evoked APs increased in low stimulus input in F1125S mice, whereas several AP parameters and current threshold did not differ significantly between either of the mutations and WT mice. These results suggest a higher level of excitability in the F802C or F1125S mice than in WT, and indicate that these novel mutations are gain of function mutations. It can be expected that a considerable number of potential patients with FEP may be the result of gain of function SCN11A mutations.
    Keywords Medicine ; R ; Science ; Q
    Subject code 616
    Language English
    Publishing date 2018-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
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