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  1. Article ; Online: Update 2021: COVID-19 aus Sicht der Infektiologie.

    Khatamzas, Elham / Kroidl, Inge

    Deutsche medizinische Wochenschrift (1946)

    2021  Volume 146, Issue 13-14, Page(s) 904–907

    Abstract: From an infectious disease perspective, there have been outstanding findings since January 2020 far beyond the knowledge gained about SARS-CoV, which hopefully will help us to manage future pandemics. Positive highlights include the increased public ... ...

    Title translation Update 2021: COVID-19 from the perspective of infectious diseases specialty.
    Abstract From an infectious disease perspective, there have been outstanding findings since January 2020 far beyond the knowledge gained about SARS-CoV, which hopefully will help us to manage future pandemics. Positive highlights include the increased public awareness of infectious disease epidemiology, the increase in immunological knowledge, and the successful use of existing vaccine development platforms and technologies. This article presents a personal selection of interesting developments in recent months.
    MeSH term(s) Antibodies, Viral/blood ; COVID-19/complications ; COVID-19/immunology ; COVID-19/prevention & control ; Humans ; Infectious Disease Medicine ; Interferon Type I/blood ; SARS-CoV-2/immunology
    Chemical Substances Antibodies, Viral ; Interferon Type I
    Language German
    Publishing date 2021-07-13
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 200446-x
    ISSN 1439-4413 ; 0012-0472
    ISSN (online) 1439-4413
    ISSN 0012-0472
    DOI 10.1055/a-1449-4964
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Update 2021: COVID-19 aus Sicht der Infektiologie

    Khatamzas, Elham / Kroidl, Inge

    DMW - Deutsche Medizinische Wochenschrift

    2021  Volume 146, Issue 13/14, Page(s) 904–907

    Keywords COVID-19 ; Schützende Immunität ; Long COVID ; Mutationen ; sozioökonomische Deprivation ; COVID-19 ; protective immune response ; long COVID ; mutations ; socioeconomic deprivation
    Language German
    Publishing date 2021-07-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 200446-x
    ISSN 1439-4413 ; 0012-0472
    ISSN (online) 1439-4413
    ISSN 0012-0472
    DOI 10.1055/a-1449-4964
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  3. Article ; Online: Effectiveness, barriers and facilitating factors of strategies for active delabelling of patients with penicillin allergy labels: a systematic review protocol.

    Nürnberg, Hannah / Khatamzas, Elham / Denkinger, Claudia / Krause, Tabea / Oetken, Lars / Rauer, Sophie / Rapp, Amelie / Hoppe-Tichy, Torsten / Morath, Benedict

    BMJ open

    2024  Volume 14, Issue 2, Page(s) e077927

    Abstract: Introduction: Up to 15% of adult patients in the clinical setting report to be allergic to penicillin. However, in most cases, penicillin allergy is not confirmed. Due to the negative aspects associated with erroneous penicillin allergy, the ... ...

    Abstract Introduction: Up to 15% of adult patients in the clinical setting report to be allergic to penicillin. However, in most cases, penicillin allergy is not confirmed. Due to the negative aspects associated with erroneous penicillin allergy, the implementation of active delabelling processes for penicillin allergy is an important part of antibiotic stewardship programmes. Depending on the clinical setting, different factors need to be considered during implementation. This review examines the effectiveness of different delabelling interventions and summarises components and structures that facilitate, support or constrain structured penicillin allergy delabelling.
    Methods and analysis: This review will adhere to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses. The databases MEDLINE (via PubMed), EMBASE and Cochrane Library were searched for studies reporting on any intervention to identify, assess or rule out uncertain penicillin allergy. To improve completeness, two further databases are also searched for grey literature. Study design, intervention type, professional groups involved, effectiveness, limitations, barriers, facilitating factors, clinical setting and associated regulatory factors will be extracted and analysed. In addition, exclusion criteria for participation in the delabelling intervention and criteria for not delabelling penicillin allergy will be summarised. In case of failed protocols, these are highlighted and quantitatively analysed if possible. Two independent reviewers will perform the screening process and data extraction. Discordant decisions will be resolved through review by a third reviewer. Bias assessment of the individual studies will be performed using the Newcastle Ottawa Scale.
    Ethics and dissemination: Because individual patient-related data are not analysed, an ethical approval is not required. The review will be published in a peer-reviewed scientific journal.
    MeSH term(s) Humans ; Penicillins/adverse effects ; Research Design ; Systematic Reviews as Topic ; Drug Hypersensitivity
    Chemical Substances Penicillins
    Language English
    Publishing date 2024-02-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2023-077927
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: COVID-19 aus Sicht der Infektiologie.

    Khatamzas, Elham / Rothe, Camilla / Kroidl, Inge

    Deutsche medizinische Wochenschrift (1946)

    2020  Volume 145, Issue 15, Page(s) e95

    Title translation COVID-19: Questions and answers from Infectious Diseases Specialty.
    Keywords covid19
    Language German
    Publishing date 2020-08-05
    Publishing country Germany
    Document type Journal Article ; Published Erratum
    ZDB-ID 200446-x
    ISSN 1439-4413 ; 0012-0472
    ISSN (online) 1439-4413
    ISSN 0012-0472
    DOI 10.1055/a-1233-3238
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  5. Article ; Online: COVID-19 aus Sicht der Infektiologie.

    Khatamzas, Elham / Rothe, Camilla / Kroidl, Inge

    Deutsche medizinische Wochenschrift (1946)

    2020  Volume 145, Issue 15, Page(s) 1051–1056

    Abstract: The control and management of infection with the novel SARS-CoV-2 virus requires multidisciplinary work between specialists on all levels. This article aims to provide an overview of the current knowledge of COVID-19 from the view of infectious diseases ... ...

    Title translation COVID-19: Questions and answers from infectiology.
    Abstract The control and management of infection with the novel SARS-CoV-2 virus requires multidisciplinary work between specialists on all levels. This article aims to provide an overview of the current knowledge of COVID-19 from the view of infectious diseases physicians including all the uncertainties of our understanding of the pathogenesis and immunity.
    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Humans ; Infectious Disease Medicine ; Pandemics ; Physicians ; Pneumonia, Viral ; SARS-CoV-2
    Keywords covid19
    Language German
    Publishing date 2020-07-30
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 200446-x
    ISSN 1439-4413 ; 0012-0472
    ISSN (online) 1439-4413
    ISSN 0012-0472
    DOI 10.1055/a-1164-3960
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Intracerebral mucormycosis after COVID-19: illustrative cases.

    Nohman, Amin I / Ivren, Meltem / Klein, Sabrina / Khatamzas, Elham / Unterberg, Andreas / Giese, Henrik

    Journal of neurosurgery. Case lessons

    2022  Volume 3, Issue 25, Page(s) CASE21567

    Abstract: Background: In this case report the authors present two female patients with intracranial mucormycosis after coronavirus disease 2019 (COVID-19).: Observations: The first patient was a 30-year-old woman with no past medical history or allergies who ... ...

    Abstract Background: In this case report the authors present two female patients with intracranial mucormycosis after coronavirus disease 2019 (COVID-19).
    Observations: The first patient was a 30-year-old woman with no past medical history or allergies who presented with headaches and vomiting. Magnetic resonance imaging (MRI) and computed tomography of the skull showed an endonasal infection, which had already destroyed the frontal skull base and caused a large frontal intracranial abscess. The second patient was a 29-year-old woman with multiple pre-existing conditions, who was initially admitted to the hospital due to a COVID-19 infection and later developed a hemiparesis of the right side. Here, the MRI scan showed an abscess configuration in the left motor cortex. In both cases, rapid therapy was performed by surgical clearance and abscess evacuation followed by antifungal, antidiabetic, and further supportive treatment for several weeks.
    Lessons: Both cases are indicative of a possible correlation of mucormycosis in the setting of severe immunosuppression involved with COVID-19, both iatrogenic with the use of steroids and previous medical history. Furthermore, young and supposedly healthy patients can also be affected by this rare disease.
    Language English
    Publishing date 2022-06-20
    Publishing country United States
    Document type Case Reports
    ISSN 2694-1902
    ISSN (online) 2694-1902
    DOI 10.3171/CASE21567
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  7. Article ; Online: Infektionsmanagement bei Immunsupprimierten.

    Mellinghoff, Sibylle C / Stemler, Jannik / Forkl, Stefanie / Khatamzas, Elham / Classen, Annika Y

    Deutsche medizinische Wochenschrift (1946)

    2022  Volume 147, Issue 13, Page(s) 840–850

    Abstract: The number of immunosuppressed patients continues to increase worldwide. The main reasons are the demographic development and improved long-term survival, also for patients under immunosuppression. A major cause of hospitalization and mortality among ... ...

    Title translation Management of infection in immunocompromised patients.
    Abstract The number of immunosuppressed patients continues to increase worldwide. The main reasons are the demographic development and improved long-term survival, also for patients under immunosuppression. A major cause of hospitalization and mortality among these patients are infections. Their management, including prevention and adequate treatment, plays a crucial role in survival and quality of life, but also with regard to economic factors.Infection management in immunocompromised patients faces new challenges today. Not only the increasing number, but also new groups of patients at risk and an increasingly aging and comorbid population pose problems for the treating physicians. While cancer medicine is no longer determined solely by radiotherapy and chemotherapy, new targeted substances are playing an increasingly important role. In addition, new targeted substances complicate adequate infection prophylaxis due to potential interactions. The worldwide increase in antibiotic-resistant pathogens complicates treatment of bacterial infections, which is associated with increased mortality, especially in the immunocompromised patient population. Further, the disruption of the microbiome shows negative antibiotic-associated effects. Hence the reasonable use of anti-infectives in prophylaxis and therapy is of great importance.There are many recommendations and guidelines for clinicians regarding the management of infections in immunocompromised patients. Overlaps of infectiology, hygiene as well as hematology and oncology sometimes lead to different recommendations. This article provides an overview of the currently existing evidence and guidelines for infection management in immunosuppressed patients.
    MeSH term(s) Anti-Bacterial Agents/therapeutic use ; Bacterial Infections/drug therapy ; Humans ; Immunocompromised Host ; Neoplasms/drug therapy ; Quality of Life
    Chemical Substances Anti-Bacterial Agents
    Language German
    Publishing date 2022-07-04
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 200446-x
    ISSN 1439-4413 ; 0012-0472
    ISSN (online) 1439-4413
    ISSN 0012-0472
    DOI 10.1055/a-1684-6763
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  8. Article ; Online: Neurosurgical device-associated infections due to Candida auris - Three cases from a single tertiary center.

    Khatamzas, Elham / Madder, Hilary / Jeffery, Katie

    The Journal of infection

    2019  Volume 78, Issue 5, Page(s) 409–421

    MeSH term(s) Aged ; Antifungal Agents/administration & dosage ; Candida/isolation & purification ; Candidiasis/diagnosis ; Candidiasis/drug therapy ; Candidiasis/microbiology ; Candidiasis/pathology ; Cerebrospinal Fluid/microbiology ; Humans ; Male ; Middle Aged ; Prosthesis-Related Infections/diagnosis ; Prosthesis-Related Infections/drug therapy ; Prosthesis-Related Infections/microbiology ; Prosthesis-Related Infections/pathology ; Tertiary Care Centers ; Ventriculoperitoneal Shunt/adverse effects
    Chemical Substances Antifungal Agents
    Language English
    Publishing date 2019-02-10
    Publishing country England
    Document type Case Reports ; Letter
    ZDB-ID 424417-5
    ISSN 1532-2742 ; 0163-4453
    ISSN (online) 1532-2742
    ISSN 0163-4453
    DOI 10.1016/j.jinf.2019.02.004
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  9. Article: COVID-19 aus Sicht der Infektiologie

    Khatamzas, Elham / Rothe, Camilla / Kroidl, Inge

    DMW - Deutsche Medizinische Wochenschrift

    2020  Volume 145, Issue 15, Page(s) e95–e95

    Language German
    Publishing date 2020-07-01
    Publisher © Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 200446-x
    ISSN 1439-4413 ; 0012-0472
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    ISSN 0012-0472
    DOI 10.1055/a-1233-3238
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  10. Article ; Online: Unexpected community-acquired co-infections during an ongoing pandemic: (one) too many diagnoses at once.

    Cordas Dos Santos, David Manuel / Fischer, Laura / von Bergwelt-Baildon, Michael / Khatamzas, Elham

    Infection

    2021  Volume 50, Issue 3, Page(s) 799–801

    MeSH term(s) Coinfection/diagnosis ; Coinfection/epidemiology ; Community-Acquired Infections/diagnosis ; Community-Acquired Infections/epidemiology ; Hospitalization ; Humans ; Longitudinal Studies ; Pandemics/prevention & control
    Language English
    Publishing date 2021-07-03
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 185104-4
    ISSN 1439-0973 ; 0300-8126 ; 0173-2129
    ISSN (online) 1439-0973
    ISSN 0300-8126 ; 0173-2129
    DOI 10.1007/s15010-021-01647-0
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