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  1. Article: An updated and extended version of the Melastomataceae probe set for target capture.

    Dagallier, Léo-Paul M J / Michelangeli, Fabián A

    Applications in plant sciences

    2024  Volume 12, Issue 1, Page(s) e11564

    Abstract: Premise: A probe set was previously designed to target 384 nuclear loci in the Melastomataceae family; however, when trying to use it, we encountered several practical and conceptual problems, such as the presence of sequences in reverse complement, ... ...

    Abstract Premise: A probe set was previously designed to target 384 nuclear loci in the Melastomataceae family; however, when trying to use it, we encountered several practical and conceptual problems, such as the presence of sequences in reverse complement, intronic regions with stop codons, and other issues. This raised concerns regarding the use of this probe set for sequence recovery in Melastomataceae.
    Methods: In order to correct these issues, we cleaned the Melastomataceae probe set, extended it with additional sequences, and compared its performance with the original version.
    Results: The final probe set targets 396 putative nuclear loci represented by 6009 template sequences. The probe set has been made available, along with details on the cleaning process, for reproducibility. We show that the new probe set performs better than the original version in terms of sequence recovery.
    Discussion: This updated, extended, and cleaned probe set will improve the availability of phylogenomic resources across the Melastomataceae family. It is fully compatible with sequence recovery and extraction pipelines. The cleaning process can also be applied to any plant-targeting probe set that would need to be cleaned or updated if new genomic resources for the targeted taxa become available.
    Language English
    Publishing date 2024-01-18
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2699923-7
    ISSN 2168-0450
    ISSN 2168-0450
    DOI 10.1002/aps3.11564
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  2. Article ; Online: Lingua Villosa Nigra Following Initiation of Antibiotic Treatment for Multidrug-Resistant Tuberculosis.

    Leo, Fabian / Semper, Hannes / Grohé, Christian

    Deutsches Arzteblatt international

    2023  Volume 119, Issue 44, Page(s) 752

    MeSH term(s) Humans ; Tongue, Hairy ; Anti-Bacterial Agents/therapeutic use ; Tuberculosis, Multidrug-Resistant/drug therapy
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2023-01-19
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2406159-1
    ISSN 1866-0452 ; 1866-0452
    ISSN (online) 1866-0452
    ISSN 1866-0452
    DOI 10.3238/arztebl.m2022.0211
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  3. Article ; Online: Correlation of respiratory muscle function and cardiopulmonary exercise testing in post-acute COVID-19 syndrome.

    Leo, Fabian / Bülau, Judith Elena / Semper, Hannes / Grohé, Christian

    Infection

    2022  Volume 51, Issue 2, Page(s) 527–530

    MeSH term(s) Humans ; Exercise Test ; Post-Acute COVID-19 Syndrome ; COVID-19/diagnosis ; Respiratory Function Tests ; Respiratory Muscles ; Muscular Diseases
    Language English
    Publishing date 2022-08-16
    Publishing country Germany
    Document type Letter ; Comment
    ZDB-ID 185104-4
    ISSN 1439-0973 ; 0300-8126 ; 0173-2129
    ISSN (online) 1439-0973
    ISSN 0300-8126 ; 0173-2129
    DOI 10.1007/s15010-022-01899-4
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  4. Article ; Online: Post-COVID und die Lunge.

    Gogoll, Christian / Leo, Fabian / Schueller, Per Otto / Grohé, Christian

    Deutsche medizinische Wochenschrift (1946)

    2021  Volume 146, Issue 21, Page(s) e113

    Title translation Post-COVID sequela of the lung - follow up and treatment.
    Language German
    Publishing date 2021-10-27
    Publishing country Germany
    Document type Journal Article ; Published Erratum
    ZDB-ID 200446-x
    ISSN 1439-4413 ; 0012-0472
    ISSN (online) 1439-4413
    ISSN 0012-0472
    DOI 10.1055/a-1676-8223
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  5. Article ; Online: Treatment of disseminated nocardiosis: a host-pathogen approach with adjuvant interferon gamma.

    Derungs, Thomas / Leo, Fabian / Loddenkemper, Christoph / Schneider, Thomas

    The Lancet. Infectious diseases

    2021  Volume 21, Issue 10, Page(s) e334–e340

    Abstract: Disseminated nocardiosis is a rare, life-threatening disease. Particularly at risk are immunocompromised patients, highlighting the crucial role of host factors. Conventional intensive antibiotic treatment has improved survival rates, but the overall ... ...

    Abstract Disseminated nocardiosis is a rare, life-threatening disease. Particularly at risk are immunocompromised patients, highlighting the crucial role of host factors. Conventional intensive antibiotic treatment has improved survival rates, but the overall prognosis of patients with disseminated nocardiosis remains unsatisfactory. In this Grand Round, we present a case of severe nocardiosis that did not respond to standard therapy. The patient's condition deteriorated when antibiotic therapy was given alone and improved substantially only after coadministration of interferon gamma. We review the literature relevant to adjuvant interferon gamma therapy of nocardiosis and discuss its potential harms and benefits. Overall, we consider such treatment as beneficial and low risk if the patient is followed-up closely. We conclude that clinicians should consider this regimen in refractory cases of severe Nocardia infection.
    MeSH term(s) Adjuvants, Pharmaceutic/therapeutic use ; Animals ; Anti-Bacterial Agents/therapeutic use ; Drug Therapy, Combination ; Host-Parasite Interactions/drug effects ; Humans ; Interferon-gamma/therapeutic use ; Nocardia/drug effects ; Nocardia/genetics ; Nocardia/physiology ; Nocardia Infections/drug therapy ; Nocardia Infections/microbiology
    Chemical Substances Adjuvants, Pharmaceutic ; Anti-Bacterial Agents ; Interferon-gamma (82115-62-6)
    Language English
    Publishing date 2021-08-20
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2061641-7
    ISSN 1474-4457 ; 1473-3099
    ISSN (online) 1474-4457
    ISSN 1473-3099
    DOI 10.1016/S1473-3099(20)30920-8
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  6. Article ; Online: Update 2021: Pulmonale Folgen nach COVID-19-Pneumonie.

    Leo, Fabian / Meybaum, Christian / Wormanns, Dag / Grohé, Christian

    Deutsche medizinische Wochenschrift (1946)

    2021  Volume 146, Issue 13-14, Page(s) 927–932

    Abstract: Acute COVID-19 pneumonia may result in persistent changes with various imaging and histopathological patterns, including organizing pneumonia and pulmonary fibrosis. In addition, SARS-CoV-2 infection is associated with increased risk of pulmonary ... ...

    Title translation Update 2021: Pulmonary Sequelae of COVID-19 Pneumonia.
    Abstract Acute COVID-19 pneumonia may result in persistent changes with various imaging and histopathological patterns, including organizing pneumonia and pulmonary fibrosis. In addition, SARS-CoV-2 infection is associated with increased risk of pulmonary vascular endothelialitis and thrombosis. Herein, current findings on pulmonary consequences of COVID-19 with implications for clinical management are summarized based on a selective literature review.
    MeSH term(s) Acute Disease ; COVID-19/complications ; COVID-19/diagnostic imaging ; COVID-19/therapy ; Cryptogenic Organizing Pneumonia/complications ; Cryptogenic Organizing Pneumonia/diagnostic imaging ; Cryptogenic Organizing Pneumonia/therapy ; Follow-Up Studies ; Humans ; Pneumonia, Viral/complications ; Pneumonia, Viral/diagnostic imaging ; Pneumonia, Viral/therapy ; Pulmonary Fibrosis/complications ; Pulmonary Fibrosis/diagnostic imaging ; Pulmonary Fibrosis/therapy
    Language German
    Publishing date 2021-07-13
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 200446-x
    ISSN 1439-4413 ; 0012-0472
    ISSN (online) 1439-4413
    ISSN 0012-0472
    DOI 10.1055/a-1449-5158
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  7. Article ; Online: COPD: Umgang mit Exazerbationen – Diagnostik, Therapie und Nachsorge.

    Leo, Fabian / Menger, Heike

    Deutsche medizinische Wochenschrift (1946)

    2019  Volume 144, Issue 1, Page(s) 21–27

    Abstract: Exacerbations are major events in the disease process in patients with chronic obstructive pulmonary disease (COPD). They have a negative effect on the quality of life and the progression of the disease. Frequent exacerbations are associated with ... ...

    Title translation Exacerbations of Chronic Obstructive Pulmonary Disease - Diagnostic Approach, Management and Follow-up Care.
    Abstract Exacerbations are major events in the disease process in patients with chronic obstructive pulmonary disease (COPD). They have a negative effect on the quality of life and the progression of the disease. Frequent exacerbations are associated with increased mortality. In addition to the optimal therapy, the prevention of further exacerbations and the attention to concomitant diseases are prognostically crucial for the patients. In this review article, current recommendations for the diagnosis, therapy and follow-up care of COPD exacerbations are summarized.
    MeSH term(s) Humans ; Pulmonary Disease, Chronic Obstructive/diagnosis ; Pulmonary Disease, Chronic Obstructive/epidemiology ; Pulmonary Disease, Chronic Obstructive/mortality ; Pulmonary Disease, Chronic Obstructive/therapy ; Risk Factors
    Language German
    Publishing date 2019-01-02
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 200446-x
    ISSN 1439-4413 ; 0012-0472
    ISSN (online) 1439-4413
    ISSN 0012-0472
    DOI 10.1055/a-0723-4172
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  8. Article: Detection of a COVID-19 cluster by universal SARS-CoV-2 testing in a geriatric hospital and implications for infection control management.

    Leo, Fabian / Tsilimi, Angelika / Hillmann, Charlotte

    Journal of infection prevention

    2021  Volume 23, Issue 1, Page(s) 25–28

    Abstract: Hospital-level COVID-19 testing strategies may require rapid changes depending on the dynamics of local epidemiology. A COVID-19 outbreak in a hospital near the authors' institution, a Geriatric Medicine centre in Berlin, Germany, prompted the ... ...

    Abstract Hospital-level COVID-19 testing strategies may require rapid changes depending on the dynamics of local epidemiology. A COVID-19 outbreak in a hospital near the authors' institution, a Geriatric Medicine centre in Berlin, Germany, prompted the implementation of comprehensive SARS-CoV-2 testing. Serial nasopharyngeal swabs were collected from all patients and staff and analysed for SARS-CoV-2 virus RNA using quantitative real-time PCR. In total, 11 of 84 patients (13.1%) and 1 of 147 employees (0.68%) tested positive. Of the 11 positive patients, 9 (81.8%) were asymptomatic at the time of testing. The data were used as the basis for adjusting local COVID-19 containment measures. Only one staff-to-staff transmission was observed, and there was no patient-to-patient, patient-to-staff or staff-to-patient transmission. Three patients infected with SARS-CoV2 died, two deaths being attributable to advanced malignant disease and one to COVID-19-associated myocarditis. In conclusion, universal SARS-CoV-2 testing revealed a cluster of predominantly asymptomatic infections, enabled appropriate local COVID-19 containment decisions and presumably contributed to the prevention of in-hospital SARS-CoV-2 transmission.
    Language English
    Publishing date 2021-08-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 2595000-9
    ISSN 1757-1782 ; 1757-1774
    ISSN (online) 1757-1782
    ISSN 1757-1774
    DOI 10.1177/17571774211033356
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  9. Article ; Online: Bilateral Pulmonary Cavitation as Predominant Phenotype in ANCA-Associated Disease.

    Leo, Fabian / Juche, Aaron / Krause, Andreas / Semper, Hannes / Grohé, Christian

    The American journal of medicine

    2021  Volume 134, Issue 6, Page(s) 754–755

    MeSH term(s) Adult ; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/complications ; Arrhythmias, Cardiac/diagnosis ; Arrhythmias, Cardiac/etiology ; COVID-19/complications ; COVID-19/diagnosis ; Electrocardiography/methods ; Female ; Humans ; Respiratory Insufficiency/etiology ; Substance Abuse, Intravenous/complications ; Takotsubo Cardiomyopathy/complications ; Takotsubo Cardiomyopathy/etiology ; Takotsubo Cardiomyopathy/physiopathology
    Language English
    Publishing date 2021-01-14
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 80015-6
    ISSN 1555-7162 ; 1873-2178 ; 0002-9343 ; 1548-2766
    ISSN (online) 1555-7162 ; 1873-2178
    ISSN 0002-9343 ; 1548-2766
    DOI 10.1016/j.amjmed.2020.11.018
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  10. Article ; Online: Capture of carbon dioxide and hydrogen by engineered Escherichia coli: hydrogen-dependent CO

    Leo, Felix / Schwarz, Fabian M / Schuchmann, Kai / Müller, Volker

    Applied microbiology and biotechnology

    2021  Volume 105, Issue 14-15, Page(s) 5861–5872

    Abstract: In times of global climate change and the fear of dwindling resources, we are facing different considerable challenges such as the replacement of fossil fuel-based energy carriers with the coincident maintenance of the increasing energy supply of our ... ...

    Abstract In times of global climate change and the fear of dwindling resources, we are facing different considerable challenges such as the replacement of fossil fuel-based energy carriers with the coincident maintenance of the increasing energy supply of our growing world population. Therefore, CO
    MeSH term(s) Acetobacterium ; Carbon Dioxide ; Deuterium ; Escherichia coli/genetics ; Formates ; Hydrogen
    Chemical Substances Formates ; Carbon Dioxide (142M471B3J) ; Hydrogen (7YNJ3PO35Z) ; Deuterium (AR09D82C7G)
    Language English
    Publishing date 2021-07-31
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 392453-1
    ISSN 1432-0614 ; 0171-1741 ; 0175-7598
    ISSN (online) 1432-0614
    ISSN 0171-1741 ; 0175-7598
    DOI 10.1007/s00253-021-11463-z
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