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Article ; Online: Numerical analysis of pressure drop reduction of bubbly flows through hydrophobic microgrooved channels.

Javaherchian, Javane / Moosavi, Ali / Tabatabaei, Seyed Ali

2023 Volume 13, Issue 1, Page(s) 18861

Abstract: Due to the high performance of hydrophobic surfaces in pressure drop reduction, they have been proposed for various applications. However, despite the extensive uses of two-phase flows in many industries, the effect of hydrophobic surfaces on the ... ...

Abstract	Due to the high performance of hydrophobic surfaces in pressure drop reduction, they have been proposed for various applications. However, despite the extensive uses of two-phase flows in many industries, the effect of hydrophobic surfaces on the pressure drop reduction of two-phase flows has not been well understood yet. Thus, in the present study, by implementing the phase-field and finite element methods, the bubbly flows as an example of two-phase flows are considered for examining the effect of hydrophobic microgrooved microchannels on the pressure drop reduction of these regimes in the laminar state. We found out that hydrophobic microgrooved surfaces not only can be efficient in the bubbly flow but also can even cause a maximum pressure drop reduction of up to 70%, which is almost 3.5 times higher than in single-phase flow. We also studied the influence of each parameter, such as bubbles volume or length, Reynolds number, capillary number, and their combination on this phenomenon. The pressure drop reduction grows by increasing the volume of the bubbles but decreases by increasing the flow velocity or the surface tension coefficient. The combination of these parameters demonstrated different results in some circumstances.
Language	English
Publishing date	2023-11-01
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-45260-7
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Article ; Online: Numerical analysis of pressure drop reduction of bubbly flows through hydrophobic microgrooved channels

Javane Javaherchian / Ali Moosavi / Seyed Ali Tabatabaei

Scientific Reports, Vol 13, Iss 1, Pp 1-

2023 Volume 13

Abstract: Abstract Due to the high performance of hydrophobic surfaces in pressure drop reduction, they have been proposed for various applications. However, despite the extensive uses of two-phase flows in many industries, the effect of hydrophobic surfaces on ... ...

Abstract	Abstract Due to the high performance of hydrophobic surfaces in pressure drop reduction, they have been proposed for various applications. However, despite the extensive uses of two-phase flows in many industries, the effect of hydrophobic surfaces on the pressure drop reduction of two-phase flows has not been well understood yet. Thus, in the present study, by implementing the phase-field and finite element methods, the bubbly flows as an example of two-phase flows are considered for examining the effect of hydrophobic microgrooved microchannels on the pressure drop reduction of these regimes in the laminar state. We found out that hydrophobic microgrooved surfaces not only can be efficient in the bubbly flow but also can even cause a maximum pressure drop reduction of up to 70%, which is almost 3.5 times higher than in single-phase flow. We also studied the influence of each parameter, such as bubbles volume or length, Reynolds number, capillary number, and their combination on this phenomenon. The pressure drop reduction grows by increasing the volume of the bubbles but decreases by increasing the flow velocity or the surface tension coefficient. The combination of these parameters demonstrated different results in some circumstances.
Keywords	Medicine ; R ; Science ; Q
Language	English
Publishing date	2023-11-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Extra-intestinal manifestations of Celiac disease in children: their prevalence and association with human leukocyte antigens and pathological and laboratory evaluations.

Salarian, Leila / Khavaran, Mohammad / Dehghani, Seyed Mohsen / Mashhadiagha, Amirali / Moosavi, Seyed Ali / Rezaeianzadeh, Shayan

BMC pediatrics

2023 Volume 23, Issue 1, Page(s) 8

Abstract: Background: Celiac disease (CD) is an autoimmune disease caused by gluten intake. Traditionally CD was believed to be a disease of the gut, although a wide range of extra-intestinal manifestations (EIM) was recognized. The exact prevalence of EIM and ... ...

Abstract	Background: Celiac disease (CD) is an autoimmune disease caused by gluten intake. Traditionally CD was believed to be a disease of the gut, although a wide range of extra-intestinal manifestations (EIM) was recognized. The exact prevalence of EIM and the associated risk factors have not been well studied. Aim: We aimed to assess the prevalence of EIM in children with CD and their association with human leukocyte antigen (HLA) typing, and pathological and laboratory indices. Method: We conducted a cross-sectional study on children and adolescents with a definite diagnosis of CD. They were followed in the main Celiac Clinic of Southern Iran. Results: We included 204 children who were visited between 2012 and 2017. Nearly 85% of them were positive for HLA-DQ2 and 40.6% for HLA-DQ8. The most prevalent intestinal complaints reported were abdominal pain (42.6%) and chronic constipation (19.1%). Failure-to-thrive (32.7%), iron deficiency anemia (25%), short stature (20.5%), and eczema (18.6%) were the most common EIMs. However, failure-to-thrive and short stature were presented at significantly younger ages, whereas those patients with concomitant type 1 diabetes mellitus (DM) were significantly older. We also found significant relationships between autoimmune thyroid disease and HLA-DQ5, and the presence of headaches with HLA-DQ7. The prevalence of HLA types of DQ2, DQ8, DQ6, and DQ7 significantly varied among different Marsh groups. Patients who were positive for HLA-DQ8, were significantly older, taller, and weightier. No significant association was found between HLA types and any of the gastrointestinal symptoms, anti-tTG and compliance to gluten free diet. Moreover, there were no statistically significant differences detected between the presence of each individual EIM, the level of IgA anti-tTG, sex, and Marsh typing. Conclusion: This study highlights the presence of EIM in CD and their associated factors. We show the potential role of HLA typing in some EIMs, which may shed light for future studies.
MeSH term(s)	Adolescent ; Humans ; Child ; Celiac Disease/complications ; Celiac Disease/diagnosis ; Celiac Disease/epidemiology ; Prevalence ; Cross-Sectional Studies ; HLA Antigens/genetics ; Diet, Gluten-Free
Chemical Substances	HLA Antigens
Language	English
Publishing date	2023-01-04
Publishing country	England
Document type	Journal Article
ZDB-ID	2041342-7
ISSN	1471-2431 ; 1471-2431
ISSN (online)	1471-2431
ISSN	1471-2431
DOI	10.1186/s12887-022-03826-w
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Article: Metabolic Syndrome in Celiac Disease: What Does Following a One-Year Gluten-Free Diet Bring?

Motazedian, Nasrin / Sayadi, Mehrab / Mashhadiagha, Amirali / Moosavi, Seyed Ali / Khademian, Fatemeh / Niknam, Ramin

Middle East journal of digestive diseases

2023 Volume 15, Issue 3, Page(s) 185–189

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2023-07-30
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2623796-9
ISSN	2008-5249 ; 2008-5230
ISSN (online)	2008-5249
ISSN	2008-5230
DOI	10.34172/mejdd.2023.342
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Article: Acute toxic effects of areca nut on central nervous system and liver: A case report.

Mahdavi Mortazavi, Seyede Maryam / Ataollahi, Maryam / Mashhadiagha, Amirali / Moosavi, Seyed Ali / Moshfeghinia, Reze / Soheili, Marzieh

Clinical case reports

2023 Volume 11, Issue 10, Page(s) e7976

Abstract: Areca nut (AN) is an addictive substance widely used in different world regions. There are several side effects associated with the use of AN, which have already been reported. However, the reports on hepatotoxicity of AN are sporadic and non-conclusive. ...

Abstract	Areca nut (AN) is an addictive substance widely used in different world regions. There are several side effects associated with the use of AN, which have already been reported. However, the reports on hepatotoxicity of AN are sporadic and non-conclusive. In the present case report, we investigated the hepatotoxicity of AN in a four-year-old Iranian girl who was transferred to our medical center with abdominal pain, vomiting, diarrhea, fever, and other symptoms such as hematuria, decreased mental status, multiple seizure episodes. After a comprehensive evaluation, it was concluded that these signs and symptoms were all attributed to AN consumption, which was given by her mother to control diarrhea. Eventually, the patient medical conditions were managed successfully, and she survived by intense medical care. In conclusion, we suggest AN should be considered a potential hepatotoxic agent.
Language	English
Publishing date	2023-10-04
Publishing country	England
Document type	Case Reports
ZDB-ID	2740234-4
ISSN	2050-0904
ISSN	2050-0904
DOI	10.1002/ccr3.7976
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Article ; Online: Enhancing neutralizing antibodies against receptor binding domain of SARS-CoV-2 by a safe natural adjuvant system.

Darvish, Maliheh / Moosavi-Nejad, Zahra / Siadat, Seyed Omid Ranaei / Fatemi, Fataneh / Khatibi, Ali

Virus research

2023 Volume 326, Page(s) 199047

Abstract: The receptor binding domain (RBD) plays a pivotal role in the viral entry as it enables the engagement of severe acute respiratory syndrome 2 (SARS-CoV-2) with the human angiotensin-converting enzyme 2 (ACE2) receptor for host cell entry. RBD is the ... ...

Abstract	The receptor binding domain (RBD) plays a pivotal role in the viral entry as it enables the engagement of severe acute respiratory syndrome 2 (SARS-CoV-2) with the human angiotensin-converting enzyme 2 (ACE2) receptor for host cell entry. RBD is the major target for developing viral inhibitors and vaccines. Expression of recombinant RBD in E.coli is highly scalable with a low-cost procedure despite its high expression level compared to expression in mammalian and yeast cells. Using an alternative natural adjuvant system instead of alum adjuvant, increased immunogenicity of RBD antigen in serological assay including direct ELISA and surrogate Virus Neutralization Test (sVNT) was demonstrated with high levels of IgGs and neutralizing antibodies in mice sera immunized with RBD:AlSa (Alum and Sodium alginate) formulation. The sVNT is a simple and fast test that can be used instead of the conventional virus neutralization test requiring live virus and BSL3 laboratory to detect total neutralizing antibodies against RBD. Additionally, results showed a safety profile for sodium alginate which supported using it as an alternative natural adjuvant.
MeSH term(s)	Animals ; Mice ; Humans ; SARS-CoV-2 ; COVID-19 ; Antibodies, Blocking ; Antibodies, Viral ; Antibodies, Neutralizing ; Spike Glycoprotein, Coronavirus/chemistry ; Mammals
Chemical Substances	aluminum sulfate (34S289N54E) ; Antibodies, Blocking ; Antibodies, Viral ; Antibodies, Neutralizing ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2
Language	English
Publishing date	2023-01-21
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	605780-9
ISSN	1872-7492 ; 0168-1702
ISSN (online)	1872-7492
ISSN	0168-1702
DOI	10.1016/j.virusres.2023.199047
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Article ; Online: Study of Resilience Safety Culture in an Iranian Airport in 2021

Elahe Azari / Mitra Hannani / Ali Asghar Khaje Vandi / Seyed Gholam Abbass Moosavi / Alireza Samiee

Muhandisī-i bihdāsht-i ḥirfah/ī, Vol 9, Iss 4, Pp 242-

2023 Volume 250

Abstract: Background and Objective: The aviation industry, despite considerable advances in technology and Safety, is still witnessing unfortunate accidents, 80% of which are caused by human factors. The present study aimed to investigate resilience safety culture ...

Abstract	Background and Objective: The aviation industry, despite considerable advances in technology and Safety, is still witnessing unfortunate accidents, 80% of which are caused by human factors. The present study aimed to investigate resilience safety culture in order to improve the level of safety culture and resilience and reduce accidents in one of Iranian's airports. Materials and Methods: In this cross-sectional study, resilient safety culture indices were weighed and ranked by the expert panel, including safety experts and airport operators, using Analytic Hierarchy Process and Expert Choice software (version 11). Moreover, the resilient safety culture questionnaire based on the above-mentioned indices was completed by the airport staff and the obtained data were analyzed in SPSS software (version 16.0). Results: According to the experts' opinions, management commitment (with a normal weight of 1.0), competence (0.79), and awareness (0.69) had the most importance and just culture (0.45), flexibility (0.39, and management of change (0.35) had the least importance. According to the airport staff's opinions, competency (4.12), just culture (3.87), and readiness (3.84) obtained the highest score, while employee participation (3.61), flexibility (3.48), and awareness (3.29) had the lowest score. Conclusion: As evidenced by the obtained results, the competency factor, which was highly rated by both staff and experts, can be effective in improving airport resilience. Improving the level of awareness among employees, which in their opinion is the least important, is one of the most important factors affecting resilience safety.
Keywords	airport ; resilience engineering ; resilience safety culture ; safety culture ; Industrial medicine. Industrial hygiene ; RC963-969
Subject code	380
Language	Persian
Publishing date	2023-02-01T00:00:00Z
Publisher	Hamadan University of Medical Sciences
Document type	Article ; Online
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Article ; Online: Human serum albumin in neurodegeneration.

Shojai, Sajjad / Haeri Rohani, Seyed-Ali / Moosavi-Movahedi, Ali Akbar / Habibi-Rezaei, Mehran

Reviews in the neurosciences

2022 Volume 33, Issue 7, Page(s) 803–817

Abstract: Serum albumin (SA) exists in relatively high concentrations, in close contact with most cells. However, in the adult brain, except for cerebrospinal fluid (CSF), SA concentration is relatively low. It is mainly produced in the liver to serve as the main ... ...

Abstract	Serum albumin (SA) exists in relatively high concentrations, in close contact with most cells. However, in the adult brain, except for cerebrospinal fluid (CSF), SA concentration is relatively low. It is mainly produced in the liver to serve as the main protein of the blood plasma. In the plasma, it functions as a carrier, chaperon, antioxidant, source of amino acids, osmoregulator, etc. As a carrier, it facilitates the stable presence and transport of the hydrophobic and hydrophilic molecules, including free fatty acids, steroid hormones, medicines, and metal ions. As a chaperon, SA binds to and protects other proteins. As an antioxidant, thanks to a free sulfhydryl group (-SH), albumin is responsible for most antioxidant properties of plasma. These functions qualify SA as a major player in, and a mirror of, overall health status, aging, and neurodegeneration. The low concentration of SA is associated with cognitive deterioration in the elderly and negative prognosis in multiple sclerosis (MS) and amyotrophic lateral sclerosis (ALS). SA has been shown to be structurally modified in neurological conditions such as Alzheimer's disease (AD). During blood-brain barrier damage albumin enters the brain tissue and could trigger epilepsy and neurodegeneration. SA is able to bind to the precursor agent of the AD, amyloid-beta (Aβ), preventing its toxic effects in the periphery, and is being tested for treating this disease. SA therapy may also be effective in brain rejuvenation. In the current review, we will bring forward the prominent properties and roles of SA in neurodegeneration.
MeSH term(s)	Adult ; Aged ; Alzheimer Disease/metabolism ; Amino Acids ; Amyloid beta-Peptides/metabolism ; Antioxidants ; Fatty Acids, Nonesterified ; Hormones ; Humans ; Serum Albumin ; Serum Albumin, Human/metabolism
Chemical Substances	Amino Acids ; Amyloid beta-Peptides ; Antioxidants ; Fatty Acids, Nonesterified ; Hormones ; Serum Albumin ; Serum Albumin, Human (ZIF514RVZR)
Language	English
Publishing date	2022-04-02
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	639035-3
ISSN	2191-0200 ; 0334-1763
ISSN (online)	2191-0200
ISSN	0334-1763
DOI	10.1515/revneuro-2021-0165
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Article ; Online: Smartphone-based device for point-of-care diagnostics of pulmonary inflammation using convolutional neural networks (CNNs).

Ghaderinia, Mohammadreza / Abadijoo, Hamed / Mahdavian, Ashkan / Kousha, Ebrahim / Shakibi, Reyhaneh / Taheri, Seyed Mohammad Reza / Simaee, Hossein / Khatibi, Ali / Moosavi-Movahedi, Ali Akbar / Khayamian, Mohammad Ali

Scientific reports

2024 Volume 14, Issue 1, Page(s) 6912

Abstract: In pulmonary inflammation diseases, like COVID-19, lung involvement and inflammation determine the treatment regime. Respiratory inflammation is typically arisen due to the cytokine storm and the leakage of the vessels for immune cells recruitment. ... ...

Abstract	In pulmonary inflammation diseases, like COVID-19, lung involvement and inflammation determine the treatment regime. Respiratory inflammation is typically arisen due to the cytokine storm and the leakage of the vessels for immune cells recruitment. Currently, such a situation is detected by the clinical judgment of a specialist or precisely by a chest CT scan. However, the lack of accessibility to the CT machines in many poor medical centers as well as its expensive service, demands more accessible methods for fast and cheap detection of lung inflammation. Here, we have introduced a novel method for tracing the inflammation and lung involvement in patients with pulmonary inflammation, such as COVID-19, by a simple electrolyte detection in their sputum samples. The presence of the electrolyte in the sputum sample results in the fern-like structures after air-drying. These fern patterns are different in the CT positive and negative cases that are detected by an AI application on a smartphone and using a low-cost and portable mini-microscope. Evaluating 160 patient-derived sputum sample images, this method demonstrated an interesting accuracy of 95%, as confirmed by CT-scan results. This finding suggests that the method has the potential to serve as a promising and reliable approach for recognizing lung inflammatory diseases, such as COVID-19.
MeSH term(s)	Humans ; Smartphone ; Neural Networks, Computer ; COVID-19/diagnosis ; Inflammation ; Point-of-Care Testing ; Electrolytes ; COVID-19 Testing
Chemical Substances	Electrolytes
Language	English
Publishing date	2024-03-22
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-54939-4
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Article ; Online: Prevalence of age-related macular degeneration in Iran and its projections through 2050: a systematic review and meta-analysis.

Roshanshad, Amirhossein / Roshanshad, Romina / Moosavi, Seyed Ali / Ardekani, Ali / Nabavizadeh, Sara Sadat / Fereidooni, Reza / Ashraf, Hossein / Vardanjani, Hossein Molavi

BMC ophthalmology

2023 Volume 23, Issue 1, Page(s) 484

Abstract: Background: Age-related Macular Degeneration (AMD) is one of the most common causes of vision loss. A substantial increase in the burden of AMD is expected in the aging populations, including the Iranians. We investigated the age and gender-specific ... ...

Abstract	Background: Age-related Macular Degeneration (AMD) is one of the most common causes of vision loss. A substantial increase in the burden of AMD is expected in the aging populations, including the Iranians. We investigated the age and gender-specific prevalence of AMD and its determinants in Iran. Methods: We systematically searched international (PubMed, Scopus, Embase, etc.) and local (IranDoc, Magiran, etc.) online databases. We included cross-sectional or cohort studies, either clinic- or population-based, published on the prevalence of AMD among Iranians, with no limitation on age. Joanna Briggs Institute (JBI) tools for critical appraisal were used. Prevalence estimates are pooled by applying random-effects modeling. Subgroup analysis and meta-regression were performed. Results: Seventeen studies with 16,120 participants were included. Based on studies in general population, the pooled prevalence of AMD was 10.8% (95% CI: 6.5-16.2%) in males, and 9.8% (95% CI: 4.7-16.4%) in females. 8.5% of moderate vision impaired, 13.6% of severe vision impaired, and 15.7% of blind participants were affected by AMD. The prevalence of AMD was 2% in 40-49, and 32.3% in the ≥ 80 population. The prevalence of AMD was 11.9% among the visually impaired vs. 8.7% in the general population. The study's sampling method, location, and mean age were correlated with the heterogeneities of the prevalence. We observed an increasing trend in the number of AMD cases (average annual percent change = 3.66%; 95% CI: 3.65-3.67%) from 1990 to 2050. The expected number of AMD cases in Iran will be near 5.5 million by 2050. Conclusion: The prevalence of AMD in Iran was somewhere between the prevalence of Asians and Europeans. Given the aging trend of the Iranian community and an average annual percent change of 3.66%, it is indispensable to adopt preventive and screening policies to diminish the burden of the disease in the future decades.
MeSH term(s)	Male ; Female ; Humans ; Iran/epidemiology ; Prevalence ; Cross-Sectional Studies ; Macular Degeneration/epidemiology ; Blindness/etiology
Language	English
Publishing date	2023-11-25
Publishing country	England
Document type	Meta-Analysis ; Systematic Review ; Journal Article
ZDB-ID	2050436-6
ISSN	1471-2415 ; 1471-2415
ISSN (online)	1471-2415
ISSN	1471-2415
DOI	10.1186/s12886-023-03218-3
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