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  1. Article ; Online: Asymptomatic waxy brown papules in the auricular concha.

    Tee, Louis Y / Tan, Sze Hwa / Rajaratnam, Ratna

    International journal of dermatology

    2020  Volume 59, Issue 10, Page(s) e347–e348

    MeSH term(s) Ear Auricle ; Humans ; Skin Abnormalities ; Waxes
    Chemical Substances Waxes
    Language English
    Publishing date 2020-07-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 412254-9
    ISSN 1365-4632 ; 0011-9059 ; 1461-1244
    ISSN (online) 1365-4632
    ISSN 0011-9059 ; 1461-1244
    DOI 10.1111/ijd.15039
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    In stock of ZB MED Cologne/Königswinter

    Ui VI Zs.189: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: COVID-19 complicated by Hashimoto's thyroiditis.

    Tee, Louis Y / Harjanto, Sumitro / Rosario, Barbara H

    Singapore medical journal

    2020  Volume 62, Issue 5, Page(s) 265

    MeSH term(s) COVID-19/complications ; China ; Hashimoto Disease/complications ; Humans ; Male ; Middle Aged ; Polymerase Chain Reaction ; SARS-CoV-2/isolation & purification
    Keywords covid19
    Language English
    Publishing date 2020-07-16
    Publishing country Singapore
    Document type Case Reports ; Letter
    ZDB-ID 604319-7
    ISSN 0037-5675
    ISSN 0037-5675
    DOI 10.11622/smedj.2020106
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 589: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Chemoprevention of keratinocyte carcinoma and actinic keratosis in solid-organ transplant recipients: Systematic review and meta-analyses.

    Tee, Louis Y / Sultana, Rehena / Tam, Steve Y C / Oh, Choon Chiat

    Journal of the American Academy of Dermatology

    2020  Volume 84, Issue 2, Page(s) 528–530

    MeSH term(s) Acitretin/administration & dosage ; Acitretin/adverse effects ; Carcinoma, Basal Cell/epidemiology ; Carcinoma, Basal Cell/etiology ; Carcinoma, Basal Cell/prevention & control ; Carcinoma, Squamous Cell/epidemiology ; Carcinoma, Squamous Cell/etiology ; Carcinoma, Squamous Cell/prevention & control ; Humans ; Keratosis, Actinic/epidemiology ; Keratosis, Actinic/etiology ; Keratosis, Actinic/prevention & control ; Niacinamide/administration & dosage ; Niacinamide/adverse effects ; Organ Transplantation/adverse effects ; Randomized Controlled Trials as Topic ; Skin Neoplasms/epidemiology ; Skin Neoplasms/etiology ; Skin Neoplasms/prevention & control ; Transplant Recipients/statistics & numerical data ; Treatment Outcome
    Chemical Substances Niacinamide (25X51I8RD4) ; Acitretin (LCH760E9T7)
    Language English
    Publishing date 2020-05-05
    Publishing country United States
    Document type Letter ; Meta-Analysis ; Systematic Review
    ZDB-ID 603641-7
    ISSN 1097-6787 ; 0190-9622
    ISSN (online) 1097-6787
    ISSN 0190-9622
    DOI 10.1016/j.jaad.2020.04.160
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1540: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: GIST of the stomach masquerading as recurrent falls in an older adult: a case report and review.

    Tee, Louis Y / Sim, Lynette / Tan, Li Feng / Lum, Jeffrey / Seetharaman, Santhosh Kumar

    BMC gastroenterology

    2021  Volume 21, Issue 1, Page(s) 381

    Abstract: Background: Gastric tumors become increasingly prevalent with advanced age but can be challenging to diagnose in older adults who may present with non-specific symptoms. Here, we report a rare case of an occult gastric tumor associated with mesenteric ... ...

    Abstract Background: Gastric tumors become increasingly prevalent with advanced age but can be challenging to diagnose in older adults who may present with non-specific symptoms. Here, we report a rare case of an occult gastric tumor associated with mesenteric panniculitis that presented with recurrent falls precipitated by vertigo.
    Case presentation: We describe a diagnostically challenging case of cryptogenic gastric tumor associated with mesenteric panniculitis in a 74-year-old female who presented with abdominal bloating and recurrent falls precipitated by vertigo, dehydration, acute kidney injury and electrolyte deficiencies, but had no alarm symptoms. Her symptoms resolved after laparoscopic wedge resection of the gastric tumor.
    Conclusions: Our case highlights that while alarm symptoms such as dysphagia, weight loss, gastrointestinal bleeding and vomiting are considered indications for endoscopy, clinicians should also maintain a high index of suspicion for gastric tumors in older patients who may present with atypical symptoms.
    MeSH term(s) Aged ; Female ; Gastrointestinal Hemorrhage ; Gastrointestinal Stromal Tumors/surgery ; Humans ; Laparoscopy ; Stomach Neoplasms/complications ; Stomach Neoplasms/diagnosis ; Stomach Neoplasms/surgery
    Language English
    Publishing date 2021-10-18
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 2041351-8
    ISSN 1471-230X ; 1471-230X
    ISSN (online) 1471-230X
    ISSN 1471-230X
    DOI 10.1186/s12876-021-01964-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Subcutaneous phaeohyphomycosis caused by

    Tee, Louis Y / Tan, Ban Hock / Tan, Ai-Ling / Busmanis, Inny / Oh, Choon Chiat

    JAAD case reports

    2019  Volume 6, Issue 1, Page(s) 66–68

    Language English
    Publishing date 2019-12-27
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2834220-3
    ISSN 2352-5126
    ISSN 2352-5126
    DOI 10.1016/j.jdcr.2019.10.027
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  7. Article: Evaluation of multi-component interventions for prevention of nosocomial pneumonia in older adults: a randomized, controlled trial.

    Rosario, Barbara H / Shafi, Humaira / Yii, Anthony C A / Tee, Louis Y / Ang, Arron S H / Png, Gek Kheng / Ang, Wendy S T / Lee, Yan Qing / Tan, Pei Ting / Sahu, Aniruddha / Zhou, Lin Fang / Zheng, Yi Ling / Slamat, Roslinda Binte / Taha, Aza A M

    European geriatric medicine

    2021  Volume 12, Issue 5, Page(s) 1045–1055

    Abstract: Aims: To evaluate the efficacy of multi-component interventions for prevention of hospital-acquired pneumonia in older patients hospitalized in geriatric wards.: Methods: A randomized, parallel-group, controlled trial was undertaken in patients aged ... ...

    Abstract Aims: To evaluate the efficacy of multi-component interventions for prevention of hospital-acquired pneumonia in older patients hospitalized in geriatric wards.
    Methods: A randomized, parallel-group, controlled trial was undertaken in patients aged 65 and above who were admitted to a tertiary hospital geriatric unit from January 1, 2016 to June 30, 2018 for an acute non-respiratory illness. Participants were randomized by to receive either a multi-component intervention (consisting of reverse Trendelenburg position, dysphagia screening, oral care and vaccinations), or usual care. The outcome measures were the proportion of patients who developed hospital-acquired pneumonia during hospitalisation, and mean time from randomization to the next hospitalisation due to respiratory infections in 1 year.
    Results: A total of 123 participants (median age, 85; 43.1% male) were randomized, (n = 59) to intervention group and (n = 64) to control group. The multi-component interventions did not significantly reduce the incidence of hospital-acquired pneumonia but did increase the mean time to next hospitalisation due to respiratory infection (11.5 months vs. 9.5 months; P = 0.049), and reduced the risk of hospitalisation in 1 year (18.6% vs. 34.4%; P = 0.049). Implementation of multi-component interventions increased diagnoses of oropharyngeal dysphagia (35.6% vs. 20.3%; P < 0.001) and improved the influenza (54.5% vs 17.2%; P < 0.001) and pneumococcal vaccination rates (52.5% vs. 20.3%; P < 0.001).
    Conclusions: The nosocomial pneumonia multi-component intervention did not significantly reduce the incidence of hospital-acquired pneumonia during hospitalisation but reduce subsequent hospitalisations for respiratory infections.
    Clinical trial registration: ClinicalTrial.gov, NCT04347395.
    MeSH term(s) Aged ; Aged, 80 and over ; COVID-19 ; Cross Infection/epidemiology ; Female ; Healthcare-Associated Pneumonia/epidemiology ; Humans ; Male ; SARS-CoV-2 ; Treatment Outcome
    Language English
    Publishing date 2021-06-03
    Publishing country Switzerland
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2556794-9
    ISSN 1878-7657 ; 1878-7649
    ISSN (online) 1878-7657
    ISSN 1878-7649
    DOI 10.1007/s41999-021-00506-3
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  8. Article: COVID-19 and Undiagnosed Pre-diabetes or Diabetes Mellitus Among International Migrant Workers in Singapore.

    Tee, Louis Y / Alhamid, Sharifah Munirah / Tan, Jeriel L / Oo, Theik Di / Chien, Jaime / Galinato, Primavera / Tan, Seow Yen / Humaira, Shafi / Fong, Raymond Kok Choon / Puar, Troy H / Loh, Wann Jia / Santosa, Anindita / Khoo, Joan / Rosario, Barbara Helen

    Frontiers in public health

    2020  Volume 8, Page(s) 584249

    Abstract: Objective: ...

    Abstract Objective:
    MeSH term(s) Adult ; COVID-19/diagnosis ; COVID-19/epidemiology ; Diabetes Mellitus/diagnosis ; Diabetes Mellitus/epidemiology ; Humans ; Male ; Middle Aged ; Prediabetic State/diagnosis ; Prediabetic State/epidemiology ; Retrospective Studies ; Risk Assessment ; SARS-CoV-2/isolation & purification ; Singapore/epidemiology ; Transients and Migrants/statistics & numerical data ; Undiagnosed Diseases/epidemiology ; Young Adult
    Language English
    Publishing date 2020-11-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711781-9
    ISSN 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2020.584249
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  9. Article: Off-target Effects in CRISPR/Cas9-mediated Genome Engineering.

    Zhang, Xiao-Hui / Tee, Louis Y / Wang, Xiao-Gang / Huang, Qun-Shan / Yang, Shi-Hua

    Molecular therapy. Nucleic acids

    2015  Volume 4, Page(s) e264

    Abstract: CRISPR/Cas9 is a versatile genome-editing technology that is widely used for studying the functionality of genetic elements, creating genetically modified organisms as well as preclinical research of genetic disorders. However, the high frequency of off- ... ...

    Abstract CRISPR/Cas9 is a versatile genome-editing technology that is widely used for studying the functionality of genetic elements, creating genetically modified organisms as well as preclinical research of genetic disorders. However, the high frequency of off-target activity (≥50%)-RGEN (RNA-guided endonuclease)-induced mutations at sites other than the intended on-target site-is one major concern, especially for therapeutic and clinical applications. Here, we review the basic mechanisms underlying off-target cutting in the CRISPR/Cas9 system, methods for detecting off-target mutations, and strategies for minimizing off-target cleavage. The improvement off-target specificity in the CRISPR/Cas9 system will provide solid genotype-phenotype correlations, and thus enable faithful interpretation of genome-editing data, which will certainly facilitate the basic and clinical application of this technology.
    Language English
    Publishing date 2015-11-17
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2662631-7
    ISSN 2162-2531
    ISSN 2162-2531
    DOI 10.1038/mtna.2015.37
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  10. Article ; Online: Platform for the interdisciplinary study of cardiovascular, metabolic and neurovascular diseases (PICMAN) protocol.

    Dalakoti, Mayank / Leow, Melvin Khee Shing / Khoo, Chin Meng / Yang, Hayang / Ling, Lieng Hsi / Muthiah, Mark / Tan, Eunice / Lee, Jonathan / Dan, Yock Young / Chew, Nicholas / Seow, Wei Qiang / Soong, Poh Loong / Gan, Louis / Gurung, Rijan / Ackers-Johnson, Matthew / Hou, Han Wei / Sachaphibulkij, Karishma / MacAry, Paul / Low, Gwen /
    Ang, Christy / Yeo, Tee Joo / Djohan, Andie Hartanto / Li, Tony / Yeung, Wesley / Soh, Rodney / Sia, Ching Hui / Panday, Vinay / Loong, Shaun S E / Tan, Benjamin Y Q / Yeo, Leonard L L / Teo, Lynette / Chow, Pierce / Foo, Roger

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 20521

    Abstract: Through extensive multisystem phenotyping, the central aim of Project PICMAN is to correlate metabolic flexibility to measures of cardiometabolic health, including myocardial diastolic dysfunction, coronary and cerebral atherosclerosis, body fat ... ...

    Abstract Through extensive multisystem phenotyping, the central aim of Project PICMAN is to correlate metabolic flexibility to measures of cardiometabolic health, including myocardial diastolic dysfunction, coronary and cerebral atherosclerosis, body fat distribution and severity of non-alcoholic fatty liver disease. This cohort will form the basis of larger interventional trials targeting metabolic inflexibility in the prevention of cardiovascular disease. Participants aged 21-72 years with no prior manifest atherosclerotic cardiovascular disease (ASCVD) are being recruited from a preventive cardiology clinic and an existing cohort of non-alcoholic fatty liver disease (NAFLD) in an academic medical centre. A total of 120 patients will be recruited in the pilot phase of this study and followed up for 5 years. Those with 10-year ASCVD risk ≥ 5% as per the QRISK3 calculator are eligible. Those with established diabetes mellitus are excluded. Participants recruited undergo a detailed assessment of health behaviours and physical measurements. Participants also undergo a series of multimodality clinical phenotyping comprising cardiac tests, vascular assessments, metabolic tests, liver and neurovascular testing. Blood samples are also being collected and banked for plasma biomarkers, 'multi-omics analyses' and for generation of induced pluripotent stem cells (iPSC). Extensive evidence points to metabolic dysregulation as an early precursor of cardiovascular disease, particularly in Asia. We hypothesise that quantifiable metabolic inflexibility may be representative of an individual in his/her silent, but high-risk progression towards insulin resistance, diabetes and cardiovascular disease. The platform for interdisciplinary cardiovascular-metabolic-neurovascular diseases (PICMAN) is a pilot, prospective, multi-ethnic cohort study.
    MeSH term(s) Humans ; Male ; Female ; Cardiovascular Diseases ; Non-alcoholic Fatty Liver Disease ; Cohort Studies ; Prospective Studies ; Cardiovascular System ; Atherosclerosis ; Risk Factors
    Language English
    Publishing date 2023-11-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-47407-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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