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  1. Article ; Online: Young apheresis platelet donors show significant and sustained growth over the last decade in the US, 2010-2019: A favorable sign of the resiliency of the platelet supply.

    Lasky, Baia / Singh, Umesh / Young, Pampee P

    Transfusion

    2023  Volume 63, Issue 7, Page(s) 1333–1343

    Abstract: Background: Platelet demand continues to rise and US hospitals frequently face shortages. The peak median age of apheresis platelet donors (APD) is believed to have increased over the last decade, raising concerns that the APD base is not being ... ...

    Abstract Background: Platelet demand continues to rise and US hospitals frequently face shortages. The peak median age of apheresis platelet donors (APD) is believed to have increased over the last decade, raising concerns that the APD base is not being adequately replenished with young donors.
    Study design/methods: American Red Cross (ARC) apheresis platelet collections were evaluated from calendar years 2010 through 2019. APD, products per procedure/split rate (PPP) and donation frequencies were stratified into age groups.
    Results/findings: The number of unique APD from calendar year 2010 through 2019 in the ARC donor pool increased from 87,573 to 115,372 donors, representing a 31.7% overall growth. Donors in the 16-40 year-old (y) age group increased by 78.8% overall, with the largest absolute increases seen in the 26-30 y (4852 donors, 99.9% growth), followed by the 31-35 y (3991, 94.1%) group. Donors aged 56+ increased by 50.4% overall, with the largest increase seen in the 66-70 y (5988 donors, 108.1% growth) group. Middle-aged donors, aged 41-55 y, demonstrated a decrease of 16.5%. Over the last decade, the youngest age groups (16-40 y) comprised 61.3% of first-time donors (FTD). Annual donation frequency increased with increasing age and PPP. The highest donation frequencies were seen in the oldest age groups.
    Conclusion: Although the peak median age of APD increased over the study period, relative contribution of the 16-40 y APD base also increased. Older donors exhibited the highest donation frequencies and thus contributed the largest volume of apheresis platelet units. Platelet donor activity declined in the middle age (41-55 y) group.
    MeSH term(s) Middle Aged ; Humans ; Adolescent ; Young Adult ; Adult ; Blood Component Removal ; Blood Platelets ; Tissue Donors ; Blood Donors ; Plateletpheresis
    Language English
    Publishing date 2023-05-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208417-x
    ISSN 1537-2995 ; 0041-1132
    ISSN (online) 1537-2995
    ISSN 0041-1132
    DOI 10.1111/trf.17400
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: COVID-19 convalescent plasma donors: Unique motivations in unique times?

    Crowder, Lauren A / Steele, Whitney R / Goodhue, Erin / Lasky, Baia / Young, Pampee P

    Transfusion

    2023  Volume 63, Issue 4, Page(s) 703–710

    Abstract: Background: Early in the SARS-CoV-2 pandemic, many blood collection organizations (BCOs) were asked to collect and distribute COVID-19 convalescent plasma (CCP) as a potential treatment for this new virus and resulting disease. However, recruiting CCP ... ...

    Abstract Background: Early in the SARS-CoV-2 pandemic, many blood collection organizations (BCOs) were asked to collect and distribute COVID-19 convalescent plasma (CCP) as a potential treatment for this new virus and resulting disease. However, recruiting CCP donors presented unique challenges for BCOs, as there were few recovered patients at this time, and like the general population, most potential CCP donors had no blood donation experience. Thus, many CCP donors were new donors, and their donation motivations were unknown.
    Materials and methods: Donors who gave CCP at least once between April 27th and September 15th, 2020, were emailed a link to an online survey regarding their experience with COVID-19 and their motivations for donating CCP and blood.
    Results: Of the 14,225 invitations sent, 3471 donors responded (24.4%). Most donors had never donated blood before (n = 1406), followed by lapsed donors (n = 1050), and recent donors (n = 951). There was a significant relationship between self-reported donation experience and fear of CCP donation (X
    Conclusions: Overwhelmingly, altruism and a sense of duty and responsibility were the reasons that CCP donors decided to donate. These insights can be useful for motivating donors for specialized donation programs or if wide scale CCP recruitment is needed in the future.
    MeSH term(s) Humans ; Motivation ; COVID-19/therapy ; SARS-CoV-2 ; COVID-19 Serotherapy ; Tissue Donors ; Blood Donors
    Language English
    Publishing date 2023-03-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208417-x
    ISSN 1537-2995 ; 0041-1132
    ISSN (online) 1537-2995
    ISSN 0041-1132
    DOI 10.1111/trf.17298
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Seroreactivity with COVID-19 antibody testing in CCP donors presenting without a SARS-CoV-2 diagnostic test.

    Goodhue Meyer, Erin K / Xu, Meng / Lasky, Baia / Young, Pampee P

    Transfusion

    2020  Volume 61, Issue 1, Page(s) 330–331

    MeSH term(s) Antibodies, Viral/immunology ; COVID-19/diagnosis ; COVID-19/immunology ; COVID-19 Testing/methods ; Diagnostic Tests, Routine ; Humans ; SARS-CoV-2/immunology ; SARS-CoV-2/pathogenicity
    Chemical Substances Antibodies, Viral
    Keywords covid19
    Language English
    Publishing date 2020-11-02
    Publishing country United States
    Document type Letter
    ZDB-ID 208417-x
    ISSN 1537-2995 ; 0041-1132
    ISSN (online) 1537-2995
    ISSN 0041-1132
    DOI 10.1111/trf.16146
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: COVID-19 convalescent plasma donor characteristics, product disposition, and comparison with standard apheresis donors.

    Lasky, Baia / Goodhue Meyer, Erin / Steele, Whitney R / Crowder, Lauren A / Young, Pampee P

    Transfusion

    2021  Volume 61, Issue 5, Page(s) 1471–1478

    Abstract: Background: With coronavirus disease 2019 (COVID-19) convalescent plasma (CCP) offering an early treatment option for COVID-19, blood collectors needed to quickly overcome obstacles to recruiting and qualifying eligible donors. We provide attributes of ... ...

    Abstract Background: With coronavirus disease 2019 (COVID-19) convalescent plasma (CCP) offering an early treatment option for COVID-19, blood collectors needed to quickly overcome obstacles to recruiting and qualifying eligible donors. We provide attributes of CCP donors and products and compare to standard donors and products.
    Study design and methods: Information on CCP donors was gathered from the American Red Cross qualification website through product collection. Data from 2019 for standard plasma/platelet apheresis (SA) and whole blood (WB) donor demographics and SA donations including product disposition and reactions were used for comparison.
    Results: Of almost 59 000 donors registering on the website, 75% reported an existing COVID-19 diagnostic polymerase chain reaction or an antibody test. The majority (56.2%) of 10 231 CCP donors were first-time donors in contrast to SA or WB donor populations, which were only 3.0% and 30.6%, respectively, first-time donors. The number of female donors was 12% higher than SA donors. Older (≥ 65 years) and younger (16-19 years) were comparatively underrepresented in CCP donors. Deferral (10.2%) and Quantity Not Sufficient rates (6.4%) for presenting CCP donations were higher than SA (8.2% and 1.1%, respectively). Human leukocyte antigen antibody reactivity was the highest cause of product loss for CCP donations vs SA donations (9.6% vs 1.3%). Acute adverse events also occurred at a higher rate among both first-time and repeat CCP donations compared to SA.
    Conclusions: CCP donors were more likely to be first-time and female donors than WB or SA donors. CCP donations had a higher rate of donor adverse reactions, deferrals, and product loss than SA donations.
    MeSH term(s) Adolescent ; Adult ; Aged ; Aged, 80 and over ; Blood Component Removal ; Blood Donors ; COVID-19/blood ; COVID-19/therapy ; Convalescence ; Female ; Humans ; Immunization, Passive ; Male ; Middle Aged ; SARS-CoV-2/metabolism
    Language English
    Publishing date 2021-03-07
    Publishing country United States
    Document type Comparative Study ; Journal Article
    ZDB-ID 208417-x
    ISSN 1537-2995 ; 0041-1132
    ISSN (online) 1537-2995
    ISSN 0041-1132
    DOI 10.1111/trf.16286
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Pathogen-reduced platelets in pediatric and neonatal patients: Demographics, transfusion rates, and transfusion reactions.

    Lasky, Baia / Nolasco, Joseph / Graff, Jazmin / Ward, Dawn C / Ziman, Alyssa / McGonigle, Andrea M

    Transfusion

    2021  Volume 61, Issue 10, Page(s) 2869–2876

    Abstract: Background: Pathogen-reduced platelets (PR PLT) are the emerging standard for proactive transfusion-transmitted infection (TTI) mitigation. There is, however, continued hesitation to transfuse PR PLT in children due to limited published data. We report ... ...

    Abstract Background: Pathogen-reduced platelets (PR PLT) are the emerging standard for proactive transfusion-transmitted infection (TTI) mitigation. There is, however, continued hesitation to transfuse PR PLT in children due to limited published data. We report demographics, rates of transfusion, and transfusion reactions (TR) associated with FDA-approved PR PLT in pediatric and neonatal patients at an academic medical center.
    Methods: Retrospective review was performed for patients <18 years receiving at least one platelet over a 300-day period at a large, tertiary care hospital. Patients were transfused PR or conventional (CONV) PLT, based on inventory availability. Statistical analysis was performed using Fisher Exact Test.
    Results: During the study period, 191 patients received 1010 platelet transfusions (892 units). Sixty-eight patients received PR PLT only (1.3 units/patient, 95% confidence interval [CI] 1.1-1.5; 1.8 transfusions/patient, 95% CI 1.4-2.2), and 56 patients received CONV PLT only (1.4 units/patient, 95% CI 1.1-1.7; 1.6 transfusions/patient, 95% CI 1.3-1.9). Patients with hematologic malignancies undergoing chemotherapy/radiation and allogeneic hematopoietic stem cell transplant received the most platelet transfusions and more commonly received both platelet types. Of 506 PR PLT units, 5 TRs occurred; 386 CONV PLT resulted in two TRs (p = .7052). Of 51 neonates, 37 received PR PLT without adverse events, including 13 receiving phototherapy. No TTIs were identified in any group.
    Conclusion: There was no significant difference in rates of transfusion or TRs between PR and CONV PLT. Our study provides additional evidence that PR PLT can be transfused to pediatric and neonatal patients without increasing the risk of acute adverse events.
    MeSH term(s) Adolescent ; Blood Platelets/cytology ; Blood Safety ; Child ; Child, Preschool ; Female ; Humans ; Infant ; Male ; Platelet Transfusion/adverse effects ; Retrospective Studies ; Risk Factors
    Language English
    Publishing date 2021-08-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208417-x
    ISSN 1537-2995 ; 0041-1132
    ISSN (online) 1537-2995
    ISSN 0041-1132
    DOI 10.1111/trf.16639
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Seroreactivity with COVID 19 antibody testing in CCP donors presenting without a SARS‐CoV‐2 diagnostic test

    Goodhue Meyer, Erin K. / Xu, Meng / Lasky, Baia / Young, Pampee

    Transfusion ; ISSN 0041-1132 1537-2995

    2020  

    Keywords Immunology ; Immunology and Allergy ; Hematology ; covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    DOI 10.1111/trf.16146
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article: Partnership between a Large Academic Medical Center and Blood Supplier to Maintain the Blood Supply during the Initial Covid19 Outbreak in the United States (US)

    Lasky, Baia J. / Slayton, Jennifer / Oaks, Debra / Petersen, Katie / Pinson, C. Wright / Andrews, Jennifer

    Transfusion

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #838263
    Database COVID19

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  8. Article: To Transfuse or Not to Transfuse: Sars-Cov-2 Donor Antibody Testing

    Meyer, Erin Goodhue / Lasky, Baia J. / Hall, Julie / Williamson, Phillip C. / Busch, Michael P. / Young, Pampee P.

    Transfusion

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #838808
    Database COVID19

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  9. Article: Regulation of the association between PSTPIP and CD2 in murine T cells.

    Bai, Y / Ding, Y / Spencer, S / Lasky, L A / Bromberg, J S

    Experimental and molecular pathology

    2001  Volume 71, Issue 2, Page(s) 115–124

    Abstract: Prominent in T cells and natural killer cells, CD2 binding protein 1 (CD2BP1) plays an important role in CD2-mediated adhesion and signal transduction. In the current study, we investigated CD2 and PSTPIP (proline, serine, threonine phosphatase ... ...

    Abstract Prominent in T cells and natural killer cells, CD2 binding protein 1 (CD2BP1) plays an important role in CD2-mediated adhesion and signal transduction. In the current study, we investigated CD2 and PSTPIP (proline, serine, threonine phosphatase interacting protein, murine homologue of CD2BP1) interactions in purified mouse splenic T cells. PSTPIP associated with CD2 in both resting and activated T cells. Following various stimuli, such as concanavalin A, anti-TCRbeta, anti-CD3epsilon, anti-CD3epsilon/phorbol myristate acetate (PMA), IL-2, or PMA/ionomycin, PSTPIP and CD2 expression, as well as their association, increased in a time-dependent fashion. While PSTPIP expression and CD2 expression were comparable across most groups, the PSTPIP-CD2 association stimulated by anti-CD3epsilon alone was significantly greater than with other stimuli. Stimulation by anti-CD3epsilon plus anti-CD28 induced even greater PSTPIP-CD2 association than anti-CD3epsilon treatment alone, indicating that CD28 initiated signals are involved in regulating this interaction. There was no direct association between CD3epsilon or CD28 and PSTPIP. Tyrosine phosphorylated PSTPIP bound poorly to CD2 compared to dephosphorylated PSTPIP, and protein tyrosine phosphatase was shown to affect both phosphorylation of PSTPIP and the CD2-PSTPIP association. In addition to CD2, PSTPIP associated with CD4, CD8, CD54, and CD62L. CD2 and CD4 ligation reciprocally regulated their association with PSTPIP. These findings indicate that T cell activation, particularly through the CD3 and CD28 signal transduction pathways, regulates PSTPIP-CD2 interactions. PSTPIP likely has additional broader effects through interactions with CD4, CD8, CD54, and CD62L, and this may influence T cell responses to antigen.
    MeSH term(s) Adaptor Proteins, Signal Transducing ; Animals ; Antibodies, Monoclonal ; Blotting, Western ; CD2 Antigens/metabolism ; CD28 Antigens/physiology ; CD3 Complex/physiology ; Carrier Proteins/metabolism ; Cytoskeletal Proteins/metabolism ; Female ; Lymphocyte Activation ; Mice ; Mice, Inbred CBA ; Mice, Knockout ; Phosphorylation ; Precipitin Tests ; Protein Tyrosine Phosphatases/pharmacology ; Receptors, Antigen, T-Cell/metabolism ; T-Lymphocytes/physiology
    Chemical Substances Adaptor Proteins, Signal Transducing ; Antibodies, Monoclonal ; CD2 Antigens ; CD28 Antigens ; CD3 Complex ; Carrier Proteins ; Cytoskeletal Proteins ; Pstpip1 protein, mouse ; Receptors, Antigen, T-Cell ; Protein Tyrosine Phosphatases (EC 3.1.3.48)
    Language English
    Publishing date 2001-10
    Publishing country Netherlands
    Document type Journal Article ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 207655-x
    ISSN 1096-0945 ; 0014-4800
    ISSN (online) 1096-0945
    ISSN 0014-4800
    DOI 10.1006/exmp.2001.2388
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Search for Subsolar-Mass Binaries in the First Half of Advanced LIGO's and Advanced Virgo's Third Observing Run.

    Abbott, R / Abbott, T D / Acernese, F / Ackley, K / Adams, C / Adhikari, N / Adhikari, R X / Adya, V B / Affeldt, C / Agarwal, D / Agathos, M / Agatsuma, K / Aggarwal, N / Aguiar, O D / Aiello, L / Ain, A / Ajith, P / Albanesi, S / Allocca, A /
    Altin, P A / Amato, A / Anand, C / Anand, S / Ananyeva, A / Anderson, S B / Anderson, W G / Andrade, T / Andres, N / Andrić, T / Angelova, S V / Ansoldi, S / Antelis, J M / Antier, S / Appert, S / Arai, K / Araya, M C / Areeda, J S / Arène, M / Arnaud, N / Aronson, S M / Arun, K G / Asali, Y / Ashton, G / Assiduo, M / Aston, S M / Astone, P / Aubin, F / Austin, C / Babak, S / Badaracco, F / Bader, M K M / Badger, C / Bae, S / Baer, A M / Bagnasco, S / Bai, Y / Baird, J / Ball, M / Ballardin, G / Ballmer, S W / Balsamo, A / Baltus, G / Banagiri, S / Bankar, D / Barayoga, J C / Barbieri, C / Barish, B C / Barker, D / Barneo, P / Barone, F / Barr, B / Barsotti, L / Barsuglia, M / Barta, D / Bartlett, J / Barton, M A / Bartos, I / Bassiri, R / Basti, A / Bawaj, M / Bayley, J C / Baylor, A C / Bazzan, M / Bécsy, B / Bedakihale, V M / Bejger, M / Belahcene, I / Benedetto, V / Beniwal, D / Bennett, T F / Bentley, J D / BenYaala, M / Bergamin, F / Berger, B K / Bernuzzi, S / Berry, C P L / Bersanetti, D / Bertolini, A / Betzwieser, J / Beveridge, D / Bhandare, R / Bhardwaj, U / Bhattacharjee, D / Bhaumik, S / Bilenko, I A / Billingsley, G / Bini, S / Birney, R / Birnholtz, O / Biscans, S / Bischi, M / Biscoveanu, S / Bisht, A / Biswas, B / Bitossi, M / Bizouard, M-A / Blackburn, J K / Blair, C D / Blair, D G / Blair, R M / Bobba, F / Bode, N / Boer, M / Bogaert, G / Boldrini, M / Bonavena, L D / Bondu, F / Bonilla, E / Bonnand, R / Booker, P / Boom, B A / Bork, R / Boschi, V / Bose, N / Bose, S / Bossilkov, V / Boudart, V / Bouffanais, Y / Bozzi, A / Bradaschia, C / Brady, P R / Bramley, A / Branch, A / Branchesi, M / Brau, J E / Breschi, M / Briant, T / Briggs, J H / Brillet, A / Brinkmann, M / Brockill, P / Brooks, A F / Brooks, J / Brown, D D / Brunett, S / Bruno, G / Bruntz, R / Bryant, J / Bulik, T / Bulten, H J / Buonanno, A / Buscicchio, R / Buskulic, D / Buy, C / Byer, R L / Cadonati, L / Cagnoli, G / Cahillane, C / Bustillo, J Calderón / Callaghan, J D / Callister, T A / Calloni, E / Cameron, J / Camp, J B / Canepa, M / Canevarolo, S / Cannavacciuolo, M / Cannon, K C / Cao, H / Capote, E / Carapella, G / Carbognani, F / Carlin, J B / Carney, M F / Carpinelli, M / Carrillo, G / Carullo, G / Carver, T L / Diaz, J Casanueva / Casentini, C / Castaldi, G / Caudill, S / Cavaglià, M / Cavalier, F / Cavalieri, R / Ceasar, M / Cella, G / Cerdá-Durán, P / Cesarini, E / Chaibi, W / Chakravarti, K / Subrahmanya, S Chalathadka / Champion, E / Chan, C-H / Chan, C / Chan, C L / Chan, K / Chandra, K / Chanial, P / Chao, S / Charlton, P / Chase, E A / Chassande-Mottin, E / Chatterjee, C / Chatterjee, Debarati / Chatterjee, Deep / Chaturvedi, M / Chaty, S / Chatziioannou, K / Chen, H Y / Chen, J / Chen, X / Chen, Y / Chen, Z / Cheng, H / Cheong, C K / Cheung, H Y / Chia, H Y / Chiadini, F / Chiarini, G / Chierici, R / Chincarini, A / Chiofalo, M L / Chiummo, A / Cho, G / Cho, H S / Choudhary, R K / Choudhary, S / Christensen, N / Chu, Q / Chua, S / Chung, K W / Ciani, G / Ciecielag, P / Cieślar, M / Cifaldi, M / Ciobanu, A A / Ciolfi, R / Cipriano, F / Cirone, A / Clara, F / Clark, E N / Clark, J A / Clarke, L / Clearwater, P / Clesse, S / Cleva, F / Coccia, E / Codazzo, E / Cohadon, P-F / Cohen, D E / Cohen, L / Colleoni, M / Collette, C G / Colombo, A / Colpi, M / Compton, C M / Constancio, M / Conti, L / Cooper, S J / Corban, P / Corbitt, T R / Cordero-Carrión, I / Corezzi, S / Corley, K R / Cornish, N / Corre, D / Corsi, A / Cortese, S / Costa, C A / Cotesta, R / Coughlin, M W / Coulon, J-P / Countryman, S T / Cousins, B / Couvares, P / Coward, D M / Cowart, M J / Coyne, D C / Coyne, R / Creighton, J D E / Creighton, T D / Criswell, A W / Croquette, M / Crowder, S G / Cudell, J R / Cullen, T J / Cumming, A / Cummings, R / Cunningham, L / Cuoco, E / Curyło, M / Dabadie, P / Canton, T Dal / Dall'Osso, S / Dálya, G / Dana, A / DaneshgaranBajastani, L M / D'Angelo, B / Danilishin, S / D'Antonio, S / Danzmann, K / Darsow-Fromm, C / Dasgupta, A / Datrier, L E H / Datta, S / Dattilo, V / Dave, I / Davier, M / Davies, G S / Davis, D / Davis, M C / Daw, E J / Dean, R / DeBra, D / Deenadayalan, M / Degallaix, J / De Laurentis, M / Deléglise, S / Del Favero, V / De Lillo, F / De Lillo, N / Del Pozzo, W / DeMarchi, L M / De Matteis, F / D'Emilio, V / Demos, N / Dent, T / Depasse, A / De Pietri, R / De Rosa, R / De Rossi, C / DeSalvo, R / De Simone, R / Dhurandhar, S / Díaz, M C / Diaz-Ortiz, M / Didio, N A / Dietrich, T / Di Fiore, L / Di Fronzo, C / Di Giorgio, C / Di Giovanni, F / Di Giovanni, M / Di Girolamo, T / Di Lieto, A / Ding, B / Di Pace, S / Di Palma, I / Di Renzo, F / Divakarla, A K / Dmitriev, A / Doctor, Z / D'Onofrio, L / Donovan, F / Dooley, K L / Doravari, S / Dorrington, I / Drago, M / Driggers, J C / Drori, Y / Ducoin, J-G / Dupej, P / Durante, O / D'Urso, D / Duverne, P-A / Dwyer, S E / Eassa, C / Easter, P J / Ebersold, M / Eckhardt, T / Eddolls, G / Edelman, B / Edo, T B / Edy, O / Effler, A / 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    Physical review letters

    2022  Volume 129, Issue 6, Page(s) 61104

    Abstract: We report on a search for compact binary coalescences where at least one binary component has a mass between 0.2  M_{⊙} and 1.0  M_{⊙} in Advanced LIGO and Advanced Virgo data collected between 1 April 2019 1500 UTC and 1 October 2019 1500 UTC. We extend ...

    Abstract We report on a search for compact binary coalescences where at least one binary component has a mass between 0.2  M_{⊙} and 1.0  M_{⊙} in Advanced LIGO and Advanced Virgo data collected between 1 April 2019 1500 UTC and 1 October 2019 1500 UTC. We extend our previous analyses in two main ways: we include data from the Virgo detector and we allow for more unequal mass systems, with mass ratio q≥0.1. We do not report any gravitational-wave candidates. The most significant trigger has a false alarm rate of 0.14  yr^{-1}. This implies an upper limit on the merger rate of subsolar binaries in the range [220-24200]  Gpc^{-3} yr^{-1}, depending on the chirp mass of the binary. We use this upper limit to derive astrophysical constraints on two phenomenological models that could produce subsolar-mass compact objects. One is an isotropic distribution of equal-mass primordial black holes. Using this model, we find that the fraction of dark matter in primordial black holes in the mass range 0.2  M_{⊙}<m_{PBH}<1.0  M_{⊙} is f_{PBH}≡Ω_{PBH}/Ω_{DM}≲6%. This improves existing constraints on primordial black hole abundance by a factor of ∼3. The other is a dissipative dark matter model, in which fermionic dark matter can collapse and form black holes. The upper limit on the fraction of dark matter black holes depends on the minimum mass of the black holes that can be formed: the most constraining result is obtained at M_{min}=1  M_{⊙}, where f_{DBH}≡Ω_{DBH}/Ω_{DM}≲0.003%. These are the first constraints placed on dissipative dark models by subsolar-mass analyses.<br />
    Language English
    Publishing date 2022-08-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208853-8
    ISSN 1079-7114 ; 0031-9007
    ISSN (online) 1079-7114
    ISSN 0031-9007
    DOI 10.1103/PhysRevLett.129.061104
    Database MEDical Literature Analysis and Retrieval System OnLINE

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