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Article ; Online: Development and validation of risk calculators for people with "thin" melanomas on their skin to predict the likelihood that their cancer will return: a plain language summary of publication.

Sharouni, Mary-Ann El / Lo, Serigne N / Varey, Alexander Hr / Elias, Sjoerd G / Witkamp, Arjen J / Sigurdsson, Vigfús / Suijkerbuijk, Karijn Pm / van Diest, Paul J / van Gils, Carla H / Blokx, Willeke Am / Scolyer, Richard A / Thompson, John F

Future oncology (London, England)

2023 Volume 19, Issue 2, Page(s) 97–102

Abstract: What is this summary about?: This is a summary of an article describing the development of risk calculators for use in people who develop a type of melanoma on their skin called "thin" melanoma to predict the likelihood that their cancer will return. ... ...

Abstract	What is this summary about?: This is a summary of an article describing the development of risk calculators for use in people who develop a type of melanoma on their skin called "thin" melanoma to predict the likelihood that their cancer will return. The article was originally published in the How were the calculators developed?: Calculations were performed to predict the chance of people with thin melanomas surviving without their melanoma recurring. Three graphical prediction calculators (called nomograms) were developed, along with easy-to-use online calculators using the same underlying calculation methods. The model was developed using data for 25,930 Dutch people diagnosed with thin melanomas (called the "development set"). To test its ability to predict melanoma recurrence, it was then compared with data for 2,968 Australian people with melanoma (the "validation set"). The calculators developed in the Dutch patients were found to accurately predict the risk of melanoma recurring for people with melanoma in the Australian "validation" group. What do the results mean?: The calculators provide estimates of the risk of the melanoma returning for people with thin melanomas. The easy-to-use online calculators are freely available on a smartphone, tablet or computer, and will assist in providing accurate estimates of recurrence risks for individuals with thin melanomas, allowing more intensive follow-up of those whose predicted risk of their melanoma returning is high.
MeSH term(s)	Humans ; Skin Neoplasms/diagnosis ; Skin Neoplasms/epidemiology ; Nomograms ; Australia ; Melanoma/diagnosis ; Melanoma/epidemiology ; Skin
Language	English
Publishing date	2023-02-10
Publishing country	England
Document type	Journal Article ; Review ; Comment
ZDB-ID	2274956-1
ISSN	1744-8301 ; 1479-6694
ISSN (online)	1744-8301
ISSN	1479-6694
DOI	10.2217/fon-2022-0525
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Article ; Online: Raman tensor of zinc-phosphide (Zn

Flór, Mischa / Stutz, Elias Z / Ramanandan, Santhanu P / Zamani, Mahdi / Paul, Rajrupa / Leran, Jean-Baptiste / Litvinchuk, Alexander P / Fontcuberta I Morral, Anna / Dimitrievska, Mirjana

Physical chemistry chemical physics : PCCP

2021 Volume 24, Issue 1, Page(s) 63–72

Abstract: Zinc phosphide ( ... ...

Abstract	Zinc phosphide (Zn
Language	English
Publishing date	2021-12-22
Publishing country	England
Document type	Journal Article
ZDB-ID	1476244-4
ISSN	1463-9084 ; 1463-9076
ISSN (online)	1463-9084
ISSN	1463-9076
DOI	10.1039/d1cp04322f
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Article ; Online: Multimodal analysis of granulocytes, monocytes, and platelets in patients with cystic fibrosis before and after Elexacaftor-Tezacaftor-Ivacaftor treatment.

Schmidt, Hanna / Höpfer, Larissa Melina / Wohlgemuth, Lisa / Knapp, Christiane Leonie / Mohamed, Adam Omar Khalaf / Stukan, Laura / Münnich, Frederik / Hüsken, Dominik / Koller, Alexander Sebastian / Stratmann, Alexander Elias Paul / Müller, Paul / Braun, Christian Karl / Fabricius, Dorit / Bode, Sebastian Felix Nepomuk / Huber-Lang, Markus / Messerer, David Alexander Christian

Frontiers in immunology

2023 Volume 14, Page(s) 1180282

Abstract: Cystic fibrosis (CF) is a monogenetic disease caused by an impairment of the cystic fibrosis transmembrane conductance regulator (CFTR). CF affects multiple organs and is associated with acute and chronic inflammation. In 2020, Elexacaftor-Tezacaftor- ... ...

Abstract	Cystic fibrosis (CF) is a monogenetic disease caused by an impairment of the cystic fibrosis transmembrane conductance regulator (CFTR). CF affects multiple organs and is associated with acute and chronic inflammation. In 2020, Elexacaftor-Tezacaftor-Ivacaftor (ETI) was approved to enhance and restore the remaining CFTR functionality. This study investigates cellular innate immunity, with a focus on neutrophil activation and phenotype, comparing healthy volunteers with patients with CF before (T1, n = 13) and after six months (T2, n = 11) of ETI treatment. ETI treatment reduced sweat chloride (T1: 95 mmol/l (83\|108) vs. T2: 32 mmol/l (25\|62), p < 0.01, median, first\|third quartile) and significantly improved pulmonal function (FEV
MeSH term(s)	Humans ; Cystic Fibrosis Transmembrane Conductance Regulator/genetics ; Cystic Fibrosis/drug therapy ; Blood Platelets ; Monocytes ; Granulocytes
Chemical Substances	Cystic Fibrosis Transmembrane Conductance Regulator (126880-72-6) ; elexacaftor (RRN67GMB0V) ; ivacaftor (1Y740ILL1Z) ; tezacaftor
Language	English
Publishing date	2023-06-29
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1180282
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Article ; Online: Impact of a Chronic Total Coronary Occlusion on the Incidence of Appropriate Implantable Cardioverter-Defibrillator Shocks and Mortality: A Substudy of the Dutch Outcome in ICD Therapy (DO-IT)) Registry.

Journal of the American Heart Association

2024 Volume 13, Issue 8, Page(s) e032033

Abstract: Background: Chronic total coronary occlusions (CTO) substantially increase the risk for sudden cardiac death. Among patients with chronic ischemic heart disease at risk for sudden cardiac death, an implantable cardioverter defibrillator (ICD) is the ... ...

Abstract	Background: Chronic total coronary occlusions (CTO) substantially increase the risk for sudden cardiac death. Among patients with chronic ischemic heart disease at risk for sudden cardiac death, an implantable cardioverter defibrillator (ICD) is the favored therapy for primary prevention of sudden cardiac death. This study sought to investigate the impact of CTOs on the risk for appropriate ICD shocks and mortality within a nationwide prospective cohort. Methods and results: This is a subanalysis of the nationwide Dutch-Outcome in ICD Therapy (DO-IT) registry of primary prevention ICD recipients in The Netherlands between September 2014 and June 2016 (n=1442). We identified patients with chronic ischemic heart disease (n=663) and assessed available coronary angiograms for CTO presence (n=415). Patients with revascularized CTOs were excluded (n=79). The primary end point was the composite of all-cause mortality and appropriate ICD shocks. Clinical follow-up was conducted for at least 2 years. A total of 336 patients were included, with an average age of 67±9 years, and 20.5% was female (n=69). An unrevascularized CTO was identified in 110 patients (32.7%). During a median follow-up period of 27 months (interquartile range, 24-32), the primary end point occurred in 21.1% of patients with CTO (n=23) compared with 11.9% in patients without CTO (n=27; Conclusions: Within this nationwide prospective registry of primary prevention ICD recipients, the presence of an unrevascularized CTO was an independent predictor for the composite outcome of all-cause mortality and appropriate ICD shocks.
MeSH term(s)	Humans ; Female ; Middle Aged ; Aged ; Coronary Occlusion/complications ; Coronary Occlusion/diagnostic imaging ; Coronary Occlusion/therapy ; Arrhythmias, Cardiac ; Defibrillators, Implantable/adverse effects ; Stroke Volume ; Incidence ; Ventricular Function, Left ; Death, Sudden, Cardiac/epidemiology ; Death, Sudden, Cardiac/etiology ; Death, Sudden, Cardiac/prevention & control ; Registries ; Risk Factors
Language	English
Publishing date	2024-04-09
Publishing country	England
Document type	Journal Article
ZDB-ID	2653953-6
ISSN	2047-9980 ; 2047-9980
ISSN (online)	2047-9980
ISSN	2047-9980
DOI	10.1161/JAHA.123.032033
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Article ; Online: Detection and characterization of putative hypervirulent Klebsiella pneumoniae isolates in microbiological diagnostics

Bernd Neumann / Claudia Stürhof / Anca Rath / Bärbel Kieninger / Elias Eger / Justus U. Müller / Alexander von Poblocki / Nadja Gerlitz / Paul Wollschläger / Wulf Schneider-Brachert / Katharina Schaufler / Kathleen Klaper / Jörg Steinmann

Scientific Reports, Vol 13, Iss 1, Pp 1-

2023 Volume 11

Abstract: Abstract Hypervirulent Klebsiella pneumoniae strains (hvKp) can cause invasive community-acquired infections in healthy patients of all ages. In this study, the prevalence of putative hvKp in a German tertiary center was investigated and hvKp were ... ...

Abstract	Abstract Hypervirulent Klebsiella pneumoniae strains (hvKp) can cause invasive community-acquired infections in healthy patients of all ages. In this study, the prevalence of putative hvKp in a German tertiary center was investigated and hvKp were characterized by phenotypic and molecular assays. All K. pneumoniae isolates in routine microbiological diagnostics from a single center were screened by string-testing over a period of 6 months. String-test positive (≥ 0.5 mm) isolates were re-evaluated on different media and under various conditions (aerobe, anaerobe). For string-test positive isolates, genes (magA, iutA, rmpA and rmpA2) associated with hypermucoviscosity and hypervirulence were amplified by multiplex PCR. PCR-positive isolates were subjected to whole-genome sequencing and sedimentation and biofilm formation assays. From 1310 screened K. pneumoniae isolates in clinical routine 100 isolates (7.6%) were string test positive. From these, 9% (n = 9) were defined as putative hvKp (string-test+/PCR+). Highest rate of string-test-positive isolates was observed on MacConkey agar under aerobic conditions. Amongst these nine putative hvKp isolates, the international lineage ST23 carrying hvKp-plasmid pKpVP-1 was the most common, but also a rare ST86 with pKpVP-2 was identified. All nine isolates showed hypermucoviscosity and weak biofilm formation. In conclusion, 9% of string-positive, respectively 0.69% of all K. pneumoniae isolates from routine were defined as putative hypervirulent. MacConkey agar was the best medium for hvKp screening.
Keywords	Medicine ; R ; Science ; Q
Language	English
Publishing date	2023-11-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Stoichiometry modulates the optoelectronic functionality of zinc phosphide (Zn

Stutz, Elias Z / Ramanandan, Santhanu P / Flór, Mischa / Paul, Rajrupa / Zamani, Mahdi / Escobar Steinvall, Simon / Sandoval Salaiza, Diego Armando / Xifra Montesinos, Clàudia / Spadaro, Maria Chiara / Leran, Jean-Baptiste / Litvinchuk, Alexander P / Arbiol, Jordi / Fontcuberta I Morral, Anna / Dimitrievska, Mirjana

Faraday discussions

2022 Volume 239, Page(s) 202–218

Abstract: Predictive synthesis-structure-property relationships are at the core of materials design for novel applications. In this regard, correlations between the compositional stoichiometry variations and functional properties are essential for enhancing the ... ...

Abstract	Predictive synthesis-structure-property relationships are at the core of materials design for novel applications. In this regard, correlations between the compositional stoichiometry variations and functional properties are essential for enhancing the performance of devices based on these materials. In this work, we investigate the effect of stoichiometry variations and defects on the structural and optoelectronic properties of monocrystalline zinc phosphide (Zn
Language	English
Publishing date	2022-10-28
Publishing country	England
Document type	Journal Article
ISSN	1364-5498
ISSN (online)	1364-5498
DOI	10.1039/d2fd00055e
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Article ; Online: C-reactive protein and white blood cell count are adverse prognostic markers for patients with advanced cancer on parenteral nutrition in a palliative care unit setting: A retrospective cohort study.

Kieler, Markus / Kössler, Paul / Milovic, Matija / Meyer, Elias / Križanová, Kristína / Kum, Lea / Friedrich, Alexander / Masel, Eva / Bauer, Raimund / Unseld, Matthias

Palliative medicine

2022 Volume 36, Issue 3, Page(s) 540–548

Abstract: Background: Parenteral nutrition is controversial in patients with advanced cancer. Nevertheless, this treatment is common practice near the end of life.: Aim: We aimed to identify factors which were associated with the outcome of patients on ... ...

Abstract	Background: Parenteral nutrition is controversial in patients with advanced cancer. Nevertheless, this treatment is common practice near the end of life. Aim: We aimed to identify factors which were associated with the outcome of patients on parenteral nutrition at an academic tertiary palliative care unit. Design: In this retrospective cohort study patients were assigned to two groups according to parenteral nutrition treatment. Inferential statistics were used to assess whether the dynamics of laboratory variables over 2 weeks of parenteral nutrition were associated with survival. Setting/participants: Patients admitted to the Department of Palliative Medicine at the Medical University of Vienna between 2016 and 2018 were included in this study. Results: Of 443 patients, 113 patients received parenteral nutrition. Patients had a lower body mass index, lower levels of bilirubin, γ-glutamyltransferase, alkaline phosphatase, and were of younger age compared to patients which did not receive parenteral nutrition. No difference in survival as measured from admission to death was found when comparing the two groups. Levels for γ-glutamyltransferase, alkaline phosphatase, and C-reactive protein significantly increased during 2 weeks of parenteral nutrition. Among patients with parenteral nutrition, an increase in C-reactive protein or white blood cell count levels was associated with lower survival. Conclusion: Patients who responded with an increase of C-reactive protein or white blood cell count during 2 weeks after reinitiation or start of parenteral nutrition had a worse survival. Our findings might support clinicians and patients in their decision to forgo parenteral nutrition in a palliative care setting.
MeSH term(s)	C-Reactive Protein ; Humans ; Leukocyte Count ; Neoplasms/complications ; Neoplasms/therapy ; Palliative Care ; Parenteral Nutrition ; Prognosis ; Retrospective Studies
Chemical Substances	C-Reactive Protein (9007-41-4)
Language	English
Publishing date	2022-02-20
Publishing country	England
Document type	Journal Article
ZDB-ID	639247-7
ISSN	1477-030X ; 0269-2163
ISSN (online)	1477-030X
ISSN	0269-2163
DOI	10.1177/02692163211073939
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Article ; Online: Detection and characterization of putative hypervirulent Klebsiella pneumoniae isolates in microbiological diagnostics.

Neumann, Bernd / Stürhof, Claudia / Rath, Anca / Kieninger, Bärbel / Eger, Elias / Müller, Justus U / von Poblocki, Alexander / Gerlitz, Nadja / Wollschläger, Paul / Schneider-Brachert, Wulf / Schaufler, Katharina / Klaper, Kathleen / Steinmann, Jörg

Scientific reports

2023 Volume 13, Issue 1, Page(s) 19025

Abstract: Hypervirulent Klebsiella pneumoniae strains (hvKp) can cause invasive community-acquired infections in healthy patients of all ages. In this study, the prevalence of putative hvKp in a German tertiary center was investigated and hvKp were characterized ... ...

Abstract	Hypervirulent Klebsiella pneumoniae strains (hvKp) can cause invasive community-acquired infections in healthy patients of all ages. In this study, the prevalence of putative hvKp in a German tertiary center was investigated and hvKp were characterized by phenotypic and molecular assays. All K. pneumoniae isolates in routine microbiological diagnostics from a single center were screened by string-testing over a period of 6 months. String-test positive (≥ 0.5 mm) isolates were re-evaluated on different media and under various conditions (aerobe, anaerobe). For string-test positive isolates, genes (magA, iutA, rmpA and rmpA2) associated with hypermucoviscosity and hypervirulence were amplified by multiplex PCR. PCR-positive isolates were subjected to whole-genome sequencing and sedimentation and biofilm formation assays. From 1310 screened K. pneumoniae isolates in clinical routine 100 isolates (7.6%) were string test positive. From these, 9% (n = 9) were defined as putative hvKp (string-test+/PCR+). Highest rate of string-test-positive isolates was observed on MacConkey agar under aerobic conditions. Amongst these nine putative hvKp isolates, the international lineage ST23 carrying hvKp-plasmid pKpVP-1 was the most common, but also a rare ST86 with pKpVP-2 was identified. All nine isolates showed hypermucoviscosity and weak biofilm formation. In conclusion, 9% of string-positive, respectively 0.69% of all K. pneumoniae isolates from routine were defined as putative hypervirulent. MacConkey agar was the best medium for hvKp screening.
MeSH term(s)	Humans ; Klebsiella pneumoniae ; Virulence Factors/genetics ; Virulence/genetics ; Agar ; Multiplex Polymerase Chain Reaction ; Klebsiella Infections/diagnosis ; Klebsiella Infections/epidemiology ; Klebsiella Infections/microbiology ; Anti-Bacterial Agents
Chemical Substances	Virulence Factors ; Agar (9002-18-0) ; Anti-Bacterial Agents
Language	English
Publishing date	2023-11-03
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-46221-w
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Article ; Online: Raman spectroscopy and lattice dynamics calculations of tetragonally-structured single crystal zinc phosphide (Zn

Stutz, Elias Z / Escobar Steinvall, Simon / Litvinchuk, Alexander P / Leran, Jean-Baptiste / Zamani, Mahdi / Paul, Rajrupa / Fontcuberta I Morral, Anna / Dimitrievska, Mirjana

Nanotechnology

2020 Volume 32, Issue 8, Page(s) 85704

Abstract: Earth-abundant and low-cost semiconductors, such as zinc phosphide ( ... ...

Abstract	Earth-abundant and low-cost semiconductors, such as zinc phosphide (Zn
Language	English
Publishing date	2020-11-09
Publishing country	England
Document type	Journal Article
ZDB-ID	1362365-5
ISSN	1361-6528 ; 0957-4484
ISSN (online)	1361-6528
ISSN	0957-4484
DOI	10.1088/1361-6528/abc91b
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Article: Kidney Function Worsening Is Linked to Parenteral-Nutrition-Dependent Survival in Palliative Care Patients

Kum, Lea / Friedrich, Alexander / Kieler, Markus / Meyer, Elias / Popov, Petar / Kössler, Paul / Kitta, Anna / Adamidis, Feroniki / Oberle, Raimund / Masel, Eva Katharina / Unseld, Matthias

Nutrients. 2022 Feb. 11, v. 14, no. 4

2022

Abstract: Background. Parenteral nutrition (PN) is frequently administered in palliative care patients suffering from cachexia. The evidence regarding the use of PN in terminally ill patients is scarce. Routine laboratory parameters might help to decide whether to ...

Abstract	Background. Parenteral nutrition (PN) is frequently administered in palliative care patients suffering from cachexia. The evidence regarding the use of PN in terminally ill patients is scarce. Routine laboratory parameters might help to decide whether to start or forgo PN, which could decrease overtreatment at the end of life. Kidney failure was frequently associated with survival. However, a relation between kidney function parameters and parenteral nutrition has not been observed thus far. The aim of this retrospective cohort study was to analyze kidney function parameters in palliative care patients under PN, as well as the relation between these parameters and overall survival. Methods. Patients who were admitted to the Department of Palliative Medicine at the Medical University of Vienna were screened for PN treatment. Whether kidney function parameters at baseline or their dynamics over the course of two weeks were associated with survival was assessed with descriptive and interferential statistics. Results. In total, 113 of 443 palliative care patients were administered parenteral nutrition for the first time. The overall survival (OS) for all patients with increased kidney function parameters at baseline was lower (creatinine: hazard ratio (HR) = 1.808, p < 0.001; urea: HR = 1.033, p < 0.001; uric acid HR = 1.055, p = 0.015). No significant increase in creatinine blood levels was observed in the first 2 weeks after the initiation of PN when compared to the non-PN group (p = 0.86). However, if creatinine blood levels increased within the PN group, lower overall survival was found (HR = 2.046, p = 0.007). Conclusion. Increased kidney function parameters, such as creatinine, urea and uric acid, might be used as negative prognostic markers in palliative care patients under PN. Moreover, an increase in creatinine during the administration of parenteral nutrition in the first 2 weeks is linked to worse outcomes. These findings may help future studies to establish objective markers for clinicians to determine whether to start or end PN in palliative cancer patients and decrease potential overtreatment at the end of life.
Keywords	blood ; cachexia ; cohort studies ; creatinine ; hazard ratio ; medicine ; parenteral feeding ; renal failure ; renal function ; urea ; uric acid ; Austria
Language	English
Dates of publication	2022-0211
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2518386-2
ISSN	2072-6643
ISSN	2072-6643
DOI	10.3390/nu14040769
Database	NAL-Catalogue (AGRICOLA)

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