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  1. Article ; Online: Human Serum and Salivary Metabolomes: Diversity and Closeness.

    Ferrari, Elena / Gallo, Mariana / Spisni, Alberto / Antonelli, Rita / Meleti, Marco / Pertinhez, Thelma A

    International journal of molecular sciences

    2023  Volume 24, Issue 23

    Abstract: Saliva, which contains molecular information that may reflect an individual's health status, has become a valuable tool for discovering biomarkers of oral and general diseases. Due to the high vascularization of the salivary glands, there is a molecular ... ...

    Abstract Saliva, which contains molecular information that may reflect an individual's health status, has become a valuable tool for discovering biomarkers of oral and general diseases. Due to the high vascularization of the salivary glands, there is a molecular exchange between blood and saliva. However, the composition of saliva is complex and influenced by multiple factors. This study aimed to investigate the possible relationships between the salivary and serum metabolomes to gain a comprehensive view of the metabolic phenotype under physiological conditions. Using
    MeSH term(s) Humans ; Salivary Glands/metabolism ; Saliva/metabolism ; Parotid Gland/metabolism ; Metabolome
    Language English
    Publishing date 2023-11-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms242316603
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  2. Article ; Online: Ultra-high performance liquid chromatography high-resolution mass spectrometry for metabolomic analysis of dental calculus from Duke Alessandro Farnese and Maria D'Aviz.

    Riboni, Nicolo' / Bianchi, Federica / Mattarozzi, Monica / Peracchia, Marianna / Meleti, Marco / Careri, Maria

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 8967

    Abstract: Dental calculus is a valuable resource for the reconstruction of dietary habits and oral microbiome of past populations. In 2020 the remains of Duke Alessandro Farnese and his wife Maria D'Aviz were exhumed to get novel insights into the causes of death. ...

    Abstract Dental calculus is a valuable resource for the reconstruction of dietary habits and oral microbiome of past populations. In 2020 the remains of Duke Alessandro Farnese and his wife Maria D'Aviz were exhumed to get novel insights into the causes of death. This study aimed to investigate the dental calculus metabolome of the noble couple by untargeted metabolomics. The pulverized samples were decalcified in a water-formic acid mixture, extracted using methanol/acetonitrile and analyzed by ultra-high performance liquid chromatography coupled to high-resolution mass spectrometry (UHPLC-HRMS) using a reversed-phase separation followed by electrospray ionization and full scan in positive and negative ion mode. Waters Synapt-G2-Si High-Definition hybrid quadrupole time-of-flight mass spectrometer was used. Significant features were then identified using MS
    MeSH term(s) Humans ; Chromatography, High Pressure Liquid/methods ; Dental Calculus ; Mass Spectrometry ; Metabolomics/methods ; Metabolome
    Language English
    Publishing date 2023-06-02
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-36177-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: High demand for global collaboration in oral medicine in the post-COVID-19 era.

    Delli, Konstantina / Georgaki, Maria / Andreou, Anastasia / Papadopoulou, Erofili / Robledo-Sierra, Jairo / Meleti, Marco / Nikitakis, Nikolaos G

    Oral diseases

    2023  

    Language English
    Publishing date 2023-05-09
    Publishing country Denmark
    Document type Journal Article
    ZDB-ID 1290529-x
    ISSN 1601-0825 ; 1354-523X
    ISSN (online) 1601-0825
    ISSN 1354-523X
    DOI 10.1111/odi.14593
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4427: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article: Mandibular metastasis from carcinoma of the bladder: Report of a case and literature review.

    Giovannacci, Ilaria / Vescovi, Paolo / Corcione, Luigi / Corradi, Domenico / Bologna-Molina, Ronell / Meleti, Marco

    Journal of clinical and experimental dentistry

    2022  Volume 14, Issue 4, Page(s) e376–e379

    Abstract: Metastases represent about 1% of all malignant tumors of the oral region. Only 12 cases of metastases to the jawbones and 3 to the oral soft tissues from a carcinoma of the bladder are reported in the English literature. Here we report a case of an 86 ... ...

    Abstract Metastases represent about 1% of all malignant tumors of the oral region. Only 12 cases of metastases to the jawbones and 3 to the oral soft tissues from a carcinoma of the bladder are reported in the English literature. Here we report a case of an 86 year-old man with a metastasis to the anterior region of the lower jaw from a transitional cell carcinoma of the bladder treated 5 years before, all-together with a literature review.
    Language English
    Publishing date 2022-04-01
    Publishing country Spain
    Document type Case Reports
    ZDB-ID 2586647-3
    ISSN 1989-5488
    ISSN 1989-5488
    DOI 10.4317/jced.57293
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  5. Article ; Online: Ultra-high performance liquid chromatography high-resolution mass spectrometry for metabolomic analysis of dental calculus from Duke Alessandro Farnese and Maria D’Aviz

    Nicolo’ Riboni / Federica Bianchi / Monica Mattarozzi / Marianna Peracchia / Marco Meleti / Maria Careri

    Scientific Reports, Vol 13, Iss 1, Pp 1-

    2023  Volume 8

    Abstract: Abstract Dental calculus is a valuable resource for the reconstruction of dietary habits and oral microbiome of past populations. In 2020 the remains of Duke Alessandro Farnese and his wife Maria D’Aviz were exhumed to get novel insights into the causes ... ...

    Abstract Abstract Dental calculus is a valuable resource for the reconstruction of dietary habits and oral microbiome of past populations. In 2020 the remains of Duke Alessandro Farnese and his wife Maria D’Aviz were exhumed to get novel insights into the causes of death. This study aimed to investigate the dental calculus metabolome of the noble couple by untargeted metabolomics. The pulverized samples were decalcified in a water-formic acid mixture, extracted using methanol/acetonitrile and analyzed by ultra-high performance liquid chromatography coupled to high-resolution mass spectrometry (UHPLC-HRMS) using a reversed-phase separation followed by electrospray ionization and full scan in positive and negative ion mode. Waters Synapt-G2-Si High-Definition hybrid quadrupole time-of-flight mass spectrometer was used. Significant features were then identified using MSE acquisition mode, recording information on exact mass precursor and fragment ions within the same run. This approach, together with data pre-treatment and multivariate statistical analysis allowed for the identification of compounds able to differentiate between the investigated samples. More than 200 metabolites were identified, being fatty acids, alcohols, aldehydes, phosphatidylcholines, phosphatidylglycerols, ceramides and phosphatidylserines the most abundant classes. Metabolites deriving from food, bacteria and fungi were also determined, providing information on the habits and oral health status of the couple.
    Keywords Medicine ; R ; Science ; Q
    Subject code 540
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Human Serum and Salivary Metabolomes

    Elena Ferrari / Mariana Gallo / Alberto Spisni / Rita Antonelli / Marco Meleti / Thelma A. Pertinhez

    International Journal of Molecular Sciences, Vol 24, Iss 23, p

    Diversity and Closeness

    2023  Volume 16603

    Abstract: Saliva, which contains molecular information that may reflect an individual’s health status, has become a valuable tool for discovering biomarkers of oral and general diseases. Due to the high vascularization of the salivary glands, there is a molecular ... ...

    Abstract Saliva, which contains molecular information that may reflect an individual’s health status, has become a valuable tool for discovering biomarkers of oral and general diseases. Due to the high vascularization of the salivary glands, there is a molecular exchange between blood and saliva. However, the composition of saliva is complex and influenced by multiple factors. This study aimed to investigate the possible relationships between the salivary and serum metabolomes to gain a comprehensive view of the metabolic phenotype under physiological conditions. Using 1 H-NMR spectroscopy, we obtained the serum metabolite profiles of 20 healthy young individuals and compared them with the metabolomes of parotid, submandibular/sublingual, and whole-saliva samples collected concurrently from the same individuals using multivariate and univariate statistical analysis. Our results show that serum is more concentrated and less variable for most of the shared metabolites than the three saliva types. While we found moderate to strong correlations between serum and saliva concentrations of specific metabolites, saliva is not simply an ultrafiltrate of blood. The intense oral metabolism prevents very strong correlations between serum and salivary concentrations. This study contributes to a better understanding of salivary metabolic composition, which is crucial for utilizing saliva in laboratory diagnostics.
    Keywords salivary metabolites ; serum metabolites ; metabolite profile ; parotid gland ; submandibular gland ; sublingual glands ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 630
    Language English
    Publishing date 2023-11-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: COVID-19 diffusion and its impact on dental practice in distant countries with similar ethnic background.

    Meleti, Marco / Cassi, Diana / Bueno, Luis / Bologna-Molina, Ronell

    Oral diseases

    2020  Volume 27 Suppl 3, Page(s) 720–722

    MeSH term(s) COVID-19 ; Dental Care ; Humans ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-06-12
    Publishing country Denmark
    Document type Journal Article
    ZDB-ID 1290529-x
    ISSN 1601-0825 ; 1354-523X
    ISSN (online) 1601-0825
    ISSN 1354-523X
    DOI 10.1111/odi.13438
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4427: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Clinicopathological Features Associated with Fluorescence Alteration: Analysis of 108 Oral Malignant and Potentially Malignant Lesions.

    Giovannacci, Ilaria / Magnoni, Cristina / Pedrazzi, Giuseppe / Vescovi, Paolo / Meleti, Marco

    Photobiomodulation, photomedicine, and laser surgery

    2020  Volume 39, Issue 1, Page(s) 53–61

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Carcinoma, Squamous Cell/diagnosis ; Early Detection of Cancer ; Fluorescence ; Humans ; Mouth Neoplasms/diagnosis ; Precancerous Conditions/diagnosis
    Language English
    Publishing date 2020-12-17
    Publishing country United States
    Document type Journal Article
    ISSN 2578-5478
    ISSN (online) 2578-5478
    DOI 10.1089/photob.2020.4838
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Oral status of a noble European couple from the 16

    Peracchia, Marianna / Meleti, Marco / Armocida, Emanuele / Toffoli, Andrea / Cucurachi, Nicola / Bussolati, Ovidio / Cecchi, Rossana

    Anthropologischer Anzeiger; Bericht uber die biologisch-anthropologische Literatur

    2021  Volume 79, Issue 1, Page(s) 69–81

    Abstract: Objective. ...

    Abstract Objective.
    MeSH term(s) Dental Caries ; Humans ; Nutritional Status ; Spouses ; Tooth ; Tooth Loss ; Tooth Wear
    Language English
    Publishing date 2021-06-23
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 396-7
    ISSN 0003-5548
    ISSN 0003-5548
    DOI 10.1127/anthranz/2021/1423
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ub I Zs.95: Show issues Location:
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  10. Article ; Online: Salivary Cytokines as Biomarkers for Oral Squamous Cell Carcinoma: A Systematic Review.

    Ferrari, Elena / Pezzi, Margherita E / Cassi, Diana / Pertinhez, Thelma A / Spisni, Alberto / Meleti, Marco

    International journal of molecular sciences

    2021  Volume 22, Issue 13

    Abstract: The prognosis of patients with oral squamous carcinoma (OSCC) largely depends on the stage at diagnosis, the 5-year survival rate being approximately 30% for advanced tumors. Early diagnosis, including the detection of lesions at risk for malignant ... ...

    Abstract The prognosis of patients with oral squamous carcinoma (OSCC) largely depends on the stage at diagnosis, the 5-year survival rate being approximately 30% for advanced tumors. Early diagnosis, including the detection of lesions at risk for malignant transformation, is crucial for limiting the need for extensive surgery and for improving disease-free survival. Saliva has gained popularity as a readily available source of biomarkers (including cytokines) useful for diagnosing specific oral and systemic conditions. Particularly, the close interaction between oral dysplastic/neoplastic cells and saliva makes such fluid an ideal candidate for the development of non-invasive and highly accurate diagnostic tests. The present review has been designed to answer the question: "Is there evidence to support the role of specific salivary cytokines in the diagnosis of OSCC?" We retrieved 27 observational studies satisfying the inclusion and exclusion criteria. Among the most frequent cytokines investigated as candidates for OSCC biomarkers, IL-6, IL-8, TNF-α are present at higher concentration in the saliva of OSCC patients than in healthy controls and may therefore serve as basis for the development of rapid tests for early diagnosis of oral cancer.
    MeSH term(s) Biomarkers ; Biomarkers, Tumor ; Carcinoma, Squamous Cell/diagnosis ; Carcinoma, Squamous Cell/metabolism ; Cytokines/metabolism ; Humans ; Liquid Biopsy/methods ; Mouth Neoplasms/diagnosis ; Mouth Neoplasms/metabolism ; Prognosis ; Saliva/metabolism
    Chemical Substances Biomarkers ; Biomarkers, Tumor ; Cytokines
    Language English
    Publishing date 2021-06-24
    Publishing country Switzerland
    Document type Journal Article ; Meta-Analysis ; Review ; Systematic Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms22136795
    Database MEDical Literature Analysis and Retrieval System OnLINE

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