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  1. Article ; Online: Sperm Mitochondria, the Driving Force Behind Human Spermatozoa Activities: Its Functions and Dysfunctions - A Narrative Review.

    Kumar, Naina

    Current molecular medicine

    2022  Volume 23, Issue 4, Page(s) 332–340

    Abstract: Male infertility is a major issue, and numerous factors contribute to it. One of the important organelles involved in the functioning of human spermatozoa is mitochondria. There are 50-75 mitochondria helically arranged in mid-piece bearing one ... ...

    Abstract Male infertility is a major issue, and numerous factors contribute to it. One of the important organelles involved in the functioning of human spermatozoa is mitochondria. There are 50-75 mitochondria helically arranged in mid-piece bearing one mitochondrial DNA each. Sperm mitochondria play a crucial role in sperm functions, including the energy production required for sperm motility and the production of reactive oxygen species, which in the physiological range helps in sperm maturation, capacitation, and acrosome reaction. It also plays a role in calcium signaling cascades, intrinsic apoptosis, and sperm hyperactivation. Any structural or functional dysfunction of sperm mitochondria results in increased production of reactive oxygen species and, a state of oxidative stress, decreased energy production, all leading to sperm DNA damage, impaired sperm motility and semen parameters, and reduced male fertility. Furthermore, human sperm mitochondrial DNA mutations can result in impaired sperm motility and parameters leading to male infertility. Numerous types of point mutations, deletions, and missense mutations have been identified in mtDNA that are linked with male infertility. Methods: Recent literature was searched from English language peer-reviewed journals from databases including PubMed, Scopus, EMBASE, Scholar, and Web of Science till September 2021. Search terms used were "Sperm mitochondria and male fertility", "Bioenergetics of sperm", "Sperm mitochondria and reactive oxygen species", "Sperm mitochondrial mutations and infertility". Conclusion: Sperm mitochondria is an important organelle involved in various functions of human spermatozoa and sperm mitochondrial DNA has emerged as one of the potent biomarkers of sperm quality and male fertility.
    MeSH term(s) Humans ; Male ; Semen ; Reactive Oxygen Species ; Sperm Motility ; Mitochondria/genetics ; Spermatozoa ; DNA, Mitochondrial/genetics ; Infertility, Male/genetics
    Chemical Substances Reactive Oxygen Species ; DNA, Mitochondrial
    Language English
    Publishing date 2022-04-07
    Publishing country Netherlands
    Document type Review ; Journal Article
    ZDB-ID 2064873-X
    ISSN 1875-5666 ; 1566-5240
    ISSN (online) 1875-5666
    ISSN 1566-5240
    DOI 10.2174/1566524022666220408104047
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5580: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: What is your diagnosis?

    Palo, Seetu / Mangla, Mishu / Kanikaram, Poojitha / Kumar, Naina

    Journal of the Turkish German Gynecological Association

    2023  Volume 24, Issue 4, Page(s) 284–286

    Language English
    Publishing date 2023-12-06
    Publishing country Turkey
    Document type Journal Article
    ZDB-ID 2425806-4
    ISSN 1309-0380 ; 1303-9695 ; 1309-0399
    ISSN (online) 1309-0380 ; 1303-9695
    ISSN 1309-0399
    DOI 10.4274/jtgga.galenos.2023.2022-12-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: COVID 19 era: a beginning of upsurge in unwanted pregnancies, unmet need for contraception and other women related issues.

    Kumar, Naina

    The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception

    2020  Volume 25, Issue 4, Page(s) 323–325

    Abstract: The Novel Coronavirus disease that was first identified in Wuhan city of China in December 2019 has emerged as one of the fastest spreading pandemics all over the world affecting millions of people and causing millions of deaths worldwide. In an attempt ... ...

    Abstract The Novel Coronavirus disease that was first identified in Wuhan city of China in December 2019 has emerged as one of the fastest spreading pandemics all over the world affecting millions of people and causing millions of deaths worldwide. In an attempt to control its spread, countries have imposed local and national lockdowns, affecting many healthcare services, especially sexual and reproductive health services which are actually essential and lifesaving. In near future this will result in a large number of grave consequences including increased unmet need for modern contraceptives, unintended pregnancies, increased unsafe abortions, maternal and neonatal deaths and other harmful practices like female genital mutilation and child marriages in developing countries. The present short review focusses on such issues which will be dramatically increased depending on the duration of lockdowns and the time for which the sexual and reproductive health services will remain halted. It also reflects the need for considering reproductive health services as essential, allowing the people to avail these services without any fear and hence, saving many more lives which will be lost not due to coronavirus infection.
    MeSH term(s) Betacoronavirus ; COVID-19 ; Contraception ; Coronavirus Infections/epidemiology ; Family Planning Services/organization & administration ; Female ; Health Services Accessibility ; Health Services Needs and Demand ; Humans ; Pandemics ; Pneumonia, Viral/epidemiology ; Pregnancy ; Pregnancy, Unwanted ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-06-22
    Publishing country England
    Document type Journal Article ; Review ; Video-Audio Media
    ZDB-ID 1397560-2
    ISSN 1473-0782 ; 1362-5187
    ISSN (online) 1473-0782
    ISSN 1362-5187
    DOI 10.1080/13625187.2020.1777398
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4819: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  4. Article: Meningioma getting a common presentation in uncommon Cowden syndrome: A case report.

    Patnaik, Ashis / Pattnaik, Naina / Sekar, Arunkumar / Singh, Dhirendra Kumar

    Journal of neurosciences in rural practice

    2023  Volume 14, Issue 4, Page(s) 756–758

    Language English
    Publishing date 2023-10-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2601242-X
    ISSN 0976-3155 ; 0976-3147
    ISSN (online) 0976-3155
    ISSN 0976-3147
    DOI 10.25259/JNRP_305_2023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: COVID 19 era

    Kumar, Naina

    The European Journal of Contraception & Reproductive Health Care

    a beginning of upsurge in unwanted pregnancies, unmet need for contraception and other women related issues

    2020  Volume 25, Issue 4, Page(s) 323–325

    Keywords Obstetrics and Gynaecology ; Pharmacology (medical) ; Reproductive Medicine ; covid19
    Language English
    Publisher Informa UK Limited
    Publishing country uk
    Document type Article ; Online
    ZDB-ID 1397560-2
    ISSN 1362-5187
    ISSN 1362-5187
    DOI 10.1080/13625187.2020.1777398
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4819: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  6. Article: What is your diagnosis?

    Mangla, Mishu / Sivakoti, Sumitra / Gabbeta, Spandana / Kumar, Naina / Shrinivas, Somalwar B / Srirambhatla, Annapurna

    Journal of the Turkish German Gynecological Association

    2023  Volume 24, Issue 3, Page(s) 220–224

    Language English
    Publishing date 2023-09-07
    Publishing country Turkey
    Document type Journal Article
    ZDB-ID 2425806-4
    ISSN 1309-0380 ; 1303-9695 ; 1309-0399
    ISSN (online) 1309-0380 ; 1303-9695
    ISSN 1309-0399
    DOI 10.4274/jtgga.galenos.2023.2022-12-13
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Stratified Mucin-Producing Intraepithelial Lesion of the Cervix in an HPV- 16 Positive Woman: A Rare Encounter.

    Kumar, Naina / Mangla, Mishu / Palo, Seetu / Gabbeta, Spandana / Aparna, J

    Infectious disorders drug targets

    2024  

    Abstract: Background: Cervical cancer is the fourth most common cancer among women globally and has a strong association with Human Papillomavirus (HPV) infection. Stratified mucinproducing intraepithelial lesion (SMILE), a variant of Adenocarcinoma in situ (AIS), ...

    Abstract Background: Cervical cancer is the fourth most common cancer among women globally and has a strong association with Human Papillomavirus (HPV) infection. Stratified mucinproducing intraepithelial lesion (SMILE), a variant of Adenocarcinoma in situ (AIS), is a rare cervical precancer lesion that is often missed or detected incidentally.
    Case presentation: The present case report briefs the finding of a 39-year-old woman who presented to the gynecological outpatient department with complaints of vaginal discharge for 6-8 months. She had no history of irregular menstrual cycles or postcoital bleeding. Her routine Pap smear revealed atypical squamous cells of undetermined significance (ASCUS) and was positive for HPV-16 type. Her cervical biopsy report revealed AIS and her histopathological report of hysterectomy revealed SMILE, a variant of AIS.
    Discussion: The SMILE variant of AIS is a rare cervical precancerous lesion characterized by the morphological overlap of both squamous intraepithelial lesions and AIS. It is often difficult to diagnose on Pap smear and is commonly associated with high-risk HPV infections. The management of SMILE is the same as that for AIS, which is the excisional procedure followed by a hysterectomy if the margins are negative and depending on the fertility desires of the patient, followed by regular follow-up with HPV testing.
    Conclusion: SMILE is a rare variant of AIS, which is often missed on cytological screening of the cervix. It is commonly associated with high-risk types of HPV. Hence, incorporating HPV testing in the screening of cervical cancer is important and recommended to increase the overall sensitivity of screening for adenocarcinoma lesions.
    Language English
    Publishing date 2024-01-29
    Publishing country United Arab Emirates
    Document type Case Reports
    ZDB-ID 2234298-9
    ISSN 2212-3989 ; 1871-5265
    ISSN (online) 2212-3989
    ISSN 1871-5265
    DOI 10.2174/0118715265284722240110114107
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5598: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  8. Article ; Online: Influence of paired pandemic of COVID-19 and HIV infection on pregnant women and children: A challenging issue.

    Kumar, Naina / Mangla, Mishu

    Journal of mother and child

    2022  Volume 25, Issue 2, Page(s) 123–126

    Abstract: COVID-19 infection started in China in December 2019 and was declared a global pandemic of international concern by the WHO in March 2020. With rapid spread of infection worldwide, health systems and health care programs came to a standstill, leaving ... ...

    Abstract COVID-19 infection started in China in December 2019 and was declared a global pandemic of international concern by the WHO in March 2020. With rapid spread of infection worldwide, health systems and health care programs came to a standstill, leaving essential services such as antenatal care and human immunodeficiency virus (HIV) comprehensive care for children and pregnant women completely devastated. Furthermore, due to lockdowns, children and pregnant women living with HIV were forced to stay at home with no access to health facilities, loss of follow-up, and discontinuation of antiretroviral drugs therapy. The present review briefs concerning the impact of COVID-19 and HIV/AIDS pandemics on children and pregnant women worldwide.
    MeSH term(s) COVID-19 ; Child ; Communicable Disease Control ; Female ; HIV Infections/drug therapy ; HIV Infections/epidemiology ; Humans ; Pandemics ; Pregnancy ; Pregnant Women ; SARS-CoV-2
    Language English
    Publishing date 2022-04-01
    Publishing country Poland
    Document type Journal Article ; Review
    ISSN 2719-535X
    ISSN (online) 2719-535X
    DOI 10.34763/jmotherandchild.20212502.d-21-00017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Synthesis and mechanistic study of ultrashort peptides that inhibits Alzheimer's Aβ-aggregation-induced neurotoxicity.

    Sehra, Naina / Parmar, Rajesh / Maurya, Indresh K / Kumar, Vinod / Tikoo, Kulbhushan / Jain, Rahul

    Bioorganic chemistry

    2024  Volume 144, Page(s) 107159

    Abstract: Misfolding/aggregation of β-amyloid peptide lead to the formation of toxic oligomers or accumulation of amyloid plaques, which is a seminal step in the progression of Alzheimer's disease (AD). Despite continuous efforts in the development of therapeutic ... ...

    Abstract Misfolding/aggregation of β-amyloid peptide lead to the formation of toxic oligomers or accumulation of amyloid plaques, which is a seminal step in the progression of Alzheimer's disease (AD). Despite continuous efforts in the development of therapeutic agents, the cure for AD remains a major challenge. Owing to specific binding affinity of structure-based peptides, we report the synthesis of new peptide-based inhibitors derived from the C-terminal sequences, Aβ
    MeSH term(s) Humans ; Alzheimer Disease/drug therapy ; Amyloid beta-Peptides/metabolism ; Cell Survival
    Chemical Substances Amyloid beta-Peptides
    Language English
    Publishing date 2024-01-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 120080-x
    ISSN 1090-2120 ; 0045-2068
    ISSN (online) 1090-2120
    ISSN 0045-2068
    DOI 10.1016/j.bioorg.2024.107159
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4207: Show issues Location:
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  10. Article ; Online: Role of admission cardiotocography in predicting the obstetric outcome in term antenatal women: A prospective observational study.

    Kumar, Naina / Yadav, Monu

    Journal of mother and child

    2022  Volume 26, Issue 1, Page(s) 43–49

    Abstract: Background: Admission cardiotocography (CTG) used for fetal heart rate monitoring is an easy, cost-effective, non-invasive screening method for fetal well-being.: Objectives: To evaluate the role of admission CTG in predicting fetal hypoxia in term ... ...

    Abstract Background: Admission cardiotocography (CTG) used for fetal heart rate monitoring is an easy, cost-effective, non-invasive screening method for fetal well-being.
    Objectives: To evaluate the role of admission CTG in predicting fetal hypoxia in term antenatal women during labour ward admission and to correlate the results with perinatal and maternal outcomes.
    Material and methods: The present prospective observational study was conducted in the Obstetrics and Gynecology Department of the rural tertiary centre in Northern India over one year on 100 term antenatal women admitted to the labour ward in the first stage of labour. Participants were subjected to admission CTG for 20 minutes, and the pattern of fetal heart rate (reactive, suspicious, ominous) was recorded. Perinatal and maternal outcomes were assessed based on the fetal heart rate pattern on the admission CTG.
    Results: Of 100 term antenatal women, 51 were low-risk and 49 were high-risk cases. In the low-risk group, 92.16% had reactive traces, 3.92% suspicious and 3.92% ominous traces on admission CTG, whereas, in the high-risk group, 40.81% had reactive, 32.65% suspicious and 26.54% ominous tracing (p < 0.0001). The most common mode of delivery in both groups with ominous tracing was cesarean section (p = 0.0001). Abnormal CTG was significantly associated with adverse perinatal outcomes including poor one-minute Apgar scores (p < 0.05), need for resuscitation and NICU admission (p < 0.05). The specificity and negative predictive value of admission CTG in low- and high-risk groups were 97.9% and 93.6%, and 85.0% and 85.0%, respectively.
    Conclusion: Admission CTG is an effective, inexpensive, non-invasive technique to detect fetal hypoxia in low-and high-risk pregnancies in developing countries with an increased workload.
    MeSH term(s) Pregnancy ; Humans ; Female ; Cardiotocography/methods ; Cesarean Section ; Fetal Hypoxia ; Labor, Obstetric ; Prospective Studies
    Language English
    Publishing date 2022-11-02
    Publishing country Poland
    Document type Observational Study ; Journal Article
    ISSN 2719-535X
    ISSN (online) 2719-535X
    DOI 10.34763/jmotherandchild.20222601.d-22-00017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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