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Article ; Online: Zika virus, vaccines, and antiviral strategies.

Masmejan, Sophie / Baud, David / Musso, Didier / Panchaud, Alice

2018 Volume 16, Issue 6, Page(s) 471–483

Abstract: Introduction: Zika virus (ZIKV) recently emerged as a global public health emergency of international concern. ZIKV is responsible for severe neurological complications in adults and infection during pregnancy and can lead to congenital Zika syndrome. ... ...

Abstract	Introduction: Zika virus (ZIKV) recently emerged as a global public health emergency of international concern. ZIKV is responsible for severe neurological complications in adults and infection during pregnancy and can lead to congenital Zika syndrome. There is no licensed vaccine or drug to prevent or treat ZIKV infection. Areas covered: The aim of this article is to provide an overview and update of the progress of research on anti-ZIKV vaccine and medications until the end of 2017, with a special emphasis on drugs that can be used during pregnancy. Expert commentary: Development of new vaccines and drugs is challenging and several points particular to ZIKV infections augment this difficulty: (1) Cross-reactions between ZIKV and other flaviviruses, the impact of ZIKV vaccination on subsequent flavivirus infections, and vice-versa, is unknown, (2) Drugs against ZIKV should be safe in pregnant women, and (3) Evaluation of the efficacy of vaccine and drugs against ZIKV in clinical trials phase II-IV will be complicated due to the decline of ZIKV circulation.
MeSH term(s)	Adult ; Animals ; Antiviral Agents/administration & dosage ; Antiviral Agents/adverse effects ; Drug Design ; Female ; Humans ; Infectious Disease Transmission, Vertical/prevention & control ; Pregnancy ; Pregnancy Complications, Infectious/virology ; Vaccination/methods ; Viral Vaccines/administration & dosage ; Zika Virus Infection/complications ; Zika Virus Infection/epidemiology ; Zika Virus Infection/prevention & control
Chemical Substances	Antiviral Agents ; Viral Vaccines
Language	English
Publishing date	2018-06-28
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2181279-2
ISSN	1744-8336 ; 1478-7210
ISSN (online)	1744-8336
ISSN	1478-7210
DOI	10.1080/14787210.2018.1483239
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Zs.A 6106: Show issues

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Article ; Online: Management of fetal tumors.

Masmejan, Sophie / Baud, David / Ryan, Greg / Van Mieghem, Tim

Best practice & research. Clinical obstetrics & gynaecology

2019 Volume 58, Page(s) 107–120

Abstract: In this review article, we discuss the most common fetal tumors, their prenatal management, and outcomes. Overall, the most important outcome predictors are tumor histology, size, vascularity, and location. Very large lesions, lesions causing cardiac ... ...

Abstract	In this review article, we discuss the most common fetal tumors, their prenatal management, and outcomes. Overall, the most important outcome predictors are tumor histology, size, vascularity, and location. Very large lesions, lesions causing cardiac failure, and hydrops and lesions obstructing the fetal airway have the poorest outcome, as they may cause fetal death or complications at the time of delivery. Fetal therapy has been developed to improve outcomes for the most severe cases and can consist of transplacental therapy (sirolimus for rhabdomyomas or steroids for hemangiomas and microcystic lung lesions) or surgical intervention (shunting of cystic masses, tumor ablation, occlusion of blood flow or airway exploration, and protection). Given the rarity of fetal tumors, patients should be referred to expert centers where care can be optimized and individualized to allow the best possible outcomes.
MeSH term(s)	Female ; Fetal Diseases/diagnostic imaging ; Fetal Diseases/pathology ; Fetal Diseases/therapy ; Fetal Therapies/adverse effects ; Fetal Therapies/methods ; Humans ; Hydrops Fetalis/diagnosis ; Neoplasms/diagnostic imaging ; Neoplasms/pathology ; Neoplasms/therapy ; Pregnancy ; Ultrasonography, Prenatal
Language	English
Publishing date	2019-01-14
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	2050090-7
ISSN	1532-1932 ; 1521-6934
ISSN (online)	1532-1932
ISSN	1521-6934
DOI	10.1016/j.bpobgyn.2019.01.006
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Article: COVID-19 et grossesse.

Masmejan, Sophie / Pomar, Leo / Lepigeon, Karine / Favre, Guillaume / Baud, David / Rieder, Wawrzyniec

Revue medicale suisse

2020 Volume 16, Issue 692, Page(s) 944–946

Abstract: The current COVID-19 pandemic has resulted in an unprecedented worldwide health crisis. The increased vulnerability of pregnant women as well as past experience from previous coronavirus epidemics are cause for concern of maternal and fetal complications. ...

Title translation	COVID-19 and pregnancy.
Abstract	The current COVID-19 pandemic has resulted in an unprecedented worldwide health crisis. The increased vulnerability of pregnant women as well as past experience from previous coronavirus epidemics are cause for concern of maternal and fetal complications. The rapid outbreak of the disease combined with the uncertainty, as a direct result of the lack of strong scientific data, has forced obstetricians to adapt their current practices pragmatically. This article reviews obstetrical management of pregnant patients infected by SARS-CoV-2 based on the current knowledge.
MeSH term(s)	Betacoronavirus ; COVID-19 ; Coronavirus Infections/complications ; Coronavirus Infections/epidemiology ; Female ; Humans ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/epidemiology ; Pregnancy ; Pregnancy Complications, Infectious ; SARS-CoV-2
Keywords	covid19
Language	French
Publishing date	2020-05-06
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2177010-4
ISSN	1660-9379
ISSN	1660-9379
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Zs.A 5998: Show issues

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Article: Zika Virus

Masmejan, Sophie / Musso, Didier / Vouga, Manon / Pomar, Leo / Dashraath, Pradip / Stojanov, Milos / Panchaud, Alice / Baud, David

Pathogens. 2020 Oct. 28, v. 9, no. 11

2020

Abstract: Zika virus (ZIKV), a neurotropic single-stranded RNA flavivirus, remains an important cause of congenital infection, fetal microcephaly, and Guillain-Barré syndrome in populations where ZIKV has adapted to a nexus involving the Aedes mosquitoes and ... ...

Abstract	Zika virus (ZIKV), a neurotropic single-stranded RNA flavivirus, remains an important cause of congenital infection, fetal microcephaly, and Guillain-Barré syndrome in populations where ZIKV has adapted to a nexus involving the Aedes mosquitoes and humans. To date, outbreaks of ZIKV have occurred in Africa, Southeast Asia, the Pacific islands, the Americas, and the Caribbean. Emerging evidence, however, suggests that the virus also has the potential to cause infections in Europe, where autochtonous transmission of the virus has been identified. This review focuses on evolving ZIKV epidemiology, modes of transmission and host-virus interactions. The clinical manifestations, diagnostic issues relating to cross-reactivity to the dengue flavivirus and concerns surrounding ZIKV infection in pregnancy are discussed. In the last section, current challenges in treatment and prevention are outlined.
Keywords	Aedes ; RNA ; Zika virus ; cross reaction ; dengue ; epidemiology ; host-pathogen relationships ; humans ; infection ; pathogens ; population ; pregnancy ; viruses ; Africa ; Caribbean ; Europe ; Pacific Ocean Islands ; South East Asia
Language	English
Dates of publication	2020-1028
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
Note	NAL-light
ZDB-ID	2695572-6
ISSN	2076-0817
ISSN	2076-0817
DOI	10.3390/pathogens9110898
Database	NAL-Catalogue (AGRICOLA)

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Article: Zika Virus.

Masmejan, Sophie / Musso, Didier / Vouga, Manon / Pomar, Leo / Dashraath, Pradip / Stojanov, Milos / Panchaud, Alice / Baud, David

Pathogens (Basel, Switzerland)

2020 Volume 9, Issue 11

Abstract	Zika virus (ZIKV), a neurotropic single-stranded RNA flavivirus, remains an important cause of congenital infection, fetal microcephaly, and Guillain-Barré syndrome in populations where ZIKV has adapted to a nexus involving the
Language	English
Publishing date	2020-10-28
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2695572-6
ISSN	2076-0817
ISSN	2076-0817
DOI	10.3390/pathogens9110898
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Article ; Online: Dengue, Zika and chikungunya during pregnancy: pre- and post-travel advice and clinical management.

Vouga, Manon / Chiu, Yen-Chi / Pomar, Léo / de Meyer, Sara V / Masmejan, Sophie / Genton, Blaise / Musso, Didier / Baud, David / Stojanov, Milos

Journal of travel medicine

2019 Volume 26, Issue 8

Abstract: Rationale for review: Young adults of childbearing age and pregnant women are travelling more frequently to tropical areas, exposing them to specific arboviral infections such as dengue, zika and chikungunya viruses, which may impact ongoing and future ... ...

Abstract	Rationale for review: Young adults of childbearing age and pregnant women are travelling more frequently to tropical areas, exposing them to specific arboviral infections such as dengue, zika and chikungunya viruses, which may impact ongoing and future pregnancies. In this narrative review, we analyse their potential consequences on pregnancy outcomes and discuss current travel recommendations. Main findings: Dengue virus may be associated with severe maternal complications, particularly post-partum haemorrhage. Its association with adverse fetal outcomes remains unclear, but prematurity, growth retardation and stillbirths may occur, particularly in cases of severe maternal infection. Zika virus is a teratogenic infectious agent associated with severe brain lesions, with similar risks to other well-known TORCH pathogens. Implications of chikungunya virus in pregnancy are mostly related to intrapartum transmission that may be associated with severe neonatal infections and long-term morbidity. Travel recommendations: Few agencies provide specific travel recommendations for travelling pregnant patients or couples trying to conceive and discrepancies exist, particularly regarding Zika virus prevention. The risks significantly depend on epidemiological factors that may be difficult to predict. Prevention relies principally on mosquito control measures. Couples trying to conceive and pregnant women should receive adequate information about the potential risks. It seems reasonable to advise pregnant women to avoid unnecessary travel to Aedes spp. endemic regions. The current rationale to avoid travel and delay conception is debatable in the absence of any epidemic. Post-travel laboratory testing should be reserved for symptomatic patients.
MeSH term(s)	Chikungunya Fever/epidemiology ; Dengue/epidemiology ; Female ; Humans ; Pregnancy ; Pregnancy Complications, Infectious/virology ; Travel ; Zika Virus Infection/epidemiology
Language	English
Publishing date	2019-12-09
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1212504-0
ISSN	1708-8305 ; 1195-1982
ISSN (online)	1708-8305
ISSN	1195-1982
DOI	10.1093/jtm/taz077
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Zs.A 4120: Show issues

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Article ; Online: Natural History of Ventriculomegaly in Fetal Agenesis of the Corpus Callosum.

Masmejan, Sophie / Blaser, Susan / Keunen, Johannes / Seaward, Gareth / Windrim, Rory / Kelly, Edmond / Ryan, Greg / Baud, David / Van Mieghem, Tim

Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine

2019 Volume 39, Issue 3, Page(s) 483–488

Abstract: Objectives: To assess the natural evolution of the size of the fetal lateral ventricles throughout pregnancy in fetuses with callosal anomalies.: Methods: Cases of fetal callosal anomalies were retrospectively classified as isolated or complex based ... ...

Abstract	Objectives: To assess the natural evolution of the size of the fetal lateral ventricles throughout pregnancy in fetuses with callosal anomalies. Methods: Cases of fetal callosal anomalies were retrospectively classified as isolated or complex based on the presence of other structural or genetic anomalies. Longitudinal ultrasound studies were reviewed, and postnatal outcomes were retrieved for isolated cases. Results: In 135 fetuses, those who first presented after 24 weeks' gestation were more likely to have ventriculomegaly (n = 58 of 68 [85%]) than those who presented before 24 weeks (n = 39 of 67 [58%]; P < .001). In 79 cases that had longitudinal follow-up, the mean increase in ventricular width was 0.6 mm/wk, without a significant difference between isolated and complex cases (mean ± SD, 0.6 ± 1.5 versus 0.6 ± 1.1 mm; P = .45). Conclusions: Callosal anomalies are associated with progressive ventriculomegaly on prenatal ultrasound imaging, without a difference between isolated and complex anomalies. This feature should be considered part of the disease spectrum. The consequence of progressive ventriculomegaly on the long-term neurodevelopmental outcome is still unknown, and further studies should be aimed at obtaining long-term follow-up of these cases.
MeSH term(s)	Adolescent ; Adult ; Agenesis of Corpus Callosum/complications ; Agenesis of Corpus Callosum/diagnostic imaging ; Agenesis of Corpus Callosum/embryology ; Corpus Callosum/diagnostic imaging ; Corpus Callosum/embryology ; Disease Progression ; Female ; Humans ; Hydrocephalus/complications ; Hydrocephalus/diagnostic imaging ; Hydrocephalus/embryology ; Middle Aged ; Pregnancy ; Retrospective Studies ; Severity of Illness Index ; Ultrasonography, Prenatal/methods ; Young Adult
Language	English
Publishing date	2019-09-09
Publishing country	England
Document type	Journal Article
ZDB-ID	604829-8
ISSN	1550-9613 ; 0278-4297
ISSN (online)	1550-9613
ISSN	0278-4297
DOI	10.1002/jum.15124
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Zs.A 1793: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Ten Year Experience of Using Cryopreserved Arterial Allografts for Distal Bypass in Critical Limb Ischaemia.

Masmejan, Sophie / Deslarzes-Dubuis, Celine / Petitprez, Severine / Longchamp, Alban / Haller, Claude / Saucy, François / Corpataux, Jean-Marc / Déglise, Sebastien

European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery

2019 Volume 57, Issue 6, Page(s) 823–831

Abstract: Objective/background: In critical limb ischaemia (CLI), current guidelines recommend revascularisation whenever possible, preferentially through endovascular means. However, in the case of long occlusions or failed endovascular attempts, distal bypasses ...

Abstract	Objective/background: In critical limb ischaemia (CLI), current guidelines recommend revascularisation whenever possible, preferentially through endovascular means. However, in the case of long occlusions or failed endovascular attempts, distal bypasses still have a place. Single segment great saphenous vein (GSV), which provides the best conduit, is often not available and currently there is no consensus about the best alternative graft. Methods: From January 2006 to December 2015, 42 cryopreserved arterial allografts were used for a distal bypass. Autologous GSVs or alternative autologous conduits were unavailable for all patients. The patients were observed for survival, limb salvage, and allograft patency. The results were analysed with Kaplan-Meier graphs. Results: Estimates of secondary patency at one, two and five years were 81%, 73%, and 57%, respectively. Estimates of primary patency rates at one, two and five years were 60%, 56%, and 26%, respectively. Estimates of limb salvage rates at one, two and five years were 89%, 89%, and 82%, respectively. Estimates of survival rates at one, two and five years were 92%, 76% and 34%, respectively. At 30 days, major amputations and major adverse cardiac events were one and zero, respectively. Six major amputations occurred during the long-term follow up. Conclusion: Despite a low primary patency rate at two years, the secondary patency of arterial allografts is acceptable for distal bypasses. This suggests that cryopreserved arterial allografts are a suitable alternative for limb saving distal bypasses in the absence of venous conduits, improving limb salvage rates and, possibly, quality of life.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Allografts ; Amputation ; Arteries/transplantation ; Critical Illness ; Cryopreservation ; Female ; Graft Occlusion, Vascular/etiology ; Graft Occlusion, Vascular/physiopathology ; Graft Occlusion, Vascular/surgery ; Humans ; Ischemia/diagnostic imaging ; Ischemia/physiopathology ; Ischemia/surgery ; Limb Salvage ; Lower Extremity/blood supply ; Male ; Middle Aged ; Reoperation ; Retrospective Studies ; Risk Factors ; Time Factors ; Treatment Outcome ; Vascular Grafting/adverse effects ; Vascular Grafting/methods ; Vascular Patency
Language	English
Publishing date	2019-05-23
Publishing country	England
Document type	Journal Article
ZDB-ID	1225869-6
ISSN	1532-2165 ; 1078-5884
ISSN (online)	1532-2165
ISSN	1078-5884
DOI	10.1016/j.ejvs.2018.11.020
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Zs.A 2283: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 381: Show issues

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Article ; Online: Zika Virus

Sophie Masmejan / Didier Musso / Manon Vouga / Leo Pomar / Pradip Dashraath / Milos Stojanov / Alice Panchaud / David Baud

Pathogens, Vol 9, Iss 898, p

2020 Volume 898

Abstract	Zika virus (ZIKV), a neurotropic single-stranded RNA flavivirus, remains an important cause of congenital infection, fetal microcephaly, and Guillain-Barré syndrome in populations where ZIKV has adapted to a nexus involving the Aedes mosquitoes and humans. To date, outbreaks of ZIKV have occurred in Africa, Southeast Asia, the Pacific islands, the Americas, and the Caribbean. Emerging evidence, however, suggests that the virus also has the potential to cause infections in Europe, where autochtonous transmission of the virus has been identified. This review focuses on evolving ZIKV epidemiology, modes of transmission and host-virus interactions. The clinical manifestations, diagnostic issues relating to cross-reactivity to the dengue flavivirus and concerns surrounding ZIKV infection in pregnancy are discussed. In the last section, current challenges in treatment and prevention are outlined.
Keywords	Zika ; Zika virus ; emerging infectious diseases ; congenital Zika syndrome ; materno-fetal infections ; Guillain-Barré syndrome ; Medicine ; R
Language	English
Publishing date	2020-10-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: Maternal Infection and Adverse Pregnancy Outcomes among Pregnant Travellers: Results of the International Zika Virus in Pregnancy Registry.

Vouga, Manon / Pomar, Léo / Soriano-Arandes, Antoni / Rodó, Carlota / Goncé, Anna / Gratacos, Eduard / Merriam, Audrey / Eperon, Isabelle / Martinez De Tejada, Begoña / Eggel, Béatrice / Masmejan, Sophie / Rochat, Laurence / Genton, Blaise / Van Mieghem, Tim / Lambert, Véronique / Malvy, Denis / Gérardin, Patrick / Baud, David / Panchaud, Alice

Viruses

2021 Volume 13, Issue 2

Abstract: In this multicentre cohort study, we evaluated the risks of maternal ZIKV infections and adverse pregnancy outcomes among exposed travellers compared to women living in areas with ZIKV circulation (residents). The risk of maternal infection was lower ... ...

Abstract	In this multicentre cohort study, we evaluated the risks of maternal ZIKV infections and adverse pregnancy outcomes among exposed travellers compared to women living in areas with ZIKV circulation (residents). The risk of maternal infection was lower among travellers compared to residents: 25.0% (
MeSH term(s)	Adult ; Cohort Studies ; Disease Outbreaks ; Epidemics ; Female ; Humans ; Pregnancy ; Pregnancy Complications, Infectious/epidemiology ; Pregnancy Complications, Infectious/physiopathology ; Pregnancy Complications, Infectious/virology ; Pregnancy Outcome ; Registries ; Travel/statistics & numerical data ; West Indies/epidemiology ; Young Adult ; Zika Virus/genetics ; Zika Virus/isolation & purification ; Zika Virus/physiology ; Zika Virus Infection/epidemiology ; Zika Virus Infection/physiopathology ; Zika Virus Infection/virology
Language	English
Publishing date	2021-02-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v13020341
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