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  1. Article ; Online: Selectively addressing total risk avoidance for certain chemicals while overlooking others: The case of per-and-poly-fluoroalkyls.

    Boretti, Alberto

    Regulatory toxicology and pharmacology : RTP

    2024  Volume 149, Page(s) 105602

    MeSH term(s) Humans ; Risk Assessment ; Hydrocarbons, Fluorinated ; Animals
    Chemical Substances Hydrocarbons, Fluorinated
    Language English
    Publishing date 2024-03-17
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 604672-1
    ISSN 1096-0295 ; 0273-2300
    ISSN (online) 1096-0295
    ISSN 0273-2300
    DOI 10.1016/j.yrtph.2024.105602
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    Zs.A 1711: Show issues Location:
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  2. Article ; Online: Curcumin-Based Fixed Dose Combination Products for Cholesterol Management: A Narrative Review.

    Boretti, Alberto

    ACS pharmacology & translational science

    2024  Volume 7, Issue 2, Page(s) 300–308

    Abstract: Curcumin, a polyphenol compound that belongs to a class of molecules known as curcuminoids, may interact with various biological macromolecules in the body, including proteins, nucleic acids, and lipids. Curcumin-based fixed-dose combination (FDC) ... ...

    Abstract Curcumin, a polyphenol compound that belongs to a class of molecules known as curcuminoids, may interact with various biological macromolecules in the body, including proteins, nucleic acids, and lipids. Curcumin-based fixed-dose combination (FDC) products enhance curcumin stability and bioavailability for better clinical use in cholesterol management. Preclinical studies on curcumin and cholesterol are mostly positive. Obstacles are the variable composition of the many different curcumin-based FDC products, the lack of standards, and the limitation of the randomized controlled trials (RCTs) conducted for specific products. Once these downfalls have been addressed, curcumin-based FDC products have great potential for cholesterol management. They can supplement the uptake of statins, reducing their dosage for the same controlling effects or even replacing them.
    Language English
    Publishing date 2024-01-09
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2575-9108
    ISSN (online) 2575-9108
    DOI 10.1021/acsptsci.3c00234
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  3. Article ; Online: mRNA vaccine boosters and impaired immune system response in immune compromised individuals: a narrative review.

    Boretti, Alberto

    Clinical and experimental medicine

    2024  Volume 24, Issue 1, Page(s) 23

    Abstract: Over the last 24 months, there has been growing evidence of a correlation between mRNA COVID-19 vaccine boosters and increased prevalence of COVID-19 infection and other pathologies. Recent works have added possible causation to correlation. mRNA vaccine ...

    Abstract Over the last 24 months, there has been growing evidence of a correlation between mRNA COVID-19 vaccine boosters and increased prevalence of COVID-19 infection and other pathologies. Recent works have added possible causation to correlation. mRNA vaccine boosters may impair immune system response in immune compromised individuals. Multiple doses of the mRNA COVID-19 vaccines may result in much higher levels of IgG 4 antibodies, or also impaired activation of CD4 + and CD8 + T cells. The opportunity for mRNA vaccine boosters to impair the immune system response needs careful consideration, as this impacts the cost-to-benefit ratio of the boosters' practice.
    MeSH term(s) Humans ; COVID-19 Vaccines/adverse effects ; mRNA Vaccines ; Immunoglobulin G ; Immune System ; RNA, Messenger
    Chemical Substances COVID-19 Vaccines ; mRNA Vaccines ; Immunoglobulin G ; RNA, Messenger
    Language English
    Publishing date 2024-01-27
    Publishing country Italy
    Document type Journal Article ; Review
    ZDB-ID 2053018-3
    ISSN 1591-9528 ; 1591-8890
    ISSN (online) 1591-9528
    ISSN 1591-8890
    DOI 10.1007/s10238-023-01264-1
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    Zs.A 5481: Show issues Location:
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  4. Article ; Online: Improving chimeric antigen receptor T-cell therapies by using artificial intelligence and internet of things technologies: A narrative review.

    Boretti, Alberto

    European journal of pharmacology

    2024  Volume 974, Page(s) 176618

    Abstract: Cancer poses a formidable challenge in the field of medical science, prompting the exploration of innovative and efficient treatment strategies. One revolutionary breakthrough in cancer therapy is Chimeric Antigen Receptor (CAR) T-cell therapy, an avant- ... ...

    Abstract Cancer poses a formidable challenge in the field of medical science, prompting the exploration of innovative and efficient treatment strategies. One revolutionary breakthrough in cancer therapy is Chimeric Antigen Receptor (CAR) T-cell therapy, an avant-garde method involving the customization of a patient's immune cells to combat cancer. Particularly successful in addressing blood cancers, CAR T-cell therapy introduces an unprecedented level of effectiveness, offering the prospect of sustained disease management. As ongoing research advances to overcome current challenges, CAR T-cell therapy stands poised to become an essential tool in the fight against cancer. Ongoing enhancements aim to improve its effectiveness and reduce time and cost, with the integration of Artificial Intelligence (AI) and Internet of Things (IoT) technologies. The synergy of AI and IoT could enable more precise tailoring of CAR T-cell therapy to individual patients, streamlining the therapeutic process. This holds the potential to elevate treatment efficacy, mitigate adverse effects, and expedite the overall progress of CAR T-cell therapies.
    Language English
    Publishing date 2024-04-26
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 80121-5
    ISSN 1879-0712 ; 0014-2999
    ISSN (online) 1879-0712
    ISSN 0014-2999
    DOI 10.1016/j.ejphar.2024.176618
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    Zs.A 522: Show issues Location:
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  5. Article ; Online: There is no reason to persist in the linear no-threshold (LNT) assumption.

    Boretti, Alberto

    Journal of environmental radioactivity

    2023  Volume 266-267, Page(s) 107239

    MeSH term(s) Radiation Monitoring ; Radiation Dosage ; Risk Assessment ; Linear Models ; Dose-Response Relationship, Radiation
    Language English
    Publishing date 2023-06-30
    Publishing country England
    Document type Letter
    ZDB-ID 1483112-0
    ISSN 1879-1700 ; 0265-931X
    ISSN (online) 1879-1700
    ISSN 0265-931X
    DOI 10.1016/j.jenvrad.2023.107239
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  6. Article ; Online: On the choice of Molnupiravir and Paxlovid as the only antivirals permitted for COVID-19 infection in Australia.

    Boretti, Alberto

    Clinical and experimental medicine

    2023  Volume 23, Issue 7, Page(s) 4033–4034

    MeSH term(s) Humans ; COVID-19 ; Australia/epidemiology ; Antiviral Agents/therapeutic use
    Chemical Substances molnupiravir (YA84KI1VEW) ; nirmatrelvir and ritonavir drug combination ; Antiviral Agents
    Language English
    Publishing date 2023-02-08
    Publishing country Italy
    Document type Letter
    ZDB-ID 2053018-3
    ISSN 1591-9528 ; 1591-8890
    ISSN (online) 1591-9528
    ISSN 1591-8890
    DOI 10.1007/s10238-023-01010-7
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    Zs.A 5481: Show issues Location:
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  7. Article ; Online: Potential use of curcumin against methicillin-resistant Staphylococcus infection.

    Boretti, Alberto

    Phytotherapy research : PTR

    2023  Volume 38, Issue 3, Page(s) 1165–1169

    MeSH term(s) Humans ; Curcumin ; Methicillin-Resistant Staphylococcus aureus ; Methicillin Resistance ; Staphylococcal Infections ; Staphylococcus ; Anti-Bacterial Agents
    Chemical Substances Curcumin (IT942ZTH98) ; Anti-Bacterial Agents
    Language English
    Publishing date 2023-04-21
    Publishing country England
    Document type Letter
    ZDB-ID 639136-9
    ISSN 1099-1573 ; 0951-418X
    ISSN (online) 1099-1573
    ISSN 0951-418X
    DOI 10.1002/ptr.7851
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    Zs.B 3092: Show issues Location:
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  8. Article ; Online: Evidence for the use of curcumin in radioprotection and radiosensitization.

    Boretti, Alberto

    Phytotherapy research : PTR

    2023  Volume 38, Issue 2, Page(s) 464–469

    Abstract: Curcumin has antineoplastic properties and is considered a chemotherapeutic and chemopreventive agent. Curcumin may be associated with radiation therapy (RT) as a radiosensitizer for cancer cells and a radioprotector for normal cells. In principle, it ... ...

    Abstract Curcumin has antineoplastic properties and is considered a chemotherapeutic and chemopreventive agent. Curcumin may be associated with radiation therapy (RT) as a radiosensitizer for cancer cells and a radioprotector for normal cells. In principle, it may result in a reduction of RT dosage for the same therapeutic effect on cancer cells, and further reduced damage to normal cells. Though the overall level of evidence is modest, limited to in vivo and in vitro experiences and practically no clinical trials, as the risks of adverse effects are extremely low, it is reasonable to promote the general supplementation with curcumin during RT targeting the reduction of side effects through anti-inflammatory mechanisms.
    MeSH term(s) Curcumin/pharmacology ; Curcumin/therapeutic use ; Antineoplastic Agents/pharmacology ; Radiation-Sensitizing Agents/pharmacology ; Radiation-Sensitizing Agents/therapeutic use
    Chemical Substances Curcumin (IT942ZTH98) ; Antineoplastic Agents ; Radiation-Sensitizing Agents
    Language English
    Publishing date 2023-03-10
    Publishing country England
    Document type Letter
    ZDB-ID 639136-9
    ISSN 1099-1573 ; 0951-418X
    ISSN (online) 1099-1573
    ISSN 0951-418X
    DOI 10.1002/ptr.7803
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    Zs.B 3092: Show issues Location:
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  9. Article ; Online: Revisiting Masselot et al. (2023): assessing the share of excess mortality linked to cold and hot weather in Europe.

    Boretti, Alberto

    International journal of biometeorology

    2023  Volume 68, Issue 3, Page(s) 527–533

    Abstract: While a considerable focus has been placed on excess fatalities during hot weather, a reanalysis of European data reveals that excess mortality attributed to cold weather is significantly more pronounced, surpassing that linked to hot weather by an order ...

    Abstract While a considerable focus has been placed on excess fatalities during hot weather, a reanalysis of European data reveals that excess mortality attributed to cold weather is significantly more pronounced, surpassing that linked to hot weather by an order of magnitude. These ratios are noteworthy: 56.32 for the United Kingdom, 43.56 for Northern Europe, 8.49 for Western Europe, 12.41 for Eastern Europe, 5.50 for Southern Europe, and an overall ratio of 10.09 for Europe as a whole. These ratios of cold to hot excess deaths indicate a significant disparity in the number of excess deaths caused by cold weather compared to those caused by hot weather. This significant difference underscores the greater health risks and vulnerabilities associated with cold weather.
    MeSH term(s) Cold Temperature ; Europe/epidemiology ; Hot Temperature ; Mortality ; United Kingdom ; Weather
    Language English
    Publishing date 2023-12-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 280324-0
    ISSN 1432-1254 ; 0020-7128
    ISSN (online) 1432-1254
    ISSN 0020-7128
    DOI 10.1007/s00484-023-02598-x
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    Zs.A 998: Show issues Location:
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  10. Article: Some Doubts Vaccine Boosters, Vaccine Passports, and Prohibition to Use Antivirals Help with Cases and Fatalities of COVID-19 Infection.

    Boretti, Alberto

    Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India

    2022  Volume 75, Issue 2, Page(s) 1290–1293

    Language English
    Publishing date 2022-11-06
    Publishing country India
    Document type Journal Article
    ZDB-ID 1471137-0
    ISSN 0973-7707 ; 2231-3796 ; 0019-5421
    ISSN (online) 0973-7707
    ISSN 2231-3796 ; 0019-5421
    DOI 10.1007/s12070-022-03202-1
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