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Article ; Online: A Tight Squeeze: Focal Tamponade and Obstructive Shock From Esophageal Stenting.

Atri, Deepak / Shappell, Claire / Dieffenbach, Paul B / Sun, Yee-Ping

JACC. Case reports

2019 Volume 1, Issue 1, Page(s) 70–72

Abstract: Cardiac tamponade is a rare cause of shock in the medical intensive care unit. This paper describes the case of a focal cardiac tamponade caused by compression of the left atrium due to an esophageal stent. Echocardiography yielded a diagnosis when other ...

Abstract	Cardiac tamponade is a rare cause of shock in the medical intensive care unit. This paper describes the case of a focal cardiac tamponade caused by compression of the left atrium due to an esophageal stent. Echocardiography yielded a diagnosis when other diagnostic methods did not. (
Language	English
Publishing date	2019-06-19
Publishing country	Netherlands
Document type	Journal Article
ISSN	2666-0849
ISSN (online)	2666-0849
DOI	10.1016/j.jaccas.2019.05.019
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: ST-Segment Elevation Myocardial Infarction Due to Right Coronary Artery Compression by Cardiac Synovial Sarcoma.

Atri, Deepak S / Tsao, Allison L / Yu, Paul B / Berry, Natalia C

JACC. Cardiovascular interventions

2019 Volume 12, Issue 17, Page(s) e145–e147

MeSH term(s)	Angioplasty, Balloon, Coronary/instrumentation ; Coronary Stenosis/diagnostic imaging ; Coronary Stenosis/etiology ; Coronary Stenosis/therapy ; Drug-Eluting Stents ; Heart Neoplasms/complications ; Heart Neoplasms/diagnostic imaging ; Heart Neoplasms/pathology ; Humans ; Male ; Middle Aged ; ST Elevation Myocardial Infarction/diagnostic imaging ; ST Elevation Myocardial Infarction/etiology ; ST Elevation Myocardial Infarction/therapy ; Sarcoma, Synovial/complications ; Sarcoma, Synovial/diagnostic imaging ; Sarcoma, Synovial/pathology ; Treatment Outcome
Language	English
Publishing date	2019-08-14
Publishing country	United States
Document type	Case Reports
ZDB-ID	2452157-7
ISSN	1876-7605 ; 1936-8798
ISSN (online)	1876-7605
ISSN	1936-8798
DOI	10.1016/j.jcin.2019.05.045
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Imidazo[2,1-b]thiazole based indoleamine-2,3-dioxygenase 1 (IDO1) inhibitor: Structure based design, synthesis, bio-evaluation and docking studies.

Singh, Rahul / Kumar, Ravinder / Roy, Ashalata / Behera, Pabitra Mohan / Atri, Ankit K / Kumar, Kushvinder / Manna, Debasis / Dixit, Anshuman / Patil, Madhuri T / Mankamna Kumari, R / Nimesh, Surendra / Salunke, Deepak B

Bioorganic & medicinal chemistry letters

2023 Volume 96, Page(s) 129532

Abstract: Indoleamine-2,3-dioxygenase 1 (IDO1) is an immunomodulatory enzyme known to catalyse the initial and rate limiting step of kynurenine pathway of l-tryptophan metabolism. IDO1 enzyme over expression plays a crucial role in progression of cancer, malaria, ... ...

Abstract	Indoleamine-2,3-dioxygenase 1 (IDO1) is an immunomodulatory enzyme known to catalyse the initial and rate limiting step of kynurenine pathway of l-tryptophan metabolism. IDO1 enzyme over expression plays a crucial role in progression of cancer, malaria, multiple sclerosis and other life-threatening diseases. Several efforts over the last two decades have been invested by the researchers for the discovery of different IDO1 inhibitors and the plasticity of the IDO1 enzyme ligand binding pocket provide ample opportunities to develop new heterocyclic scaffolds targeting this enzyme. In the present work, based on the X-ray crystal structure of human IDO1 coordinated with few ligands, we designed and synthesized new fused heterocyclic compounds and evaluated their potential human IDO1 inhibitory activity (compound 30 and 41 showed IC
MeSH term(s)	Humans ; Structure-Activity Relationship ; Enzyme Inhibitors/chemistry ; HEK293 Cells ; Indoleamine-Pyrrole 2,3,-Dioxygenase ; Protein Binding
Chemical Substances	Enzyme Inhibitors ; Indoleamine-Pyrrole 2,3,-Dioxygenase
Language	English
Publishing date	2023-10-20
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1063195-1
ISSN	1464-3405 ; 0960-894X
ISSN (online)	1464-3405
ISSN	0960-894X
DOI	10.1016/j.bmcl.2023.129532
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Jg. 1995 - 2021: Lesesall (2.OG)
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Article ; Online: COVID-19 for the Cardiologist: Basic Virology, Epidemiology, Cardiac Manifestations, and Potential Therapeutic Strategies.

Atri, Deepak / Siddiqi, Hasan K / Lang, Joshua P / Nauffal, Victor / Morrow, David A / Bohula, Erin A

JACC. Basic to translational science

2020 Volume 5, Issue 5, Page(s) 518–536

Abstract: Coronavirus disease-2019 (COVID-19), a contagious disease caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2), has reached pandemic status. As it spreads across the world, it has overwhelmed health care systems, strangled the global ... ...

Abstract	Coronavirus disease-2019 (COVID-19), a contagious disease caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2), has reached pandemic status. As it spreads across the world, it has overwhelmed health care systems, strangled the global economy, and led to a devastating loss of life. Widespread efforts from regulators, clinicians, and scientists are driving a rapid expansion of knowledge of the SARS-CoV-2 virus and COVID-19. The authors review the most current data, with a focus on the basic understanding of the mechanism(s) of disease and translation to the clinical syndrome and potential therapeutics. The authors discuss the basic virology, epidemiology, clinical manifestation, multiorgan consequences, and outcomes. With a focus on cardiovascular complications, they propose several mechanisms of injury. The virology and potential mechanism of injury form the basis for a discussion of potential disease-modifying therapies.
Keywords	covid19
Language	English
Publishing date	2020-04-10
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2452-302X
ISSN (online)	2452-302X
DOI	10.1016/j.jacbts.2020.04.002
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Risks and complications associated with dental implant failure: Critical update.

Dutta, Shubha Ranjan / Passi, Deepak / Singh, Purnima / Atri, Mansi / Mohan, Stuti / Sharma, Abhimanyu

National journal of maxillofacial surgery

2020 Volume 11, Issue 1, Page(s) 14–19

Abstract: Risks and complications have been identified with dental implant failure though there is continuous innovation in implant systems and various interceptive treatment modalities. The success rate of dental implants has increased over a period of years as a ...

Abstract	Risks and complications have been identified with dental implant failure though there is continuous innovation in implant systems and various interceptive treatment modalities. The success rate of dental implants has increased over a period of years as a treatment option for the rehabilitation of missing teeth. The dental implants are designed that best suits the various types of bone. Endosseous implants fail due to many reasons. Different reasons for the implant failure and their contributing factors have been discussed in this review article. A better understanding of the factors responsible for the implant failure will provide clinical decision-making and may enhance the field of implant dentistry. This article summarizes the factors causing implant failure. This paper presents the results of a survey of dentists practicing implant dentistry and updates regarding their knowledge of risk factors that they consider to be important for predicting dental implant failure.
Language	English
Publishing date	2020-06-18
Publishing country	India
Document type	Journal Article ; Review
ZDB-ID	2653583-X
ISSN	2229-3418 ; 0975-5950
ISSN (online)	2229-3418
ISSN	0975-5950
DOI	10.4103/njms.NJMS_75_16
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Prevalence, knowledge, attitude and nicotine dependence among ESI-insured populations of Delhi NCR region: Institutional study.

Agarwal, Aashita / Singh, Lakshita / Atri, Mansi / Gupta, Mayank / Sharma, Abhimanyu / Passi, Deepak

Journal of family medicine and primary care

2020 Volume 9, Issue 10, Page(s) 5271–5275

Abstract: Aim: To assess the prevalence of tobacco consumption among the ESI-insured patients. The study also assessed the knowledge, practice, and attitude among industrial workers as well as nicotine dependence with different forms of tobacco products consumed.! ...

Abstract	Aim: To assess the prevalence of tobacco consumption among the ESI-insured patients. The study also assessed the knowledge, practice, and attitude among industrial workers as well as nicotine dependence with different forms of tobacco products consumed. Materials and methods: A cross-sectional study was conducted among industrial workers from various industries (small and large scale) insured under the employee state insurance corporation scheme. The study was conducted for 3 months included 500 workers of which 470 were males and 30 were females. A predesigned, pretested, and structured interviewed administered questionnaire was used to collect the data on sociodemographic factors, reasons for tobacco consumed, and level of dependencies among industrial workers. Questionnaire also included questions related to awareness regarding health hazards and lesion present in the oral cavity as a result of tobacco consumption. Fegarstrom scale was used to access nicotine dependency level. A Hindi translated version of Fegarstrom test for Nicotine dependence in the questionnaire was used which included six standard questions for both smokeless and smoked form. Result: Majority of both males and females consumed tobacco in smokeless (58.8%) form. Out of which 92.85% in males and 7.15% in females followed by the smoke (28.8%) form. 93.04% in males and (7%) in females (79.86%) of the tobacco users in our study were aware that consuming tobacco causes health related problems. 38.6% of the users have moderate dependency in both smoke and smokeless form. Seventy six percent of the consumers feel that they didn't have any changes in the mouth by consuming tobacco and thus never thought of quitting tobacco. Conclusion: Tobacco consumption among the ESI-insured patients is high. Execution of tobacco cessation programs are required to curb this trend.
Language	English
Publishing date	2020-10-30
Publishing country	India
Document type	Journal Article
ZDB-ID	2735275-4
ISSN	2278-7135 ; 2249-4863
ISSN (online)	2278-7135
ISSN	2249-4863
DOI	10.4103/jfmpc.jfmpc_34_20
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: CRISPR-Cas9 Genome Editing of Primary Human Vascular Cells In Vitro.

Atri, Deepak S / Lee-Kim, Vivian S / Vellarikkal, Shamsudheen K / Sias-Garcia, Oscar / Yanamandala, Mounica / Schniztler, Gavin R / Gupta, Rajat M

Current protocols

2021 Volume 1, Issue 11, Page(s) e291

Abstract: Genome editing of primary human cells with CRISPR-Cas9 is a powerful tool to study gene function. For many cell types, there are efficient protocols for editing with optimized plasmids for Cas9 and sgRNA expression. Vascular cells, however, remain ... ...

Abstract	Genome editing of primary human cells with CRISPR-Cas9 is a powerful tool to study gene function. For many cell types, there are efficient protocols for editing with optimized plasmids for Cas9 and sgRNA expression. Vascular cells, however, remain refractory to plasmid-based delivery of CRISPR machinery for in vitro genome editing due to low transfection efficiency, poor expression of the Cas9 machinery, and toxic effects of the selection antibiotics. Here, we describe a method for high-efficiency editing of primary human vascular cells in vitro using nucleofection for direct delivery of sgRNA:Cas9-NLS ribonucleoprotein complexes. This method is more rapid and its high editing efficiency eliminates the need for additional selection steps. The edited cells can be employed in diverse applications, such as gene expression measurement or functional assays to assess various genetic perturbation effects in vitro. This method proves effective in vascular cells that are refractory to standard genome manipulation techniques using viral plasmid delivery. We anticipate that this technique will be applied to other non-vascular cell types that face similar barriers to efficient genome editing. © 2021 Wiley Periodicals LLC. Basic Protocol: CRISPR-Cas9 genome editing of primary human vascular cells in vitro.
MeSH term(s)	CRISPR-Cas Systems/genetics ; Gene Editing ; Gene Expression ; Humans ; Plasmids ; Transfection
Language	English
Publishing date	2021-11-08
Publishing country	United States
Document type	Journal Article
ISSN	2691-1299
ISSN (online)	2691-1299
DOI	10.1002/cpz1.291
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: COVID-19 for the Cardiologist

Atri, Deepak / Siddiqi, Hasan K. / Lang, Joshua P. / Nauffal, Victor / Morrow, David A. / Bohula, Erin A.

JACC: Basic to Translational Science

2020 Volume 5, Issue 5, Page(s) 518–536

Keywords	Cardiology and Cardiovascular Medicine ; covid19
Language	English
Publisher	Elsevier BV
Publishing country	us
Document type	Article ; Online
ISSN	2452-302X
DOI	10.1016/j.jacbts.2020.04.002
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Oral submucous fibrosis: Newer proposed classification with critical updates in pathogenesis and management strategies.

Passi, Deepak / Bhanot, Prateek / Kacker, Dhruv / Chahal, Deepak / Atri, Mansi / Panwar, Yoshi

National journal of maxillofacial surgery

2017 Volume 8, Issue 2, Page(s) 89–94

Abstract: Oral submucous fibrosis (OSMF) is an oral precancerous condition characterized by inflammation and progressive fibrosis of the submucosal tissues resulting in marked rigidity and trismus. OSMF still remains a dilemma to the clinicians due to elusive ... ...

Abstract	Oral submucous fibrosis (OSMF) is an oral precancerous condition characterized by inflammation and progressive fibrosis of the submucosal tissues resulting in marked rigidity and trismus. OSMF still remains a dilemma to the clinicians due to elusive pathogenesis and less well-defined classification systems. Over the years, many classification systems have been documented in medical literature based on clinical, histopathological, or functional aspects. However, none of these classifications have achieved universal acceptance. Each classification has its own merits and demerits. An attempt is made to provide and update the knowledge of classification system of OSMF so that it can assist the clinicians, beneficial in researches and academics in categorizing this potentially malignant disease for early detection, prompt management, and reducing the mortality. Along with this, pathogenesis and management have also been discussed.
Language	English
Publishing date	2017-06-19
Publishing country	India
Document type	Journal Article ; Review
ZDB-ID	2653583-X
ISSN	2229-3418 ; 0975-5950
ISSN (online)	2229-3418
ISSN	0975-5950
DOI	10.4103/njms.NJMS_32_17
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Understanding Cancer Stem Cells in Head and Neck Squamous Cell Carcinoma

Shubha Ranjan Dutta / Deepak Passi / Dhruv Kacker / Deepak Chahal / Mansi Atri

Journal of Clinical and Diagnostic Research, Vol 12, Iss 1, Pp EE01-EE

A Critical Update in Development of New Approaches

2018 Volume 05

Abstract: Cancer Stem Cells (CSCs) have an important role in Head and Neck Squamous Cell Carcinoma (HNSCC). HNSCC is considered as one of the major health problems throughout the world. These self-renewing cells are responsible for resistance to conventional anti- ... ...

Abstract	Cancer Stem Cells (CSCs) have an important role in Head and Neck Squamous Cell Carcinoma (HNSCC). HNSCC is considered as one of the major health problems throughout the world. These self-renewing cells are responsible for resistance to conventional anti-cancer therapy. CSCs have the ability of cancer recurrence; metastasis and can form a heterogeneous tumour. The idea of 'CSCs' has led the scientific community to a new era in the field of research and possibly effective treatment modalities for cancer in the future. This paper aims primarily to review the recent advancements made in the use of stem cells in the treatment of cancer. Secondly, this review presents a discussion on the consideration of CSCs being the backbone in the development of cancer and, precisely the role played by the CSCs in carcinogenesis and its outcome leading to development of possible cancer treatment in the future. Medical databases including Pubmed Central, Google Scholar, Scopus, Copernicus, Science Direct, etc., were used to find all relevant articles related to HNSCC and its relation with CSCs, various mechanisms and therapeutic approaches. Various therapeutic approaches have been employed for the management of HNSCC such as surgical method, chemotherapies and radiotherapies and combinations or formulations of different drugs, but in most cases complete cure has been a failure. This is mostly because the CSCs escape such therapies. However, recent developments have led to the use of targeted therapy such as targeting cell surface markers or signalling pathways, targeting micro environment or blocking epithelial mesenchymal transition, immunotherapy and other approaches as well, leading to the complete eradication of CSCs in HNSCC successfully. Thus, this review presents a better understanding of CSCs and its mechanism of action for development of new treatment modalities.
Keywords	cancer cells ; radiotherapies ; targeted therapy ; therapeutic ; tumour ; Medicine ; R
Subject code	610
Language	English
Publishing date	2018-01-01T00:00:00Z
Publisher	JCDR Research and Publications Private Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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