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Article ; Online: A biological and a mathematical model of SLE treated by mesenchymal stem cells covering all the stages of the disease.

Yazdani, Ali / Bahrami, Fariba / Pourgholaminejad, Arash / Moghadasali, Reza

Theory in biosciences = Theorie in den Biowissenschaften

2023 Volume 142, Issue 2, Page(s) 167–179

Abstract: In this study, we proposed a biological model explaining the progress of autoimmune activation along different stages of systemic lupus erythematosus (SLE). For any upcoming stage of SLE, any new component is introduced, when it is added to the model. ... ...

Abstract	In this study, we proposed a biological model explaining the progress of autoimmune activation along different stages of systemic lupus erythematosus (SLE). For any upcoming stage of SLE, any new component is introduced, when it is added to the model. Particularly, the interaction of mesenchymal stem cells, with the components of the model, is specified in a way that both the inflammatory and anti-inflammatory functions of these cells would be covered. The biological model is then recapitulated to a model with less complexity that explains the main features of the problem. Later, a 7th-order mathematical model for SLE is proposed, based on this simplified model. Finally, the range of validity of the proposed mathematical model was assessed. For this purpose, we simulated the model and analyzed the simulation results in case of some known behaviors of the disease, such as tolerance breach, the appearance of systemic inflammation, development of clinical signs, and occurrence of flares and improvements. The model was able to reproduce these events, qualitatively.
MeSH term(s)	Humans ; Lupus Erythematosus, Systemic/diagnosis ; Lupus Erythematosus, Systemic/drug therapy ; Mesenchymal Stem Cells ; Models, Theoretical
Language	English
Publishing date	2023-04-18
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1376847-5
ISSN	1611-7530 ; 1431-7613
ISSN (online)	1611-7530
ISSN	1431-7613
DOI	10.1007/s12064-023-00390-4
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Article ; Online: Modeling codelivery of CD73 inhibitor and dendritic cell-based vaccines in cancer immunotherapy.

Arabameri, Abazar / Pourgholaminejad, Arash

Computational biology and chemistry

2021 Volume 95, Page(s) 107585

Abstract: Dendritic cells (DCs) are the dominant class of antigen-presenting cells in humans; therefore, a range of DC-based approaches have been established to promote an immune response against cancer cells. The efficacy of DC-based immunotherapeutic approaches ... ...

Abstract	Dendritic cells (DCs) are the dominant class of antigen-presenting cells in humans; therefore, a range of DC-based approaches have been established to promote an immune response against cancer cells. The efficacy of DC-based immunotherapeutic approaches is markedly affected by the immunosuppressive factors related to the tumor microenvironment, such as adenosine. In this paper, based on immunological theories and experimental data, a hybrid model is designed that offers some insights into the effects of DC-based immunotherapy combined with adenosine inhibition. The model combines an individual-based model for describing tumor-immune system interactions with a set of ordinary differential equations for adenosine modeling. Computational simulations of the proposed model clarify the conditions for the onset of a successful immune response against cancer cells. Global and local sensitivity analysis of the model highlights the importance of adenosine blockage for strengthening effector cells. The model is used to determine the most effective suppressive mechanism caused by adenosine, proper vaccination time, and the appropriate time interval between injections.
MeSH term(s)	5'-Nucleotidase/immunology ; Cancer Vaccines/immunology ; Computational Biology ; Dendritic Cells/immunology ; GPI-Linked Proteins/immunology ; Humans ; Immunotherapy ; Models, Immunological ; Neoplasms/immunology ; Neoplasms/therapy
Chemical Substances	Cancer Vaccines ; GPI-Linked Proteins ; 5'-Nucleotidase (EC 3.1.3.5) ; NT5E protein, human (EC 3.1.3.5)
Language	English
Publishing date	2021-09-25
Publishing country	England
Document type	Journal Article
ISSN	1476-928X
ISSN (online)	1476-928X
DOI	10.1016/j.compbiolchem.2021.107585
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Article ; Online: COVID-19 immunopathology with emphasis on Th17 response and cell-based immunomodulation therapy: Potential targets and challenges.

Pourgholaminejad, Arash / Pahlavanneshan, Saghar / Basiri, Mohsen

Scandinavian journal of immunology

2022 Volume 95, Issue 2, Page(s) e13131

Abstract: The role of the immune system against coronavirus disease 2019 (COVID-19) is unknown in many aspects, and the protective or pathologic mechanisms of the immune response are poorly understood. Pro-inflammatory cytokine release and a consequent cytokine ... ...

Abstract	The role of the immune system against coronavirus disease 2019 (COVID-19) is unknown in many aspects, and the protective or pathologic mechanisms of the immune response are poorly understood. Pro-inflammatory cytokine release and a consequent cytokine storm can lead to acute respiratory distress syndrome (ARDS) and result in multi-organ failure. There are many T cell subsets during anti-viral immunity. The Th17-associated response, as a pro-inflammatory pathway, and its consequent outcomes in many autoimmune disorders play a fundamental role in progression of systemic hyper-inflammation during COVID-19. Therapeutic strategies based on immunomodulation therapy could be helpful for targeting hyper-inflammatory immune responses in COVID-19, especially Th17-related inflammation and hyper-cytokinemia. Cell-based immunotherapeutic approaches including mesenchymal stem cells (MSCs), tolerogenic dendritic cells (tolDCs) and regulatory T cells (Tregs) seem to be promising strategies as orchestrators of the immune response against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In this review, we highlight Th17-related immunopathology of SARS-CoV-2 infection and discuss cell-based immunomodulatory strategies and their mechanisms for regulation of the hyper-inflammation during COVID-19.
MeSH term(s)	Adoptive Transfer/methods ; COVID-19/immunology ; COVID-19/pathology ; COVID-19/therapy ; Cell- and Tissue-Based Therapy/methods ; Cytokine Release Syndrome/pathology ; Cytokines/blood ; Dendritic Cells/transplantation ; Humans ; Immunomodulation/immunology ; Mesenchymal Stem Cell Transplantation ; SARS-CoV-2/immunology ; T-Lymphocytes, Regulatory/transplantation ; Th17 Cells/immunology
Chemical Substances	Cytokines
Language	English
Publishing date	2022-01-03
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	120476-2
ISSN	1365-3083 ; 0300-9475
ISSN (online)	1365-3083
ISSN	0300-9475
DOI	10.1111/sji.13131
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Article ; Online: A survey on the seroprevalence of toxocariasis and related risk factors in Eosinophilic children of Northwest Iran.

Pourgholaminejad, Arash / Razipour, Habib / Heydarian, Peyman / Ashrafi, Keyhan / Roushan, Zahra Atrkar / Sharifdini, Meysam

African health sciences

2023 Volume 22, Issue 3, Page(s) 617–625

Abstract: Background: Toxocariasis is a serious zoonotic helminthic disease caused by the nematodes; : Aim: A cross-sectional study was conducted to determine the seroprevalence of toxocariasis and related risk factors in eosinophilic children referred to the ... ...

Abstract	Background: Toxocariasis is a serious zoonotic helminthic disease caused by the nematodes; Aim: A cross-sectional study was conducted to determine the seroprevalence of toxocariasis and related risk factors in eosinophilic children referred to the pediatrics hospital of Qazvin province northwest Iran during 2019-2020. Methods: A total of 200 blood samples were collected from eosinophilic children referred to the Qods Pediatrics Hospital. Demographic data, clinical symptoms, and dogs- and soil-contact history were collected. The presence of anti- Results: Anti- Conclusion: The prevalence of toxocariasis in eosinophilic children is a serious health problem in the study area. Therefore, serologic evaluation for the diagnosis of
MeSH term(s)	Animals ; Dogs ; Toxocariasis/diagnosis ; Toxocariasis/epidemiology ; Seroepidemiologic Studies ; Iran/epidemiology ; Cross-Sectional Studies ; Toxocara ; Zoonoses ; Enzyme-Linked Immunosorbent Assay ; Antibodies, Helminth ; Eosinophilia ; Risk Factors ; Immunoglobulin G
Chemical Substances	Antibodies, Helminth ; Immunoglobulin G
Language	English
Publishing date	2023-02-24
Publishing country	Uganda
Document type	Journal Article
ZDB-ID	2240308-5
ISSN	1729-0503 ; 1680-6905
ISSN (online)	1729-0503
ISSN	1680-6905
DOI	10.4314/ahs.v22i3.66
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Article: Stroke Associated with SARS-CoV-2 Infection and its Pathogenesis: A Systematic Review.

Kazemi, Samaneh / Pourgholaminejad, Arash / Saberi, Alia

Basic and clinical neuroscience

2021 Volume 12, Issue 5, Page(s) 569–586

Abstract: Introduction: The change of stroke incidence during the COVID-19 pandemic period and the proposed mechanisms of the relationship between SARS-CoV-2 and stroke is reviewed.: Methods: Web of Science, PMC/Medline, and Scopus databases were searched ... ...

Abstract	Introduction: The change of stroke incidence during the COVID-19 pandemic period and the proposed mechanisms of the relationship between SARS-CoV-2 and stroke is reviewed. Methods: Web of Science, PMC/Medline, and Scopus databases were searched until July 2020 without time and language limitations. After quality assessment, 22 articles were included in this study. Results: Based on the results, it is impossible to conclude any definite relationship between the rising or decreasing stroke frequency or the shift in the ischemic and hemorrhagic ratio and SARS-CoV-2 infection. However, it appears that SARS-CoV-2 infection has some correlation with stroke. The supposed mechanisms for the SARS-CoV-2-related hemorrhagic stroke include 1) SARS-CoV-2-related vasculopathy with the endothelial damage of small vessels, 2) viral infection-induced platelet dysfunction or thrombocytopenia, and 3) activation of the proinflammatory cascade leading to coagulopathy. The helpful strategies are receiving therapeutic anticoagulation for high D-dimer or a known thrombus due to SARS-CoV-2 infection, as well as using extracorporeal membrane oxygenation (ECMO) in some patients. Furthermore, the possible mechanisms for the SARS-CoV-2-related ischemic stroke include 1) dysregulation of angiotensin-converting enzyme 2 (a key host cellular receptor for SARSCoV-2)-related physiologic functions, 2) endothelial cell damages, 3) thrombo-inflammation, and 4) coagulopathy and coagulation abnormalities related to SARS-CoV-2 infection. Conclusion: A better understanding of the SARS-CoV-2 pathogenesis and its relation to neurologic abnormalities such as stroke can help to design new therapeutic approaches.
Language	English
Publishing date	2021-09-01
Publishing country	Iran
Document type	Journal Article ; Review
ZDB-ID	2652444-2
ISSN	2228-7442 ; 2008-126X
ISSN (online)	2228-7442
ISSN	2008-126X
DOI	10.32598/bcn.2021.3277.1
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Article ; Online: Interleukin-17, C-reactive protein, Neutrophil-to-Lymphocyte ratio, Lymphocyte-to-Monocyte ratio, and lipid profiles in healthy menopausal women with or without hot flashes: A cross-sectional study.

Didevar, Nazila / Rezasoltani, Parvaneh / Pourgholaminejad, Arash / Kazemnezhad Leyli, Ehsan / Seyednoori, Tahereh / Zahiri Sorouri, Ziba

PloS one

2023 Volume 18, Issue 11, Page(s) e0291804

Abstract: Introduction: The reciprocation between systemic inflammatory markers (SIMs), dyslipidemia, and hot flashes (HFs) can play a part in the pathogenesis of endothelial dysfunction through menopause. This study intended to determine the association between ... ...

Abstract	Introduction: The reciprocation between systemic inflammatory markers (SIMs), dyslipidemia, and hot flashes (HFs) can play a part in the pathogenesis of endothelial dysfunction through menopause. This study intended to determine the association between some SIMs, lipids, and HFs in healthy menopausal women. Materials and methods: We designed a cross-sectional study in which 160 healthy menopausal women aged 40-60 were enrolled. Concerning their HFs status, they were stratified into two groups by consecutive sampling: without HFs (n = 40) and with HFs (n = 120). In addition to clinical variables and HFs experience, we measured the fasting serum levels of SIMs and lipid profiles (LPs), including Interleukin-17 (IL-17), high- sensitivity C-Reactive Protein (hs-CRP), Total Cholesterol (TC), Triglycerides (TG), Low-Density Lipoprotein Cholesterol (LDL-C), and High-Density Lipoprotein Cholesterol (HDL-C) in each group. Then, we calculated TC/HDL-C concerning the related variables and determined Neutrophil-to-Lymphocyte Ratio (NLR), and Lymphocyte-to-Monocyte Ratio (LMR), according to Complete Blood Count (CBC) quantitative parameters in each group. Furthermore, we used logistic regression analysis to assess the association between SIMs, LPs, and HFs. Settings: We performed this study in a governmental teaching hospital, Guilan/Rasht, Iran, from April to September 2021. Results: The two groups of menopausal women without and with HFs were not significantly different regarding the median of IL-17, hs-CRP, NLR, LMR, TG, HDL-C, and TC/HDL-C, and the mean of TC and LDL-C. Based on multiple logistic regression, TG levels appeared to be associated with the incidence of HFs (B = 0.004, P = 0.040, Odds Ratio:1.004, 95%CI:1.000-1.009). NLR seemed to have an increasing impact on the HFs severity, according to ordinal logistic regression (B = 0.779, P = 0.005, Odds Ratio = 2.180, 95%CI:1.270-3.744). Furthermore, hs-CRP negatively correlated with TG (r = -0.189, P = 0.039) and TC/HDL-C (r = -0.268, P = 0.003) in menopausal women with HFs. Conclusion: This study indicated an association between SIMs, lipids, and HFs. These connections may suggest HFs as links between SIMs/LPs alterations and their outcomes.
MeSH term(s)	Humans ; Female ; C-Reactive Protein/metabolism ; Cross-Sectional Studies ; Interleukin-17 ; Cholesterol, LDL ; Hot Flashes ; Neutrophils/metabolism ; Lipopolysaccharides ; Monocytes/metabolism ; Menopause ; Triglycerides ; Cholesterol, HDL ; Lymphocytes/metabolism
Chemical Substances	C-Reactive Protein (9007-41-4) ; Interleukin-17 ; Cholesterol, LDL ; Lipopolysaccharides ; Triglycerides ; Cholesterol, HDL
Language	English
Publishing date	2023-11-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0291804
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Article ; Online: Virology, pathophysiology and neuroinvasion mechanisms of SARS-CoV-2

Arash Pourgholaminejad / Samaneh Kazemi / Alia Saberi

Romanian Journal of Neurology, Vol 20, Iss 3, Pp 288-

A mini literature review

2021 Volume 291

Abstract: Coronavirus-2 (CoV-2) is known as a respiratory pathogen for which the accumulation of evidence suggest that the severe acute respiratory syndrome (SARS) can cause critical pathologies in vulnerable patients. The coronavirus disease-2019 (COVID-19) ... ...

Abstract	Coronavirus-2 (CoV-2) is known as a respiratory pathogen for which the accumulation of evidence suggest that the severe acute respiratory syndrome (SARS) can cause critical pathologies in vulnerable patients. The coronavirus disease-2019 (COVID-19) pandemic is an example of a multi-systemic infectious disease. In addition of respiratory manifestations and severe pneumonia related to COVID-19, The SARS-CoV-2 can penetrate into the central nervous system (CNS) and participate in the induction of neurological disorders and promote some neuropathies. Knowledge of the spectrum of SARS-CoV-2-associated pathophysiology and neuroinvasion pathways will lead to improved clinical outcomes and better treatment algorithms. The aim of this review is to summarize available knowledge on the identification of virology, neuroinvasion mechanisms and the pathophysiology of SARS-CoV-2 in the CNS.
Keywords	sars-cov-2 ; central nervous system ; pathophysiology ; Medicine ; R ; Neurology. Diseases of the nervous system ; RC346-429
Subject code	610
Language	English
Publishing date	2021-09-01T00:00:00Z
Publisher	Amaltea Medical Publishing House
Document type	Article ; Online
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Article ; Online: Interleukin-17, C-reactive protein, Neutrophil-to-Lymphocyte ratio, Lymphocyte-to-Monocyte ratio, and lipid profiles in healthy menopausal women with or without hot flashes

Nazila Didevar / Parvaneh Rezasoltani / Arash Pourgholaminejad / Ehsan Kazemnezhad Leyli / Tahereh Seyednoori / Ziba Zahiri Sorouri

PLoS ONE, Vol 18, Iss 11, p e

A cross-sectional study.

2023 Volume 0291804

Abstract: Introduction The reciprocation between systemic inflammatory markers (SIMs), dyslipidemia, and hot flashes (HFs) can play a part in the pathogenesis of endothelial dysfunction through menopause. This study intended to determine the association between ... ...

Abstract	Introduction The reciprocation between systemic inflammatory markers (SIMs), dyslipidemia, and hot flashes (HFs) can play a part in the pathogenesis of endothelial dysfunction through menopause. This study intended to determine the association between some SIMs, lipids, and HFs in healthy menopausal women. Materials and methods We designed a cross-sectional study in which 160 healthy menopausal women aged 40-60 were enrolled. Concerning their HFs status, they were stratified into two groups by consecutive sampling: without HFs (n = 40) and with HFs (n = 120). In addition to clinical variables and HFs experience, we measured the fasting serum levels of SIMs and lipid profiles (LPs), including Interleukin-17 (IL-17), high- sensitivity C-Reactive Protein (hs-CRP), Total Cholesterol (TC), Triglycerides (TG), Low-Density Lipoprotein Cholesterol (LDL-C), and High-Density Lipoprotein Cholesterol (HDL-C) in each group. Then, we calculated TC/HDL-C concerning the related variables and determined Neutrophil-to-Lymphocyte Ratio (NLR), and Lymphocyte-to-Monocyte Ratio (LMR), according to Complete Blood Count (CBC) quantitative parameters in each group. Furthermore, we used logistic regression analysis to assess the association between SIMs, LPs, and HFs. Settings We performed this study in a governmental teaching hospital, Guilan/Rasht, Iran, from April to September 2021. Results The two groups of menopausal women without and with HFs were not significantly different regarding the median of IL-17, hs-CRP, NLR, LMR, TG, HDL-C, and TC/HDL-C, and the mean of TC and LDL-C. Based on multiple logistic regression, TG levels appeared to be associated with the incidence of HFs (B = 0.004, P = 0.040, Odds Ratio:1.004, 95%CI:1.000-1.009). NLR seemed to have an increasing impact on the HFs severity, according to ordinal logistic regression (B = 0.779, P = 0.005, Odds Ratio = 2.180, 95%CI:1.270-3.744). Furthermore, hs-CRP negatively correlated with TG (r = -0.189, P = 0.039) and TC/HDL-C (r = -0.268, P = 0.003) in menopausal women with ...
Keywords	Medicine ; R ; Science ; Q
Subject code	630
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The role of Th17 cells in auto-inflammatory neurological disorders.

Tahmasebinia, Foozhan / Pourgholaminejad, Arash

Progress in neuro-psychopharmacology & biological psychiatry

2017 Volume 79, Issue Pt B, Page(s) 408–416

Abstract: The role of T helper 17 (Th17) cells in auto-inflammatory neurological disorders such as Multiple Sclerosis (MS), Alzheimer's disease (AD), Parkinson's disease (PD) and schizophrenia has not been clarified completely. Th17-derived pro-inflammatory ... ...

Abstract	The role of T helper 17 (Th17) cells in auto-inflammatory neurological disorders such as Multiple Sclerosis (MS), Alzheimer's disease (AD), Parkinson's disease (PD) and schizophrenia has not been clarified completely. Th17-derived pro-inflammatory cytokines including IL-17, IL-21, IL-22, IL-23, GM-CSF, and IFN-γ have a critical role in the pathogenesis of these disorders. In this review, we demonstrate the role of Th17 cells and their related cytokines in the immunopathology of above-mentioned disorders to get a better understanding of neuroinflammatory mechanisms mediated by Th17 cells associated with events leading to neurodegeneration.
MeSH term(s)	Alzheimer Disease/immunology ; Animals ; Humans ; Inflammation/immunology ; Multiple Sclerosis/immunology ; Parkinson Disease/immunology ; Schizophrenia/immunology ; Th17 Cells/physiology
Language	English
Publishing date	2017-07-29
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	781181-0
ISSN	1878-4216 ; 0278-5846
ISSN (online)	1878-4216
ISSN	0278-5846
DOI	10.1016/j.pnpbp.2017.07.023
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Article: Comparing the Effects of Long-term Exposure to Extremely Low-frequency Electromagnetic Fields With Different Values on Learning, Memory, Anxiety, and β-amyloid Deposition in Adult Rats.

Faraji, Nafiseh / Salehi, Iraj / Alizadeh, Akram / Pourgholaminejad, Arash / Komaki, Alireza / Azandaryani, Masoumeh Taheri / Sadeghian, Reihaneh / Golipoor, Zoleikha

Basic and clinical neuroscience

2021 Volume 12, Issue 6, Page(s) 849–860

Abstract: Introduction: Extremely Low-Frequency Electromagnetic Fields (ELF-EMFs) have gathered significant consideration for their possible pathogenicity. However, their effects on the nervous system's functions were not fully clarified. This study aimed to ... ...

Abstract	Introduction: Extremely Low-Frequency Electromagnetic Fields (ELF-EMFs) have gathered significant consideration for their possible pathogenicity. However, their effects on the nervous system's functions were not fully clarified. This study aimed to assay the impact of ELF-EMFs with different intensities on memory, anxiety, antioxidant activity, β-amyloid (Aβ) deposition, and microglia population in rats. Methods: Fifty male adult rats were randomly separated into 5 groups; 4 were exposed to a flux density of 1, 100, 500, and 2000 microtesla (μT), 50 Hz frequency for one h/day for two months, and one group as a control group. The control group was without ELF-EMF stimulation. After 8 weeks, passive avoidance and Elevated Plus Maze (EPM) tests were performed to assess memory formation and anxiety-like behavior, respectively. Total free thiol groups and the index of lipid peroxidation were evaluated. Additionally, for detection of Aβ deposition and stained microglia in the brain, anti-β-amyloid and anti-Iba1 antibodies were used. Results: The step-through latency in the retention test in ELF-EMF exposure groups (100500 & 2000 μT) was significantly greater than the control group (P<0.05). Furthermore, the frequency of the entries into the open arms in ELF-EMF exposure groups (especially 2000 μT) decreased than the control group (P<0.05). No Aβ depositions were detected in the hippocampus of different groups. An increase in microglia numbers in the 100, 500, and 2000 μT groups was observed compared to the control and one μT group. Conclusion: Exposure to ELF-EMF had an anxiogenic effect on rats, promoted memory, and induced oxidative stress. No Aβ depositions were detected in the brain. Moreover, the positive impact of ELF-EMF was observed on the microglia population in the brain. Highlights: ELF-EMFs have gathered significant consideration for their possible pathogenicity.ELF-EMFs' effects on the nervous system's functions were not clarified yet.Positive impact of ELF-EMF was observed on the microglia population in the brain. Plain language summary: ELF-EMFs effects on human health are a considerable concern. Studies revealed the adverse effects of ELF-EMF in neurological disorders such as Alzheimer's Disease (AD). Anxiety could be an early manifestation of AD. There is a correlation between occupational exposure to ELF-EMF and AD. Recently the researchers interested in the study of the effects of ELF-EMFs on the human body. Some studies examined the molecular mechanisms and the influence of ELF-EMFs on the biologic mechanisms in the body. Also, Microglia act in the Central Nervous system (CNS) immune responses; over-activated microglia can be responsible for devastating and progressive neurotoxic consequences in neurodegenerative disorders. This study aimed to evaluate the memory, anxiety, antioxidant activity, β-amyloid deposition, and frequency of the microglial cells exposed to microtesla (μT) and 2000 (μT) ELF-EMFs.
Language	English
Publishing date	2021-11-01
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2652444-2
ISSN	2228-7442 ; 2008-126X
ISSN (online)	2228-7442
ISSN	2008-126X
DOI	10.32598/bcn.2021.1204.2
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