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Article ; Online: Systematic review shows that suction-based airway clearance devices for foreign body airway obstruction are promising.

Parri, Niccolò / Madera, Anna / D'Aiuto, Francesca / Zampogna, Stefania / Milani, Gregorio Paolo

Acta paediatrica (Oslo, Norway : 1992)

2024

Language	English
Publishing date	2024-04-02
Publishing country	Norway
Document type	Journal Article
ZDB-ID	203487-6
ISSN	1651-2227 ; 0365-1436 ; 0803-5253
ISSN (online)	1651-2227
ISSN	0365-1436 ; 0803-5253
DOI	10.1111/apa.17229
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Article ; Online: To B or not to B. The rationale for quantifying B-lines in pediatric lung diseases.

Parri, Niccolò / Allinovi, Marco / Giacalone, Martina / Corsini, Iuri

Pediatric pulmonology

2022

Abstract: Lung ultrasound (LUS) is emerging as adjunct tool to be used during clinical assessment. Among the different hallmarks of LUS, B-lines are well known artifacts, which are not correlated with identifiable structures, but which can be used for pathological ...

Abstract	Lung ultrasound (LUS) is emerging as adjunct tool to be used during clinical assessment. Among the different hallmarks of LUS, B-lines are well known artifacts, which are not correlated with identifiable structures, but which can be used for pathological classification. The presence of multiple B-lines is a sonographic sign of lung interstitial syndrome. It has been demonstrated in adults that there is a direct correlation between the number of B-lines and the severity of the interstitial involvement of lung disease. Counting B-lines is an attempt to enrich the clinical assessment and clinical information, beyond obtaining a simple dichotomous answer. Semiquantitative or quantitative B-line assessment has been shown to correlate with fluid overload and demonstrated prognostic implications in specific neonatal and pediatric conditions. LUS with quantitative B-lines assessment is promising. Current evidence allows for quantification of B-lines in a limited number of neonatal and pediatric diseases.
Language	English
Publishing date	2022-10-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	632784-9
ISSN	1099-0496 ; 8755-6863
ISSN (online)	1099-0496
ISSN	8755-6863
DOI	10.1002/ppul.26185
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Article ; Online: Contrast-enhanced ultrasound in pediatric blunt abdominal trauma: a systematic review.

Pegoraro, Francesco / Giusti, Giulia / Giacalone, Martina / Parri, Niccolò

Journal of ultrasound

2022 Volume 25, Issue 3, Page(s) 419–427

Abstract: Purpose: Intra-abdominal injury is a major cause of morbidity in children. Computed tomography (CT) is the reference standard for the evaluation of hemodynamically stable abdominal trauma. CT has an increased risk of long-term radiation induced ... ...

Abstract	Purpose: Intra-abdominal injury is a major cause of morbidity in children. Computed tomography (CT) is the reference standard for the evaluation of hemodynamically stable abdominal trauma. CT has an increased risk of long-term radiation induced malignancies and a possible risk associated with the use of iodinated contrast media. Contrast-enhanced ultrasound (CEUS) might represent an alternative to CT in stable children with blunt abdominal trauma (BAT). Nonetheless, CEUS in pediatrics remains limited by the lack of strong evidence. The purpose of this study was to offer a systematic review on the use of CEUS in pediatric abdominal trauma. Methods: Electronic search of PubMed, EMBASE and Cochrane databases of studies investigating CEUS for abdominal trauma in children. The risk of bias was assessed using the ROBINS-I tool. Results: This systematic review included 7 studies. CEUS was performed with different ultrasound equipment, always with a curvilinear transducer. Six out of seven studies used a second-generation contrast agent. No immediate adverse reactions were reported. The dose of contrast agent and the scanning technique varied between studies. All CEUS exams were performed by radiologists, in the radiology department or at the bedside. No standard training was reported to become competent in CEUS. The range of sensitivity and specificity of CEUS were 85.7 to 100% and 89 to 100%, respectively. Conclusion: CEUS appears to be safe and accurate to identify abdominal solid organ injuries in children with BAT. Further research is necessary to assess the feasibility of CEUS by non-radiologists, the necessary training, and the benefit-cost ratio of CEUS as a tool to potentially reduce CT scans.
MeSH term(s)	Abdominal Injuries/diagnostic imaging ; Child ; Contrast Media ; Humans ; Tomography, X-Ray Computed/adverse effects ; Ultrasonography/methods ; Wounds, Nonpenetrating/diagnostic imaging
Chemical Substances	Contrast Media
Language	English
Publishing date	2022-01-18
Publishing country	Italy
Document type	Journal Article ; Review ; Systematic Review
ZDB-ID	2365426-0
ISSN	1876-7931 ; 1971-3495
ISSN (online)	1876-7931
ISSN	1971-3495
DOI	10.1007/s40477-021-00623-6
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Article ; Online: Efficacy of ibuprofen in musculoskeletal post-traumatic pain in children: A systematic review.

Parri, Niccolò / Lazzeri, Simone

PloS one

2020 Volume 15, Issue 12, Page(s) e0243314

Abstract: Musculoskeletal (MSK) injuries are one of the most frequent reason for pain-related evaluation in the emergency department (ED) in children. There is still no consensus as to what constitutes the best analgesic for MSK pain in children. However, ... ...

Abstract	Musculoskeletal (MSK) injuries are one of the most frequent reason for pain-related evaluation in the emergency department (ED) in children. There is still no consensus as to what constitutes the best analgesic for MSK pain in children. However, ibuprofen is reported to be the most commonly prescribed analgesic and is considered the standard first-line treatment for MSK injury pain in children, even if it is argued that it provides inadequate relief for many patients. The purpose of this study was to review the most recent literature to assess the efficacy of ibuprofen for pain relief in MSK injuries in children evaluated in the ED. We performed a systematic review of randomized controlled trials on pharmacological interventions in children and adolescents under 19 years of age with MSK injuries according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. The primary outcome was the risk ratio for successful reduction in pain scores. Six studies met the inclusion criteria and provided data on 1028 children. A meta-analysis was not performed since studies were not comparable due to the different analgesic treatment used. No significant difference in term of main pain score reduction between all the analgesics used in the included studies was noted. Patients who received oral opioids had side effects more frequently when compared to children who received ibuprofen. The combination of effect on pain relief and tolerability would suggest ibuprofen as the initial drug of choice in providing relief from mild-to-moderate MSK pain in children in the ED. The results obtained in this review and current research suggest that there's no straightforward statistically significant evidence of the optimal analgesic agent to be used. However, ibuprofen may be preferable as the initial drug of choice in providing relief from MSK pain due to the favorable combination of effectiveness and safety profile. In fact, despite the non-significant pain reduction as compared to children who received opioids, there are less side effect associated to ibuprofen within studies. The wide range of primary outcomes measured in respect of pain scores and timing of recorded measures warrants a future standardization of study designs.
MeSH term(s)	Adolescent ; Adult ; Analgesics, Non-Narcotic/adverse effects ; Analgesics, Non-Narcotic/therapeutic use ; Anti-Inflammatory Agents, Non-Steroidal/adverse effects ; Anti-Inflammatory Agents, Non-Steroidal/therapeutic use ; Child ; Female ; Humans ; Ibuprofen/adverse effects ; Ibuprofen/therapeutic use ; Male ; Musculoskeletal Pain/drug therapy ; Musculoskeletal Pain/physiopathology ; Pain Management ; Wounds and Injuries/drug therapy ; Wounds and Injuries/physiopathology
Chemical Substances	Analgesics, Non-Narcotic ; Anti-Inflammatory Agents, Non-Steroidal ; Ibuprofen (WK2XYI10QM)
Language	English
Publishing date	2020-12-03
Publishing country	United States
Document type	Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't ; Systematic Review
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0243314
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Efficacy of ibuprofen in musculoskeletal post-traumatic pain in children

Niccolò Parri / Simone Lazzeri

PLoS ONE, Vol 15, Iss 12, p e

A systematic review.

2020 Volume 0243314

Abstract	Musculoskeletal (MSK) injuries are one of the most frequent reason for pain-related evaluation in the emergency department (ED) in children. There is still no consensus as to what constitutes the best analgesic for MSK pain in children. However, ibuprofen is reported to be the most commonly prescribed analgesic and is considered the standard first-line treatment for MSK injury pain in children, even if it is argued that it provides inadequate relief for many patients. The purpose of this study was to review the most recent literature to assess the efficacy of ibuprofen for pain relief in MSK injuries in children evaluated in the ED. We performed a systematic review of randomized controlled trials on pharmacological interventions in children and adolescents under 19 years of age with MSK injuries according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. The primary outcome was the risk ratio for successful reduction in pain scores. Six studies met the inclusion criteria and provided data on 1028 children. A meta-analysis was not performed since studies were not comparable due to the different analgesic treatment used. No significant difference in term of main pain score reduction between all the analgesics used in the included studies was noted. Patients who received oral opioids had side effects more frequently when compared to children who received ibuprofen. The combination of effect on pain relief and tolerability would suggest ibuprofen as the initial drug of choice in providing relief from mild-to-moderate MSK pain in children in the ED. The results obtained in this review and current research suggest that there's no straightforward statistically significant evidence of the optimal analgesic agent to be used. However, ibuprofen may be preferable as the initial drug of choice in providing relief from MSK pain due to the favorable combination of effectiveness and safety profile. In fact, despite the non-significant pain reduction as compared to children who ...
Keywords	Medicine ; R ; Science ; Q
Subject code	360
Language	English
Publishing date	2020-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Lung ultrasound in the neonatal intensive care unit: Review of the literature and future perspectives.

Corsini, Iuri / Parri, Niccolò / Ficial, Benjamim / Dani, Carlo

Pediatric pulmonology

2020 Volume 55, Issue 7, Page(s) 1550–1562

Abstract: Lung ultrasound (LU) has been increasingly used as a point-of-care method in recent years. LU has numerous advantages compared to traditional imaging tools such as chest X-ray (radiography) (CXR): it is faster and portable, does not use ionizing ... ...

Abstract	Lung ultrasound (LU) has been increasingly used as a point-of-care method in recent years. LU has numerous advantages compared to traditional imaging tools such as chest X-ray (radiography) (CXR): it is faster and portable, does not use ionizing radiation, is performed by the same physician who cares for the patient, and can be repeated to follow the progress of the disease and the response to treatment. There is a large body of evidence that LU has an excellent diagnostic effectiveness compared to CXR, not only in adults and children, but also in neonates. This review article describes how to perform LU, how to interpret findings, and how to use LU to diagnose and differentiate common neonatal pulmonary diseases. Strengths but also limits of the technique are highlighted. Finally, we describe the recent revolutionary role of LU. The development of scoring methods in neonates with respiratory distress syndrome allowed to quantify the severity of the disease and to assist the physician in the clinical management and follow-up.
MeSH term(s)	Artifacts ; Diagnosis, Differential ; Humans ; Infant, Newborn ; Intensive Care Units, Neonatal ; Lung/diagnostic imaging ; Lung Diseases/diagnosis ; Ultrasonography
Language	English
Publishing date	2020-04-27
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	632784-9
ISSN	1099-0496 ; 8755-6863
ISSN (online)	1099-0496
ISSN	8755-6863
DOI	10.1002/ppul.24792
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Article ; Online: Point-of-Care Lung Ultrasound in Neonatology: Ready or Not, Here It Comes!

Corsini, Iuri / Parri, Niccolò / Dani, Carlo

Chest

2020 Volume 157, Issue 4, Page(s) 759–760

MeSH term(s)	Humans ; Lung/diagnostic imaging ; Neonatology ; Point-of-Care Systems ; Reproducibility of Results ; Ultrasonography
Language	English
Publishing date	2020-03-19
Publishing country	United States
Document type	Editorial ; Comment
ZDB-ID	1032552-9
ISSN	1931-3543 ; 0012-3692
ISSN (online)	1931-3543
ISSN	0012-3692
DOI	10.1016/j.chest.2020.01.007
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Article ; Online: Children with Covid-19 in Pediatric Emergency Departments in Italy.

Parri, Niccolò / Lenge, Matteo / Buonsenso, Danilo

The New England journal of medicine

2020 Volume 383, Issue 2, Page(s) 187–190

MeSH term(s)	Betacoronavirus ; COVID-19 ; Child ; China ; Coronavirus Infections ; Emergency Service, Hospital ; Humans ; Italy ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
Keywords	covid19
Language	English
Publishing date	2020-05-01
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	207154-x
ISSN	1533-4406 ; 0028-4793
ISSN (online)	1533-4406
ISSN	0028-4793
DOI	10.1056/NEJMc2007617
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Article ; Online: Lung ultrasound in pediatric patients: the clinician's point of view.

Corsini, Iuri / Parri, Niccolò / Ficial, Benjamim / Dani, Carlo

Pediatric radiology

2020 Volume 50, Issue 11, Page(s) 1635–1636

MeSH term(s)	Child ; Humans ; Ultrasonography
Language	English
Publishing date	2020-09-01
Publishing country	Germany
Document type	Letter ; Comment
ZDB-ID	124459-0
ISSN	1432-1998 ; 0301-0449
ISSN (online)	1432-1998
ISSN	0301-0449
DOI	10.1007/s00247-020-04815-w
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Article ; Online: Dissemination and Use of Point-of-Care Ultrasound by Pediatricians in Europe: A Research in European Pediatric Emergency Medicine Network Collaborative Survey.

Parri, Niccolò / Berant, Ron / Giacalone, Martina / Jones, Sarah Dianne / Friedman, Nir

Pediatric emergency care

2022 Volume 38, Issue 10, Page(s) e1594–e1600

Abstract: Objective: We surveyed the dissemination and use of point-of-care ultrasound (POCUS), physician training levels, and barriers and limitations to use of POCUS among pediatricians and pediatric emergency medicine (PEM) physicians across Europe and Israel.! ...

Abstract	Objective: We surveyed the dissemination and use of point-of-care ultrasound (POCUS), physician training levels, and barriers and limitations to use of POCUS among pediatricians and pediatric emergency medicine (PEM) physicians across Europe and Israel. Methods: A questionnaire was distributed through the PEM section of the European Society for Emergency Medicine and the Research in European Pediatric Emergency Medicine Network. Results: A total of 581 physicians from 22 countries fully completed the questionnaire. Participants were primarily pediatric attending physicians (34.9% [203 of 581]) and PEM attending physicians (28.6% [166 of 581]). Most of the respondents, 58.5% (340 of 581), reported using POCUS in their practice, and 61.9% (359/581) had undergone POCUS training. Point-of-care ultrasound courses represented the most common method of becoming proficient in POCUS. Overall, the Focused Assessment with Sonography in Trauma scan was the mostly taught application, with 76.3% (274 of 359). Resuscitative, diagnostic, and procedural POCUS were rated as very useful or useful by the most of respondents.The lack of qualified personnel to train (76.9% [447 of 581]), and the insufficient time for physicians to learn, POCUS (63.7% [370 of 581]) were identified as the main limitations to POCUS implementation. Conclusions: The dissemination of pediatric POCUS in the European and Israeli centers we surveyed is limited, and its applications are largely restricted to the Focused Assessment with Sonography in Trauma examination. This is likely related to lack of training programs. In contrast, the potential value of use of POCUS in PEM practice is recognized by the majority of respondents.
MeSH term(s)	Child ; Emergency Medicine/education ; Humans ; Pediatric Emergency Medicine ; Pediatricians ; Point-of-Care Systems ; Surveys and Questionnaires ; Ultrasonography
Language	English
Publishing date	2022-05-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	632588-9
ISSN	1535-1815 ; 0749-5161
ISSN (online)	1535-1815
ISSN	0749-5161
DOI	10.1097/PEC.0000000000002767
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