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Article: Simultaneous seroprevalence of

Seck, Mame Cheikh / Gueye, Papa A T / Engo, Pasca E / Faye, Cheikh / Mbow, Moustapha / Diongue, Khadim / Diallo, Mamadou A / Ndiaye, Mouhamadou / Badiane, Aida S / Ndiaye, Daouda

Tropical parasitology

2023 Volume 13, Issue 1, Page(s) 34–39

Abstract: Context: Toxoplasma gondii: Aims: This study aimed to determine for the first time the simultaneous seroprevalence of toxoplasmosis and rubella among pregnant women in Dakar.: Materials and methods: In this retrospective study, anti-: Results: ... ...

Abstract	Context: Toxoplasma gondii Aims: This study aimed to determine for the first time the simultaneous seroprevalence of toxoplasmosis and rubella among pregnant women in Dakar. Materials and methods: In this retrospective study, anti- Results: Overall, data from 2589 women were analyzed. The median age was 29 years (interquartile range: 23.14-34.86). Serum IgG and IgM were positive for Conclusions: Data from this first-time study regarding simultaneous seroprevalence of toxoplasmosis and rubella among pregnant women in Senegal indicate a continuing high risk of congenital toxoplasmosis and congenital rubella syndrome in Dakar. Further studies are needed to fully assess the efficacy of rubella vaccination in women of childbearing age.
Language	English
Publishing date	2023-05-19
Publishing country	India
Document type	Journal Article
ZDB-ID	2628177-6
ISSN	2229-7758 ; 2229-5070
ISSN (online)	2229-7758
ISSN	2229-5070
DOI	10.4103/tp.tp_29_22
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Article ; Online: Antimalarial artesunate-mefloquine versus praziquantel in African children with schistosomiasis: an open-label, randomized controlled trial.

Nature medicine

2024 Volume 30, Issue 1, Page(s) 130–137

Abstract: Schistosomiasis treatment entirely relies on a single drug, praziquantel, prompting research into alternative therapeutics. Here we evaluated the efficacy and safety of the antimalarial combination artesunate-mefloquine for the treatment of ... ...

Abstract	Schistosomiasis treatment entirely relies on a single drug, praziquantel, prompting research into alternative therapeutics. Here we evaluated the efficacy and safety of the antimalarial combination artesunate-mefloquine for the treatment of schistosomiasis in a proof-of-concept, pragmatic, open-label, randomized controlled trial in primary schools of six villages endemic for schistosomiasis in northern Senegal. Children (6-14 years) were eligible if Schistosoma eggs were detected by microscopy in urine and/or stool. In total, 726 children were randomized 1:1 to praziquantel (standard care: 40 mg kg
MeSH term(s)	Child ; Female ; Humans ; Male ; Antimalarials/adverse effects ; Artesunate/adverse effects ; Mefloquine/adverse effects ; Praziquantel/adverse effects ; Schistosomiasis/drug therapy ; Treatment Outcome ; Adolescent
Chemical Substances	Antimalarials ; Artesunate (60W3249T9M) ; Mefloquine (TML814419R) ; Praziquantel (6490C9U457)
Language	English
Publishing date	2024-01-04
Publishing country	United States
Document type	Journal Article ; Pragmatic Clinical Trial ; Randomized Controlled Trial
ZDB-ID	1220066-9
ISSN	1546-170X ; 1078-8956
ISSN (online)	1546-170X
ISSN	1078-8956
DOI	10.1038/s41591-023-02719-4
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Article ; Online: Seroepidemiology of Toxoplasmosis in Hemodialysis Patients in Senegal

Parasitologia, Vol 3, Iss 15, Pp 142-

2023 Volume 150

Abstract: Toxoplasmosis in immunocompromised patients results in either reactivation of latent toxoplasmosis or acute infection. In the framework of the kidney transplantation program in Senegal, the serological screening of potential pre-transplant and ... ...

Abstract	Toxoplasmosis in immunocompromised patients results in either reactivation of latent toxoplasmosis or acute infection. In the framework of the kidney transplantation program in Senegal, the serological screening of potential pre-transplant and transplanted patients can prevent the disease. This study aimed to assess the seroprevalence of toxoplasmosis in a cohort of hemodialysis patients, candidates for kidney transplantation. To this end, a multicentre cross-sectional study was conducted in 2020 in six dialysis units from five regions. Blood samples and sociodemographic data were collected from each patient. IgG and IgM against T. gondii antibodies were assessed by a chemiluminescent method using Architect ci4100, and statistical analysis was performed using R software. Overall, 211 hemodialysis patients aged from 18 to 77 years were enrolled. The mean age was 42.62 years ± 13.6, and the sex ratio M/F was 1.24. The overall seroprevalence of T. gondii was 41.7%, with the highest value being recorded in the region of Kaolack (44.4%). Patients aged over 60 years were more typically infected, at a proportion of 56.0%. Regarding sex, males elicited a higher prevalence (44.4.%) than females did. Patients of an upper socioeconomic status were less affected, and contact with cats was not associated with toxoplasmosis. By education level, the illiterate group was most affected one. Overall, this first study of toxoplasmosis among Senegalese hemodialysis patients indicates high seroprevalence.
Keywords	seroprevalence ; toxoplasmosis ; hemodialysis patients ; Senegal ; Infectious and parasitic diseases ; RC109-216 ; Biology (General) ; QH301-705.5
Subject code	616 ; 610
Language	English
Publishing date	2023-04-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: Prevalence of SARS-CoV-2 antibodies in hemodialysis patients in Senegal: a multicenter cross-sectional study.

Seck, Sidy Mohamed / Mbow, Moustapha / Kane, Yaya / Cisse, Mouhamadou Moustapha / Faye, Gnagna / Kama, Adama / Sarr, Moussa / Nitcheu, Pamela / Dahaba, Mohamed / Diallo, Ibrahima Mbemba / Diawara, Mame Selly / Latou, Lotingo Nehemie Motoula / Dia, Yacine / Mboup, Souleymane

BMC nephrology

2021 Volume 22, Issue 1, Page(s) 384

Abstract: Background: Hemodialysis patients are among high-risk groups for COVID-19. Africa is the continent with the lowest number of cases in the general population but we have little information about the disease burden in dialysis patients.: Objectives: ... ...

Abstract	Background: Hemodialysis patients are among high-risk groups for COVID-19. Africa is the continent with the lowest number of cases in the general population but we have little information about the disease burden in dialysis patients. Objectives: This study aimed to describe the seroprevalence of SARS-CoV-2 antibodies in the hemodialysis population of Senegal. Patients and methods: We conducted a multicenter cross-sectional survey, between June and September 2020 involving 10 public dialysis units randomly selected in eight regions of Senegal. After seeking their consent, we included 303 patients aged ≥ 18 years and hemodialysis for ≥ 3 months. Clinical symptoms and biological parameters were collected from medical records. Patients' blood samples were tested with Abbott SARS-CoV-2 Ig G assay using an Architect system. Statistical tests were performed with STATA 12.0. Results: Seroprevalence of SARS-CoV-2 antibodies was 21.1% (95% CI = 16.7-26.1%). We noticed a wide variability in SARS-CoV-2 seroprevalence between regions ranging from 5.6 to 51.7%. Among the 38 patients who underwent nasal swab testing, only six had a PCR-confirmed infection and all of them did seroconvert. Suggestive clinical symptoms were reported by 28.1% of seropositive patients and the majority of them presented asymptomatic disease. After multivariate analysis, a previous contact with a confirmed case and living in a high population density region were associated with the presence of SARS-CoV-2 antibodies. Conclusion: This study presents to our knowledge the first seroprevalence data in African hemodialysis patients. Compared to data from other continents, we found a higher proportion of patients with SARS-CoV-2 antibodies but a lower lethality rate.
MeSH term(s)	Adolescent ; Adult ; Aged ; Antibodies, Viral/blood ; COVID-19/blood ; COVID-19/complications ; COVID-19/epidemiology ; Contact Tracing ; Cross-Sectional Studies ; Educational Status ; Female ; Geography, Medical ; Health Surveys ; Humans ; Immunoglobulin G/blood ; Kidney Failure, Chronic/complications ; Kidney Failure, Chronic/therapy ; Male ; Middle Aged ; Population Density ; Prevalence ; Renal Dialysis ; SARS-CoV-2/immunology ; Senegal/epidemiology ; Seroepidemiologic Studies ; Symptom Assessment ; Young Adult
Chemical Substances	Antibodies, Viral ; Immunoglobulin G
Language	English
Publishing date	2021-11-17
Publishing country	England
Document type	Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
ZDB-ID	2041348-8
ISSN	1471-2369 ; 1471-2369
ISSN (online)	1471-2369
ISSN	1471-2369
DOI	10.1186/s12882-021-02582-w
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Article ; Online: COVID-19 in Africa: Dampening the storm?

Mbow, Moustapha / Lell, Bertrand / Jochems, Simon P / Cisse, Badara / Mboup, Souleymane / Dewals, Benjamin G / Jaye, Assan / Dieye, Alioune / Yazdanbakhsh, Maria

Science (New York, N.Y.)

2020 Volume 369, Issue 6504, Page(s) 624–626

MeSH term(s)	Africa/epidemiology ; Age Factors ; Antibodies, Neutralizing/immunology ; Antibodies, Viral/immunology ; Betacoronavirus/genetics ; Betacoronavirus/immunology ; Betacoronavirus/pathogenicity ; COVID-19 ; Communicable Disease Control ; Coronavirus Infections/epidemiology ; Coronavirus Infections/immunology ; Coronavirus Infections/prevention & control ; Coronavirus Infections/virology ; Cytokine Release Syndrome/etiology ; Humans ; Immunity, Cellular ; Macrophages, Alveolar/immunology ; Pandemics/prevention & control ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/immunology ; Pneumonia, Viral/prevention & control ; Pneumonia, Viral/virology ; SARS-CoV-2 ; T-Lymphocytes/immunology
Chemical Substances	Antibodies, Neutralizing ; Antibodies, Viral
Keywords	covid19
Language	English
Publishing date	2020-08-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	128410-1
ISSN	1095-9203 ; 0036-8075
ISSN (online)	1095-9203
ISSN	0036-8075
DOI	10.1126/science.abd3902
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Article ; Online: Seroprevalence of SARS-CoV-2 IgG antibodies in a healthcare setting during the first pandemic wave in Senegal.

Ahouidi, Ambroise D / Anderson, Mark / Diédhiou, Cyrille K / Dia, Aminata / Mbow, Moustapha / Dia, Yacine / Mboup, Aminata / Gaye, Astou Gueye / Manga, Noel M / Cloherty, Gavin / Mboup, Souleymane

IJID regions

2021 Volume 2, Page(s) 96–98

Abstract: This study investigated the seroprevalence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) immunoglobulin G (IgG) during the first pandemic wave in Senegal. The seroprevalence rate of SARS-CoV-2 IgG was assessed in 10 cities in Senegal by ...

Abstract	This study investigated the seroprevalence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) immunoglobulin G (IgG) during the first pandemic wave in Senegal. The seroprevalence rate of SARS-CoV-2 IgG was assessed in 10 cities in Senegal by testing plasma from volunteers attending healthcare clinics for reasons unrelated to coronavirus disease 2019 (
Language	English
Publishing date	2021-12-24
Publishing country	England
Document type	Journal Article
ISSN	2772-7076
ISSN (online)	2772-7076
DOI	10.1016/j.ijregi.2021.12.008
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Article: COVID-19 in Africa: Dampening the storm?

Mbow, Moustapha / Lell, Bertrand / Jochems, Simon P / Cisse, Badara / Mboup, Souleymane / Dewals, Benjamin G / Jaye, Assan / Dieye, Alioune / Yazdanbakhsh, Maria

Science

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #696224
Database	COVID19

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Article ; Online: COVID-19 in Africa

Mbow, Moustapha / Lell, Bertrand / Jochems, Simon P. / Cisse, Badara / Mboup, Souleymane / Dewals, Benjamin G. / Jaye, Assan / Dieye, Alioune / Yazdanbakhsh, Maria

Science

Dampening the storm?

2020 Volume 369, Issue 6504, Page(s) 624–626

Keywords	Multidisciplinary ; covid19
Language	English
Publisher	American Association for the Advancement of Science (AAAS)
Publishing country	us
Document type	Article ; Online
ZDB-ID	128410-1
ISSN	1095-9203 ; 0036-8075
ISSN (online)	1095-9203
ISSN	0036-8075
DOI	10.1126/science.abd3902
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Article: Heterogeneity of the Omicron variant in Senegal.

Diédhiou, Cyrille Kouligueul / Padane, Abdou / Gueye, Khadim / Ndiour, Samba / Mboup, Aminata / Mbow, Moustapha / Lo, Cheikh Ibrahima / Leye, Nafissatou / Sow Ndoye, Aissatou / Ndiaye, Anna Julienne Selbé / Diagne, Ndéye Diabou / Ndiaye, Seyni / Dia, Yacine Amet / Lo, Gora / Wade, Djibril / Diaw, Papa Alassane / Sarr, Marièma / Beye, Mamadou / Cissé, Badara /

Sokhna, Cheikh / Camara, Makhtar / Ahouidi, Ambroise / Touré Kane, Ndéye Coumba / Mboup, Souleymane

New microbes and new infections

2022 Volume 47, Page(s) 100990

Abstract: Omicron variant continues to progress in Senegal with the appearance of new contaminations.•IRESSEF detected the first positive case of the Omicron variant on Friday, December 3, 2021.•Since this date, the number of Omicron variant infections has ... ...

Abstract	•Omicron variant continues to progress in Senegal with the appearance of new contaminations.•IRESSEF detected the first positive case of the Omicron variant on Friday, December 3, 2021.•Since this date, the number of Omicron variant infections has increased over the weeks.•Molecular surveillance of the Omicron variant allowed us to identify a strong variation of this variant in our country.
Language	English
Publishing date	2022-05-28
Publishing country	England
Document type	Journal Article
ZDB-ID	2750179-6
ISSN	2052-2975
ISSN	2052-2975
DOI	10.1016/j.nmni.2022.100990
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Article ; Online: New classification of periodontal diseases (NCPD): an application in a sub-Saharan country.

Ndjidda Bakari, William / Thiam, Diabel / Mbow, Ndeye Lira / Samb, Anna / Guirassy, Mouhamadou Lamine / Diallo, Ahmad Moustapha / Diouf, Abdoulaye / Diallo, Adam Seck / Benoist, Henri Michel

BDJ open

2021 Volume 7, Issue 1, Page(s) 16

Abstract: Purpose: To determine the clinical and radiological profile of periodontitis according to the 2018 NCPD, in a Dakar (Senegal) based periodontal clinic.: Methods: This is a descriptive study based on patient's records in the periodontology clinic. The ...

Abstract	Purpose: To determine the clinical and radiological profile of periodontitis according to the 2018 NCPD, in a Dakar (Senegal) based periodontal clinic. Methods: This is a descriptive study based on patient's records in the periodontology clinic. The study was conducted between November 2018 and February 2020 (15 months). All periodontitis cases were included in the study. Incomplete records (due to lack of radiographic workup or unusable periodontal charting) were excluded. Periodontitis diagnosis was established based on criteria used in the 2018 NCPD. Statistical analysis was carried out using SPSS version 20.0, with the significance threshold set at 0.05. Results: A total number of 517 patient records were collected during the study period but only 127 periodontitis records were complete. The mean age of participants was 46.8 ± 13.8 years and 63.8% of participants were males. The mean plaque index and bleeding on probing (BOP) were 74% ± 21.3 and 58.1% ± 25.1, respectively. The mean maximum clinical attachment loss was 8.7 mm ±2.7, with a probing depth greater than 6 mm present in 50.4% of the sample. The median number of missing teeth was 3 (interquartile range 5-1). Pathological mobility was present in 60.6% of the patients and 78.0% had occlusion problems. Bone crest defect at the most affected site was moderate in 52.8% of cases. The ratio of bone loss to age greater than one concerned 66.1% of the sample. Generalised (81.9%), Stage IV (70.1%) and grade C (69.3%) were the most encountered diagnosis. The disease severity was associated with age (r = 0.241; P < 0.001), BOP (r = 0.230; P = 0.013) and the number of teeth with pathological mobility (r = 0.318; P < 0.001). Conclusion: Patients with periodontitis in this study had advanced forms of the disease and required multidisciplinary care. Clinical hindsight is necessary to improve this classification.
Language	English
Publishing date	2021-04-26
Publishing country	England
Document type	Journal Article
ISSN	2056-807X
ISSN (online)	2056-807X
DOI	10.1038/s41405-021-00071-8
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