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Article: COVID-19 in Children: An Ample Review.

Ciuca, Ioana M

2020 Volume 13, Page(s) 661–669

Abstract: The aim of this review was to describe the current knowledge about coronavirus disease 2019 (COVID-19, which is caused by severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2]) in children, from epidemiological, clinical, and laboratory ... ...

Abstract	The aim of this review was to describe the current knowledge about coronavirus disease 2019 (COVID-19, which is caused by severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2]) in children, from epidemiological, clinical, and laboratory perspectives, including knowledge on the disease course, treatment, and prognosis. An extensive literature search was performed to identify papers on COVID-19 (SARS-CoV-2 infection) in children, published between January 1, 2020 and April 1, 2020. There were 44 relevant papers on COVID-19 in children. The results showed that COVID-19 occurs in 0.39-12.3% of children. Clinical signs and symptoms are comparable to those in adults, but milder forms and a large percentage of asymptomatic carriers are found among children. Elevated inflammatory markers are associated with complications and linked to various co-infections. Chest computed tomography (CT) scans in children revealed structural changes similar to those found in adults, with consolidations surrounded by halos being somewhat specific for children with COVID-19. The recommended treatment includes providing symptomatic therapy, with no specific drug recommendations for children. The prognosis is much better for children compared to adults. This review highlights that COVID-19 in children is similar to the disease in the adult population, but with particularities regarding clinical manifestations, laboratory test results, chest imaging, and treatment. The prognosis is much better for children compared to adults, but with the progression of the pandemic; the cases in children might change in the future.
Keywords	covid19
Language	English
Publishing date	2020-06-25
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2495128-6
ISSN	1179-1594
ISSN	1179-1594
DOI	10.2147/RMHP.S257180
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: COVID-19 in Children

Ciuca, Ioana M

Risk Management and Healthcare Policy

An Ample Review

2020 Volume Volume 13, Page(s) 661–669

Keywords	Public Health, Environmental and Occupational Health ; Health Policy ; covid19
Language	English
Publisher	Informa UK Limited
Publishing country	uk
Document type	Article ; Online
ZDB-ID	2495128-6
ISSN	1179-1594
ISSN	1179-1594
DOI	10.2147/rmhp.s257180
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Book ; Online: COVID-19 in Children

Ciuca, Ioana M

An Ample Review

2020

Abstract: Ioana M Ciuca Pediatric Department, University of Medicine and Pharmacy “Victor Babes”, Pediatric ... Pulmonology Unit, Clinical County Hospital, Timisoara, RomaniaCorrespondence: Ioana M CiucaPediatric ... ioana@umft.roAbstract: The aim of this review was to describe the current knowledge about coronavirus ...

Abstract	Ioana M Ciuca Pediatric Department, University of Medicine and Pharmacy “Victor Babes”, Pediatric Pulmonology Unit, Clinical County Hospital, Timisoara, RomaniaCorrespondence: Ioana M CiucaPediatric Department, University of Medicine and Pharmacy “Victor Babes”, Pediatric Pulmonology Unit, Clinical County Hospital, Evlia Celebi 1-3, Timisoara 300 226, RomaniaTel + 40 744 513 283Fax +40 256 494529Email ciuca.ioana@umft.roAbstract: The aim of this review was to describe the current knowledge about coronavirus disease 2019 (COVID-19, which is caused by severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2]) in children, from epidemiological, clinical, and laboratory perspectives, including knowledge on the disease course, treatment, and prognosis. An extensive literature search was performed to identify papers on COVID-19 (SARS-CoV-2 infection) in children, published between January 1, 2020 and April 1, 2020. There were 44 relevant papers on COVID-19 in children. The results showed that COVID-19 occurs in 0.39– 12.3% of children. Clinical signs and symptoms are comparable to those in adults, but milder forms and a large percentage of asymptomatic carriers are found among children. Elevated inflammatory markers are associated with complications and linked to various co-infections. Chest computed tomography (CT) scans in children revealed structural changes similar to those found in adults, with consolidations surrounded by halos being somewhat specific for children with COVID-19. The recommended treatment includes providing symptomatic therapy, with no specific drug recommendations for children. The prognosis is much better for children compared to adults. This review highlights that COVID-19 in children is similar to the disease in the adult population, but with particularities regarding clinical manifestations, laboratory test results, chest imaging, and treatment. The prognosis is much better for children compared to adults, but with the progression of the pandemic; the cases in children might change in the future.Keywords: pediatric, COVID-19, SARS-CoV-2 infection, child
Keywords	Risk Management and Healthcare Policy ; covid19
Subject code	610
Language	English
Publishing date	2020-06-25
Publisher	Dove Press
Publishing country	us
Document type	Article ; Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: COVID-19 in children: An ample review

Ciuca, Ioana M.

Risk Manage. Healthc. Policy

Abstract	The aim of this review was to describe the current knowledge about coronavirus disease 2019 (COVID-19, which is caused by severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2]) in children, from epidemiological, clinical, and laboratory perspectives, including knowledge on the disease course, treatment, and prognosis. An extensive literature search was performed to identify papers on COVID-19 (SARS-CoV-2 infection) in children, published between January 1, 2020 and April 1, 2020. There were 44 relevant papers on COVID-19 in children. The results showed that COVID-19 occurs in 0.39–12.3% of children. Clinical signs and symptoms are comparable to those in adults, but milder forms and a large percentage of asymptomatic carriers are found among children. Elevated inflammatory markers are associated with complications and linked to various co-infections. Chest computed tomography (CT) scans in children revealed structural changes similar to those found in adults, with consolidations surrounded by halos being somewhat specific for children with COVID-19. The recommended treatment includes providing symptomatic therapy, with no specific drug recommendations for children. The prognosis is much better for children compared to adults. This review highlights that COVID-19 in children is similar to the disease in the adult population, but with particularities regarding clinical manifestations, laboratory test results, chest imaging, and treatment. The prognosis is much better for children compared to adults, but with the progression of the pandemic; the cases in children might change in the future.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #636459
Database	COVID19

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Article ; Online: Pediatric pneumonia (PedPne) lung ultrasound score and inflammatory markers: A pilot study.

Ciuca, Ioana M / Dediu, Mihaela / Pop, Liviu L

Pediatric pulmonology

2021 Volume 57, Issue 2, Page(s) 576–582

Abstract: Introduction: Pneumonia is the principal cause of death among children worldwide. Lung ultrasound (LUS) is a reliable tool for the diagnosis and assessment of community-acquired pneumonia in children. Furthermore, objective parameters, including the ... ...

Abstract	Introduction: Pneumonia is the principal cause of death among children worldwide. Lung ultrasound (LUS) is a reliable tool for the diagnosis and assessment of community-acquired pneumonia in children. Furthermore, objective parameters, including the pneumonia LUS score, might be useful for pneumonia monitoring. Thus, our aim was to present a newly developed LUS score for pediatric pneumonia (PedPne) and evaluate its relationship with commonly assessed inflammatory markers. Methods: Children referred to the Pediatric Pneumology Clinic between September 2017 and February 2018 with suspected pneumonia were screened for eligibility for inclusion in the study and informed consent was obtained. In addition to clinical assessment, LUS was performed during consultation, and inflammatory biomarkers, including C-reactive protein level, erythrocyte sedimentation rate (ESR), and leukocyte count, were measured in all inpatients. An LUS score for pneumonia and pleurisy in children (pediatric pneumonia lung ultrasound score [PedPne LUS]) was subsequently developed. Chest radiography (CXR) was also performed according to local guidelines for pneumonia diagnosis. Spearman's correlation test was used to evaluate the correlation between the PedPne score and inflammatory markers. Results: A total of 217 patients were screened, of which 64 patients diagnosed with consolidated pneumonia were included in this study. The median PedPne LUS score of the included patients was 8.02, which was consistent with the consolidations detected on LUS and confirmed by CXR. A very strong positive correlation was found between the LUS PedPne score and C-reactive protein and ESR, and a good correlation was found with the leukocyte count. Conclusion: The LUS pneumonia score is a reliable parameter for the evaluation of pneumonia, and shows a strong correlation with inflammatory biomarkers. The PedPne LUS score is a potential noninvasive surrogate parameter of inflammation in pediatric pneumonia.
MeSH term(s)	Biomarkers ; Child ; Humans ; Lung/diagnostic imaging ; Pilot Projects ; Pneumonia/diagnostic imaging ; Ultrasonography
Chemical Substances	Biomarkers
Language	English
Publishing date	2021-11-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	632784-9
ISSN	1099-0496 ; 8755-6863
ISSN (online)	1099-0496
ISSN	8755-6863
DOI	10.1002/ppul.25760
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Article ; Online: COVID-19 in Children

Ciuca IM

Risk Management and Healthcare Policy, Vol Volume 13, Pp 661-

An Ample Review

2020 Volume 669

Abstract	Ioana M Ciuca Pediatric Department, University of Medicine and Pharmacy “Victor Babes”, Pediatric Pulmonology Unit, Clinical County Hospital, Timisoara, RomaniaCorrespondence: Ioana M CiucaPediatric Department, University of Medicine and Pharmacy “Victor Babes”, Pediatric Pulmonology Unit, Clinical County Hospital, Evlia Celebi 1-3, Timisoara 300 226, RomaniaTel + 40 744 513 283Fax +40 256 494529Email ciuca.ioana@umft.roAbstract: The aim of this review was to describe the current knowledge about coronavirus disease 2019 (COVID-19, which is caused by severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2]) in children, from epidemiological, clinical, and laboratory perspectives, including knowledge on the disease course, treatment, and prognosis. An extensive literature search was performed to identify papers on COVID-19 (SARS-CoV-2 infection) in children, published between January 1, 2020 and April 1, 2020. There were 44 relevant papers on COVID-19 in children. The results showed that COVID-19 occurs in 0.39– 12.3% of children. Clinical signs and symptoms are comparable to those in adults, but milder forms and a large percentage of asymptomatic carriers are found among children. Elevated inflammatory markers are associated with complications and linked to various co-infections. Chest computed tomography (CT) scans in children revealed structural changes similar to those found in adults, with consolidations surrounded by halos being somewhat specific for children with COVID-19. The recommended treatment includes providing symptomatic therapy, with no specific drug recommendations for children. The prognosis is much better for children compared to adults. This review highlights that COVID-19 in children is similar to the disease in the adult population, but with particularities regarding clinical manifestations, laboratory test results, chest imaging, and treatment. The prognosis is much better for children compared to adults, but with the progression of the pandemic; the cases in children might change in the future.Keywords: pediatric, COVID-19, SARS-CoV-2 infection, child
Keywords	pediatric ; covid 19 ; sars-cov2 infection ; child ; Public aspects of medicine ; RA1-1270
Subject code	610
Language	English
Publishing date	2020-06-01T00:00:00Z
Publisher	Dove Medical Press
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Oral Glucose Tolerance Test in Patients with Cystic Fibrosis Compared to the Overweight and Obese: A Different Approach in Understanding the Results.

Mogoi, Mirela / Pop, Liviu Laurentiu / Dediu, Mihaela / Ciuca, Ioana Mihaiela

Children (Basel, Switzerland)

2022 Volume 9, Issue 4

Abstract: 1) Background: In cystic fibrosis (CF), the oral glucose tolerance test (OGTT) is recommended from 10 years old annually to screen and diagnose cystic fibrosis-related diabetes (CFRD). Alternative OGTT characteristics (glucose curve shape, time to ... ...

Abstract	(1) Background: In cystic fibrosis (CF), the oral glucose tolerance test (OGTT) is recommended from 10 years old annually to screen and diagnose cystic fibrosis-related diabetes (CFRD). Alternative OGTT characteristics (glucose curve shape, time to glucose peak, one-hour glucose value, and three-hour glucose value with the new shape curve) were studied in other populations considered at high risk for diabetes; (2) Methods: The study analyses classical and alternative OGGT characteristics from 44 children (22 CF, 22 obese without CF), mean age: 12.9 ± 2.2 years evaluated in a single-center from Romania. (3) Results: In 59.1% of children with CF, the predominant OGTT pattern was: abnormal glucose metabolism or CFRD, with a monophasic curve shape, a late peak glucose level, and 1 h glucose ≥ 155 mg/dL, showing a very different pattern compared with sex and age-matched obese children. Statistical estimation agreement between the late glucose peak (K = 0.60;
Language	English
Publishing date	2022-04-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2732685-8
ISSN	2227-9067
ISSN	2227-9067
DOI	10.3390/children9040533
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Article: The Relation between Vitamin D Level and Lung Clearance Index in Cystic Fibrosis-A Pilot Study.

Dediu, Mihaela / Ciuca, Ioana Mihaiela / Pop, Liviu Laurentiu / Iacob, Daniela

Children (Basel, Switzerland)

2022 Volume 9, Issue 3

Abstract: Background: Life expectancy has increased in cystic fibrosis (CF) patients; however, the rate of mortality is still high, and in a majority of cases, the cause of death is due to respiratory deterioration. Vitamin D plays an important role in immunity ... ...

Abstract	Background: Life expectancy has increased in cystic fibrosis (CF) patients; however, the rate of mortality is still high, and in a majority of cases, the cause of death is due to respiratory deterioration. Vitamin D plays an important role in immunity and infection prophylaxis, as its deficiency is associated with frequent infections. In CF patients, a deficit of liposoluble vitamins is common, despite daily supplementation. The aim of this study is to evaluate the relation between vitamin D status and lung function expressed by lung clearance index (LCI) in patients with CF. We also assessed the relation of factors such as nutritional status, genotype, and associated comorbidities such as Pseudomonas infection, cystic fibrosis-related diabetes (CFRD), and cystic fibrosis liver disease (CFLD) with vitamin D and LCI. Methods: A cross-sectional study was conducted at the National Cystic Fibrosis Center by analyzing patients with CF who presented in our center between November 2017 and November 2019. We enrolled in the study patients diagnosed with CF, who were followed up in our CF center and who were able to perform lung function tests. Patients in exacerbation were excluded. Results: A strong negative correlation was found between vitamin D and LCI (r = -0.69, Conclusion: In CF patients, vitamin D plays an important role, and its deficit correlates with an impaired LCI. Vitamin D deficit is a risk factor in patients with associated comorbidities such as CFLD and CFRD. Chronic infection with Pseudomonas, the presence of impaired nutritional status, and CFLD are associated with a prolonged LCI.
Language	English
Publishing date	2022-03-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2732685-8
ISSN	2227-9067
ISSN	2227-9067
DOI	10.3390/children9030329
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Article: Biomarkers in Cystic Fibrosis Lung Disease - A Review.

Ciuca, Ioana Mihaiela / Marian, Paula / Monica, Marc

Romanian journal of anaesthesia and intensive care

2020 Volume 27, Issue 2, Page(s) 34–36

Abstract: Cystic fibrosis is a polymorphic disease, marked by multiple and difficult-to-treat respiratory exacerbations with severe evolution. The lung disease dictates the disease's evolution and it must be diagnosed early and treated accordingly, but the ... ...

Abstract	Cystic fibrosis is a polymorphic disease, marked by multiple and difficult-to-treat respiratory exacerbations with severe evolution. The lung disease dictates the disease's evolution and it must be diagnosed early and treated accordingly, but the diagnosis is sometimes challenging because of the lack of a sensible tool. In the era of the biomarkers, the need for a sensitive and reliable one would be extremely important, considering that inflammation secondary to infections produce irreversible structural changes in the cystic fibrosis lungs. The present paper reviews the studied biomarkers in inflammation and infection with potential role in cystic fibrosis lung disease.
Language	English
Publishing date	2020-10-11
Publishing country	Romania
Document type	Journal Article ; Review
ZDB-ID	2977912-1
ISSN	2502-0307 ; 2392-7518
ISSN (online)	2502-0307
ISSN	2392-7518
DOI	10.2478/rjaic-2020-0011
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Lung Ultrasound Is More Sensitive for Hospitalized Consolidated Pneumonia Diagnosis Compared to CXR in Children.

Ciuca, Ioana Mihaiela / Dediu, Mihaela / Marc, Monica Steluta / Lukic, Mirabela / Horhat, Delia Ioana / Pop, Liviu Laurentiu

Children (Basel, Switzerland)

2021 Volume 8, Issue 8

Abstract: Background: Pneumonia is the leading cause of death among children; thus, a correct early diagnosis would be ideal. The imagistic diagnosis still uses chest X-ray (CXR), but lung ultrasound (LUS) proves to be reliable for pneumonia diagnosis. The aim of ...

Abstract	Background: Pneumonia is the leading cause of death among children; thus, a correct early diagnosis would be ideal. The imagistic diagnosis still uses chest X-ray (CXR), but lung ultrasound (LUS) proves to be reliable for pneumonia diagnosis. The aim of our study was to evaluate the sensitivity and specificity of LUS compared to CXR in consolidated pneumonia. Methods: Children with clinical suspicion of bacterial pneumonia were screened by LUS for pneumonia, followed by CXR. The agreement relation between LUS and CXR regarding the detection of consolidation was evaluated by Cohen's kappa test. Results: A total of 128 patients with clinical suspicion of pneumonia were evaluated; 74 of them were confirmed by imagery and biological inflammatory markers. The highest frequency of pneumonia was in the 0-3 years age group (37.83%). Statistical estimation of the agreement between LUS and CXR in detection of the consolidation found an almost perfect agreement, with a Cohen's kappa coefficient of K = 0.89 ± 0.04 SD, Conclusion: Lung ultrasound is a reliable method for the detection of pneumonia consolidation in hospitalized children, with sensitivity and specificity superior to CXR. LUS should be used for rapid and safe evaluation of child pneumonia.
Language	English
Publishing date	2021-07-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2732685-8
ISSN	2227-9067
ISSN	2227-9067
DOI	10.3390/children8080659
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