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  1. Article: [Reverse genetic system for rabies virus vaccine Evelyn-Rokitnicki-Abelseth strain].

    Guo, Li / Feng, Na / Yang, Songtao / Wang, Xijun / Ge, Jinying / Xia, Xianzhu / Bu, Zhigao

    Wei sheng wu xue bao = Acta microbiologica Sinica

    2009  Volume 49, Issue 7, Page(s) 949–954

    Abstract: Objective: To establish a reverse genetic system of rabies virus for producing safe and efficient rabies vaccine.: Method: By reverse genetic and molecular cloning technique, we established two rabies virus rescue systems including (1) help plasmids ... ...

    Abstract Objective: To establish a reverse genetic system of rabies virus for producing safe and efficient rabies vaccine.
    Method: By reverse genetic and molecular cloning technique, we established two rabies virus rescue systems including (1) help plasmids expressing N, P and L protein, and (2) CMV/T7 and T7 promoter.
    Results: Wild-type rERA-VC was rescued by both systems, and had the same growth kinetics as parental virus. The third generation virus could grow to high titer.
    Conclusion: The established reverse genetic system for rescuing wild-type rERA-VC provides the possibility of producing safe and efficient rabies virus vaccines.
    MeSH term(s) Animals ; Cell Line ; Cloning, Molecular ; Cricetinae ; Genetic Techniques ; Rabies/immunology ; Rabies/virology ; Rabies Vaccines/genetics ; Rabies Vaccines/immunology ; Rabies virus/genetics ; Rabies virus/immunology ; Rabies virus/physiology ; Viral Proteins/genetics ; Viral Proteins/immunology ; Virus Replication
    Chemical Substances Rabies Vaccines ; Viral Proteins
    Language Chinese
    Publishing date 2009-07
    Publishing country China
    Document type English Abstract ; Evaluation Studies ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 412683-x
    ISSN 0001-6209 ; 0098-9150
    ISSN 0001-6209 ; 0098-9150
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    Zs.A 1161: Show issues Location:
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  2. Article ; Online: Pudgy mouse rib deformities emanate from abnormal paravertebral longitudinal cartilage/bone accumulations.

    Shapiro, Frederic / Wang, Jamie / Flynn, Evelyn / Wu, Joy Y

    Biology open

    2024  Volume 13, Issue 1

    Abstract: The pudgy (pu/pu) mouse, caused by a recessive mutation in the Notch family Delta like-3 gene (Dll3), has severe rib, vertebral body and intervertebral disc abnormalities. Using whole-mount preparations and serial histologic sections we demonstrate: 1) ... ...

    Abstract The pudgy (pu/pu) mouse, caused by a recessive mutation in the Notch family Delta like-3 gene (Dll3), has severe rib, vertebral body and intervertebral disc abnormalities. Using whole-mount preparations and serial histologic sections we demonstrate: 1) localized paravertebral longitudinal cartilage/bone accumulations (PVLC/BAs) invariably associated with branched, fused and asymmetrically spaced ribs that emanate from it laterally; 2) abnormal rib formation immediately adjacent to abnormal vertebral body and intervertebral disc formation in asymmetric right/left fashion; and 3) patterns of rib deformation that differ in each mouse. Normal BALB/c embryo and age-matched non-affected pu/+ mice assessments allow for pu/pu comparisons. The Dll3 Notch family gene is involved in normal somitogenesis via the segmentation clock mechanism. Although pathogenesis of rib deformation is initially triggered by the Dll3 gene mutation, these findings of abnormal asymmetric costo-vertebral region structure imply that differing patterns cannot be attributed to this single gene mutation alone. All findings implicate a dual mechanism of malformation: the Dll3 gene mutation leading to subtle timing differences in traveling oscillation waves of the segmentation clock and further subsequent misdirection of tissue formation by altered chemical reaction-diffusion and epigenetic landscape responses. PVLC/BAs appear as primary supramolecular structures underlying severe rib malformation associated both with time-sensitive segmentation clock mutations and subsequent reactions.
    MeSH term(s) Animals ; Mice ; Cartilage ; Embryo, Mammalian ; Epigenomics ; Mutation ; Receptors, Notch ; Ribs/abnormalities ; Intracellular Signaling Peptides and Proteins/genetics ; Membrane Proteins/genetics
    Chemical Substances Receptors, Notch ; Dll3 protein, mouse ; Intracellular Signaling Peptides and Proteins ; Membrane Proteins
    Language English
    Publishing date 2024-01-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 2632264-X
    ISSN 2046-6390 ; 2046-6390
    ISSN (online) 2046-6390
    ISSN 2046-6390
    DOI 10.1242/bio.060139
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  3. Article ; Online: Prior actions influence cost-benefit-related decision-making during mouse foraging behaviours.

    Dylda, Evelyn / Wang, Kuan Hong

    The European journal of neuroscience

    2022  Volume 56, Issue 2, Page(s) 3861–3874

    Abstract: Food foraging is essential for the fitness of animals. Previous studies have suggested that optimal foraging strategies involve a cost-benefit analysis comparing reward versus effort to guide action choices. Little is known how prior experience with ... ...

    Abstract Food foraging is essential for the fitness of animals. Previous studies have suggested that optimal foraging strategies involve a cost-benefit analysis comparing reward versus effort to guide action choices. Little is known how prior experience with different actions to obtain rewards may affect subsequent foraging choices. Here, we report a sunflower seed foraging test to investigate how effort and prior actions influence decision-making in laboratory mice. Sunflower seeds are a natural food favourite for mice, and mice spend effort to peel the hard shells to obtain the seeds. In our test, peeled and unpeeled sunflower seeds were placed at different ends of a Y-maze. Mice were free to explore the maze and make foraging decisions. Naïve mice were more likely to choose peeled seeds requiring low effort versus unpeeled seeds requiring high effort. Furthermore, mice with prior seed peeling experience significantly reduced preference for peeled seeds during the subsequent Y-maze foraging test, compared with mice pre-exposed to peeled seeds only. This experience-dependent shift in foraging choice was associated with reduced seed peeling time and improved motor skills with practice, and predictable on a trial-by-trial basis by a probabilistic decision-making model with the amount of peeled and unpeeled seeds consumed as inputs. Together, these results suggest that laboratory mice make rational foraging choices based on effort estimation and moreover, prior actions to obtain reward alter effort estimation and decision-making through motor skill learning. This naturalist behavioural task may be applied to dissect neural mechanisms in adaptive decision-making during foraging.
    MeSH term(s) Animals ; Choice Behavior ; Cost-Benefit Analysis ; Decision Making ; Maze Learning ; Mice ; Reward
    Language English
    Publishing date 2022-05-26
    Publishing country France
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 645180-9
    ISSN 1460-9568 ; 0953-816X
    ISSN (online) 1460-9568
    ISSN 0953-816X
    DOI 10.1111/ejn.15689
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    Zs.A 2548: Show issues Location:
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  4. Article ; Online: Allergens and atopic dermatitis.

    Wang, Evelyn A / Leung, Donald Y M

    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology

    2022  Volume 128, Issue 6, Page(s) 624–625

    MeSH term(s) Allergens ; Dermatitis, Atopic ; Humans ; Immunoglobulin E
    Chemical Substances Allergens ; Immunoglobulin E (37341-29-0)
    Language English
    Publishing date 2022-01-10
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1228189-x
    ISSN 1534-4436 ; 0003-4738 ; 1081-1206
    ISSN (online) 1534-4436
    ISSN 0003-4738 ; 1081-1206
    DOI 10.1016/j.anai.2022.01.005
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  5. Article ; Online: COVID-19 in Children: An Epidemiology Study from China.

    Wang, Evelyn / Brar, Kanwaljit

    The journal of allergy and clinical immunology. In practice

    2020  Volume 8, Issue 6, Page(s) 2118–2120

    MeSH term(s) Adolescent ; Age Distribution ; COVID-19/epidemiology ; Child ; Child, Preschool ; China/epidemiology ; Female ; Humans ; Infant ; Male ; Retrospective Studies ; Severity of Illness Index
    Language English
    Publishing date 2020-04-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2020.04.024
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  6. Article ; Online: A descriptive survey of specialty pharmacy team members' perceptions of interactions with field representatives from pharmaceutical companies.

    Wang, Evelyn Y / Lee, Lydia / Lee, Yehun / Mullen, Maura E / Hill, Aaron W / Rotolo, Shannon M

    Journal of managed care & specialty pharmacy

    2023  Volume 29, Issue 10, Page(s) 1151–1157

    Abstract: BACKGROUND: ...

    Abstract BACKGROUND:
    MeSH term(s) Humans ; Pharmacy ; Pharmaceutical Services ; Pharmacists ; Surveys and Questionnaires ; Pharmaceutical Preparations
    Chemical Substances Pharmaceutical Preparations
    Language English
    Publishing date 2023-09-29
    Publishing country United States
    Document type Journal Article
    ISSN 2376-1032
    ISSN (online) 2376-1032
    DOI 10.18553/jmcp.2023.29.10.1151
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  7. Article ; Online: Chronic Urticaria in Children: an Update on Diagnosis and Treatment.

    Wang, Evelyn A / Chan, Sanny K

    Current allergy and asthma reports

    2020  Volume 20, Issue 8, Page(s) 31

    Abstract: Purpose of review: Both adults and children are frequently affected by symptoms of itchy urticarial lesions that cause considerable distress and impact nearly all their daily activities. A comprehensive history is critical to identify the etiology in ... ...

    Abstract Purpose of review: Both adults and children are frequently affected by symptoms of itchy urticarial lesions that cause considerable distress and impact nearly all their daily activities. A comprehensive history is critical to identify the etiology in patients who have chronic spontaneous urticaria (CSU) (those with symptoms for > 6 weeks) and is more important than extensive laboratory serum tests. Unfortunately, most of the current treatment guidelines have been based on data from adult studies since there is rare data on children. These treatment algorithms have been subsequently used to extrapolate treatments for children.
    Recent findings: Current treatment regiments do not achieve complete success in all patients, neither adults nor children. As the pathophysiology of chronic urticaria slowly becomes defined, novel therapies are being tested which target these individual molecular pathways to treat those that continue to experience symptoms. Future studies are required to establish the natural history, risks/benefits and efficacy of current medications, and biologics used to treat CSU in children.
    MeSH term(s) Child ; Chronic Disease ; Chronic Urticaria/diagnosis ; Chronic Urticaria/therapy ; Humans
    Language English
    Publishing date 2020-06-06
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2057370-4
    ISSN 1534-6315 ; 1529-7322
    ISSN (online) 1534-6315
    ISSN 1529-7322
    DOI 10.1007/s11882-020-00929-1
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    Zs.A 5548: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  9. Article ; Online: Mindful awareness and resilience skills for adolescents (MARS-A): a mixed-methods study of a mindfulness-based intervention for a heterogeneous adolescent clinical population.

    Vo, Dzung X / Tabi, Katarina / Bhullar, Manreet / Johnson, Andrea / Locke, Jake / Wang, Sophia / Stewart, S Evelyn / Marshall, Sheila K

    International journal of adolescent medicine and health

    2024  Volume 36, Issue 1, Page(s) 25–35

    Abstract: Objectives: Mindful Awareness and Resilience Skills for Adolescents (MARS-A) is a mindfulness-based intervention adapted for the adolescent population. While previous studies have explored the benefits of MARS-A in various single-diagnosis populations, ... ...

    Abstract Objectives: Mindful Awareness and Resilience Skills for Adolescents (MARS-A) is a mindfulness-based intervention adapted for the adolescent population. While previous studies have explored the benefits of MARS-A in various single-diagnosis populations, the aim of this study was to assess MARS-A for a heterogenous clinical adolescent population with mental health and/or chronic diagnoses, focusing on the underlying suffering present in all these conditions rather than its effects on a single diagnosis itself.
    Methods: Qualitative data was collected through interviews to understand post-intervention participant perspectives and experiences. Quantitative data was collected through measures to investigate preliminary secondary outcomes.
    Results: After participating in MARS-A, participants reported qualitative benefits in enhanced well-being, including coping with difficult emotions and managing sleep and/or pain. Quantitative results showed a reduction in functional disability, psychological distress, perceived stress, and depressive symptoms; increase in positive affect; and benefit in coping with pain and chronic conditions.
    Conclusions: MARS-A shows great potential in a heterogeneous clinical adolescent population.
    MeSH term(s) Humans ; Adolescent ; Resilience, Psychological ; Mindfulness/methods ; Emotions ; Coping Skills ; Pain
    Language English
    Publishing date 2024-02-01
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 639287-8
    ISSN 2191-0278 ; 0334-0139
    ISSN (online) 2191-0278
    ISSN 0334-0139
    DOI 10.1515/ijamh-2023-0112
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  10. Article ; Online: Determinants of influenza vaccine uptake among pregnant women: Demographics and medical care access.

    Marin, Evelyn S / McCall-Hosenfeld, Jennifer / Weng, Xingran / Wang, Li

    International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics

    2023  Volume 162, Issue 1, Page(s) 125–132

    Abstract: Objective: To investigate how sociodemographic and medical care access variables are associated with influenza vaccine uptake among pregnant women in the USA.: Methods: This is an observational study using 2015-2019 data from the US Behavioral Risk ... ...

    Abstract Objective: To investigate how sociodemographic and medical care access variables are associated with influenza vaccine uptake among pregnant women in the USA.
    Methods: This is an observational study using 2015-2019 data from the US Behavioral Risk Factor Surveillance System. Pregnant women aged 18-49 years were included. Weighted χ
    Results: A total of 9149 pregnant women were included, of whom 39.9% received the influenza vaccine. Age, income, education and race/ethnicity were significantly associated with influenza vaccination. The following medical access factors were associated with a higher likelihood of receiving the influenza vaccine: having insurance (odds ratio [OR] 1.43, 95% confidence interval [CI] 1.04-1.97), having had a checkup in the past year (OR 1.69, 95% CI 1.40-2.03), and having a primary care provider (OR 1.45, 95% CI 1.18-1.78). In subgroup analysis by race/ethnicity, non-Hispanic black women had the least difference in influenza vaccine uptake between those with medical care access and those without.
    Conclusion: Our findings suggest that the influenza vaccine uptake level was far from optimal among pregnant women. Influenza vaccine uptake was associated with social demographics and medical care access among pregnant women.
    MeSH term(s) Female ; Pregnancy ; Humans ; Pregnant Women ; Influenza Vaccines ; Influenza, Human/prevention & control ; Pregnancy Complications, Infectious/prevention & control ; Ethnicity ; Vaccination
    Chemical Substances Influenza Vaccines
    Language English
    Publishing date 2023-04-20
    Publishing country United States
    Document type Observational Study ; Journal Article
    ZDB-ID 80149-5
    ISSN 1879-3479 ; 0020-7292
    ISSN (online) 1879-3479
    ISSN 0020-7292
    DOI 10.1002/ijgo.14798
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