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  1. Article: New Perspectives in Liver Transplantation: From Regeneration to Bioengineering

    RUSSO, FRANCESCO PAOLO / Burra, Patrizia

    Bioengineering, 6(3):81

    2019  

    Abstract: Advanced liver diseases have very high morbidity and mortality due to associated complications, and liver transplantation represents the only current therapeutic option. However, due to worldwide donor shortages, new alternative approaches are mandatory ... ...

    Abstract Advanced liver diseases have very high morbidity and mortality due to associated complications, and liver transplantation represents the only current therapeutic option. However, due to worldwide donor shortages, new alternative approaches are mandatory for such patients. Regenerative medicine could be the more appropriate answer to this need. Advances in knowledge of physiology of liver regeneration, stem cells, and 3D scaffolds for tissue engineering have accelerated the race towards efficient therapies for liver failure. In this review, we propose an update on liver regeneration, cell-based regenerative medicine and bioengineering alternatives to liver transplantation.
    Keywords liver tissue bioengineering ; end-stage liver diseases ; liver bioreactors ; liver regeneration ; regenerative medicine
    Language English
    Document type Article
    Database Repository for Life Sciences

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  2. Article: Pharmacist-led patient education improves medication self-management and adherence in chronic hepatitis D virus patients: insights from the EXPLAIN project.

    Mengato, Daniele / Trivellato, Sabrina / Pedrolo, Caterina / Russo, Francesco Paolo / Venturini, Francesca

    European journal of hospital pharmacy : science and practice

    2024  

    Language English
    Publishing date 2024-04-10
    Publishing country England
    Document type Letter
    ZDB-ID 2650179-X
    ISSN 2047-9964 ; 2047-9956
    ISSN (online) 2047-9964
    ISSN 2047-9956
    DOI 10.1136/ejhpharm-2024-004170
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Liver Transplantation in People Living with HIV: Still an Experimental Procedure or Standard of Care?

    Lynch, Erica Nicola / Russo, Francesco Paolo

    Life (Basel, Switzerland)

    2023  Volume 13, Issue 10

    Abstract: Liver transplantation (LT) is the only curative treatment for various liver diseases, including acute liver failure, end-stage liver disease, and selected unresectable liver malignancies. Combination antiretroviral therapy has improved outcomes for ... ...

    Abstract Liver transplantation (LT) is the only curative treatment for various liver diseases, including acute liver failure, end-stage liver disease, and selected unresectable liver malignancies. Combination antiretroviral therapy has improved outcomes for people living with HIV (PLWH), transforming the status of acquired immune deficiency syndrome from a fatal disease to a chronic and manageable condition. These powerful antiviral therapies have not only increased the number of HIV+ enlisted patients by improving their survival but also made the use of HIV+ organs a viable option. In this review, we summarise current knowledge on the peculiarities of liver transplantation in PLWH. In particular, we focus on the indications, contraindications, specific considerations for treatment, and outcomes of LT in PLWH. Finally, we present available preliminary data on the use of HIV+ liver allografts.
    Language English
    Publishing date 2023-09-27
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life13101975
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Outcomes and Follow-Up after Hepatitis C Eradication with Direct-Acting Antivirals.

    Lynch, Erica Nicola / Russo, Francesco Paolo

    Journal of clinical medicine

    2023  Volume 12, Issue 6

    Abstract: Treatment of hepatitis C (HCV) has been revolutionized with the introduction of direct-acting antivirals (DAAs). Patients can be treated at more advanced stages of liver disease, with a growing number of cirrhotic patients achieving sustained virological ...

    Abstract Treatment of hepatitis C (HCV) has been revolutionized with the introduction of direct-acting antivirals (DAAs). Patients can be treated at more advanced stages of liver disease, with a growing number of cirrhotic patients achieving sustained virological response (SVR). Long-term outcomes for cured patients and the optimal follow-up care of patients after SVR are yet to be defined, because most studies on cirrhotic patients cured with DAAs have a short follow-up period. There are many open questions related to patient management after viral eradication with DAAs, such as which could be the most reliable non-invasive tool to predict liver-related complications, or to what extent viral eradication reduces the risk of liver disease progression in the long term. Growing evidence supports the personalization of follow-up care based on individual risk. The aim of this narrative review is to analyze the impact of viral eradication with DAAs on clinically significant portal hypertension, hepatocellular carcinoma, and extrahepatic manifestations, as well as to summarize indications for optimal follow-up care of HCV patients treated with DAAs.
    Language English
    Publishing date 2023-03-12
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12062195
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  5. Article ; Online: NLRP3 Inflammasome in Acute and Chronic Liver Diseases.

    Sayaf, Katia / Battistella, Sara / Russo, Francesco Paolo

    International journal of molecular sciences

    2024  Volume 25, Issue 8

    Abstract: NLRP3 (NOD-, LRR-, and pyrin domain-containing protein 3) is an intracellular complex that upon external stimuli or contact with specific ligands, recruits other components, forming the NLRP3 inflammasome. The NLRP3 inflammasome mainly mediates ... ...

    Abstract NLRP3 (NOD-, LRR-, and pyrin domain-containing protein 3) is an intracellular complex that upon external stimuli or contact with specific ligands, recruits other components, forming the NLRP3 inflammasome. The NLRP3 inflammasome mainly mediates pyroptosis, a highly inflammatory mode of regulated cell death, as well as IL-18 and IL-1β production. Acute and chronic liver diseases are characterized by a massive influx of pro-inflammatory stimuli enriched in reactive oxygen species (ROS) and damage-associated molecular patterns (DAMPs) that promote the assemblage and activation of the NLRP3 inflammasome. As the major cause of inflammatory cytokine storm, the NLRP3 inflammasome exacerbates liver diseases, even though it might exert protective effects in regards to hepatitis C and B virus infection (HCV and HBV). Here, we summarize the current knowledge concerning NLRP3 inflammasome function in both acute and chronic liver disease and in the post liver transplant setting, focusing on the molecular mechanisms involved in NLRP3 activity.
    MeSH term(s) NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Humans ; Inflammasomes/metabolism ; Liver Diseases/metabolism ; Liver Diseases/immunology ; Liver Diseases/pathology ; Animals ; Chronic Disease ; Acute Disease ; Reactive Oxygen Species/metabolism
    Chemical Substances NLR Family, Pyrin Domain-Containing 3 Protein ; Inflammasomes ; NLRP3 protein, human ; Reactive Oxygen Species
    Language English
    Publishing date 2024-04-20
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25084537
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  6. Article ; Online: Sars-Cov-2 vaccination in liver transplant recipients: The 'holy grail' in a hostile environment.

    Burra, Patrizia / Russo, Francesco Paolo

    Liver international : official journal of the International Association for the Study of the Liver

    2022  Volume 42, Issue 6, Page(s) 1225–1228

    MeSH term(s) Antibodies, Viral ; COVID-19/prevention & control ; COVID-19 Vaccines ; Humans ; Liver Transplantation ; SARS-CoV-2 ; Transplant Recipients ; Vaccination
    Chemical Substances Antibodies, Viral ; COVID-19 Vaccines
    Language English
    Publishing date 2022-05-17
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2102783-3
    ISSN 1478-3231 ; 1478-3223
    ISSN (online) 1478-3231
    ISSN 1478-3223
    DOI 10.1111/liv.15226
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1632: Show issues Location:
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  7. Article ; Online: COVID-19 in Padua, Italy: not just an economic and health issue.

    Russo, Francesco Paolo

    Nature medicine

    2020  Volume 26, Issue 6, Page(s) 806

    MeSH term(s) Aged ; Aged, 80 and over ; Betacoronavirus/isolation & purification ; Betacoronavirus/pathogenicity ; COVID-19 ; Coronavirus Infections/epidemiology ; Coronavirus Infections/mortality ; Coronavirus Infections/pathology ; Coronavirus Infections/virology ; Female ; Health Services Research/trends ; Humans ; Italy/epidemiology ; Male ; Middle Aged ; Pandemics ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/mortality ; Pneumonia, Viral/pathology ; Pneumonia, Viral/virology ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-05-10
    Publishing country United States
    Document type News
    ZDB-ID 1220066-9
    ISSN 1546-170X ; 1078-8956
    ISSN (online) 1546-170X
    ISSN 1078-8956
    DOI 10.1038/s41591-020-0884-6
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    Zs.A 4212: Show issues Location:
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  8. Article ; Online: Advocating for the implementation of the new nomenclature for steatotic liver disease: A call to action for the national associations.

    Russo, Francesco Paolo / Francque, Sven M / Shawcross, Debbie L / Krag, Aleksander A

    Journal of hepatology

    2023  Volume 80, Issue 3, Page(s) 384–386

    MeSH term(s) Humans ; Fatty Liver ; Liver
    Language English
    Publishing date 2023-12-18
    Publishing country Netherlands
    Document type Editorial
    ZDB-ID 605953-3
    ISSN 1600-0641 ; 0168-8278
    ISSN (online) 1600-0641
    ISSN 0168-8278
    DOI 10.1016/j.jhep.2023.12.011
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    Zs.A 2027: Show issues Location:
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  9. Article ; Online: COVID-19 in Padua, Italy

    Russo, Francesco Paolo

    not just an economic and health issue

    2020  

    Keywords covid19
    Language English
    Publisher NATURE PUBLISHING GROUP
    Publishing country it
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Mean platelet volume is not a useful prognostic biomarker in patients with cirrhosis.

    Zanetto, Alberto / Campello, Elena / Toffanin, Serena / Russo, Francesco Paolo / Senzolo, Marco / Simioni, Paolo

    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver

    2023  Volume 55, Issue 11, Page(s) 1576–1578

    MeSH term(s) Humans ; Prognosis ; Mean Platelet Volume ; Liver Cirrhosis ; Fibrosis ; Biomarkers
    Chemical Substances Biomarkers
    Language English
    Publishing date 2023-08-07
    Publishing country Netherlands
    Document type Letter ; Comment
    ZDB-ID 1459373-7
    ISSN 1878-3562 ; 1125-8055
    ISSN (online) 1878-3562
    ISSN 1125-8055
    DOI 10.1016/j.dld.2023.08.001
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    Zs.A 1134: Show issues Location:
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