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  1. Article ; Online: Cancer treatment-induced bone loss.

    Choi, Yong Jun

    The Korean journal of internal medicine

    2024  

    Abstract: Cancer treatment-induced bone loss (CTBL) is associated with anti-tumor treatments, including endocrine therapies, chemotherapeutic treatments, radiotherapy, glucocorticoids, and tyrosine kinase inhibitors. Osteoporosis, characterized by the loss of bone ...

    Abstract Cancer treatment-induced bone loss (CTBL) is associated with anti-tumor treatments, including endocrine therapies, chemotherapeutic treatments, radiotherapy, glucocorticoids, and tyrosine kinase inhibitors. Osteoporosis, characterized by the loss of bone mass, can increase the risk of fractures, leading to mortality and long-term disability, even after cancer remission. Cancer and osteoporosis have marked clinical and pathogenetic similarities. Both have a multifactorial etiology, affect the geriatric population, and markedly influence quality of life. Lifestyle management, including calcium and vitamin D supplementation, is recommended but the supporting evidence is limited. Oral and injectable bisphosphonates are effective for osteoporosis and malignant bone disease. Bisphosphonates increase bone mineral density (BMD) in patients with CTBL. Denosumab is also used in the management of CTBL; in clinical trials, it improved BMD and reduced the risk of fracture. Currently, there are no bone anabolic therapies for patients with cancer. Appropriate therapies are necessary to maintain optimal bone health, particularly in patients at heightened risk.
    Language English
    Publishing date 2024-03-05
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 639023-7
    ISSN 2005-6648 ; 1226-3303
    ISSN (online) 2005-6648
    ISSN 1226-3303
    DOI 10.3904/kjim.2023.386
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 3028: Show issues Location:
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  2. Article: Sarcopenia in Outcome in Chronic Obstructive Pulmonary Disease: Is the Tip of the Iceberg?: Authors' Reply.

    Choi, Yong Jun / Byun, Min Kwang

    Tuberculosis and respiratory diseases

    2024  

    Language English
    Publishing date 2024-03-19
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2161256-0
    ISSN 1738-3536 ; 0378-0066
    ISSN 1738-3536 ; 0378-0066
    DOI 10.4046/trd.2023.0187
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5937: Show issues Location:
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  3. Article: Tongue-in-Groove: A Novel Implant Design for a Blow-Out Fracture.

    Byeon, Je-Yeon / Hwang, Yong-Seon / Choi, Hwan-Jun / Lee, Da-Woon / Kim, Jun-Hyuk

    Journal of clinical medicine

    2024  Volume 13, Issue 6

    Abstract: ... ...

    Abstract Background
    Language English
    Publishing date 2024-03-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13061766
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Letter to the Editor: Enhancing COVID-19 vaccination coverage using financial incentives: arguments to help health providers counterbalance erroneous claims.

    Choi, Yong-Jun

    Epidemiology and health

    2021  Volume 43, Page(s) e2021087

    MeSH term(s) COVID-19 ; COVID-19 Vaccines ; Humans ; Motivation ; SARS-CoV-2 ; Vaccination Coverage
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2021-10-22
    Publishing country Korea (South)
    Document type Journal Article ; Comment
    ZDB-ID 2590698-7
    ISSN 2092-7193 ; 2092-7193
    ISSN (online) 2092-7193
    ISSN 2092-7193
    DOI 10.4178/epih.e2021087
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Drawing Guideline for

    Kim, Jeehyoung / Lee, Jung Soo / Choi, Won Jun / Yun, Ji Yong

    Journal of Korean medical science

    2024  Volume 39, Issue 16, Page(s) e149

    Abstract: The appropriate plot effectively conveys the author's conclusions to the readers. ...

    Abstract The appropriate plot effectively conveys the author's conclusions to the readers.
    Language English
    Publishing date 2024-04-29
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 639262-3
    ISSN 1598-6357 ; 1011-8934
    ISSN (online) 1598-6357
    ISSN 1011-8934
    DOI 10.3346/jkms.2024.39.e149
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 3163: Show issues Location:
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  6. Article ; Online: Complete Genome Sequence of

    Jeong, Sun-Wook / Choi, Yong Jun

    Microbiology resource announcements

    2022  Volume 11, Issue 12, Page(s) e0081222

    Abstract: ... ...

    Abstract Erythrobacter
    Language English
    Publishing date 2022-11-14
    Publishing country United States
    Document type Journal Article
    ISSN 2576-098X
    ISSN (online) 2576-098X
    DOI 10.1128/mra.00812-22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Reply: Response to Significance of the Regular Publication of Statistics on National Health Indicators in Academic Journals and the Prospects of Korea National Antimicrobial Use Analysis System (KONAS).

    Kim, Bongyoung / Kim, Yong Chan / Kim, Hyung-Sook / Park, Se Yoon / Choi, Jun Yong

    Infection & chemotherapy

    2024  Volume 55, Issue 4, Page(s) 512–514

    Language English
    Publishing date 2024-01-05
    Publishing country Korea (South)
    Document type Letter
    ZDB-ID 2573798-3
    ISSN 2093-2340
    ISSN 2093-2340
    DOI 10.3947/ic.2023.0107
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6842: Show issues Location:
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  8. Article ; Online: The HIV Care Cascade in Korea: Status of UNAIDS 90-90-90 Targets.

    Choi, Jun Yong

    Journal of Korean medical science

    2020  Volume 35, Issue 6, Page(s) e55

    MeSH term(s) Acquired Immunodeficiency Syndrome ; HIV Infections ; Humans ; Republic of Korea
    Language English
    Publishing date 2020-02-17
    Publishing country Korea (South)
    Document type Editorial ; Comment
    ZDB-ID 639262-3
    ISSN 1598-6357 ; 1011-8934
    ISSN (online) 1598-6357
    ISSN 1011-8934
    DOI 10.3346/jkms.2020.35.e55
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 3163: Show issues Location:
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  9. Article: Impact of Nontreatment Duration and Keratopathy on Major Adverse Cardiovascular Events in Fabry Disease: A Nationwide Cohort Study.

    Yang, Aram / Kim, Sinae / Choi, Yong Jun

    Journal of clinical medicine

    2024  Volume 13, Issue 2

    Abstract: Fabry disease (FD) is a rare inherited X-linked lysosomal storage disorder that results in the progressive accumulation of glycosphingolipids in multiple organs. Early FD-specific treatments may improve clinical outcomes; however, clinical evidence about ...

    Abstract Fabry disease (FD) is a rare inherited X-linked lysosomal storage disorder that results in the progressive accumulation of glycosphingolipids in multiple organs. Early FD-specific treatments may improve clinical outcomes; however, clinical evidence about early FD treatment is limited. We aimed to determine the cardiovascular outcomes of patients with FD who received enzyme replacement therapy. This nationwide observational study was conducted using the National Health Claims database of the Korean population with FD. The primary outcome was major adverse cardiovascular events (MACEs). MACE risk factors in FD were evaluated using time-dependent Cox regression. Between January 2007 and April 2022, 188 patients with FD were analyzed. Among them, 22 (11.7%) experienced MACE (males: 14/95 [14.7%]; females: 8/93 [8.6%]). The mean age at MACE diagnosis was 53.5 ± 11.0 years in all patients with FD, which was lower in males compared with in females (49.7 ± 9.6 vs. 60.0 ± 10.7 years,
    Language English
    Publishing date 2024-01-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13020479
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Molecular Dynamics Simulations of Matrix Metalloproteinase 13 and the Analysis of the Specificity Loop and the S1'-Site.

    Choi, Jun Yong / Chung, Eugene

    International journal of molecular sciences

    2023  Volume 24, Issue 13

    Abstract: The specificity loop of Matrix Metalloproteinases (MMPs) is known to regulate recognition of their substrates, and the S1'-site surrounded by the loop is a unique place to address the selectivity of ligands toward each MMP. Molecular dynamics (MD) ... ...

    Abstract The specificity loop of Matrix Metalloproteinases (MMPs) is known to regulate recognition of their substrates, and the S1'-site surrounded by the loop is a unique place to address the selectivity of ligands toward each MMP. Molecular dynamics (MD) simulations of apo-MMP-13 and its complex forms with various ligands were conducted to identify the role of the specificity loop for the ligand binding to MMP-13. The MD simulations showed the dual role of T247 as a hydrogen bond donor to the ligand, as well as a contributor to the formation of the van der Waal surface area, with T245 and K249 on the S1'-site. The hydrophobic surface area mediated by T247 blocks the access of water molecules to the S1'-site of MMP-13 and stabilizes the ligand in the site. The F252 residue is flexible in order to search for the optimum location in the S1'-site of the apo-MMP-13, but once a ligand binds to the S1'-site, it can form offset π-π or edge-to-π stacking interactions with the ligand. Lastly, H222 and Y244 provide the offset π-π and π-CH(Cβ) interactions on each side of the phenyl ring of the ligand, and this sandwiched interaction could be critical for the ligand binding to MMP-13.
    MeSH term(s) Molecular Dynamics Simulation ; Matrix Metalloproteinase 13/metabolism ; Ligands ; Matrix Metalloproteinase Inhibitors/chemistry ; Matrix Metalloproteinase 2/metabolism ; Binding Sites
    Chemical Substances Matrix Metalloproteinase 13 (EC 3.4.24.-) ; Ligands ; Matrix Metalloproteinase Inhibitors ; Matrix Metalloproteinase 2 (EC 3.4.24.24)
    Language English
    Publishing date 2023-06-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241310577
    Database MEDical Literature Analysis and Retrieval System OnLINE

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