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Article: Children with chronic disease and COVID-19.

Evliyaoğlu, Olcay

Turk pediatri arsivi

2020 Volume 55, Issue 2, Page(s) 93–94

Keywords	covid19
Language	English
Publishing date	2020-06-19
Publishing country	Turkey
Document type	Editorial
ISSN	1306-0015
ISSN	1306-0015
DOI	10.14744/TurkPediatriArs.2020.57805
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Article ; Online: Reply; Testotoxicosis: Report of Two Cases, One with a Novel Mutation in LHCGR Gene.

Evliyaoğlu, Olcay

Journal of clinical research in pediatric endocrinology

2016 Volume 8, Issue 1, Page(s) 107

MeSH term(s)	Androgen Antagonists/therapeutic use ; Aromatase Inhibitors/therapeutic use ; Humans ; Mutation/genetics ; Prognosis ; Puberty, Precocious/drug therapy ; Puberty, Precocious/genetics ; Receptors, LH/genetics
Chemical Substances	Androgen Antagonists ; Aromatase Inhibitors ; Receptors, LH
Language	English
Publishing date	2016-03-05
Publishing country	Turkey
Document type	Case Reports ; Letter
ZDB-ID	2641608-6
ISSN	1308-5735 ; 1308-5727
ISSN (online)	1308-5735
ISSN	1308-5727
DOI	10.4274/jcrpe.2765
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Article: Thyroid Nodules in Children and Adolescents: A Single Institution's Experience.

Dağdeviren Çakır, Aydilek / Turan, Hande / Ercan, Oya / Evliyaoğlu, Olcay

Turkish archives of pediatrics

2023 Volume 58, Issue 4, Page(s) 401–406

Abstract: Objective: The risk of malignancy in pediatric thyroid nodules is higher compared to the risk in adults. Our aim was to investigate the clinical, radiological, and histopathological characteristics of pediatric thyroid nodules.: Materials and methods!# ...

Abstract	Objective: The risk of malignancy in pediatric thyroid nodules is higher compared to the risk in adults. Our aim was to investigate the clinical, radiological, and histopathological characteristics of pediatric thyroid nodules. Materials and methods: The data of 132 children and adolescents who had thyroid nodules were collected retrospectively from medical records. Results: The mean age of the patients was 12.07 ± 4.08 years and 67% were female. Fine-needle aspiration biopsy was performed in 86 patients (65%) and the results were as follows: benign in 53.4% (n = 46), atypia or follicular lesion of undetermined significance in 3.5% (n = 3), suspicious for follicular neoplasia in 2.3% (n = 2), and malignancy in 32.5% (n = 28). The overall malignancy rate was 22.7% (n = 30). Malignancy was detected after surgery in 2 thyroid nodules belonging to the atypia or follicular lesion of undetermined significance category. Malignancy was detected in 7 patients who had autoimmune thyroiditis and in 1 patient who had congenital dyshormonogenesis. The malignancy rate of the nodules in the patients, who had autoimmune thyroiditis, was found to be 13.4%. Mixed echogenicity, microcalcifications, nodules larger than 10 mm, abnormal lymph nodes, and irregular borders were more common in the malignant group. The nodule size, abnormal lymph nodes, and irregular borders were found to be significant in terms of predicting malignancy. Conclusion: We found malignancy in 22.7% of the thyroid nodules, and the malignancy rate of nodules in the patients, who had autoimmune thyroiditis, was 13.4%. The nodule size, abnormal lymph nodes, and irregular nodule borders emerged as the most significant risk factors for malignancy.
Language	English
Publishing date	2023-06-14
Publishing country	Turkey
Document type	Journal Article
ISSN	2757-6256
ISSN	2757-6256
DOI	10.5152/TurkArchPediatr.2023.22302
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Article ; Online: Acute Kidney Injury After Thyroid Hormone Withdrawal in an Adolescent with Papillary Thyroid Carcinoma.

Özer, Yavuz / Gülmez, Rüveyda / Turan, Hande / Tarçın, Gürkan / Bingöl Aydın, Dilek / Evliyaoğlu, Olcay / Ercan, Oya

Journal of clinical research in pediatric endocrinology

2024

Abstract: Objectives: We report a patient with papillary thyroid carcinoma (PTC) who developed acute kidney injury (AKI) and elevated creatine kinase (CK) after thyroid hormone withdrawal (THW) prior to radioiodine therapy.: Case presentation: A 12-year-old ... ...

Abstract	Objectives: We report a patient with papillary thyroid carcinoma (PTC) who developed acute kidney injury (AKI) and elevated creatine kinase (CK) after thyroid hormone withdrawal (THW) prior to radioiodine therapy. Case presentation: A 12-year-old female patient who had undergone total thyroidectomy for PTC one year ago presented with leg pain for the past 2 days. Following THW 3 weeks ago, the case had received 70 mCI radioiodine treatment 6 days ago. Serum creatinine (1.53 mg/dL, normal range [NR]: 0.3-1.1), aspartate aminotransferase (102 IU/L, NR: 0-40) and CK (3451 IU/L, NR: 26-174) levels were elevated. Thyrotropin level was elevated (>100 µIU/ml, NR: 0.51-4.3), and free T4 level was decreased (0.05 ng/dL, NR: 0.98-1.63). Serum creatinine and CK levels decreased after intravenous hydration and levothyroxine treatment. Conclusion: In PTC cases with thyroidectomy, kidney function and CK elevation should be assessed after THW and dehydration should be prevented.
Language	English
Publishing date	2024-02-20
Publishing country	Turkey
Document type	Journal Article
ZDB-ID	2641608-6
ISSN	1308-5735 ; 1308-5727
ISSN (online)	1308-5735
ISSN	1308-5727
DOI	10.4274/jcrpe.galenos.2024.2023-11-10
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Article ; Online: Effect of the COVID-19 quarantine on metabolic control in children and adolescents with type 1 diabetes.

Turan, Hande / Güneş Kaya, Didem / Tarçın, Gürkan / Evliyaoğlu, Saadet Olcay

Endocrinologia, diabetes y nutricion

2022 Volume 69, Issue 3, Page(s) 201–208

Abstract: Introduction: Metabolic control in type 1 diabetes (T1D) depends on many factors such as eating habits, exercise and lifestyle. The objective of this study was to investigate how these factors were affected during the coronavirus disease 2019 (COVID-19) ...

Abstract	Introduction: Metabolic control in type 1 diabetes (T1D) depends on many factors such as eating habits, exercise and lifestyle. The objective of this study was to investigate how these factors were affected during the coronavirus disease 2019 (COVID-19) lockdown and impacted metabolic control in children with T1D. Materials and method: One hundred children with T1D were enrolled in the study. Anthropometric measurements, snack and meal frequency, carbohydrate consumption, HbA1c levels, and exercise patterns were recorded and compared before and after the lockdown. Subjects were divided into two subgroups-patients with decreased and patients with increased HbA1c levels after the lockdown-and comparisons of the same parameters were also made between these two subgroups. Results: In the overall group, the mean HbA1c level was significantly higher after the lockdown compared to before (p=0.035). Meal schedules changed due to delayed sleep and waking times, and total daily carbohydrate consumption increased in the subgroup with increased HbA1c while it decreased in the subgroup with decreased HbA1c (p<0.001 for both). Conclusion: Our study supports the notion that blood sugar management in children with T1D worsened during the COVID-19 pandemic. Although it is not possible to explain this with any one factor, some behavioral changes observed in our study, such as inactivity, irregular meal frequency and timing, and irregular sleep and waking patterns appeared to be associated with blood sugar management.
MeSH term(s)	Adolescent ; Blood Glucose/metabolism ; COVID-19 ; Child ; Communicable Disease Control ; Diabetes Mellitus, Type 1 ; Glycated Hemoglobin A ; Humans ; Pandemics/prevention & control ; Quarantine ; SARS-CoV-2
Chemical Substances	Blood Glucose ; Glycated Hemoglobin A
Language	English
Publishing date	2022-02-01
Publishing country	Spain
Document type	Journal Article
ISSN	2530-0180
ISSN (online)	2530-0180
DOI	10.1016/j.endien.2022.02.014
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Article ; Online: Clinical, biochemical, and radiological follow-up results of children and adolescents with Hashimoto's thyroiditis: a single-center experience.

Erbaş, İrem Ceren / Erbaş, İbrahim Mert / Evliyaoğlu, Olcay

Journal of pediatric endocrinology & metabolism : JPEM

2021 Volume 34, Issue 8, Page(s) 987–994

Abstract: Objectives: Hashimoto's thyroiditis (HT) is the most common cause of goiter and acquired hypothyroidism in children and adolescents, especially in areas without endemic iodine deficiency. We aimed to evaluate the follow-up results of children and ... ...

Abstract	Objectives: Hashimoto's thyroiditis (HT) is the most common cause of goiter and acquired hypothyroidism in children and adolescents, especially in areas without endemic iodine deficiency. We aimed to evaluate the follow-up results of children and adolescents diagnosed with HT, including clinical, biochemical, and radiological findings and treatment approaches. Methods: HT patients, who were diagnosed between 2012 and 2018 years in a single-center, were assessed retrospectively. Results: Two hundred and twenty-four cases were included in the study, 75.9% of whom were girls (female/male ratio: 3.1) and 66.5% were pubertal. The median age of the cases at first admission was 12.5 (9.2-15) years. The median follow-up period of 196 patients, who continued their follow-up regularly, was 2.1 (0.7-4.8) years. When autoantibody levels were analyzed according to gender, mean anti-Tg levels were higher in girls (p=0.028), whereas anti-TPO levels were similar (p=0.372). A nodule was detected in the ultrasonographic follow-up of 29 (13%) patients. Papillary thyroid carcinoma was observed in 10.3% (n=3) of those with nodules. When the last ultrasonography findings of 188 patients with available radiological follow-up data were compared with their initial evaluation, the rate of heterogeneous parenchymal echogenicity increased significantly (p=0.008). The need for l-thyroxine dosage augmented over time. Conclusions: Although HT is more common in adolescent girls, it can be encountered in both genders and at all ages in childhood. The incidence of malignancy was not higher in patients with nodules associated with HT than the reported incidences of malignancy in nodules not associated with HT.
MeSH term(s)	Adolescent ; Biomarkers/analysis ; Child ; Female ; Follow-Up Studies ; Hashimoto Disease/physiopathology ; Humans ; Male ; Prognosis ; Retrospective Studies ; Thyroid Hormones/metabolism ; Thyroid Neoplasms/diagnostic imaging ; Thyroid Neoplasms/pathology ; Thyroid Nodule/diagnostic imaging ; Thyroid Nodule/metabolism ; Thyroid Nodule/pathology ; Ultrasonography/methods
Chemical Substances	Biomarkers ; Thyroid Hormones
Language	English
Publishing date	2021-06-15
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1231070-0
ISSN	2191-0251 ; 0334-018X
ISSN (online)	2191-0251
ISSN	0334-018X
DOI	10.1515/jpem-2021-0035
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Article: A rare intrauterine onset growth retardation syndrome caused by mosaic 19p13.3 microduplication: evaluation of GH/IGF- 1 axis and GH therapy response.

Özer, Emre / Karaman, Birsen / Güneş, Nilay / Evliyaoğlu, Olcay / Tüysüz, Beyhan

The Turkish journal of pediatrics

2021 Volume 63, Issue 1, Page(s) 174–180

Abstract: Background: 19p13.3 microduplication syndrome is a newly defined intrauterine onset growth retardation syndrome characterized by microcephaly, moderate intellectual disability, speech delay, and mild dysmorphic features. The PIAS4 gene located in this ... ...

Abstract	Background: 19p13.3 microduplication syndrome is a newly defined intrauterine onset growth retardation syndrome characterized by microcephaly, moderate intellectual disability, speech delay, and mild dysmorphic features. The PIAS4 gene located in this region plays a crucial role as a transcriptional co-regulator in various cellular pathways including STAT, p53/TP53 and growth hormone (GH) signaling and mutations in this gene are thought to be responsible for clinical features. Case: We present a 10 year-old girl with intrauterine onset growth retardation, microcephaly, and mild facial dysmorphic features. Treatment with GH was started at 4 years and 9 months of age targeting the severe short stature (-3.65 standard deviation score, SDS) since she had significant IGF-1 response to exogenous GH. Microarray study demonstrated a 19p13.3 microduplication of 4.4 Mb. FISH analyses revealed mosaic extra signals (27.5% on blood lymphocytes, and 47% on buccal epithelium) of 19p13.3 region. At the age of 10, her height was at -2.37 SDS, and she had mild intellectual disability which has been described in 19p13.3 microduplication syndrome. Conclusion: We present here a patient with typical findings of 19p13.3 microduplication syndrome and also with a prominent response to GH treatment, which has not been reported previously in this syndrome.
MeSH term(s)	Child ; Female ; Fetal Growth Retardation ; Growth Hormone/therapeutic use ; Humans ; Intellectual Disability/genetics ; Microcephaly ; Syndrome
Chemical Substances	Growth Hormone (9002-72-6)
Language	English
Publishing date	2021-02-24
Publishing country	Turkey
Document type	Case Reports ; Research Support, Non-U.S. Gov't
ZDB-ID	123487-0
ISSN	0041-4301
ISSN	0041-4301
DOI	10.24953/turkjped.2021.01.022
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Article ; Online: Effect of the COVID-19 quarantine on metabolic control in children and adolescents with type 1 diabetes.

Turan, Hande / Güneş Kaya, Didem / Tarçın, Gürkan / Evliyaoğlu, Saadet Olcay

Endocrinologia, diabetes y nutricion

2021

Abstract	Introduction: Metabolic control in type 1 diabetes (T1D) depends on many factors such as eating habits, exercise and lifestyle. The objective of this study was to investigate how these factors were affected during the coronavirus disease 2019 (COVID-19) lockdown and impacted metabolic control in children with T1D. Materials and method: One hundred children with T1D were enrolled in the study. Anthropometric measurements, snack and meal frequency, carbohydrate consumption, HbA1c levels, and exercise patterns were recorded and compared before and after the lockdown. Subjects were divided into two subgroups-patients with decreased and patients with increased HbA1c levels after the lockdown-and comparisons of the same parameters were also made between these two subgroups. Results: In the overall group, the mean HbA1c level was significantly higher after the lockdown compared to before (p=0.035). Meal schedules changed due to delayed sleep and waking times, and total daily carbohydrate consumption increased in the subgroup with increased HbA1c while it decreased in the subgroup with decreased HbA1c (p<0.001 for both). Conclusion: Our study supports the notion that blood sugar management in children with T1D worsened during the COVID-19 pandemic. Although it is not possible to explain this with any one factor, some behavioral changes observed in our study, such as inactivity, irregular meal frequency and timing, and irregular sleep and waking patterns appeared to be associated with blood sugar management.
Language	Spanish
Publishing date	2021-06-08
Publishing country	Spain
Document type	Journal Article
ISSN	2530-0180
ISSN (online)	2530-0180
DOI	10.1016/j.endinu.2021.05.003
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Article ; Online: Evaluation of the left ventricular systolic function and myocardial deformation by real-time three-dimensional (four-dimensional) and speckle-tracking echocardiography in children with type 1 diabetes mellitus.

Eroğlu, Ayşe G / Yüksel, Esra K / Karagözlü, Fatih / Acar, Hazal C / Gökalp, Selman / Evliyaoğlu, Olcay

Cardiology in the young

2022 Volume 33, Issue 4, Page(s) 603–607

Abstract: Aim: This study aimed to evaluate the role of real-time three-dimensional (known as four-dimensional) echocardiography and three-dimensional speckle-tracking echocardiography for the early detection of left ventricular systolic dysfunction in ... ...

Abstract	Aim: This study aimed to evaluate the role of real-time three-dimensional (known as four-dimensional) echocardiography and three-dimensional speckle-tracking echocardiography for the early detection of left ventricular systolic dysfunction in asymptomatic children with type 1 diabetes mellitus. Materials and method: This cross-sectional study included 38 patients (mean age 15.4 ± 2.9, 42.1% male) and 38 age, gender, and body measurements matched healthy children. Each patient underwent an interview about medical history, a detailed clinical examination, blood laboratory tests, conventional echocardiography, and tissue Doppler imaging. Left ventricular ejection fraction; global longitudinal, circumferential, radial strain; twist; and torsion were measured by real-time three-dimensional and speckle-tracking echocardiography. Results: Conventional echocardiography and tissue Doppler imaging showed normal left ventricular systolic function in the patients. Although left ventricular ejection fraction (61.6 ± 1.4%, 61.8 ± 1.1%, p = 0.386), global longitudinal [-26.6 (-27.7 to -26.1)%, -26.2 (-27.7 to -24.9)%, p = 0.224], and radial strain [44.4 (42.4-45.9)%, 43.9 (41-46.1)%, p = 0.513] were similar to the controls, circumferential strain (-27.3 ± 1.3%, -28.0 ± 1.6%, p = 0.048) and twist (9.5 ± 2.3°, 11.4 ± 3.0°, p = 0.003) were decreased in the patients compared with controls. Conclusion: We found that even in children with asymptomatic type 1 diabetes mellitus with normal left ventricular ejection fraction, circumferential function was impaired and rotation pattern was changed. This novel echocardiographic method might be an important tool for detecting left ventricular systolic dysfunction in type 1 diabetes mellitus children before it becomes overt on conventional echocardiography and tissue Doppler imaging.
MeSH term(s)	Humans ; Male ; Child ; Female ; Ventricular Function, Left ; Diabetes Mellitus, Type 1/complications ; Stroke Volume ; Cross-Sectional Studies ; Echocardiography/methods ; Ventricular Dysfunction, Left/diagnostic imaging ; Ventricular Dysfunction, Left/etiology ; Echocardiography, Three-Dimensional/methods
Language	English
Publishing date	2022-05-16
Publishing country	England
Document type	Journal Article
ZDB-ID	1078466-4
ISSN	1467-1107 ; 1047-9511
ISSN (online)	1467-1107
ISSN	1047-9511
DOI	10.1017/S1047951122001408
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Article ; Online: Correction: Clinical indicators that influence a clinician's decision to start L-thyroxine treatment in prematurity with transient hypothyroxinemia.

Yilmaz, Aslan / Ozer, Yavuz / Kaya, Nesrin / Cakir, Aydilek Dagdeviren / Culpan, Hazal Cansu / Perk, Yildiz / Vural, Mehmet / Evliyaoglu, Olcay

Italian journal of pediatrics

2023 Volume 49, Issue 1, Page(s) 130

Language	English
Publishing date	2023-09-29
Publishing country	England
Document type	Published Erratum
ZDB-ID	2088556-8
ISSN	1824-7288 ; 1720-8424
ISSN (online)	1824-7288
ISSN	1720-8424
DOI	10.1186/s13052-023-01539-z
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