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  1. Article ; Online: Exploratory study on the body distribution of skin color, pigmentation and, degree of tan in Central European Caucasian Women.

    Schmalwieser, Alois W / Götzinger, Sabine / Schwabel, Florian

    Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology

    2024  Volume 23, Issue 3, Page(s) 493–502

    Abstract: It is well known that skin color varies by body site and with season. However, little quantitative data on the topography of skin color and pigmentation are available. Therefore, exploratory cutaneous colorimetric measurements in 20 in central European ... ...

    Abstract It is well known that skin color varies by body site and with season. However, little quantitative data on the topography of skin color and pigmentation are available. Therefore, exploratory cutaneous colorimetric measurements in 20 in central European Caucasian women aged 20 to 60 years have been made at 18 body sites. Tri-stimulus L*a*b*-values, hue, and chroma are considered to describe skin color. Based on the "Individual Typology Angle", the "Degree of Tan" was introduced to quantify the difference between constitutive and facultative pigmentation. Measurements were done in late winter and early summer to estimate potential changes by solar ultraviolet radiation. These measurements made evident that skin color obviously differs across the body in late winter. Even nearby body sites can be recognized as differently colored. A remaining degree of tan was found at permanent and intermittent exposed body sites. The remaining tan was not most pronounced at the permanently exposed sites but on the intermediate ones like the shoulder. In early summer, the degree of tan has most developed at the hands, arms, and instep, followed by the face. This study showed that besides basic differences between body sites in winter, accumulation, and degradation of tan also vary between body sites.
    MeSH term(s) Humans ; Female ; Skin Pigmentation ; Ultraviolet Rays ; Skin ; Colorimetry ; Solar Energy
    Language English
    Publishing date 2024-02-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 2072584-X
    ISSN 1474-9092 ; 1474-905X
    ISSN (online) 1474-9092
    ISSN 1474-905X
    DOI 10.1007/s43630-024-00533-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The Role of Children and Young People in the Transmission of SARS-CoV-2.

    Götzinger, Florian / Strenger, Volker

    The Pediatric infectious disease journal

    2021  Volume 41, Issue 4, Page(s) e172–e174

    MeSH term(s) Adolescent ; Age Factors ; COVID-19/epidemiology ; COVID-19/metabolism ; COVID-19/transmission ; COVID-19/virology ; Child ; Child Day Care Centers ; Child, Preschool ; Communicable Diseases, Emerging/epidemiology ; Communicable Diseases, Emerging/transmission ; Communicable Diseases, Emerging/virology ; Disease Outbreaks ; Disease Susceptibility ; Host-Pathogen Interactions/genetics ; Host-Pathogen Interactions/immunology ; Humans ; Public Health Surveillance ; Risk Assessment ; SARS-CoV-2 ; Schools ; Young Adult
    Language English
    Publishing date 2021-10-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 392481-6
    ISSN 1532-0987 ; 0891-3668
    ISSN (online) 1532-0987
    ISSN 0891-3668
    DOI 10.1097/INF.0000000000003497
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Tuberkulose – Update 2022.

    Kainz, Katharina / Brinkmann, Folke / Bogyi, Matthias / Feiterna-Sperling, Cornelia / Götzinger, Florian / Mädel, Clemens / Thee, Stephanie / Krüger, Renate

    Monatsschrift Kinderheilkunde : Organ der Deutschen Gesellschaft fur Kinderheilkunde

    2023  Volume 171, Issue 6, Page(s) 553–564

    Abstract: According to the annual global reports from the Word Health Organization (WHO), children under 15 years of age represent 11% of all cases of tuberculosis (TB) globally. Nearly 50% of these cases are children below 5 years old. This continuing medical ... ...

    Title translation Tuberculosis-Update 2022.
    Abstract According to the annual global reports from the Word Health Organization (WHO), children under 15 years of age represent 11% of all cases of tuberculosis (TB) globally. Nearly 50% of these cases are children below 5 years old. This continuing medical education (CME) article provides an overview of the current recommendations and innovations based on the revised WHO guidelines on TB management in children and adolescents published in 2022.
    Language German
    Publishing date 2023-05-23
    Publishing country Germany
    Document type English Abstract ; Journal Article
    ZDB-ID 137102-2
    ISSN 1433-0474 ; 0026-9298
    ISSN (online) 1433-0474
    ISSN 0026-9298
    DOI 10.1007/s00112-023-01768-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The ability of the neonatal immune response to handle SARS-CoV-2 infection.

    Götzinger, Florian / Santiago-Garcia, Begoña / Fumadó-Pérez, Victòria / Brinkmann, Folke / Tebruegge, Marc

    The Lancet. Child & adolescent health

    2021  Volume 5, Issue 3, Page(s) e6–e7

    MeSH term(s) COVID-19 ; Cohort Studies ; Humans ; Immunity ; Infant, Newborn ; Prospective Studies ; SARS-CoV-2 ; United Kingdom ; Watchful Waiting
    Language English
    Publishing date 2021-01-21
    Publishing country England
    Document type Letter ; Comment
    ISSN 2352-4650
    ISSN (online) 2352-4650
    DOI 10.1016/S2352-4642(21)00002-X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Conference proceedings: [No title information]

    Fajgelj, Veronika Barbara / Bogyi, Matthias / Götzinger, Florian / Kainz, Katharina / Langthaler, Michael / Wasserer, Andreas / Zacharasiewicz, Angela

    Klinische Pädiatrie

    2023  Volume 235, Issue 02

    Event/congress 44. Jahrestagung der Gesellschaft für Pädiatrische Pneumologie, Frankfurt, 2023-03-16
    Language German
    Publishing date 2023-03-01
    Publisher Georg Thieme Verlag
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 120650-3
    ISSN 1439-3824 ; 0300-8630
    ISSN (online) 1439-3824
    ISSN 0300-8630
    DOI 10.1055/s-0043-1761531
    Database Thieme publisher's database

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  6. Article ; Online: A Yersiniabactin-producing Klebsiella aerogenes Strain Causing an Outbreak in an Austrian Neonatal Intensive Care Unit.

    Baier-Grabner, Sebastian / Equiluz-Bruck, Susanne / Endress, David / Blaschitz, Marion / Schubert, Sören / Indra, Alexander / Fudel, Marta / Frischer, Thomas / Götzinger, Florian

    The Pediatric infectious disease journal

    2022  Volume 41, Issue 7, Page(s) 593–599

    Abstract: Background: Yersiniabactin, a siderophore with a high affinity to iron, has been described as a potential virulence factor in Enterobacteriaceae. Klebsiella aerogenes is a Gram-negative rod known to cause invasive infection in very low birth weight ... ...

    Abstract Background: Yersiniabactin, a siderophore with a high affinity to iron, has been described as a potential virulence factor in Enterobacteriaceae. Klebsiella aerogenes is a Gram-negative rod known to cause invasive infection in very low birth weight infants but is an unusual pathogen to cause outbreaks in neonatal intensive care units (NICU).
    Methods: We performed a retrospective analysis of all patients colonized with K. aerogenes in our NICU from September to December 2018. Each infant with an occurrence of K. aerogenes in any microbiological culture was defined as a case. Clinical data were taken from medical charts. K. aerogenes isolates were genotyped using whole-genome sequencing combined with core genome multilocus sequencing type analysis. Yersiniabactin production was evaluated by luciferase assay.
    Results: In total 16 patients were colonized with K. aerogenes over the 3-month period and 13 patients remained asymptomatic or developed late-onset neonatal sepsis from another pathogen. Three patients developed necrotizing enterocolitis, 2 complicated by sepsis and 1 of them died. All symptomatic patients were premature infants with low birth weight. Genetic sequencing confirmed an outbreak with the same strain, all samples expressed the high-pathogenicity island, necessary for the production of yersiniabactin. Six exemplary cases were proven to produce yersiniabactin in vitro.
    Conclusion: This is the first report of an outbreak of a yersiniabactin-producing K. aerogenes strain causing invasive infection in preterm infants. We hypothesize that, due to improved iron uptake, this strain was associated with higher virulence than non-yersiniabactin-producing strains. Extended search for virulence factors and genetic sequencing could be pivotal in the management of NICU outbreaks in the future.
    MeSH term(s) Austria ; Cross Infection/microbiology ; Disease Outbreaks ; Enterobacter aerogenes ; Humans ; Infant ; Infant, Newborn ; Infant, Premature ; Intensive Care Units, Neonatal ; Iron ; Klebsiella Infections/epidemiology ; Klebsiella Infections/microbiology ; Klebsiella pneumoniae/genetics ; Phenols ; Retrospective Studies ; Thiazoles ; beta-Lactamases
    Chemical Substances Phenols ; Thiazoles ; yersiniabactin ; Iron (E1UOL152H7) ; beta-Lactamases (EC 3.5.2.6)
    Language English
    Publishing date 2022-06-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 392481-6
    ISSN 1532-0987 ; 0891-3668
    ISSN (online) 1532-0987
    ISSN 0891-3668
    DOI 10.1097/INF.0000000000003553
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Limited role of children in transmission of SARS-CoV-2 virus in households-Immunological analysis of 26 familial clusters.

    Sieber, Justyna / Schmidthaler, Klara / Kopanja, Sonja / Weseslindtner, Lukas / Stiasny, Karin / Götzinger, Florian / Graf, Alexandra / Krotka, Pavla / Hoz, Jakub / Schoof, Anja / Dwivedi, Varsha / Frischer, Thomas / Szépfalusi, Zsolt

    Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology

    2023  Volume 34, Issue 1, Page(s) e13913

    Abstract: Background: The impact of children on the transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remains uncertain. This study provides an insight into distinct patterns of SARS-CoV-2 household transmission in case of pediatric and ...

    Abstract Background: The impact of children on the transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remains uncertain. This study provides an insight into distinct patterns of SARS-CoV-2 household transmission in case of pediatric and adult index cases as well as age-dependent susceptibility to SARS-CoV-2 infection.
    Methods: Immune analysis, medical interviewing, and contact tracing of 26 families with confirmed SARS-CoV-2 infection cases have been conducted. Blood samples were analyzed serologically with the use of a SARS-CoV-2-specific IgG assay and virus neutralization test (VNT). Uni- and multivariable linear regression and mixed effect logistic regression models were used to describe potential risk factors for higher contagiousness and susceptibility to SARS-CoV-2 infection.
    Results: SARS-CoV-2 infection could be confirmed in 67 of 124 family members. Fourteen children and 11 adults could be defined as index cases in their households. Forty of 82 exposed family members were defined as secondarily infected. The mean secondary attack rate in households was 0.48 and was significantly higher in households with adult than with pediatric index cases (0.85 vs 0.19; p < 0.0001). The age (grouped into child and adult) of index case, severity of disease, and occurrence of lower respiratory symptoms in index cases were significantly associated with secondary transmission rates in households. Children seem to be equally susceptible to acquire a SARS-CoV-2 infection as adults, but they suffer milder courses of the disease or remain asymptomatic.
    Conclusion: SARS-CoV-2 transmission from infected children to other household members occurred rarely in the first wave of the pandemic, despite close physical contact and the lack of hygienic measures.
    MeSH term(s) Adult ; Child ; Humans ; SARS-CoV-2 ; COVID-19/epidemiology ; Family Characteristics ; Contact Tracing ; Risk Factors ; Antibodies, Viral ; Immunoglobulin G
    Chemical Substances Antibodies, Viral ; Immunoglobulin G
    Language English
    Publishing date 2023-02-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 1057059-7
    ISSN 1399-3038 ; 0905-6157 ; 0906-5784
    ISSN (online) 1399-3038
    ISSN 0905-6157 ; 0906-5784
    DOI 10.1111/pai.13913
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Detection of viable SARS-CoV-2 on the hands of hospitalized children with COVID-19.

    Haas, Meryl / Fürhacker, Paola / Hodek, Jan / Stangl, Petra / Alon, Isabelle / Kainz, Katharina / Fajgelj, Veronika / Mädel, Clemens / Dotzler, Sophia / Götzinger, Florian / Ulrychová, Lucie / Preuner, Sandra / Fortschegger, Michaela / Schinnerl, Dagmar / Walter, Christina / Obrova, Klara / Weber, Jan / Zacharasiewicz, Angela / Lion, Thomas

    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

    2023  Volume 29, Issue 9, Page(s) 1211–1213

    MeSH term(s) Child ; Humans ; COVID-19/diagnosis ; SARS-CoV-2 ; Child, Hospitalized ; Hand
    Language English
    Publishing date 2023-06-13
    Publishing country England
    Document type Letter
    ZDB-ID 1328418-6
    ISSN 1469-0691 ; 1470-9465 ; 1198-743X
    ISSN (online) 1469-0691
    ISSN 1470-9465 ; 1198-743X
    DOI 10.1016/j.cmi.2023.06.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Characterization of the antibody response to SARS-CoV-2 in a mildly affected pediatric population.

    Kopanja, Sonja / Gattinger, Pia / Schmidthaler, Klara / Sieber, Justyna / Niepodziana, Katarzyna / Schlederer, Thomas / Weseslindtner, Lukas / Stiasny, Karin / Götzinger, Florian / Pickl, Winfried F / Frischer, Thomas / Valenta, Rudolf / Szépfalusi, Zsolt

    Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology

    2022  Volume 33, Issue 2, Page(s) e13737

    Abstract: Background: While children usually experience a mild course of COVID-19, and a severe disease is more common in adults, the features, specificities, and functionality of the SARS-CoV-2-specific antibody response in the pediatric population are of ... ...

    Abstract Background: While children usually experience a mild course of COVID-19, and a severe disease is more common in adults, the features, specificities, and functionality of the SARS-CoV-2-specific antibody response in the pediatric population are of interest.
    Methods: We performed a detailed analysis of IgG antibodies specific for SARS-CoV-2-derived antigens S and RBD by ELISA in 26 SARS-CoV-2 seropositive schoolchildren with mild or asymptomatic disease course, and in an equally sized, age- and gender-matched control group. Furthermore, a detailed mapping of IgG reactivity to a panel of microarrayed SARS-CoV-2 proteins and S-derived peptides was performed by microarray technology. The capacity of the antibody response to block RBD-ACE2 binding and virus neutralization were assessed. Results were compared with those obtained in an adult COVID-19 convalescent population.
    Results: After mild COVID-19, anti-S and RBD-specific IgG antibodies were developed by 100% and 84.6% of pediatric subjects, respectively. No difference was observed in regards to symptoms and gender. Mounted antibodies recognized conformational epitopes of the spike protein and were capable to neutralize the virus up to a titer of ≥80 and to inhibit the ACE2-RBD interaction by up to 65%. SARS-CoV-2-specific IgG responses in children were comparable to mildly affected adult patients.
    Conclusion: SARS-CoV-2 asymptomatic and mildly affected pediatric patients develop a SARS-CoV-2-specific antibody response, which is comparable regarding antigen, epitope recognition, and the ability to inhibit the RBD-ACE2 interaction to that observed in adult patients after mild COVID-19.
    MeSH term(s) Adult ; Antibodies, Neutralizing ; Antibodies, Viral ; Antibody Formation ; COVID-19 ; Child ; Humans ; SARS-CoV-2 ; Spike Glycoprotein, Coronavirus/chemistry ; Spike Glycoprotein, Coronavirus/metabolism
    Chemical Substances Antibodies, Neutralizing ; Antibodies, Viral ; Spike Glycoprotein, Coronavirus
    Language English
    Publishing date 2022-02-25
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1057059-7
    ISSN 1399-3038 ; 0905-6157 ; 0906-5784
    ISSN (online) 1399-3038
    ISSN 0905-6157 ; 0906-5784
    DOI 10.1111/pai.13737
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Evaluation of RT-qPCR of mouthwash and buccal swabs for detection of SARS-CoV-2 in children and adults.

    Laferl, Hermann / Seitz, Tamara / Baier-Grabner, Sebastian / Kelani, Hasan / Scholz, Elisabeth / Heger, Florian / Götzinger, Florian / Frischer, Prof Thomas / Wenisch, Christoph / Allerberger, Prof Franz

    American journal of infection control

    2021  Volume 50, Issue 2, Page(s) 176–181

    Abstract: Background: The use of nasopharyngeal (NP) swabs as a specimen collection method to diagnose SARS-CoV-2 infection is frequently perceived as uncomfortable by patients and requires trained personnel. In this study, detection rate of SARS-CoV-2 in ... ...

    Abstract Background: The use of nasopharyngeal (NP) swabs as a specimen collection method to diagnose SARS-CoV-2 infection is frequently perceived as uncomfortable by patients and requires trained personnel. In this study, detection rate of SARS-CoV-2 in mouthwash samples and buccal swabs were compared in both children and adults.
    Material and methods: In patients admitted to hospital with confirmed COVID-19 within the previous 72 hours, NP and buccal swabs as well as mouthwash samples were collected. RT-qPCR was performed on all samples.
    Results: In total, 170 samples were collected from 155 patients (137 adults and 18 children). Approximately 91.7% of the collected NP swabs were positive in RT-PCR compared to 63.1% of mouthwash samples and 42.4% of buccal swabs. Compared to NP swabs, the sensitivity of using mouthwash was 96.3% and 65.4% for buccal swabs in NP swab samples with a CT value <25. With increasing CT values, sensitivity decreased in both mouthwash and buccal swabs. The virus load was highest during the first week of infection, with a continuous decline observed in all three collection methods over time.
    Discussion: Mouthwash presents an alternative collection method for detecting SARS-CoV-2 in the case of unfeasible NP swab sampling. Buccal swabs should not be used due to their low sensitivity.
    MeSH term(s) Adult ; COVID-19 ; Child ; Humans ; Mouthwashes ; Nasopharynx ; SARS-CoV-2 ; Specimen Handling
    Chemical Substances Mouthwashes
    Language English
    Publishing date 2021-10-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 392362-9
    ISSN 1527-3296 ; 0196-6553
    ISSN (online) 1527-3296
    ISSN 0196-6553
    DOI 10.1016/j.ajic.2021.10.019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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