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  1. Article ; Online: COVID-19 in children and young people.

    Felsenstein, Susanna / Hedrich, Christian M

    The Lancet. Rheumatology

    2020  Volume 2, Issue 9, Page(s) e514–e516

    Keywords covid19
    Language English
    Publishing date 2020-06-29
    Publishing country England
    Document type Journal Article
    ISSN 2665-9913
    ISSN (online) 2665-9913
    DOI 10.1016/S2665-9913(20)30212-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: A hitchhiker's guide through the COVID-19 galaxy.

    Felsenstein, Susanna / Reiff, Andreas Otto

    Clinical immunology (Orlando, Fla.)

    2021  Volume 232, Page(s) 108849

    Abstract: Numerous reviews have summarized the epidemiology, pathophysiology and the various therapeutic aspects of Coronavirus disease 2019 (COVID-19), but a practical guide on "how to treat whom with what and when" based on an understanding of the immunological ... ...

    Abstract Numerous reviews have summarized the epidemiology, pathophysiology and the various therapeutic aspects of Coronavirus disease 2019 (COVID-19), but a practical guide on "how to treat whom with what and when" based on an understanding of the immunological background of the disease stages remains missing. This review attempts to combine the current knowledge about the immunopathology of COVID-19 with published evidence of available and emerging treatment options. We recognize that the information about COVID-19 and its treatment is rapidly changing, but hope that this guide offers those on the frontline of this pandemic an understanding of the host response in COVID-19 patients and supports their ongoing efforts to select the best treatments tailored to their patient's clinical status.
    MeSH term(s) Animals ; COVID-19/immunology ; Humans ; SARS-CoV-2/drug effects ; SARS-CoV-2/immunology ; COVID-19 Drug Treatment
    Language English
    Publishing date 2021-09-24
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1459903-x
    ISSN 1521-7035 ; 1521-6616
    ISSN (online) 1521-7035
    ISSN 1521-6616
    DOI 10.1016/j.clim.2021.108849
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: SARS-CoV-2 infections in children and young people.

    Felsenstein, Susanna / Hedrich, Christian M

    Clinical immunology (Orlando, Fla.)

    2020  Volume 220, Page(s) 108588

    Abstract: Though recent reports link SARS-CoV-2 infections with hyper-inflammatory states in children, most children experience no/mild symptoms, and hospitalization and mortality rates are low in the age group. As symptoms are usually mild and seroconversion ... ...

    Abstract Though recent reports link SARS-CoV-2 infections with hyper-inflammatory states in children, most children experience no/mild symptoms, and hospitalization and mortality rates are low in the age group. As symptoms are usually mild and seroconversion occurs at low frequencies, it remains unclear whether children significantly contribute to community transmission. Several hypotheses try to explain age-related differences in disease presentation and severity. Possible reasons for milder presentations in children as compared to adults include frequent contact to seasonal coronaviruses, presence of cross-reactive antibodies, and/or co-clearance with other viruses. Increased expression of ACE2 in young people may facilitate virus infection, while limiting inflammation and reducing the risk of severe disease. Further potential factors include recent vaccinations and a more diverse memory T cell repertoire. This manuscript reviews age-related host factors that may protect children from COVID-19 and complications associated, and addresses the confusion around seropositivity and immunity.
    MeSH term(s) Adaptive Immunity/drug effects ; Adolescent ; Antibodies, Viral/blood ; Asymptomatic Diseases ; Betacoronavirus/drug effects ; Betacoronavirus/immunology ; Betacoronavirus/pathogenicity ; COVID-19 ; Child ; Coronaviridae/drug effects ; Coronaviridae/immunology ; Coronaviridae/pathogenicity ; Coronaviridae Infections/epidemiology ; Coronaviridae Infections/immunology ; Coronaviridae Infections/prevention & control ; Coronaviridae Infections/virology ; Coronavirus Infections/epidemiology ; Coronavirus Infections/immunology ; Coronavirus Infections/prevention & control ; Coronavirus Infections/virology ; Cross Protection ; Female ; Humans ; Immune Evasion/genetics ; Immune Evasion/immunology ; Immunity, Innate/drug effects ; Male ; Pandemics/prevention & control ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/immunology ; Pneumonia, Viral/prevention & control ; Pneumonia, Viral/virology ; SARS-CoV-2 ; T-Lymphocyte Subsets/immunology ; T-Lymphocyte Subsets/virology ; United Kingdom/epidemiology ; Vaccination ; Young Adult
    Chemical Substances Antibodies, Viral
    Keywords covid19
    Language English
    Publishing date 2020-09-06
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1459903-x
    ISSN 1521-7035 ; 1521-6616
    ISSN (online) 1521-7035
    ISSN 1521-6616
    DOI 10.1016/j.clim.2020.108588
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 880: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: COVID-19 in children and young people

    Felsenstein, Susanna / Hedrich, Christian M

    The Lancet Rheumatology

    2020  Volume 2, Issue 9, Page(s) e514–e516

    Keywords covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ISSN 2665-9913
    DOI 10.1016/s2665-9913(20)30212-5
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  6. Article: COVID-19 bei Kindern und Jugendlichen

    Felsenstein, Susanna / Hedrich, Christian M.

    Arthritis + Rheuma

    2020  Volume 40, Issue 5, Page(s) 347

    Language German
    Document type Article
    ZDB-ID 605764-0
    ISSN 0176-5167
    Database Current Contents Medicine

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1579: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: SARS-CoV-2 infections in children and young people

    Felsenstein, Susanna / Hedrich, Christian M.

    Clinical Immunology

    2020  Volume 220, Page(s) 108588

    Keywords Immunology ; Immunology and Allergy ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 1459903-x
    ISSN 1521-7035 ; 1521-6616
    ISSN (online) 1521-7035
    ISSN 1521-6616
    DOI 10.1016/j.clim.2020.108588
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 880: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: SARS-CoV-2 infections in children and young people

    Felsenstein, Susanna / Hedrich, Christian M

    Clin Immunol

    Abstract: Though recent reports link SARS-CoV-2 infections with hyper-inflammatory states in children, most children experience no/mild symptoms, and hospitalization and mortality rates are low in the age group. As symptoms are usually mild and seroconversion ... ...

    Abstract Though recent reports link SARS-CoV-2 infections with hyper-inflammatory states in children, most children experience no/mild symptoms, and hospitalization and mortality rates are low in the age group. As symptoms are usually mild and seroconversion occurs at low frequencies, it remains unclear whether children significantly contribute to community transmission. Several hypotheses try to explain age-related differences in disease presentation and severity. Possible reasons for milder presentations in children as compared to adults include frequent contact to seasonal coronaviruses, presence of cross-reactive antibodies, and/or co-clearance with other viruses. Increased expression of ACE2 in young people may facilitate virus infection, while limiting inflammation and reducing the risk of severe disease. Further potential factors include recent vaccinations and a more diverse memory T cell repertoire. This manuscript reviews age-related host factors that may protect children from COVID-19 and complications associated, and addresses the confusion around seropositivity and immunity.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #743920
    Database COVID19

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  9. Article ; Online: COVID-19 bei Kindern und Jugendlichen

    Felsenstein, Susanna / Hedrich, Christian M.

    Arthritis und Rheuma

    2020  Volume 40, Issue 05, Page(s) 347–357

    Abstract: ZUSAMMENFASSUNG Das neuartige Coronavirus SARS-CoV-2 ist der Auslöser von COVID-19, einer Erkrankung, die Millionen von Menschenleben weltweit bedroht. Ca. 10–20 % aller Erwachsenen mit COVID-19 entwickeln schwere oder lebensbedrohliche Verläufe, die von ...

    Abstract ZUSAMMENFASSUNG Das neuartige Coronavirus SARS-CoV-2 ist der Auslöser von COVID-19, einer Erkrankung, die Millionen von Menschenleben weltweit bedroht. Ca. 10–20 % aller Erwachsenen mit COVID-19 entwickeln schwere oder lebensbedrohliche Verläufe, die von Akutem Atemnotsyndrom (ARDS), Koagulopathie und/oder Zytokinsturm gekennzeichnet sind. Kinder und Jugendliche haben ein geringeres Risiko, symptomatisch zu erkranken und/oder schwere Verläufe zu entwickeln, was vermuten lässt, dass es altersabhängige Wirtsmechanismen gibt, die schweren Verläufen entgegenwirken könnten. Obwohl kürzlich hochinflammatorische, teils lebensbedrohliche Erkrankungen bei Kindern und Jugendlichen beschrieben wurden und viel Beachtung fanden, bleiben sie insgesamt bisher relativ selten. Ob Kinder signifikant zur Transmission auf Populationsebene beitragen, ist unklar, muss aber zumindest weiter angenommen werden. Mehrere Hypothesen versuchen Unterschiede im Hinblick auf klinischen Verlauf und Erkrankungsrisiko zwischen den Altersgruppen und einzelnen Individuen zu erklären. Dieser Artikel fasst den aktuellen Wissensstand zur Immunpathogenese von COVID-19 mit Fokus auf das Kindes- und Jugendalter zusammen.
    Keywords covid19
    Language German
    Publisher Georg Thieme Verlag KG
    Publishing country de
    Document type Article ; Online
    ZDB-ID 605764-0
    ISSN 0176-5167
    ISSN 0176-5167
    DOI 10.1055/a-1255-8937
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1579: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  10. Article: COVID-19 bei Kindern und Jugendlichen

    Felsenstein, Susanna / Hedrich, Christian M.

    Arthritis und Rheuma

    2020  Volume 40, Issue 05, Page(s) 347–357

    Abstract: Das neuartige Coronavirus SARS-CoV-2 ist der Auslöser von COVID-19, einer Erkrankung, die Millionen von Menschenleben weltweit bedroht. Ca. 10–20 % aller Erwachsenen mit COVID-19 entwickeln schwere oder lebensbedrohliche Verläufe, die von Akutem ... ...

    Abstract Das neuartige Coronavirus SARS-CoV-2 ist der Auslöser von COVID-19, einer Erkrankung, die Millionen von Menschenleben weltweit bedroht. Ca. 10–20 % aller Erwachsenen mit COVID-19 entwickeln schwere oder lebensbedrohliche Verläufe, die von Akutem Atemnotsyndrom (ARDS), Koagulopathie und/oder Zytokinsturm gekennzeichnet sind. Kinder und Jugendliche haben ein geringeres Risiko, symptomatisch zu erkranken und/oder schwere Verläufe zu entwickeln, was vermuten lässt, dass es altersabhängige Wirtsmechanismen gibt, die schweren Verläufen entgegenwirken könnten. Obwohl kürzlich hochinflammatorische, teils lebensbedrohliche Erkrankungen bei Kindern und Jugendlichen beschrieben wurden und viel Beachtung fanden, bleiben sie insgesamt bisher relativ selten. Ob Kinder signifikant zur Transmission auf Populationsebene beitragen, ist unklar, muss aber zumindest weiter angenommen werden. Mehrere Hypothesen versuchen Unterschiede im Hinblick auf klinischen Verlauf und Erkrankungsrisiko zwischen den Altersgruppen und einzelnen Individuen zu erklären. Dieser Artikel fasst den aktuellen Wissensstand zur Immunpathogenese von COVID-19 mit Fokus auf das Kindes- und Jugendalter zusammen.

    SARS-CoV-2 is the pathogen causing COVID-19, a pandemic threatening millions of lives globally. Children and young people (CYP) usually do not develop severe disease. However, a minority of CYP contracting SARS-CoV-2 infections have been reported to develop severe hyper-inflammatory phenotypes. Host mechanisms centrally contribute to disease pathology and resulting clinical phenotypes. Several hypotheses try to explain age-related differences in disease presentation and severity, including prevalence of seasonal coronavirus infections in CYP and cross-relative antibodies, and co-clearance with other virus infections. Furthermore, high expression of transmembrane ACE2 may modulate inflammation in children while mediating infection of epithelial cells. Further protective mechanisms in CYP may include recent vaccinations and a diverse T cell repertoire. Thus, it remains an important, but unanswered question whether CYP significantly contribute to community transmission. Here, the authors review age-related host factors in COVID-19, and address the confusion around seropositivity and immunity.
    Keywords COVID ; SARS-CoV-2 ; Kinder ; Inflammation ; Therapie ; Pathologie ; COVID ; SARS-CoV-2 ; children ; inflammation ; treatment ; pathology
    Language German
    Publishing date 2020-10-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2223481-0
    ISSN 2567-5753 ; 0176-5167
    ISSN (online) 2567-5753
    ISSN 0176-5167
    DOI 10.1055/a-1255-8937
    Database Thieme publisher's database

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