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  1. Article ; Online: The influenza universe in an mRNA vaccine.

    Kelvin, Alyson A / Falzarano, Darryl

    Science (New York, N.Y.)

    2022  Volume 378, Issue 6622, Page(s) 827–828

    Abstract: An mRNA-lipid nanoparticle vaccine protects animals from 20 influenza lineages. ...

    Abstract An mRNA-lipid nanoparticle vaccine protects animals from 20 influenza lineages.
    MeSH term(s) Animals ; Influenza B virus/immunology ; Influenza Vaccines/genetics ; Influenza Vaccines/immunology ; Influenza, Human/prevention & control ; mRNA Vaccines/genetics ; mRNA Vaccines/immunology ; Vaccines, Synthetic/genetics ; Vaccines, Synthetic/immunology ; Alphainfluenzavirus/immunology ; Mice ; Ferrets
    Chemical Substances Influenza Vaccines ; Lipid Nanoparticles ; mRNA Vaccines ; Vaccines, Synthetic
    Language English
    Publishing date 2022-11-24
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.adf0900
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: COVID-19 in children: the link in the transmission chain.

    Kelvin, Alyson A / Halperin, Scott

    The Lancet. Infectious diseases

    2020  Volume 20, Issue 6, Page(s) 633–634

    MeSH term(s) Betacoronavirus ; COVID-19 ; Child ; Coronavirus Infections/epidemiology ; Humans ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-03-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2061641-7
    ISSN 1474-4457 ; 1473-3099
    ISSN (online) 1474-4457
    ISSN 1473-3099
    DOI 10.1016/S1473-3099(20)30236-X
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  3. Article ; Online: microRNA-185 Inhibits SARS-CoV-2 Infection through the Modulation of the Host's Lipid Microenvironment.

    Ahmed, Nadine / Francis, Magen E / Ahmed, Noreen / Kelvin, Alyson A / Pezacki, John Paul

    Viruses

    2023  Volume 15, Issue 9

    Abstract: With the emergence of the ... ...

    Abstract With the emergence of the novel
    MeSH term(s) Humans ; COVID-19 ; SARS-CoV-2/genetics ; Antiviral Agents/pharmacology ; MicroRNAs/genetics ; Lipids
    Chemical Substances spike protein, SARS-CoV-2 ; Antiviral Agents ; MicroRNAs ; Lipids ; MIRN185 microRNA, human
    Language English
    Publishing date 2023-09-14
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v15091921
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  4. Article: Corrigendum: Population genomics of American mink using genotype data.

    Hu, Guoyu / Do, Duy Ngoc / Manafiazar, Ghader / Kelvin, Alyson A / Sargolzaei, Mehdi / Plastow, Graham / Wang, Zhiquan / Miar, Younes

    Frontiers in genetics

    2023  Volume 14, Page(s) 1221683

    Abstract: This corrects the article DOI: 10.3389/fgene.2023.1175408.]. ...

    Abstract [This corrects the article DOI: 10.3389/fgene.2023.1175408.].
    Language English
    Publishing date 2023-05-19
    Publishing country Switzerland
    Document type Published Erratum
    ZDB-ID 2606823-0
    ISSN 1664-8021
    ISSN 1664-8021
    DOI 10.3389/fgene.2023.1221683
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  6. Article ; Online: Sex differences in the cardiac stress response following SARS-CoV-2 infection of ferrets.

    Rouhana, Sarah / Jacyniak, Kathy / Francis, Magen E / Falzarano, Darryl / Kelvin, Alyson A / Pyle, W Glen

    American journal of physiology. Heart and circulatory physiology

    2023  Volume 325, Issue 5, Page(s) H1153–H1167

    Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection damages the heart, increasing the risk of adverse cardiovascular events. Female sex protects against complications of infection; females are less likely to experience severe illness ... ...

    Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection damages the heart, increasing the risk of adverse cardiovascular events. Female sex protects against complications of infection; females are less likely to experience severe illness or death, although their risk for postacute sequelae of COVID-19 ("long COVID") is higher than in males. Despite the important role of the heart in COVID-19 outcomes, molecular elements in the heart impacted by SARS-CoV-2 are poorly understood. Similarly, the role sex has on the myocardial effects of SARS-CoV-2 infection has not been investigated at a molecular level. We intranasally inoculated female and male ferrets with SARS-CoV-2 and assessed myocardial stress signals, inflammation, and the innate immune response for 14 days. Myocardial phosphorylated GSK3α/β decreased at
    MeSH term(s) Female ; Male ; Animals ; Humans ; COVID-19 ; SARS-CoV-2 ; Ferrets ; Post-Acute COVID-19 Syndrome ; Sex Characteristics ; Sequestosome-1 Protein ; Inflammation ; Cardiovascular Diseases
    Chemical Substances Sequestosome-1 Protein
    Language English
    Publishing date 2023-09-22
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 603838-4
    ISSN 1522-1539 ; 0363-6135
    ISSN (online) 1522-1539
    ISSN 0363-6135
    DOI 10.1152/ajpheart.00101.2023
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  7. Article ; Online: Influenza imprinting in childhood and the influence on vaccine response later in life.

    Kelvin, Alyson A / Zambon, Maria

    Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin

    2019  Volume 24, Issue 48

    MeSH term(s) Antibodies, Viral/immunology ; Child ; Female ; Humans ; Immunologic Memory ; Influenza A Virus, H1N1 Subtype/immunology ; Influenza A Virus, H3N2 Subtype/immunology ; Influenza Vaccines/administration & dosage ; Influenza Vaccines/immunology ; Influenza, Human/epidemiology ; Influenza, Human/prevention & control ; Influenza, Human/virology ; Male
    Chemical Substances Antibodies, Viral ; Influenza Vaccines
    Language English
    Publishing date 2019-12-03
    Publishing country Sweden
    Document type Journal Article
    ZDB-ID 1338803-4
    ISSN 1560-7917 ; 1025-496X
    ISSN (online) 1560-7917
    ISSN 1025-496X
    DOI 10.2807/1560-7917.ES.2019.24.48.1900720
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  8. Article ; Online: COVID-19 in children

    Kelvin, Alyson A / Halperin, Scott

    The Lancet Infectious Diseases

    the link in the transmission chain

    2020  Volume 20, Issue 6, Page(s) 633–634

    Keywords Infectious Diseases ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 2061641-7
    ISSN 1474-4457 ; 1473-3099
    ISSN (online) 1474-4457
    ISSN 1473-3099
    DOI 10.1016/s1473-3099(20)30236-x
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Zs.A 5743: Show issues Location:
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  9. Article: Influenza virus immune imprinting dictates the clinical outcomes in ferrets challenged with highly pathogenic avian influenza virus H5N1.

    Nuñez, Ivette A / Jang, Hyesun / Huang, Ying / Kelvin, Alyson / Ross, Ted M

    Frontiers in veterinary science

    2023  Volume 10, Page(s) 1286758

    Abstract: Zoonotic transmission of H5N1 highly pathogenic avian influenza virus (HPAIV) into the human population is an increasing global threat. The recent 2022 HPAIV outbreak significantly highlighted this possibility, increasing concern in the general ... ...

    Abstract Zoonotic transmission of H5N1 highly pathogenic avian influenza virus (HPAIV) into the human population is an increasing global threat. The recent 2022 HPAIV outbreak significantly highlighted this possibility, increasing concern in the general population. The clinical outcomes of H5N1 influenza virus exposure can be determined by an individual's primary influenza virus infection (imprinting) or vaccination status. Immunological imprinting with Group 1 - (H1N1, H2N2, and H2N3) increases survival rates following H5N1 viral infection compared to Group 2 - (H3N2) imprinted individuals. Vaccination against H5N1 influenza viruses can offer protection to at-risk populations; however, stockpiled inactivated H5N1 influenza vaccines are not readily available to the public. We hypothesize that the immunological response to vaccination and subsequent clinical outcome following H5N1 influenza virus infection is correlated with the immunological imprinting status of an individual. To test this hypothesis, our lab established a ferret pre-immune model of disease. Naïve ferrets were intranasally inoculated with seasonal influenza viruses and allowed to recover for 84 days prior to H5N1 virus infection. Ferrets imprinted following H1N1 and H2N3 virus infections were completely protected against lethal H5N1 influenza virus challenge (100% survival), with few to no clinical symptoms. In comparison, H3N2 influenza virus-imprinted ferrets had severe clinical symptoms, delayed disease progression, and a sublethal phenotype (40% mortality). Consecutive infections with H1N1 influenza viruses followed by an H3N2 influenza virus infection did not abrogate the immune protection induced by the original H1N1 influenza virus infection. In addition, ferrets consecutively infected with H1N1 and H2N3 viruses had no clinical symptoms or weight loss. H3N2 pre-immune ferrets were vaccinated with a broadly reactive H5 HA-based or H1 NA-based vaccine (Hu-CO 2). These ferrets were protected against H5N1 influenza virus challenge, whereas ferrets vaccinated with the H1N1 wild-type CA/09 rHA vaccine had similar phenotypes as non-vaccinated H3N2-imprinted ferrets with 40% survival. Overall, Group 2 imprinted ferrets, which were vaccinated with heterologous Group 1 HA vaccines, had redirected immune responses to Group 1 influenza viral antigens and rescued a sublethal phenotype to complete protection.
    Language English
    Publishing date 2023-12-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2834243-4
    ISSN 2297-1769
    ISSN 2297-1769
    DOI 10.3389/fvets.2023.1286758
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  10. Article ; Online: Molecular mechanisms responsible for SARS-CoV-2 antibody waning and vaccine escape in Omicron sublineages BA.4 and BA.5.

    Hewins, Benjamin / Richardson, Christopher / Rubino, Salvatore / Kelvin, Alyson / Toloue Ostadgavahi, Ali / Kelvin, David J

    Journal of infection in developing countries

    2022  Volume 16, Issue 7, Page(s) 1122–1125

    Abstract: Mutations in the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genome continue to threaten the global landscape of the coronavirus disease 2019 (COVID-19) pandemic. The Omicron variant (B.1.1.529) rapidly displaced previous 'variants of ... ...

    Abstract Mutations in the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genome continue to threaten the global landscape of the coronavirus disease 2019 (COVID-19) pandemic. The Omicron variant (B.1.1.529) rapidly displaced previous 'variants of concern' (VoC) in 2021 due to its high rate of transmissibility and multitude of mutations. This global influx of infections saturated healthcare systems, overwhelmed testing capacity and case reporting, and increased the COVID-19 death toll. Global health leaders are now being faced with the most transmissible COVID-19 variants yet, the Omicron sublineages BA.4 and BA.5, which contain additional spike protein (S) mutations from previous Omicron and VoC serotypes. With universally observed antibody waning, increasing vaccine-variant mismatch, and resuming international travel, the stage is set for unprecedented levels of breakthrough infections and superspreading events. In this paper, we raise awareness to these novel variants and provide context for the high likelihood of an upcoming wave of infection capable of inflicting significant disease burden on a global scale.
    MeSH term(s) Antibodies, Viral ; COVID-19 ; Humans ; SARS-CoV-2/genetics ; Viral Vaccines
    Chemical Substances Antibodies, Viral ; Viral Vaccines
    Language English
    Publishing date 2022-07-28
    Publishing country Italy
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2394024-4
    ISSN 1972-2680 ; 2036-6590
    ISSN (online) 1972-2680
    ISSN 2036-6590
    DOI 10.3855/jidc.17010
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