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Article ; Online: The increasing complexity of arbovirus serology: An in-depth systematic review on cross-reactivity.

Kasbergen, Louella M R / Nieuwenhuijse, David F / de Bruin, Erwin / Sikkema, Reina S / Koopmans, Marion P G

2023 Volume 17, Issue 9, Page(s) e0011651

Abstract: Diagnosis of arbovirus infection or exposure by antibody testing is becoming increasingly difficult due to global expansion of arboviruses, which induce antibodies that may (cross-)react in serological assays. We provide a systematic review of the ... ...

Abstract	Diagnosis of arbovirus infection or exposure by antibody testing is becoming increasingly difficult due to global expansion of arboviruses, which induce antibodies that may (cross-)react in serological assays. We provide a systematic review of the current knowledge and knowledge gaps in differential arbovirus serology. The search included Medline, Embase and Web of Science databases and identified 911 publications which were reduced to 102 after exclusion of studies not providing data on possible cross-reactivity or studies that did not meet the inclusion criteria regarding confirmation of virus exposure of reference population sets. Using a scoring system to further assess quality of studies, we show that the majority of the selected papers (N = 102) provides insufficient detail to support conclusions on specificity of serological outcomes with regards to elucidating antibody cross-reactivity. Along with the lack of standardization of assays, metadata such as time of illness onset, vaccination, infection and travel history, age and specificity of serological methods were most frequently missing. Given the critical role of serology for diagnosis and surveillance of arbovirus infections, better standards for reporting, as well as the development of more (standardized) specific serological assays that allow discrimination between exposures to multiple different arboviruses, are a large global unmet need.
MeSH term(s)	Humans ; Arboviruses ; Arbovirus Infections/diagnosis ; Hematologic Tests
Language	English
Publishing date	2023-09-22
Publishing country	United States
Document type	Systematic Review ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2429704-5
ISSN	1935-2735 ; 1935-2735
ISSN (online)	1935-2735
ISSN	1935-2735
DOI	10.1371/journal.pntd.0011651
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Development and validation of the MosquitoWise survey to assess perceptions towards mosquitoes and mosquito-borne viruses in Europe.

Abourashed, Ayat / de Best, Pauline A / Doornekamp, Laura / Sikkema, Reina S / van Gorp, Eric C M / Timen, Aura / Bartumeus, Frederic / Palmer, John R B / Koopmans, Marion P G

Scientific reports

2024 Volume 14, Issue 1, Page(s) 1777

Abstract: Due to climate change and the expanding geographical ranges of key mosquito species, several mosquito-borne viruses (MBVs) have recently emerged in Europe. Understanding people's perceptions and behaviours towards these viruses and the mosquitoes capable ...

Abstract	Due to climate change and the expanding geographical ranges of key mosquito species, several mosquito-borne viruses (MBVs) have recently emerged in Europe. Understanding people's perceptions and behaviours towards these viruses and the mosquitoes capable of transmitting them is crucial for implementing effective prevention measures and targeted communication campaigns. However, there is currently no appropriate validated survey for European populations to assess this. This study developed and validated a standardized survey, based on the Health Belief Model (HBM), to assess perceptions of mosquitoes and MBVs among Europe's residents. The survey was distributed online to United Kingdom (UK), Dutch and Spanish participants through panel providers. Survey validity and reliability were tested using confirmatory factor analysis (CFA) and Cronbach's alpha. The optimised survey was completed by 336 UK, 438 Dutch and 475 Spanish residents, respectively, and the HBM items passed our validity and reliability testing in all three countries. The final survey has 57 questions, including 19 validated HBM items, and questions to assess demographic characteristics, knowledge, prevention measures and behavioural determinants. Our MosquitoWise survey bridges researchers' understandings of European residents' perceptions and knowledge as a first step to improve preventive behaviour towards mosquitoes and MBVs and guide prevention and communication initiatives.
MeSH term(s)	Animals ; Humans ; Culicidae ; Reproducibility of Results ; Viruses ; Europe ; United Kingdom ; Surveys and Questionnaires
Language	English
Publishing date	2024-01-20
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-52219-9
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Landscape level associations between birds, mosquitoes and microclimates: possible consequences for disease transmission?

Krol, Louie / Remmerswaal, Laure / Groen, Marvin / van der Beek, Jordy G / Sikkema, Reina S / Dellar, Martha / van Bodegom, Peter M / Geerling, Gertjan W / Schrama, Maarten

Parasites & vectors

2024 Volume 17, Issue 1, Page(s) 156

Abstract: Background: Mosquito-borne diseases are on the rise. While climatic factors have been linked to disease occurrences, they do not explain the non-random spatial distribution in disease outbreaks. Landscape-related factors, such as vegetation structure, ... ...

Abstract	Background: Mosquito-borne diseases are on the rise. While climatic factors have been linked to disease occurrences, they do not explain the non-random spatial distribution in disease outbreaks. Landscape-related factors, such as vegetation structure, likely play a crucial but hitherto unquantified role. Methods: We explored how three critically important factors that are associated with mosquito-borne disease outbreaks: microclimate, mosquito abundance and bird communities, vary at the landscape scale. We compared the co-occurrence of these three factors in two contrasting habitat types (forest versus grassland) across five rural locations in the central part of the Netherlands between June and September 2021. Results: Our results show that forest patches provide a more sheltered microclimate, and a higher overall abundance of birds. When accounting for differences in landscape characteristics, we also observed that the number of mosquitoes was higher in isolated forest patches. Conclusions: Our findings indicate that, at the landscape scale, variation in tree cover coincides with suitable microclimate and high Culex pipiens and bird abundance. Overall, these factors can help understand the non-random spatial distribution of mosquito-borne disease outbreaks.
MeSH term(s)	Animals ; Culicidae ; Microclimate ; Culex ; Birds ; West Nile virus ; West Nile Fever ; Mosquito Vectors
Language	English
Publishing date	2024-03-26
Publishing country	England
Document type	Journal Article
ZDB-ID	2409480-8
ISSN	1756-3305 ; 1756-3305
ISSN (online)	1756-3305
ISSN	1756-3305
DOI	10.1186/s13071-024-06239-z
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Rapid response screening for emerging zoonotic pathogens, barriers and opportunities: A study for enhanced preparedness of the Netherlands.

Streng, Kiki / de Best, Pauline A / Timen, Aura / Koopmans, Marion P G / van der Poel, Wim H M / Sikkema, Reina S

One health (Amsterdam, Netherlands)

2023 Volume 16, Page(s) 100507

Abstract: Background: Outbreaks of zoonotic emerging infectious diseases (EIDs) require rapid identification of potential reservoir hosts and mapping disease spread in these hosts to inform risk assessment and adequate control measures. Animals are often ... ...

Abstract	Background: Outbreaks of zoonotic emerging infectious diseases (EIDs) require rapid identification of potential reservoir hosts and mapping disease spread in these hosts to inform risk assessment and adequate control measures. Animals are often understudied when a novel EID is detected in humans and acquisition of animal samples is hampered by practical, ethical, and legal barriers, of which there is currently no clear overview. Therefore, the three aims of this study are (1) to map potentially available collections of animal samples, (2) to assess possibilities and barriers for reuse of these samples and (3) to assess possibilities and barriers for active animal and environmental sampling in the Netherlands. Methods: A literature search was performed to identify ongoing sampling activities and opportunities for reuse or active sampling. Semi-structured interviews with stakeholder organizations were conducted to gain further insight into the three research questions. Results: Various sample collections of surveillance, diagnostic and research activities exist in the Netherlands. Sample size, coverage, storage methods and type of samples collected differs per animal species which influences reuse suitability. Organizations are more likely to share samples, for reuse in outbreak investigations, when they have a pre-existing relationship with the requesting institute. Identified barriers for sharing were, among others, unfamiliarity with legislation and unsuitable data management systems. Active sampling of animals or the environment is possible through several routes. Related barriers are acquiring approval from animal- or property owners, conflicts with anonymization, and time needed to acquire ethical approval. Conclusion: The animal sample collections identified would be very valuable for use in outbreak investigations. Barriers for sharing may be overcome by increasing familiarity with legislation, building (international) sharing networks and agreements before crises occur and developing systems for sample registration and biobanking. Proactive setting up of ethical approvals will allow for rapid animal sample collection to identify EID hosts and potential spillovers.
Language	English
Publishing date	2023-02-14
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2834831-X
ISSN	2352-7714
ISSN	2352-7714
DOI	10.1016/j.onehlt.2023.100507
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: The pathology of co-infection with Usutu virus and

Agliani, Gianfilippo / Giglia, Giuseppe / de Bruin, Erwin / van Mastrigt, Tjomme / Blom, Rody / Sikkema, Reina S / Kik, Marja / Koopmans, Marion P G / Gröne, Andrea / Van den Brand, Judith M A

One health (Amsterdam, Netherlands)

2023 Volume 16, Page(s) 100534

Abstract: Usutu virus (USUV) is a mosquito-borne zoonotic flavivirus causing mortality in Eurasian blackbirds ( ...

Abstract	Usutu virus (USUV) is a mosquito-borne zoonotic flavivirus causing mortality in Eurasian blackbirds (
Language	English
Publishing date	2023-04-01
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2834831-X
ISSN	2352-7714
ISSN	2352-7714
DOI	10.1016/j.onehlt.2023.100534
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A species-independent lateral flow microarray immunoassay to detect WNV and USUV NS1-specific antibodies in serum

Bijan Godarzi / Felicity Chandler / Anne van der Linden / Reina S. Sikkema / Erwin de Bruin / Edwin Veldhuizen / Aart van Amerongen / Andrea Gröne

One Health, Vol 18, Iss , Pp 100668- (2024)

2024

Abstract: Arboviruses such as West Nile Virus (WNV) and Usutu Virus (USUV) are emerging pathogens that circulate between mosquitoes and birds, occasionally spilling over into humans and horses. Current serological screening methods require access to a well- ... ...

Abstract	Arboviruses such as West Nile Virus (WNV) and Usutu Virus (USUV) are emerging pathogens that circulate between mosquitoes and birds, occasionally spilling over into humans and horses. Current serological screening methods require access to a well-equipped laboratory and are not currently available for on-site analysis. As a proof of concept, we propose here a species-independent lateral flow microarray immunoassay (LMIA) able to quickly detect and distinguish between WNV Non-Structural 1 (NS1) and USUV NS1-specific antibodies. A double antigen approach was used to test sera collected from humans, horses, European jackdaws (Corvus monedula), and common blackbirds (Turdus merula). Optimization of the concentration of capture antigen spotted on the LMIA membrane and the amount of detection antigen conjugated to detector particles indicated that maximizing both parameters increased assay sensitivity. Upon screening of a larger serum panel, the optimized LMIA showed significantly higher spot intensity for a homologous binding event. Using a Receiver Operating Characteristics (ROC) curve, WNV NS1 LMIA results in humans, horses, and C. monedula showed good correlation when compared to “gold standard” WNV FRNT90. The most optimal derived sensitivity and specificity of the WNV NS1 LMIA relative to corresponding WNV FRNT90-confirmed sera were determined to be 96% and 86%, respectively. While further optimization is required, this study demonstrates the feasibility of developing a species-independent LMIA for on-site analysis of WNV, USUV, and other arboviruses. Such a tool would be useful for the on-site screening and monitoring of relevant species in more remote or low-income regions.
Keywords	Arboviruses ; West Nile Virus ; Usutu Virus ; One Health ; Lateral Flow Assay (LFA) ; Serology ; Medicine (General) ; R5-920
Subject code	630
Language	English
Publishing date	2024-06-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Author Correction: The next phase of SARS-CoV-2 surveillance: real-time molecular epidemiology.

Oude Munnink, Bas B / Worp, Nathalie / Nieuwenhuijse, David F / Sikkema, Reina S / Haagmans, Bart / Fouchier, Ron A M / Koopmans, Marion

Nature medicine

2021 Volume 27, Issue 11, Page(s) 2048

Language	English
Publishing date	2021-10-02
Publishing country	United States
Document type	Published Erratum
ZDB-ID	1220066-9
ISSN	1546-170X ; 1078-8956
ISSN (online)	1546-170X
ISSN	1078-8956
DOI	10.1038/s41591-021-01567-4
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The multi-dimensional challenges of controlling respiratory virus transmission in indoor spaces: Insights from the linkage of a microscopic pedestrian simulation and SARS-CoV-2 transmission model.

Atamer Balkan, Büsra / Chang, You / Sparnaaij, Martijn / Wouda, Berend / Boschma, Doris / Liu, Yangfan / Yuan, Yufei / Daamen, Winnie / de Jong, Mart C M / Teberg, Colin / Schachtschneider, Kevin / Sikkema, Reina S / van Veen, Linda / Duives, Dorine / Ten Bosch, Quirine A

PLoS computational biology

2024 Volume 20, Issue 3, Page(s) e1011956

Abstract: SARS-CoV-2 transmission in indoor spaces, where most infection events occur, depends on the types and duration of human interactions, among others. Understanding how these human behaviours interface with virus characteristics to drive pathogen ... ...

Abstract	SARS-CoV-2 transmission in indoor spaces, where most infection events occur, depends on the types and duration of human interactions, among others. Understanding how these human behaviours interface with virus characteristics to drive pathogen transmission and dictate the outcomes of non-pharmaceutical interventions is important for the informed and safe use of indoor spaces. To better understand these complex interactions, we developed the Pedestrian Dynamics-Virus Spread model (PeDViS), an individual-based model that combines pedestrian behaviour models with virus spread models incorporating direct and indirect transmission routes. We explored the relationships between virus exposure and the duration, distance, respiratory behaviour, and environment in which interactions between infected and uninfected individuals took place and compared this to benchmark 'at risk' interactions (1.5 metres for 15 minutes). When considering aerosol transmission, individuals adhering to distancing measures may be at risk due to the buildup of airborne virus in the environment when infected individuals spend prolonged time indoors. In our restaurant case, guests seated at tables near infected individuals were at limited risk of infection but could, particularly in poorly ventilated places, experience risks that surpass that of benchmark interactions. Combining interventions that target different transmission routes can aid in accumulating impact, for instance by combining ventilation with face masks. The impact of such combined interventions depends on the relative importance of transmission routes, which is hard to disentangle and highly context dependent. This uncertainty should be considered when assessing transmission risks upon different types of human interactions in indoor spaces. We illustrated the multi-dimensionality of indoor SARS-CoV-2 transmission that emerges from the interplay of human behaviour and the spread of respiratory viruses. A modelling strategy that incorporates this in risk assessments can help inform policy makers and citizens on the safe use of indoor spaces with varying inter-human interactions.
MeSH term(s)	Humans ; SARS-CoV-2 ; COVID-19/prevention & control ; Pedestrians ; Respiratory Aerosols and Droplets ; Ventilation
Language	English
Publishing date	2024-03-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	2193340-6
ISSN	1553-7358 ; 1553-734X
ISSN (online)	1553-7358
ISSN	1553-734X
DOI	10.1371/journal.pcbi.1011956
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Towards reliable whole genome sequencing for outbreak preparedness and response.

Nieuwenhuijse, David F / van der Linden, Anne / Kohl, Robert H G / Sikkema, Reina S / Koopmans, Marion P G / Oude Munnink, Bas B

BMC genomics

2022 Volume 23, Issue 1, Page(s) 569

Abstract: Background: To understand the dynamics of infectious diseases, genomic epidemiology is increasingly advocated, with a need for rapid generation of genetic sequences during outbreaks for public health decision making. Here, we explore the use of ... ...

Abstract	Background: To understand the dynamics of infectious diseases, genomic epidemiology is increasingly advocated, with a need for rapid generation of genetic sequences during outbreaks for public health decision making. Here, we explore the use of metagenomic sequencing compared to specific amplicon- and capture-based sequencing, both on the Nanopore and the Illumina platform for generation of whole genomes of Usutu virus, Zika virus, West Nile virus, and Yellow Fever virus. Results: We show that amplicon-based Nanopore sequencing can be used to rapidly obtain whole genome sequences in samples with a viral load up to Ct 33 and capture-based Illumina is the most sensitive method for initial virus determination. Conclusions: The choice of sequencing approach and platform is important for laboratories wishing to start whole genome sequencing. Depending on the purpose of genome sequencing the best choice can differ. The insights presented in this work and the shown differences in data characteristics can guide labs to make a well informed choice.
MeSH term(s)	Disease Outbreaks ; Genome, Viral ; High-Throughput Nucleotide Sequencing/methods ; Humans ; Metagenomics/methods ; Nanopore Sequencing ; Whole Genome Sequencing/methods ; Zika Virus/genetics ; Zika Virus Infection
Language	English
Publishing date	2022-08-09
Publishing country	England
Document type	Journal Article
ZDB-ID	2041499-7
ISSN	1471-2164 ; 1471-2164
ISSN (online)	1471-2164
ISSN	1471-2164
DOI	10.1186/s12864-022-08749-5
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: A species-independent lateral flow microarray immunoassay to detect WNV and USUV NS1-specific antibodies in serum.

Godarzi, Bijan / Chandler, Felicity / van der Linden, Anne / Sikkema, Reina S / de Bruin, Erwin / Veldhuizen, Edwin / van Amerongen, Aart / Gröne, Andrea

One health (Amsterdam, Netherlands)

2023 Volume 18, Page(s) 100668

Abstract	Arboviruses such as West Nile Virus (WNV) and Usutu Virus (USUV) are emerging pathogens that circulate between mosquitoes and birds, occasionally spilling over into humans and horses. Current serological screening methods require access to a well-equipped laboratory and are not currently available for on-site analysis. As a proof of concept, we propose here a species-independent lateral flow microarray immunoassay (LMIA) able to quickly detect and distinguish between WNV Non-Structural 1 (NS1) and USUV NS1-specific antibodies. A double antigen approach was used to test sera collected from humans, horses, European jackdaws (
Language	English
Publishing date	2023-12-27
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2834831-X
ISSN	2352-7714
ISSN	2352-7714
DOI	10.1016/j.onehlt.2023.100668
Database	MEDical Literature Analysis and Retrieval System OnLINE

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