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  1. Article ; Online: The diagnosis and management of chronic lung allograft dysfunction.

    Verleden, Geert M / Hendriks, Jeroen M H / Verleden, Stijn E

    Current opinion in pulmonary medicine

    2024  

    Abstract: Purpose of review: Chronic lung allograft dysfunction (CLAD) remains a life-threatening complication following lung transplantation. Different CLAD phenotypes have recently been defined, based on the combination of pulmonary function testing and chest ... ...

    Abstract Purpose of review: Chronic lung allograft dysfunction (CLAD) remains a life-threatening complication following lung transplantation. Different CLAD phenotypes have recently been defined, based on the combination of pulmonary function testing and chest computed tomography (CT) scanning and spurred renewed interests in differential diagnosis, risk factors and management of CLAD.
    Recent findings: Given their crucial importance in the differential diagnosis, we will discuss the latest development in assessing the pulmonary function and chest CT scan, but also their limitations in proper CLAD phenotyping, especially with regards to patients with baseline allograft dysfunction. Since no definitive treatment exists, it remains important to timely identify clinical risk factors, but also to assess the presence of specific patterns or biomarkers in tissue or in broncho alveolar lavage in relation to CLAD (phenotypes). We will provide a comprehensive overview of the latest advances in risk factors and biomarker research in CLAD. Lastly, we will also review novel preventive and curative treatment strategies for CLAD.
    Summary: Although this knowledge has significantly advanced the field of lung transplantation, more research is warranted because CLAD remains a life-threatening complication for all lung transplant recipients.
    Language English
    Publishing date 2024-02-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1285505-4
    ISSN 1531-6971 ; 1070-5287 ; 1078-1641
    ISSN (online) 1531-6971
    ISSN 1070-5287 ; 1078-1641
    DOI 10.1097/MCP.0000000000001053
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Nonpharmacological interventions in COPD.

    Janssens, Wim / Verleden, Geert M

    European respiratory review : an official journal of the European Respiratory Society

    2023  Volume 32, Issue 167

    MeSH term(s) Humans ; Pulmonary Emphysema ; Pulmonary Disease, Chronic Obstructive/diagnosis ; Pulmonary Disease, Chronic Obstructive/drug therapy ; Lung Transplantation
    Language English
    Publishing date 2023-03-22
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 1077620-5
    ISSN 1600-0617 ; 0905-9180
    ISSN (online) 1600-0617
    ISSN 0905-9180
    DOI 10.1183/16000617.0028-2023
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    Zs.A 3265: Show issues Location:
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  3. Article ; Online: Lung transplantation for COPD/pulmonary emphysema.

    Verleden, Geert M / Gottlieb, Jens

    European respiratory review : an official journal of the European Respiratory Society

    2023  Volume 32, Issue 167

    Abstract: COPD and α-1 antitrypsin deficiency emphysema remain one of the major indications for lung transplantation. If all other treatment possibilities are exhausted or not possible (including rehabilitation, oxygen therapy, noninvasive ventilation, lung volume ...

    Abstract COPD and α-1 antitrypsin deficiency emphysema remain one of the major indications for lung transplantation. If all other treatment possibilities are exhausted or not possible (including rehabilitation, oxygen therapy, noninvasive ventilation, lung volume reduction), patients may qualify for lung transplantation. Strict selection criteria are implemented with a lot of relative and absolute contraindications. Because of an ongoing donor shortage, only a minority of endstage COPD patients will finally get transplanted. The procedure may involve a single or a double lung transplantation, dependent on the experience of the centre, the waiting list, the availability of donor lungs and the patient's risk-benefit ratio. In general, the life expectancy as well as the health-related quality of life after lung transplantation for COPD are usually increased, and may be somewhat better after double compared with single lung transplantation. Several specific complications can be encountered, such as the development of solid organ cancer and chronic lung allograft dysfunction, which develops in up to 50% of patients within 5 years of their transplant and has a major impact on long-term survival, because of the current inefficient treatment modalities.
    MeSH term(s) Humans ; Pulmonary Emphysema/diagnosis ; Pulmonary Emphysema/surgery ; Pulmonary Emphysema/complications ; Quality of Life ; Lung Transplantation ; Lung/surgery ; alpha 1-Antitrypsin Deficiency/diagnosis ; alpha 1-Antitrypsin Deficiency/surgery ; alpha 1-Antitrypsin Deficiency/complications
    Language English
    Publishing date 2023-03-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 1077620-5
    ISSN 1600-0617 ; 0905-9180
    ISSN (online) 1600-0617
    ISSN 0905-9180
    DOI 10.1183/16000617.0116-2022
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  4. Article ; Online: The role of tissue eosinophils after lung transplantation: back into business?

    Verleden, Geert M

    Transplant international : official journal of the European Society for Organ Transplantation

    2020  Volume 34, Issue 1, Page(s) 59–61

    MeSH term(s) Eosinophils ; Humans ; Lung ; Lung Transplantation
    Language English
    Publishing date 2020-10-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 639435-8
    ISSN 1432-2277 ; 0934-0874
    ISSN (online) 1432-2277
    ISSN 0934-0874
    DOI 10.1111/tri.13774
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  5. Article ; Online: Novel biomarkers of chronic lung allograft dysfunction: is there anything reliable?

    Verleden, Stijn E / Verleden, Geert M

    Current opinion in organ transplantation

    2021  Volume 27, Issue 1, Page(s) 1–6

    Abstract: Purpose of review: Chronic lung allograft dysfunction (CLAD) remains a major barrier preventing long-term survival following lung transplantation. As our clinical knowledge regarding its definition and presentation has significantly improved over the ... ...

    Abstract Purpose of review: Chronic lung allograft dysfunction (CLAD) remains a major barrier preventing long-term survival following lung transplantation. As our clinical knowledge regarding its definition and presentation has significantly improved over the last years, adequate biomarkers to predict development of CLAD, phenotype of CLAD or prognosis post-CLAD diagnosis are definitely needed.
    Recent findings: Radiological and physiological markers are gradually entering routine clinical practice. In-depth investigation of biological samples including broncho-alveolar lavage, biopsy and serum has generated potential biomarkers involved in fibrogenesis, airway injury and inflammation but none of these are universally accepted or implemented although progress has been made, specifically regarding donor-derived cell-free DNA and donor-specific antibodies.
    Summary: Although a lot of promising biomarkers have been put forward, a very limited number has made it to routine clinical practice. Nevertheless, a biomarker that leads to earlier detection or more adequate disease phenotyping would advance the field enormously.
    MeSH term(s) Allografts ; Biomarkers ; Chronic Disease ; Humans ; Lung ; Lung Transplantation/adverse effects ; Transplantation, Homologous
    Chemical Substances Biomarkers
    Language English
    Publishing date 2021-12-23
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1390429-2
    ISSN 1531-7013 ; 1087-2418
    ISSN (online) 1531-7013
    ISSN 1087-2418
    DOI 10.1097/MOT.0000000000000944
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  6. Book: Pulmonary manifestations of systemic diseases

    Verleden, Geert M.

    (European respiratory monograph ; 34)

    2005  

    Author's details ed. by G. M. Verleden
    Series title European respiratory monograph ; 34
    Collection
    Language English
    Size VIII, 306 S. : Ill., graph. Darst.
    Publisher European Respiratory Soc. Journals
    Publishing place Sheffield, UK
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT015360918
    ISBN 1-904097-39-1 ; 1-904097-43-X ; 978-1-904097-39-6 ; 978-1-904097-43-3
    Database Catalogue ZB MED Medicine, Health

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  7. Book: Surgery for non-neoplastic disorders of the chest

    Verleden, Geert M.

    a clinical update

    (European respiratory monograph ; 29)

    2004  

    Author's details ed. by G. M. Verleden
    Series title European respiratory monograph ; 29
    Collection
    Language English
    Size 245 S. : Ill., graph. Darst.
    Publisher European Respiratory Soc. Journals
    Publishing place Sheffield, UK
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT015359736
    ISBN 1-904097-33-2 ; 978-1-904097-33-4
    Database Catalogue ZB MED Medicine, Health

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  8. Article ; Online: Living-donor lobar lung transplantation for pulmonary hypertension: living on the edge?

    Van Raemdonck, Dirk / Vos, Robin / Verleden, Geert M / Ceulemans, Laurens J

    European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery

    2023  Volume 63, Issue 4

    MeSH term(s) Humans ; Hypertension, Pulmonary/surgery ; Living Donors ; Lung Transplantation ; Lung
    Language English
    Publishing date 2023-03-23
    Publishing country Germany
    Document type Journal Article ; Comment
    ZDB-ID 639293-3
    ISSN 1873-734X ; 1010-7940 ; 1567-4258
    ISSN (online) 1873-734X
    ISSN 1010-7940 ; 1567-4258
    DOI 10.1093/ejcts/ezad097
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    Zs.A 2303: Show issues Location:
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  9. Article ; Online: Chronic lung allograft dysfunction and restrictive allograft syndrome: are phenotypes robust and helpful?

    Verleden, Geert M / Godinas, Laurent / Vos, Robin / Verleden, Stijn E

    Current opinion in organ transplantation

    2022  Volume 27, Issue 3, Page(s) 211–216

    Abstract: Purpose of review: New chronic lung allograft dysfunction (CLAD) consensus documents were published in 2019, defining four phenotypes; bronchiolitis obliterans syndrome, restrictive allograft syndrome, mixed and undefined. Clearly, validation of these ... ...

    Abstract Purpose of review: New chronic lung allograft dysfunction (CLAD) consensus documents were published in 2019, defining four phenotypes; bronchiolitis obliterans syndrome, restrictive allograft syndrome, mixed and undefined. Clearly, validation of these guidelines in a real life cohort is critical.
    Recent findings: Indeed, validation has been performed recently, both after bilateral lung transplantation (LTx) and after single LTx illustrating that precise phenotyping based on pulmonary function alone can be difficult. Undertaking regular chest computed tomography scanning does appear very helpful in establishing the prognosis of the patients with CLAD.
    Summary: Pulmonary function changes may not always identify the exact phenotype of CLAD and we provide further evidence for the important role of chest imaging at diagnosis and during the follow-up of patients with CLAD.
    MeSH term(s) Allografts ; Bronchiolitis Obliterans/diagnostic imaging ; Bronchiolitis Obliterans/etiology ; Graft vs Host Disease ; Humans ; Lung/diagnostic imaging ; Lung Transplantation/adverse effects ; Lung Transplantation/methods ; Phenotype
    Language English
    Publishing date 2022-05-30
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1390429-2
    ISSN 1531-7013 ; 1087-2418
    ISSN (online) 1531-7013
    ISSN 1087-2418
    DOI 10.1097/MOT.0000000000000962
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  10. Article ; Online: Interalveolar pore morphology in (pre-)COPD stages and associations with small airways.

    Verleden, Stijn E / Lapperre, Therese S / Snoeckx, Annemiek / Wen, Wen / Yogeswaran, Suresh K / Verleden, Geert M / Verplancke, Veronique / Wener, Reinier R L / Koljenovic, Senada / Peeters, Dieter J E / Hendriks, Jeroen M H

    The European respiratory journal

    2024  Volume 63, Issue 2

    MeSH term(s) Humans ; Pulmonary Disease, Chronic Obstructive
    Language English
    Publishing date 2024-02-29
    Publishing country England
    Document type Letter
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.02263-2023
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    Zs.MO 292: Show issues

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